Brief Information of the Compound and Protein
Compound Name
11-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-5-methyl-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepine-11-carbonitrile
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PubChem ID
CID: 10649043
SID: 15680656
Canonical SMILES
CN1c2ccccc2C(CCCN2CCC(O)(CC2)c2ccc(Cl)cc2)(C#N)c2ccccc2C1=O
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Compound Formula C30H30ClN3O2
Compound Structure
Protein Name
C-C chemokine receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Uniprot ID
P32246
Gene Name
CCR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 3300 nM
   TI
   LI
   LO
   TS
2
Ki = 32 nM
   TI
   LI
   LO
   TS