General Information of the Compound
Compound ID
CP0463769
Compound Name
2-(4-Benzyloxy-phenyl)-5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-pentanenitrile
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Structure
Formula
C29H31ClN2O2
Molecular Weight
475.032
Canonical SMILES
OC1(CCN(CCCC(C#N)c2ccc(OCc3ccccc3)cc2)CC1)c1ccc(Cl)cc1
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InChI
InChI=1S/C29H31ClN2O2/c30-27-12-10-26(11-13-27)29(33)16-19-32(20-17-29)18-4-7-25(21-31)24-8-14-28(15-9-24)34-22-23-5-2-1-3-6-23/h1-3,5-6,8-15,25,33H,4,7,16-20,22H2
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InChIKey
MKNAGUCXNAHDEQ-UHFFFAOYSA-N
Physicochemical Property
logP
6.28998
Rotatable Bonds
9
Heavy Atom Count
34
Polar Areas
56.49
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10672205
SID: 15704974
ChEMBL ID
CHEMBL344499
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01070, C-C chemokine receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 3430 nM
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