Protein Information

General Information of the Protein

Protein ID	PT01070
Protein Name	C-C chemokine receptor type 1
Secondarily Protein Name	HM145 LD78 receptor Macrophage inflammatory protein 1-alpha receptor RANTES-R
Gene Name	CCR1
Secondarily Gene Name	CMKBR1 CMKR1 SCYAR1
Sequence	METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Chemokine receptor > CC chemokine receptor
Function	Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Show/Hide
Uniprot ID	Primary ID: P32246 Secondarily ID: Q86VA9 Show/Hide
HGNC ID	HGNC:1602
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0131315 Compound Info	1-((E)-1-Cyclooct-1-enyl)methyl-4-[(2,7-dichloro-9H-xanthene-9-carbonyl)-amino]-1-ethyl-piperidinium; iodide Show/Hide	C30H37Cl2IN2O2	1
1	IC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0377804 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(3-hydroxy-propyl)-urea Show/Hide	C32H40ClN3O3	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0454737 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(2-dimethylamino-ethyl)-urea Show/Hide	C33H43ClN4O2	1
1	IC50 = 67 nM Bioactivity Info	TI LI LO TS
CP0434605 Compound Info	1-tert-Butyl-3-{5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-urea Show/Hide	C33H42ClN3O2	1
1	IC50 = 71 nM Bioactivity Info	TI LI LO TS
CP0528916 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-cyclohexylmethyl-urea Show/Hide	C36H46ClN3O2	1
1	IC50 = 125 nM Bioactivity Info	TI LI LO TS
CP0438433 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-pyridin-4-yl-urea Show/Hide	C34H37ClN4O2	1
1	IC50 = 167 nM Bioactivity Info	TI LI LO TS
CP0495894 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(4-hydroxy-butyl)-urea Show/Hide	C33H42ClN3O3	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0376961 Compound Info	2-(Benzothiazol-2-ylsulfanyl)-N-[1-(4-chloro-benzyl)-piperidin-4-yl]-acetamide Show/Hide	C21H22ClN3OS2	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0403530 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-[2-(4-fluoro-phenyl)-ethyl]-urea Show/Hide	C37H41ClFN3O2	1
1	IC50 = 295 nM Bioactivity Info	TI LI LO TS
CP0448851 Compound Info	1-(1-Benzyl-piperidin-4-yl)-3-{5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-urea Show/Hide	C41H49ClN4O2	1
1	IC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0373271 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(2-piperidin-1-yl-ethyl)-urea Show/Hide	C36H47ClN4O2	1
1	IC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0085008 Compound Info	2-(Benzothiazol-2-ylsulfanyl)-N-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-acetamide Show/Hide	C21H21Cl2N3OS2	1
1	IC50 = 450 nM Bioactivity Info	TI LI LO TS
CP0479827 Compound Info	4-(3-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-ureido)-piperidine-1-carboxylic acid methyl ester Show/Hide	C36H45ClN4O4	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0149004 Compound Info	5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,2-diphenylpentanenitrile Show/Hide	C28H29ClN2O	1
1	IC50 = 630 nM Bioactivity Info	TI LI LO TS
CP0522231 Compound Info	1-(5-Amino-4,4-diphenyl-pentyl)-4-(4-chloro-phenyl)-piperidin-4-ol Show/Hide	C28H33ClN2O	1
1	IC50 = 760 nM Bioactivity Info	TI LI LO TS
CP0438827 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(4-methoxy-phenyl)-urea Show/Hide	C36H40ClN3O3	1
1	IC50 = 780 nM Bioactivity Info	TI LI LO TS
CP0476971 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(4-trifluoromethyl-phenyl)-urea Show/Hide	C36H37ClF3N3O2	1
1	IC50 = 890 nM Bioactivity Info	TI LI LO TS
CP0377866 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(2,5-difluoro-phenyl)-urea Show/Hide	C35H36ClF2N3O2	1
1	IC50 = 1340 nM Bioactivity Info	TI LI LO TS
CP0395200 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-(3-trifluoromethyl-phenyl)-urea Show/Hide	C36H37ClF3N3O2	1
1	IC50 = 1410 nM Bioactivity Info	TI LI LO TS
CP0228253 Compound Info	2-(6-Amino-benzothiazol-2-ylsulfanyl)-N-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-acetamide Show/Hide	C21H22Cl2N4OS2	1
1	IC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0431303 Compound Info	N-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-2-[(6-ethoxy-1,3-benzothiazol-2-yl)sulfanyl]acetamide Show/Hide	C23H25Cl2N3O2S2	1
1	IC50 = 3600 nM Bioactivity Info	TI LI LO TS
CP0499483 Compound Info	2-(Benzothiazol-2-ylsulfanyl)-N-(1-benzyl-piperidin-3-ylmethyl)-acetamide Show/Hide	C22H25N3OS2	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS
CP0393456 Compound Info	2-(Benzothiazol-2-ylsulfanyl)-N-(1-benzyl-piperidin-4-yl)-acetamide Show/Hide	C21H23N3OS2	1
1	IC50 = 7100 nM Bioactivity Info	TI LI LO TS
CP0430863 Compound Info	2-(Benzothiazol-2-ylsulfanyl)-N-[1-(3-chloro-benzyl)-piperidin-4-yl]-acetamide Show/Hide	C21H22ClN3OS2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0515799 Compound Info	2-{[1-(3,4-Dichloro-benzyl)-piperidin-4-ylcarbamoyl]-methylsulfanyl}-benzothiazole-6-carboxylic acid ethyl ester Show/Hide	C24H25Cl2N3O3S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0376365 Compound Info	1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(4-methoxy-phenyl)-urea Show/Hide	C27H31N3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0380249 Compound Info	1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(1H-indazol-6-yl)-urea Show/Hide	C27H29N5O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0383417 Compound Info	1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(3-methoxy-phenyl)-urea Show/Hide	C27H31N3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0389821 Compound Info	1-{2-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-phenyl}-3-(3-cyano-phenyl)-urea Show/Hide	C28H30N4O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0402897 Compound Info	1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(3-hydroxy-propyl)-urea Show/Hide	C23H31N3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0405256 Compound Info	1-Benzyl-3-[2-(4-benzyl-piperidin-1-ylmethyl)-phenyl]-urea Show/Hide	C27H31N3O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0438432 Compound Info	1-{2-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-ethyl]-phenyl}-3-(3-cyano-phenyl)-urea Show/Hide	C28H30N4O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0438500 Compound Info	1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-phenyl-urea Show/Hide	C26H29N3O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0448842 Compound Info	1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(1H-indazol-5-yl)-urea Show/Hide	C27H29N5O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0448903 Compound Info	1-{2-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-ethyl]-phenyl}-3-(2,5-difluoro-phenyl)-urea Show/Hide	C27H29F2N3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0461057 Compound Info	1-{2-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-ethyl]-phenyl}-3-(3-methoxy-phenyl)-urea Show/Hide	C28H33N3O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0463755 Compound Info	1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(3-cyano-phenyl)-urea Show/Hide	C27H28N4O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0493942 Compound Info	1-{2-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-phenyl}-3-(3-methoxy-phenyl)-urea Show/Hide	C28H33N3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0871032 Compound Info	CENICRIVIROC MESYLATE Show/Hide	C42H56N4O7S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0086294 Compound Info	4-[4-[4-[[5-(trifluoromethyl)pyridin-2-yl]amino]cyclohexyl]sulfonylphenyl]pyridine-2-carboxamide Show/Hide	C24H23F3N4O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0396564 Compound Info	6-[[1-(4-methylphenyl)sulfonylpiperidin-4-yl]amino]pyridine-3-carbonitrile Show/Hide	C18H20N4O2S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0416486 Compound Info	6-[[1-(4-phenylphenyl)sulfonylpiperidin-4-yl]amino]pyridine-3-carbonitrile Show/Hide	C23H22N4O2S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0416487 Compound Info	5-[4-[4-[[5-(trifluoromethyl)pyridin-2-yl]amino]cyclohexyl]sulfonylphenyl]pyridine-2-carboxamide Show/Hide	C24H23F3N4O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0416488 Compound Info	4-[4-[4-[[5-(trifluoromethyl)pyridin-2-yl]amino]cyclohexyl]sulfonylphenyl]benzamide Show/Hide	C25H24F3N3O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0457807 Compound Info	4-[4-[4-[[5-(trifluoromethyl)pyridin-2-yl]amino]cyclohexyl]sulfonylphenyl]benzonitrile Show/Hide	C25H22F3N3O2S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0218739 Compound Info	4-Benzyl-1-(4-phenyl-butyl)-piperidine Show/Hide	C22H29N	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0268787 Compound Info	4-Benzyl-1-phenethyl-piperidine Show/Hide	C20H25N	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0372694 Compound Info	5-(4-Benzyl-piperidin-1-yl)-2,2-diphenyl-pentanenitrile Show/Hide	C29H32N2	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0374740 Compound Info	5-(4-Benzyl-piperazin-1-yl)-2,2-diphenyl-pentanenitrile Show/Hide	C28H31N3	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0424962 Compound Info	1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(2,5-difluoro-phenyl)-urea Show/Hide	C26H27F2N3O	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0460734 Compound Info	1-[2-(4-Benzyl-piperidin-1-ylmethyl)-phenyl]-3-(2-piperidin-1-yl-ethyl)-urea Show/Hide	C27H38N4O	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0465469 Compound Info	1-(1-Benzyl-piperidin-4-yl)-3-[2-(4-benzyl-piperidin-1-ylmethyl)-phenyl]-urea Show/Hide	C32H40N4O	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0545278 Compound Info	1,4-Dibenzyl-piperidine Show/Hide	C19H23N	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0374727 Compound Info	1-Benzyl-3-{5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-urea Show/Hide	C36H40ClN3O2	1
1	IC50 < 780 nM Bioactivity Info	TI LI LO TS
CP0383392 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-methyl-urea Show/Hide	C30H36ClN3O2	1
1	IC50 < 780 nM Bioactivity Info	TI LI LO TS
CP0424944 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-phenyl-urea Show/Hide	C35H38ClN3O2	1
1	IC50 < 780 nM Bioactivity Info	TI LI LO TS
CP0479823 Compound Info	1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-isopropyl-urea Show/Hide	C32H40ClN3O2	1
1	IC50 < 780 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000752 , PBMC iPSC #1

Cell Line Info

Cell Line ID: CL000040 , THP-1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0533941 Compound Info	US8536198, 106 Show/Hide	C26H40ClN3O4	1
1	IC50 = 0.7 nM
CP0101580 Compound Info	2,7-dichloro-N-[1-[[(1E)-cycloocten-1-yl]methyl]-1-ethylpiperidin-1-ium-4-yl]-9H-xanthene-9-carboxamide Show/Hide	C30H37Cl2N2O2+	1
1	IC50 = 0.9 nM
CP0218244 Compound Info	US8536198, 80 Show/Hide	C26H32ClN3O5S	1
1	IC50 = 1 nM
CP0324165 Compound Info	US8536198, 86 Show/Hide	C25H35ClN2O3	1
1	IC50 = 1.3 nM
CP0070160 Compound Info	N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]cyclopentanecarboxamide Show/Hide	C24H35ClN2O3	2
1	IC50 = 1.4 nM
2	IC50 = 2.5 nM
CP0576017 Compound Info	US8536198, 84 Show/Hide	C25H35ClN2O4	1
1	IC50 = 1.5 nM
CP0188479 Compound Info	US8536198, 85 Show/Hide	C27H31ClN2O5	1
1	IC50 = 1.6 nM
CP0544478 Compound Info	US8536198, 89 Show/Hide	C27H32ClN3O4	1
1	IC50 = 1.8 nM
CP0336179 Compound Info	N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-methylbutanamide Show/Hide	C23H35ClN2O3	2
1	IC50 = 1.9 nM
2	IC50 = 2.9 nM
CP0530142 Compound Info	US8536198, 2 Show/Hide	C27H33ClN2O3	1
1	IC50 = 2.1 nM
CP0053909 Compound Info	1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-hydroxy-2-methylpropyl)urea Show/Hide	C23H36ClN3O4	3
1	IC50 = 4.2 nM
2	IC50 = 25 nM
3	IC50 = 42 nM
CP0087963 Compound Info	N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-hydroxy-3-methylbutanamide Show/Hide	C23H35ClN2O4	1
1	IC50 = 5.2 nM
CP0031036 Compound Info	1-(4-fluorophenyl)-N-[1-(2-methylsulfonylpyridin-4-yl)cyclopropyl]pyrazolo[3,4-c]pyridine-4-carboxamide Show/Hide	C22H18FN5O3S	5
1	IC50 = 5.4 nM
2	IC50 ~ 2.4 nM
3	IC50 ~ 5.4 nM
4	IC50 ~ 9 nM
5	IC50 ~ 24 nM
CP0365664 Compound Info	US8536198, 9 Show/Hide	C26H32ClN3O3	1
1	IC50 = 11.5 nM
CP0328895 Compound Info	US8536198, 7 Show/Hide	C24H35ClN2O4	1
1	IC50 = 12.1 nM
CP0533942 Compound Info	US8536198, 83 Show/Hide	C25H35ClN2O4	1
1	IC50 = 14 nM
CP0346252 Compound Info	US8536198, 76 Show/Hide	C24H36ClN3O4	1
1	IC50 = 14.6 nM
CP0561610 Compound Info	US8536198, 60 Show/Hide	C29H37ClN2O3	1
1	IC50 = 15.7 nM
CP0390696 Compound Info	US8536198, 11 Show/Hide	C27H31ClN2O4	1
1	IC50 = 17.2 nM
CP0443758 Compound Info	US8536198, 35 Show/Hide	C27H34ClN3O3	1
1	IC50 = 18.5 nM
CP0263817 Compound Info	US8536198, 57 Show/Hide	C25H31ClN4O3	1
1	IC50 = 18.7 nM
CP0087964 Compound Info	N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide Show/Hide	C23H27ClN2O2	2
1	IC50 = 30 nM
2	IC50 = 78 nM
CP0215327 Compound Info	(R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea hydrochloride Show/Hide	C21H24ClFN4O3	3
1	IC50 = 31 nM
2	Kd = 1 nM
3	Ki = 1 nM
CP0149004 Compound Info	5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,2-diphenylpentanenitrile Show/Hide	C28H29ClN2O	1
1	IC50 = 48 nM
CP0102510 Compound Info	9H-Xanthene-9-carboxylic acid (1-cyclooctylmethyl-piperidin-4-yl)-amide Show/Hide	C28H36N2O2	1
1	IC50 = 140 nM
CP0139362 Compound Info	9H-Xanthene-9-carboxylic acid (1-cyclohexylmethyl-piperidin-4-yl)-amide Show/Hide	C26H32N2O2	1
1	IC50 = 200 nM
CP0085008 Compound Info	2-(Benzothiazol-2-ylsulfanyl)-N-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-acetamide Show/Hide	C21H21Cl2N3OS2	1
1	IC50 = 450 nM
CP0292246 Compound Info	9H-Xanthene-9-carboxylic acid (1-hexyl-piperidin-4-yl)-amide Show/Hide	C25H32N2O2	1
1	IC50 = 510 nM
CP0533943 Compound Info	US8536198, 68 Show/Hide	C28H35ClN2O4	1
1	IC50 = 580.6 nM
CP0324163 Compound Info	US8536198, 61 Show/Hide	C22H31ClN2O4	1
1	IC50 = 767.5 nM
CP0286357 Compound Info	9H-Xanthene-9-carboxylic acid (1-cyclodecylmethyl-piperidin-4-yl)-amide Show/Hide	C30H40N2O2	1
1	IC50 = 800 nM
CP0317914 Compound Info	US8536198, 104 Show/Hide	C28H35ClN2O3	1
1	IC50 = 818 nM
CP0544479 Compound Info	US8536198, 67 Show/Hide	C28H35ClN2O4	1
1	IC50 = 857.8 nM
CP0354161 Compound Info	US8536198, 58 Show/Hide	C28H42ClN3O3	1
1	IC50 = 931.8 nM
CP0140224 Compound Info	US8536198, 41 Show/Hide	C22H31ClN2O4	1
1	IC50 = 996.7 nM
CP0544574 Compound Info	US8536198, 10 Show/Hide	C29H35ClN2O5	1
1	IC50 = 1065 nM
CP0059738 Compound Info	9H-Xanthene-9-carboxylic acid (1-benzyl-piperidin-4-yl)-amide Show/Hide	C26H26N2O2	1
1	IC50 > 10000 nM
CP0301810 Compound Info	9H-Xanthene-9-carboxylic acid (1-naphthalen-2-ylmethyl-piperidin-4-yl)-amide Show/Hide	C30H28N2O2	1
1	IC50 > 10000 nM
CP0145810 Compound Info	N-[(2S,3S,5R)-5-carbamoyl-1-(3-fluorophenyl)-3,8-dihydroxy-8-methylnonan-2-yl]quinoxaline-2-carboxamide Show/Hide	C26H31FN4O4	1
1	Ki = 74 nM

Clinical Information about the Protein

Target 1 ( C-C chemokine receptor type 1 (CCR1) )

Target Type	Clinical trial Target
Disease	2 Target-related Diseases				2
1	Rheumatoid arthritis [ICD-11: FA20]
2	Autoimmune diabetes [ICD-11: 5A10]
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	BMS-817399	Drug Info	Phase 2	Rheumatoid arthritis
2	CCX-354	Drug Info	Phase 2	Autoimmune diabetes

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT03048	C-C chemokine receptor type 1	Mus musculus, Mouse	Protein Info
PT04322	Probable C-C chemokine receptor type 3	Mus musculus, Mouse	Protein Info
PT05277	C-C chemokine receptor type 3	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han