General Information of the Compound
Compound ID
CP0845677
Compound Name
4-(4-Chloro-phenyl)-1-(4,4-diphenyl-butyl)-4-hydroxy-piperidinium iodide
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Structure
Formula
C27H31ClINO
Molecular Weight
547.908
Canonical SMILES
I.OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1
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InChI
InChI=1S/C27H30ClNO.HI/c28-25-15-13-24(14-16-25)27(30)17-20-29(21-18-27)19-7-12-26(22-8-3-1-4-9-22)23-10-5-2-6-11-23;/h1-6,8-11,13-16,26,30H,7,12,17-21H2;1H
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InChIKey
CDPQHIVVKVCQKX-UHFFFAOYSA-N
Physicochemical Property
logP
6.8537
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
23.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49796697
ChEMBL ID
CHEMBL142004
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01070, C-C chemokine receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 8700 nM
   TI
   LI
   LO
   TS
2
Ki = 116 nM
   TI
   LI
   LO
   TS