Brief Information of the Compound and Protein
Compound Name
(R)-2-(1-(4-chlorobenzyl)-1H-1,2,4-triazol-5-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide
    Show/Hide
PubChem ID
CID: 25254218
SID: 58088275
Canonical SMILES
FC(F)(F)c1ccc(NC(=O)N2CCC[C@@H]2c2ncnn2Cc2ccc(Cl)cc2)cc1
    Show/Hide
Compound Formula C21H19ClF3N5O
Compound Structure
Protein Name
C-C chemokine receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Uniprot ID
P32246
Gene Name
CCR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS