N-[4-fluoro-2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]phenyl]acetamide

N-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]acetamide

N-[2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]acetamide

1-cyclopropyl-3-[2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]urea

N-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-fluorophenyl]acetamide

N-[2-[(2S)-2-amino-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propoxy]-4-hydroxyphenyl]acetamide

1-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-3-cyclopropylurea

N-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-methoxyphenyl]acetamide

N-[2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]phenyl]acetamide

N-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]phenyl]acetamide

1-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-3-methylurea

N-[2-[(2S)-2-amino-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propoxy]-4-hydroxyphenyl]acetamide

N-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]phenyl]pyrrolidine-1-carboxamide

1-[5-chloro-2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-3-cyclopropylurea

1-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-methoxyphenyl]-3-cyclopropylurea

1-cyclopropyl-3-[2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-methoxyphenyl]urea

[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]urea

1-[2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]-3-methylurea

1-[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-methoxyphenyl]-3-methylurea

(R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea hydrochloride

[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-fluorophenyl]urea

N-[2-[(2S)-2-amino-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propoxy]-4-methoxyphenyl]acetamide

[2-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]phenyl]urea

5-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4H-1,4-benzoxazin-3-one

N-[2-[(2S)-2-amino-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propoxy]-4-methoxyphenyl]acetamide

(R)-N2-(4-Chlorobenzyl)-N1-[2,6-dimethyl-4-(trifluoromethyl)phenyl]-N2-methylpyrrolidine-1,2-dicarboxamide

1-[2-[(2S)-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-methoxyphenyl]-3-methylurea

(R)-2-(4-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide

N-[2-[(2S)-2-amino-3-spiro[3H-1-benzofuran-2,4'-piperidine]-1'-ylpropoxy]-4-hydroxyphenyl]acetamide

(R)-2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide

(R)-N2-(4-Chlorobenzyl)-N1-[2-fluoro-4-(trifluoromethyl)phenyl]-N2-methylpyrrolidine-1,2-dicarboxamide

(R)-2-(1-(4-chlorobenzyl)-1H-1,2,4-triazol-5-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide

N-[2-[(2S)-2-amino-3-spiro[3H-1-benzofuran-2,4'-piperidine]-1'-ylpropoxy]-4-methoxyphenyl]acetamide

8-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one

8-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-1H-quinolin-2-one

(R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[2-methyl-4-(trifluoromethyl)phenyl]pyrrolidine-1,2-dicarboxamide

2-(1-(4-chlorobenzyl)-1H-imidazol-2-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide

(R)-2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide

5-[(2S)-2-amino-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propoxy]-4H-1,4-benzoxazin-3-one

(R)-N2-(4-Chlorobenzyl)-N1-[2-chloro-4-(trifluoromethyl)phenyl]-N2-methylpyrrolidine-1,2-dicarboxamide

(1S)-N1-(4-chlorobenzyl)-N1-methyl-N2-(4-(trifluoromethyl)phenyl)cyclopentane-1,2-dicarboxamide

(2S)-1-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-3-[(2-methyl-1-benzofuran-4-yl)oxy]propan-2-ol

(R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

(R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-ethylpyrrolidine-1,2-dicarboxamide

(R)-N2-(4-Chlorobenzyl)-N1-(4-methoxyphenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-butyronitrile

(R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-(2-hydroxyethyl)pyrrolidine-1,2-dicarboxamide

8-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-1H-quinazoline-2,4-dione

8-[(2S)-2-amino-3-(5-fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propoxy]-1H-quinolin-2-one

(R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-p-tolylpyrrolidine-1,2-dicarboxamide

4-(4-Chloro-phenyl)-1-(4-cyano-4-naphthalen-2-yl-butyl)-4-hydroxy-1-methyl-piperidinium iodide

(R)-N2-(4-Chlorobenzyl)-N1-(4-fluorophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

(R)-N2-(4-Chlorobenzyl)-N1-(4-cyanophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

(R)-2-(1-(4-chlorobenzyl)-3-methyl-1H-1,2,4-triazol-5-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide

(R)-N2-(4-Fluorobenzyl)-N1-(4-chlorophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

(2S)-1-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-3-[(2-methyl-1,3-benzothiazol-4-yl)oxy]propan-2-ol

(2S)-1-[(2-amino-1,3-benzothiazol-4-yl)oxy]-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propan-2-ol

6-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-hexanenitrile

4-(4-Chloro-phenyl)-1-(4,4-diphenyl-butyl)-4-hydroxy-1-methyl-piperidinium iodide

2-(3-Bromo-4-methoxy-phenyl)-5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-pentanenitrile

5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,2-diphenylpentanenitrile

(R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-(3-(trifluoromethyl)phenyl)pyrrolidine-1,2-dicarboxamide

5-{3-[4-(4-Fluoro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-5,11-dihydro-10-thia-dibenzo[a,d]cycloheptene-5-carbonitrile

2-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-2-phenyl-succinonitrile

11-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-5-methyl-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepine-11-carbonitrile

(R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-propylpyrrolidine-1,2-dicarboxamide

(R)-N2-(4-Chloro-3-methylbenzyl)-N1-(4-chlorophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

(2R)-N1-(4-Chlorophenyl)-N2-[1-(4-chlorophenyl)ethyl]-N2-methylpyrrolidine-1,2-dicarboxamide

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-phenyl-2-piperidin-1-yl-pentanenitrile

5-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-5H-dibenzo[a,d]cycloheptene-5-carbonitrile

7-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-heptanenitrile

(R)-N2-(4-Methylbenzyl)-N1-(4-chlorophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

2-{4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-cyano-butyl}-benzonitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-cyano-2-phenyl-pentanoic acid ethyl ester

5-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-5,11-dihydro-10-thia-dibenzo[a,d]cycloheptene-5-carbonitrile

4-(4-Chloro-phenyl)-1-(4-cyano-4-naphthalen-2-yl-butyl)-4-hydroxy-piperidinium iodide

11-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-6,11-dihydro-dibenzo[b,e]oxepine-11-carbonitrile

5-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-carbonitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(3-chloro-propyl)-2-phenyl-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-thiophen-2-yl-pentanenitrile

4-(4-Chloro-phenyl)-1-(4,4-diphenyl-butyl)-4-hydroxy-piperidinium iodide

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(3-hydroxy-phenyl)-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-thiophen-3-yl-pentanenitrile

1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylaminocarbonyl)oxime

4-[1-(4-Cyano-4,4-diphenyl-butyl)-4-hydroxy-piperidin-4-yl]-benzonitrile

(R)-N2-(4-Cyanobenzyl)-N1-(4-chlorophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

2-N-[(4-chlorophenyl)methyl]-2-N-methyl-1-N-[4-(trifluoromethyl)phenyl]piperidine-1,2-dicarboxamide

(S)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[4-(trifluoromethyl)phenyl]pyrrolidine-1,2-dicarboxamide

(R)-N2-(2-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-(2-hydroxyethyl)pyrrolidine-1,2-dicarboxamide

(R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)pyrrolidine-1,2-dicarboxamide

(R)-N2-(4-Methoxybenzyl)-N1-(4-chlorophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

(R)-N2-(4-Chloro-2-methylbenzyl)-N1-(4-chlorophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

(R)-N2-[4-(Trifluoromethyl)benzyl]-N1-(4-chlorophenyl)-N2-methylpyrrolidine-1,2-dicarboxamide

(R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[4-(trifluoromethyl)phenyl]azetidine-1,2-dicarboxamide

(R)-N2-(3-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-(2-hydroxyethyl)pyrrolidine-1,2-dicarboxamide

4-(4-Chloro-phenyl)-1-(4-cyano-4,4-diphenyl-butyl)-4-hydroxy-1-methyl-piperidinium iodide

1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-piperidin-4-yl-urea

5-{3-[4-(4-Bromo-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-5,11-dihydro-10-thia-dibenzo[a,d]cycloheptene-5-carbonitrile

9-{3-[4-(4-Bromo-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-9,10-dihydro-anthracene-9-carbonitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-cyano-2-phenyl-pentanoic acid methyl ester

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-phenyl-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-ethyl-2-phenyl-pentanenitrile

5-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile

5-[4-Hydroxy-4-(4-trifluoromethyl-phenyl)-piperidin-1-yl]-2,2-diphenyl-pentanenitrile

5-[3-(4-Hydroxy-4-o-tolyl-piperidin-1-yl)-propyl]-5,11-dihydro-10-thia-dibenzo[a,d]cycloheptene-5-carbonitrile

5-[3-(4-Hydroxy-4-phenyl-piperidin-1-yl)-propyl]-5,11-dihydro-10-thia-dibenzo[a,d]cycloheptene-5-carbonitrile

5-(4'-Hydroxy-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-yl)-2,2-diphenyl-pentanenitrile

5-{3-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-5,11-dihydro-10-thia-dibenzo[a,d]cycloheptene-5-carbonitrile

5-[4-Hydroxy-4-(4-iodo-phenyl)-piperidin-1-yl]-2,2-diphenyl-pentanenitrile

9-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-9H-xanthene-9-carbonitrile

1-(5-Amino-4,4-diphenyl-pentyl)-4-(4-chloro-phenyl)-piperidin-4-ol

2-(2-Chloro-phenyl)-5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-pentafluorophenyl-pentanenitrile

5-[4-Hydroxy-4-(4-methoxy-phenyl)-piperidin-1-yl]-2,2-diphenyl-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-methoxy-phenyl)-pentanenitrile

2-(2-Bromo-phenyl)-5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(2-fluoro-phenyl)-pentanenitrile

5-[4-(3-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-cyclohexyl-2-phenyl-pentanenitrile

5-[3-(4-Benzyl-4-hydroxy-piperidin-1-yl)-propyl]-5,11-dihydro-10-thia-dibenzo[a,d]cycloheptene-5-carbonitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanoic acid methyl ester

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(1-methyl-1H-pyrrol-2-yl)-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-methyl-2-phenyl-pentanenitrile

2-(4-Chloro-phenyl)-5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(3-nitro-phenyl)-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-fluoro-phenyl)-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-pyridin-2-yl-pentanenitrile

5-{3-[4-Hydroxy-4-(3-trifluoromethyl-phenyl)-piperidin-1-yl]-propyl}-5,11-dihydro-10-thia-dibenzo[a,d]cycloheptene-5-carbonitrile

5-(4-Hydroxy-4-naphthalen-2-yl-piperidin-1-yl)-2,2-diphenyl-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(2-hydroxy-phenyl)-pentanenitrile

5-(4'-Hydroxy-3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-yl)-2,2-diphenyl-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(3-phenoxy-phenyl)-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-pyridin-3-yl-pentanenitrile

5-(4-Hydroxy-4-thiophen-2-yl-piperidin-1-yl)-2,2-diphenyl-pentanenitrile

5-[4-(4-Dimethylamino-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanenitrile

9-[3-(4-Hydroxy-4-phenyl-piperidin-1-yl)-propyl]-9,10-dihydro-anthracene-9-carbonitrile

5-[4-(3,5-Dichloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanenitrile

5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-ethoxy-phenyl)-pentanenitrile

2-(4-Benzyloxy-phenyl)-5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-pentanenitrile

5-(4-Butyl-4-hydroxy-piperidin-1-yl)-2,2-diphenyl-pentanenitrile

5-[4-(hydroxymethyl)-4-phenylpiperidin-1-yl]-2,2-diphenylpentanenitrile