General Information of the Protein
Protein ID
PT03048
Protein Name
C-C chemokine receptor type 1
Secondarily
Protein Name
Macrophage inflammatory protein 1-alpha receptor
RANTES-R
Gene Name
CCR1
Secondarily
Gene Name
Cmkbr1
Sequence
MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTHRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Function
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
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Uniprot ID
Primary ID:
P51675

Secondarily ID:
Q6ZWR7
Q91VP9
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0448801
 Compound Info 
N-[5-chloro-2-[(E)-3-[3-[(4-fluorophenyl)methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-3-oxoprop-1-enyl]-4-methoxyphenyl]acetamide
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C25H27ClFN3O3
  1
1
IC50 = 4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378208
 Compound Info 
N-[5-chloro-2-[(E)-3-[3-[(4-fluorophenyl)methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-3-oxoprop-1-enyl]phenyl]-2-(dimethylamino)acetamide
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C26H30ClFN4O2
  1
1
IC50 = 40 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378011
 Compound Info 
N-[6-[(E)-3-[3-[(4-fluorophenyl)methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-3-oxoprop-1-enyl]quinolin-7-yl]acetamide
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C27H27FN4O2
  1
1
IC50 = 50 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378207
 Compound Info 
(R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-5-chloro-4-methoxyphenyl)acetamide
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C24H27ClFN3O3
  1
1
IC50 = 50 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378206
 Compound Info 
(R)-1-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-5-chlorophenyl)urea
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C22H24ClFN4O2
  1
1
IC50 = 300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0445798
 Compound Info 
N-[5-chloro-2-[(E)-3-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamide
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C22H23ClFN3O2
  1
1
IC50 = 448 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0428270
 Compound Info 
(R)-N-(3-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)naphthalen-2-yl)acetamide
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C27H28FN3O2
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0050382
 Compound Info 
(R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-5-chlorophenyl)acetamide
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C23H25ClFN3O2
  1
1
IC50 = 580 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0428267
 Compound Info 
N-[5-chloro-2-[(E)-3-[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamide
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C24H27ClFN3O2
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0442404
 Compound Info 
(R)-N-(6-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)quinolin-7-yl)acetamide
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C26H27FN4O2
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0853916
 Compound Info 
BX 471
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C21H25Cl2FN4O3
  1
1
IC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378007
 Compound Info 
(R)-N-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethylamino)-5-chlorophenyl)acetamide
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C22H26ClFN4O2
  1
1
IC50 = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378209
 Compound Info 
(R)-N-(2-(1-(4-fluorobenzyl)-3-methylpiperazine-4-carbonyl)-5-chloro-1H-indol-7-yl)acetamide
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C23H24ClFN4O2
  1
1
IC50 = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0428291
 Compound Info 
(R)-N-(2-(1-(4-fluorobenzyl)-3-methylpiperazine-4-carbonyl)-5-chlorobenzofuran-7-yl)acetamide
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C23H23ClFN3O3
  1
1
IC50 = 4800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392271
 Compound Info 
N-[5-chloro-2-[(E)-3-[(2S,5R)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamide
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C24H27ClFN3O2
  1
1
IC50 = 23000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000534 , WEHI-274.1
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0131315
 Compound Info 
1-((E)-1-Cyclooct-1-enyl)methyl-4-[(2,7-dichloro-9H-xanthene-9-carbonyl)-amino]-1-ethyl-piperidinium; iodide
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C30H37Cl2IN2O2
  1
1 IC50 = 5.8 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01070 C-C chemokine receptor type 1 Homo sapiens, Human
 Protein Info 
PT04322 Probable C-C chemokine receptor type 3 Mus musculus, Mouse
 Protein Info 
PT05277 C-C chemokine receptor type 3 Rattus norvegicus, Rat
 Protein Info