General Information of the Compound
Compound ID
CP0467549
Compound Name
5-(4'-Hydroxy-3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-yl)-2,2-diphenyl-pentanenitrile
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Structure
Formula
C27H29N3O
Molecular Weight
411.549
Canonical SMILES
OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccccn1
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InChI
InChI=1S/C27H29N3O/c28-22-26(23-10-3-1-4-11-23,24-12-5-2-6-13-24)15-9-19-30-20-16-27(31,17-21-30)25-14-7-8-18-29-25/h1-8,10-14,18,31H,9,15-17,19-21H2
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InChIKey
NHNHEWYPECEYCE-UHFFFAOYSA-N
Physicochemical Property
logP
4.65508
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
60.15
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10525695
SID: 15551694
ChEMBL ID
CHEMBL358283
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01070, C-C chemokine receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 906 nM
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   LI
   LO
   TS