General Information of the Compound
Compound ID
CP0531883
Compound Name
(R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-propylpyrrolidine-1,2-dicarboxamide
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Structure
Formula
C22H25Cl2N3O2
Molecular Weight
434.367
Canonical SMILES
CCCN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1
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InChI
InChI=1S/C22H25Cl2N3O2/c1-2-13-26(15-16-5-7-17(23)8-6-16)21(28)20-4-3-14-27(20)22(29)25-19-11-9-18(24)10-12-19/h5-12,20H,2-4,13-15H2,1H3,(H,25,29)/t20-/m1/s1
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InChIKey
GXSNTASJGADFMU-HXUWFJFHSA-N
Physicochemical Property
logP
5.4285
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
52.65
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25231299
SID: 57583223
ChEMBL ID
CHEMBL509457
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01070, C-C chemokine receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 3600 nM
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