Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,2-diphenylpentanenitrile
    Show/Hide
 PubChem ID
CID: 9889700
SID: 14857342
Canonical SMILES
OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)cc1
    Show/Hide
Compound Formula C28H29ClN2O
Compound Structure
Protein Name
 Protein Info 
C-C chemokine receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Uniprot ID
P32246
Gene Name
CCR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
2
Ki = 52 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 48 nM