General Information of the Compound
Compound ID
CP0555838
Compound Name
(2S)-1-[(2-amino-1,3-benzothiazol-4-yl)oxy]-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propan-2-ol
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Structure
Formula
C22H24ClN3O3S
Molecular Weight
445.972
Canonical SMILES
Nc1nc2c(OC[C@@H](O)CN3CCC4(Cc5cc(Cl)ccc5O4)CC3)cccc2s1
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InChI
InChI=1S/C22H24ClN3O3S/c23-15-4-5-17-14(10-15)11-22(29-17)6-8-26(9-7-22)12-16(27)13-28-18-2-1-3-19-20(18)25-21(24)30-19/h1-5,10,16,27H,6-9,11-13H2,(H2,24,25)/t16-/m0/s1
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InChIKey
WZHDJJWUENEWGM-INIZCTEOSA-N
Physicochemical Property
logP
3.7413
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
80.84
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 72947880
ChEMBL ID
CHEMBL3099956
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01070, C-C chemokine receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1300 nM
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