General Information of the Protein
Protein ID
PT04322
Protein Name
Probable C-C chemokine receptor type 3
Secondarily
Protein Name
Macrophage inflammatory protein 1-alpha receptor-like 2
Gene Name
CCR3
Secondarily
Gene Name
Cmkbr1l2
Cmkbr3
Sequence
MAFNTDEIKTVVESFETTPYEYEWAPPCEKVRIKELGSWLLPPLYSLVFIIGLLGNMMVVLILIKYRKLQIMTNIYLFNLAISDLLFLFTVPFWIHYVLWNEWGFGHYMCKMLSGFYYLALYSEIFFIILLTIDRYLAIVHAVFALRARTVTFATITSIITWGLAGLAALPEFIFHESQDSFGEFSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIRLIFVVMIVFFIFWTPYNLVLLFSAFHSTFLETSCQQSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKHLRLFFHRNVAVYLGKYIPFLPGEKMERTSSVSPSTGEQEISVVF
    Show/Hide
Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Function
Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1.
    Show/Hide
Uniprot ID
Primary ID:
P51678

Secondarily ID:
Q8K3M7
    Show/Hide
Ensembl ID
ENSG00000183625
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0208643
 Compound Info 
1-((3S,4S)-4-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)-1-acetylpiperidin-3-yl)-3-(5-acetyl-4-methylthiazol-2-yl)urea
   Show/Hide
C27H36FN5O3S
  1
1
IC50 = 3.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0035037
 Compound Info 
1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-acetylphenyl)urea
   Show/Hide
C28H36FN3O2
  1
1
IC50 = 54 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0351715
 Compound Info 
2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-1H-indole
   Show/Hide
C24H28F2N2S
  1
1
Ki = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0410593
 Compound Info 
[6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-1H-indol-2-yl]methanol
   Show/Hide
C23H26F2N2OS
  1
1
Ki = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0864098
 Compound Info 
rac-3-(1-(3-(4-fluorophenylthio)propyl)piperidin-4-yl)-2-(1-methoxyethyl)-1H-indole
   Show/Hide
C25H31FN2OS
  1
1
Ki = 24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0532718
 Compound Info 
6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-2-methyl-1H-indole
   Show/Hide
C23H26F2N2S
  1
1
Ki = 37 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380930
 Compound Info 
2-ethyl-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-6-methyl-1H-indole
   Show/Hide
C25H31FN2S
  1
1
Ki = 48 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0857596
 Compound Info 
rac-6-fluoro-3-(1-(3-(4-fluorophenylthio)propyl)piperidin-4-yl)-2-(1-methoxyethyl)-1H-indole
   Show/Hide
C25H30F2N2OS
  1
1
Ki = 52 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0536641
 Compound Info 
2-ethyl-6-fluoro-3-[1-[3-(4-methylphenyl)sulfanylpropyl]piperidin-4-yl]-1H-indole
   Show/Hide
C25H31FN2S
  1
1
Ki = 62 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0687892
 Compound Info 
(R)-1-(1-(3,4-dichlorophenyl)-4-(4-(2-ethyl-6-fluoro-1H-indol-3-yl)piperidin-1-yl)butan-2-yl)-3-ethylurea
   Show/Hide
C28H35Cl2FN4O
  1
1
Ki = 64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474282
 Compound Info 
2-ethyl-6-fluoro-3-[1-(3-phenylsulfanylpropyl)piperidin-4-yl]-1H-indole
   Show/Hide
C24H29FN2S
  1
1
Ki = 65 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0086680
 Compound Info 
2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-1-[4-(2H-tetrazol-5-yl)phenyl]indole
   Show/Hide
C31H32F2N6S
  1
1
Ki = 72 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0400264
 Compound Info 
2-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]acetic acid
   Show/Hide
C26H30F2N2O2S
  1
1
Ki = 74 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380926
 Compound Info 
2-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-4-carboxylic acid
   Show/Hide
C30H31F2N3O2S
  1
1
Ki = 79 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396924
 Compound Info 
2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-1-methylindole
   Show/Hide
C25H30F2N2S
  1
1
Ki = 85 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474284
 Compound Info 
[3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-1H-indol-2-yl]methanol
   Show/Hide
C23H27FN2OS
  1
1
Ki = 92 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0410592
 Compound Info 
ethyl 2-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-4-carboxylate
   Show/Hide
C32H35F2N3O2S
  1
1
Ki = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474285
 Compound Info 
6-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-2-carboxylic acid
   Show/Hide
C30H31F2N3O2S
  1
1
Ki = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0086998
 Compound Info 
4-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]benzoic acid
   Show/Hide
C31H32F2N2O2S
  1
1
Ki = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0508511
 Compound Info 
2-ethyl-6-fluoro-3-[1-[3-(4-methoxyphenyl)sulfanylpropyl]piperidin-4-yl]-1H-indole
   Show/Hide
C25H31FN2OS
  1
1
Ki = 130 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0536673
 Compound Info 
4-[3-[4-(2-ethyl-6-fluoro-1H-indol-3-yl)piperidin-1-yl]propylsulfanyl]phenol
   Show/Hide
C24H29FN2OS
  1
1
Ki = 210 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396925
 Compound Info 
ethyl 2-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]acetate
   Show/Hide
C28H34F2N2O2S
  1
1
Ki = 230 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396928
 Compound Info 
6-[3-[1-[(3R)-4-(3,4-dichlorophenyl)-3-(ethylcarbamoylamino)butyl]piperidin-4-yl]-2-ethyl-6-fluoroindol-1-yl]pyridine-3-carboxylic acid
   Show/Hide
C34H38Cl2FN5O3
  1
1
Ki = 270 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474280
 Compound Info 
2-ethyl-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-1H-indol-6-ol
   Show/Hide
C24H29FN2OS
  1
1
Ki = 370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474281
 Compound Info 
2-ethyl-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-1H-indole-6-carboxamide
   Show/Hide
C25H30FN3OS
  1
1
Ki = 380 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0400263
 Compound Info 
2-ethyl-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-1H-indole
   Show/Hide
C24H29FN2S
  1
1
Ki = 400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380929
 Compound Info 
ethyl 6-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-2-carboxylate
   Show/Hide
C32H35F2N3O2S
  1
1
Ki = 410 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0086677
 Compound Info 
6-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-3-carboxylic acid
   Show/Hide
C30H31F2N3O2S
  1
1
Ki = 630 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433174
 Compound Info 
2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]-1-phenylindole
   Show/Hide
C30H32F2N2S
  1
1
Ki = 650 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396927
 Compound Info 
methyl 6-[3-[1-[(3R)-4-(3,4-dichlorophenyl)-3-(ethylcarbamoylamino)butyl]piperidin-4-yl]-2-ethyl-6-fluoroindol-1-yl]pyridine-3-carboxylate
   Show/Hide
C35H40Cl2FN5O3
  1
1
Ki = 660 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396929
 Compound Info 
ethyl 6-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-3-carboxylate
   Show/Hide
C32H35F2N3O2S
  1
1
Ki = 740 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474283
 Compound Info 
4-[3-[4-(2-ethyl-6-fluoro-1H-indol-3-yl)piperidin-1-yl]propylsulfanyl]benzamide
   Show/Hide
C25H30FN3OS
  1
1
Ki = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0234704
 Compound Info 
ethyl 4-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]benzoate
   Show/Hide
C33H36F2N2O2S
  1
1
Ki = 2600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT05277 C-C chemokine receptor type 3 Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT01070 C-C chemokine receptor type 1 Homo sapiens, Human
 Protein Info 
PT03048 C-C chemokine receptor type 1 Mus musculus, Mouse
 Protein Info