General Information of the Protein
Protein ID
PT02174
Protein Name
Melatonin receptor type 1B
Gene Name
MTNR1B
Sequence
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine-derivative receptor (family A GPCR)
>
Melatonin receptor
Function
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
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Uniprot ID
P49286
Ensembl ID
ENSG00000134640
HGNC ID
HGNC:7464
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Compound ID Compound Name Compound Formula
CP0396582
N-[3-[5-methoxy-2-[2-(3-methoxyphenyl)ethyl]phenyl]propyl]propanamide
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C22H29NO3
 2
1
EC50 = 0.024 nM
   TI
   LI
   LO
   TS
2
Ki = 0.55 nM
   TI
   LI
   LO
   TS
CP0409354
N-[3-[5-methoxy-2-[(3-methoxyphenyl)methoxy]phenyl]propyl]propanamide
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C21H27NO4
 3
1
EC50 = 0.05 nM
   TI
   LI
   LO
   TS
2
Ki = 0.291 nM
   TI
   LI
   LO
   TS
3
Ki = 1.698 nM
   TI
   LI
   LO
   TS
CP0444081
N-[2-(2-ethoxy-7,8-dihydrofuro[2,3-g]benzimidazol-1-yl)ethyl]acetamide
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C15H19N3O3
 2
1
EC50 = 0.05 nM
   TI
   LI
   LO
   TS
2
Ki = 0.24 nM
   TI
   LI
   LO
   TS
CP0520740
N-[2-(2-methoxy-7,8-dihydrofuro[2,3-g]benzimidazol-1-yl)ethyl]acetamide
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C14H17N3O3
 2
1
EC50 = 0.06 nM
   TI
   LI
   LO
   TS
2
Ki = 0.38 nM
   TI
   LI
   LO
   TS
CP0034701
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
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C13H16N2O2
 19
1
EC50 = 0.069 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.07 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.42 nM
   TI
   LI
   LO
   TS
4
EC50 = 0.47 nM
   TI
   LI
   LO
   TS
5
EC50 = 0.49 nM
   TI
   LI
   LO
   TS
6
EC50 = 0.82 nM
   TI
   LI
   LO
   TS
7
EC50 = 0.8511 nM
   TI
   LI
   LO
   TS
8
Ki = 0.12 nM
   TI
   LI
   LO
   TS
9
Ki = 0.13 nM
   TI
   LI
   LO
   TS
10
Ki = 0.15 nM
   TI
   LI
   LO
   TS
11
Ki = 0.21 nM
   TI
   LI
   LO
   TS
12
Ki = 0.23 nM
   TI
   LI
   LO
   TS
13
Ki = 0.29 nM
   TI
   LI
   LO
   TS
14
Ki = 0.35 nM
   TI
   LI
   LO
   TS
15
Ki = 0.41 nM
   TI
   LI
   LO
   TS
16
Ki = 0.429 nM
   TI
   LI
   LO
   TS
17
Ki = 0.52 nM
   TI
   LI
   LO
   TS
18
Ki = 0.741 nM
   TI
   LI
   LO
   TS
19
Ki = 0.955 nM
   TI
   LI
   LO
   TS
CP0178199
Agomelatine
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C15H17NO2
 7
1
EC50 = 0.06918 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.1 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.18 nM
   TI
   LI
   LO
   TS
4
Ki = 0.2 nM
   TI
   LI
   LO
   TS
5
Ki = 0.21 nM
   TI
   LI
   LO
   TS
6
Ki = 0.27 nM
   TI
   LI
   LO
   TS
7
Ki = 0.3802 nM
   TI
   LI
   LO
   TS
CP0454903
1-[2-(2-methoxyquinolin-8-yl)ethyl]-3-methylurea
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C14H17N3O2
 1
1
EC50 = 0.09 nM
   TI
   LI
   LO
   TS
CP0548271
N-[2-(2-ethoxy-6-methoxybenzimidazol-1-yl)ethyl]butanamide
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C16H23N3O3
 2
1
EC50 = 0.09 nM
   TI
   LI
   LO
   TS
2
Ki = 0.28 nM
   TI
   LI
   LO
   TS
CP0045783
N-[2-(5-methoxy-2-phenyl-1-benzofuran-3-yl)ethyl]acetamide
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C19H19NO3
 1
1
EC50 = 0.096 nM
   TI
   LI
   LO
   TS
CP0454899
1-[2-(2-methoxyquinolin-8-yl)ethyl]-3-methylthiourea
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C14H17N3OS
 1
1
EC50 = 0.1 nM
   TI
   LI
   LO
   TS
CP0396581
N-[3-[5-methoxy-2-[2-(3-methoxyphenyl)ethynyl]phenyl]propyl]propanamide
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C22H25NO3
 2
1
EC50 = 0.11 nM
   TI
   LI
   LO
   TS
2
Ki = 0.073 nM
   TI
   LI
   LO
   TS
CP0214091
But-3-enoic acid [2-(2-benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-amide
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C22H23NO3
 1
1
EC50 = 0.17 nM
   TI
   LI
   LO
   TS
CP0534038
N-[2-(2-ethoxy-6-methoxybenzimidazol-1-yl)ethyl]propanamide
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C15H21N3O3
 2
1
EC50 = 0.19 nM
   TI
   LI
   LO
   TS
2
Ki = 1.4 nM
   TI
   LI
   LO
   TS
CP0417995
N-[3-[5-methoxy-2-(3-methoxyphenyl)phenyl]propyl]propanamide
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C20H25NO3
 2
1
EC50 = 0.2 nM
   TI
   LI
   LO
   TS
2
Ki = 0.339 nM
   TI
   LI
   LO
   TS
CP0428960
2-(2-methoxyquinolin-8-yl)ethylurea
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C13H15N3O2
 1
1
EC50 = 0.2 nM
   TI
   LI
   LO
   TS
CP0428961
1-ethyl-3-[2-(2-methoxyquinolin-8-yl)ethyl]urea
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C15H19N3O2
 1
1
EC50 = 0.2 nM
   TI
   LI
   LO
   TS
CP0428962
N-[2-(2-methoxyquinolin-8-yl)ethyl]acetamide
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C14H16N2O2
 1
1
EC50 = 0.2 nM
   TI
   LI
   LO
   TS
CP0429915
N-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]acetamide
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C18H21NO2
 2
1
EC50 = 0.2 nM
   TI
   LI
   LO
   TS
2
Ki = 0.1 nM
   TI
   LI
   LO
   TS
CP0459154
N-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]acetamide
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C17H19NO2
 2
1
EC50 = 0.2 nM
   TI
   LI
   LO
   TS
2
Ki = 0.2 nM
   TI
   LI
   LO
   TS
CP0514069
N-[3-[5-methoxy-2-[(3-methoxyphenyl)methyl]phenyl]propyl]propanamide
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C21H27NO3
 2
1
EC50 = 0.24 nM
   TI
   LI
   LO
   TS
2
Ki = 3.39 nM
   TI
   LI
   LO
   TS
CP0534080
N-[2-(2-ethoxy-6-methoxybenzimidazol-1-yl)ethyl]acetamide
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C14H19N3O3
 2
1
EC50 = 0.26 nM
   TI
   LI
   LO
   TS
2
Ki = 0.93 nM
   TI
   LI
   LO
   TS
CP0419698
US10781182, Compound IA2-121
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C14H18ClN3O3
 2
1
EC50 = 0.27 nM
   TI
   LI
   LO
   TS
2
Ki = 0.93 nM
   TI
   LI
   LO
   TS
CP0485368
1-ethyl-3-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]urea
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C19H24N2O2
 2
1
EC50 = 0.3 nM
   TI
   LI
   LO
   TS
2
Ki = 0.3 nM
   TI
   LI
   LO
   TS
CP0419699
US10781182, Compound IA2-142
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C15H20ClN3O3
 2
1
EC50 = 0.3 nM
   TI
   LI
   LO
   TS
2
Ki = 1.6 nM
   TI
   LI
   LO
   TS
CP0444082
US10781182, Compound IA2-120
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C15H21N3O3
 2
1
EC50 = 0.35 nM
   TI
   LI
   LO
   TS
2
Ki = 4.5 nM
   TI
   LI
   LO
   TS
CP0847772
2,2-difluoro-N-(3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl)acetamide
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C16H17F2NO3
 2
1
EC50 = 0.3715 nM
   TI
   LI
   LO
   TS
2
Ki = 0.3467 nM
   TI
   LI
   LO
   TS
CP0192453
But-3-enoic acid {2-[5-methoxy-2-(3-methoxy-benzyl)-benzofuran-3-yl]-ethyl}-amide
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C23H25NO4
 1
1
EC50 = 0.39 nM
   TI
   LI
   LO
   TS
CP0454898
methyl N-[2-(2-methoxyquinolin-8-yl)ethyl]carbamate
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C14H16N2O3
 1
1
EC50 = 0.4 nM
   TI
   LI
   LO
   TS
CP0429916
2-methoxy-N-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]acetamide
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C18H21NO3
 2
1
EC50 = 0.4 nM
   TI
   LI
   LO
   TS
2
Ki = 0.1 nM
   TI
   LI
   LO
   TS
CP0217078
N-[2-[5-methoxy-2-[(2-methoxyphenyl)methyl]-1-benzofuran-3-yl]ethyl]acetamide
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C21H23NO4
 1
1
EC50 = 0.41 nM
   TI
   LI
   LO
   TS
CP0418574
N-[2-[7-methoxy-3-[3-(methylamino)phenyl]naphthalen-1-yl]ethyl]acetamide
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C22H24N2O2
 2
1
EC50 = 0.5 nM
   TI
   LI
   LO
   TS
2
Ki = 0.51 nM
   TI
   LI
   LO
   TS
CP0565247
N-[2-(2,6-dimethoxybenzimidazol-1-yl)ethyl]acetamide
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C13H17N3O3
 2
1
EC50 = 0.52 nM
   TI
   LI
   LO
   TS
2
Ki = 3.1 nM
   TI
   LI
   LO
   TS
CP0380668
N-[2-(4-ethyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]acetamide
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C15H19N3O2
 2
1
EC50 = 0.53 nM
   TI
   LI
   LO
   TS
2
Ki = 0.42 nM
   TI
   LI
   LO
   TS
CP0419697
N-[2-(2-ethoxy-6-methoxybenzimidazol-1-yl)ethyl]cyclopropanecarboxamide
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C16H21N3O3
 2
1
EC50 = 0.56 nM
   TI
   LI
   LO
   TS
2
Ki = 3.9 nM
   TI
   LI
   LO
   TS
CP0401351
N-[2-[3-[3-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]butanamide
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C24H27NO3
 2
1
EC50 = 0.6 nM
   TI
   LI
   LO
   TS
2
Ki = 0.28 nM
   TI
   LI
   LO
   TS
CP0877970
rac-2-fluoro-N-(3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl)acetamide
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C16H18FNO3
 2
1
EC50 = 0.631 nM
   TI
   LI
   LO
   TS
2
Ki = 0.537 nM
   TI
   LI
   LO
   TS
CP0424931
N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]acetamide
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C18H15F2NOS2
 2
1
EC50 = 0.64 nM
   TI
   LI
   LO
   TS
2
Ki = 0.87 nM
   TI
   LI
   LO
   TS
CP0452012
N-[2-(5-fluoro-1-benzothiophen-3-yl)ethyl]acetamide
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C12H12FNOS
 2
1
EC50 = 0.68 nM
   TI
   LI
   LO
   TS
2
Ki = 4.87 nM
   TI
   LI
   LO
   TS
CP0401365
N-[2-[3-[3-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]propanamide
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C23H25NO3
 2
1
EC50 = 0.7 nM
   TI
   LI
   LO
   TS
2
Ki = 0.52 nM
   TI
   LI
   LO
   TS
CP0462764
N-[2-(6-methoxypyrrolo[2,3-b]pyridin-1-yl)ethyl]butanamide
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C14H19N3O2
 1
1
EC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0121891
N-[2-(8-methoxybenzo[e][1]benzofuran-1-yl)ethyl]acetamide
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C17H17NO3
 2
1
EC50 = 0.7 nM
   TI
   LI
   LO
   TS
2
Ki = 0.09 nM
   TI
   LI
   LO
   TS
CP0406657
3-(2-methoxyquinolin-8-yl)-N-methylpropanamide
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C14H16N2O2
 1
1
EC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0414939
1-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]-3-propylurea
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C20H26N2O2
 2
1
EC50 = 0.7 nM
   TI
   LI
   LO
   TS
2
Ki = 0.2 nM
   TI
   LI
   LO
   TS
CP0098513
N-[2-[5-methoxy-2-[(3-methoxyphenyl)methyl]-1-benzofuran-3-yl]ethyl]acetamide
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C21H23NO4
 2
1
EC50 = 0.72 nM
   TI
   LI
   LO
   TS
2
Ki = 0.25 nM
   TI
   LI
   LO
   TS
CP0458570
N-[2-[3-[3-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide
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C22H23NO3
 2
1
EC50 = 0.76 nM
   TI
   LI
   LO
   TS
2
Ki = 0.36 nM
   TI
   LI
   LO
   TS
CP0548268
N-[2-(6-methoxy-2-methylsulfanylbenzimidazol-1-yl)ethyl]acetamide
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C13H17N3O2S
 2
1
EC50 = 0.76 nM
   TI
   LI
   LO
   TS
2
Ki = 3.2 nM
   TI
   LI
   LO
   TS
CP0847771
(R)-2-fluoro-N-(3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl)acetamide
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C16H18FNO3
 2
1
EC50 = 0.7943 nM
   TI
   LI
   LO
   TS
2
Ki = 0.9772 nM
   TI
   LI
   LO
   TS
CP0488406
3-(2-methoxyquinolin-8-yl)-N-methylsulfonylpropanamide
   Show/Hide
C14H16N2O4S
 1
1
EC50 = 0.8 nM
   TI
   LI
   LO
   TS
CP0450973
US10781182, Compound IA2-143
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C13H16ClN3O3
 2
1
EC50 = 0.86 nM
   TI
   LI
   LO
   TS
2
Ki = 0.8 nM
   TI
   LI
   LO
   TS
CP0410497
(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methylurea
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C16H18N2O2
 2
1
EC50 = 0.9 nM
   TI
   LI
   LO
   TS
2
Ki = 0.1 nM
   TI
   LI
   LO
   TS
CP0105645
N-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]cyclopropanecarboxamide
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C18H17NO3
 2
1
EC50 = 0.98 nM
   TI
   LI
   LO
   TS
2
Ki = 0.6 nM
   TI
   LI
   LO
   TS
CP0414625
N-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]acetamide
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C16H15NO3
 2
1
EC50 = 0.98 nM
   TI
   LI
   LO
   TS
2
Ki = 0.4 nM
   TI
   LI
   LO
   TS
CP0433987
N-[2-[3-[3-(bromomethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide
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C22H22BrNO2
 2
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
2
Ki = 0.56 nM
   TI
   LI
   LO
   TS
CP0432632
N-(1-phenyl-3,4-dihydro-2H-quinolin-3-yl)propanamide
   Show/Hide
C18H20N2O
 2
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
2
Ki = 2 nM
   TI
   LI
   LO
   TS
CP0405073
N-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]methanesulfonamide
   Show/Hide
C16H19NO3S
 2
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
2
Ki = 0.1 nM
   TI
   LI
   LO
   TS
CP0458757
4-azamelatonin
   Show/Hide
C12H15N3O2
 1
1
EC50 = 1.1 nM
   TI
   LI
   LO
   TS
CP0121949
2-fluoro-N-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]acetamide
   Show/Hide
C16H14FNO3
 2
1
EC50 = 1.1 nM
   TI
   LI
   LO
   TS
2
Ki = 0.7 nM
   TI
   LI
   LO
   TS
CP0474650
1-ethyl-3-[2-(2-methoxyquinolin-8-yl)ethyl]thiourea
   Show/Hide
C15H19N3OS
 1
1
EC50 = 1.1 nM
   TI
   LI
   LO
   TS
CP0847773
(R)-N-(3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl)propionamide
   Show/Hide
C17H21NO3
 2
1
EC50 = 1.259 nM
   TI
   LI
   LO
   TS
2
Ki = 0.3162 nM
   TI
   LI
   LO
   TS
CP0301499
N-[2-[5-methoxy-2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzofuran-3-yl]ethyl]acetamide
   Show/Hide
C21H20F3NO3
 1
1
EC50 = 1.26 nM
   TI
   LI
   LO
   TS
CP0387872
N-[2-[3-(3-formylphenyl)-7-methoxynaphthalen-1-yl]ethyl]acetamide
   Show/Hide
C22H21NO3
 2
1
EC50 = 1.3 nM
   TI
   LI
   LO
   TS
2
Ki = 0.42 nM
   TI
   LI
   LO
   TS
CP0418572
N-[2-[3-(3-aminophenyl)-7-methoxynaphthalen-1-yl]ethyl]acetamide
   Show/Hide
C21H22N2O2
 2
1
EC50 = 1.3 nM
   TI
   LI
   LO
   TS
2
Ki = 0.27 nM
   TI
   LI
   LO
   TS
CP0486875
N-[2-(2-methoxy-5,6,7,8-tetrahydropyrido[2,3-b]indol-9-yl)ethyl]acetamide
   Show/Hide
C16H21N3O2
 1
1
EC50 = 1.3 nM
   TI
   LI
   LO
   TS
CP0377934
N-[2-[7-(cyclohexylmethyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide
   Show/Hide
C22H29NO2
 2
1
EC50 = 1.318 nM
   TI
   LI
   LO
   TS
2
Ki = 0.012 nM
   TI
   LI
   LO
   TS
CP0462765
N-[2-(6-methoxypyrrolo[2,3-b]pyridin-1-yl)ethyl]propanamide
   Show/Hide
C13H17N3O2
 1
1
EC50 = 1.4 nM
   TI
   LI
   LO
   TS
CP0406180
N-[(8-methoxybenzo[e][1]benzofuran-1-yl)methyl]acetamide
   Show/Hide
C16H15NO3
 2
1
EC50 = 1.4 nM
   TI
   LI
   LO
   TS
2
Ki = 0.7 nM
   TI
   LI
   LO
   TS
CP0435113
N-[2-[3-[3-(dimethylamino)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide
   Show/Hide
C23H26N2O2
 2
1
EC50 = 1.5 nM
   TI
   LI
   LO
   TS
2
Ki = 0.94 nM
   TI
   LI
   LO
   TS
CP0469375
1-ethyl-3-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]thiourea
   Show/Hide
C19H24N2OS
 2
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
2
Ki = 3 nM
   TI
   LI
   LO
   TS
CP0548270
US10781182, Compound IA2-140
   Show/Hide
C14H19N3O3
 2
1
EC50 = 2.01 nM
   TI
   LI
   LO
   TS
2
Ki = 11 nM
   TI
   LI
   LO
   TS
CP0467650
N-[2-(6-methoxypyrrolo[2,3-b]pyridin-1-yl)ethyl]acetamide
   Show/Hide
C12H15N3O2
 1
1
EC50 = 2.1 nM
   TI
   LI
   LO
   TS
CP0436558
N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]but-3-enamide
   Show/Hide
C20H17F2NOS2
 2
1
EC50 = 2.15 nM
   TI
   LI
   LO
   TS
2
Ki = 0.24 nM
   TI
   LI
   LO
   TS
CP0399205
N-[2-(7-methoxy-3-phenylnaphthalen-1-yl)ethyl]acetamide
   Show/Hide
C21H21NO2
 2
1
EC50 = 2.4 nM
   TI
   LI
   LO
   TS
2
Ki = 0.37 nM
   TI
   LI
   LO
   TS
CP0419695
N-[2-(2-ethoxy-6-methoxybenzimidazol-1-yl)ethyl]cyclobutanecarboxamide
   Show/Hide
C17H23N3O3
 2
1
EC50 = 2.49 nM
   TI
   LI
   LO
   TS
2
Ki = 23 nM
   TI
   LI
   LO
   TS
CP0877971
rac-N-(1-hydroxy-3-(7-methoxynaphthalen-1-yl)propan-2-yl)propionamide
   Show/Hide
C17H21NO3
 2
1
EC50 = 2.754 nM
   TI
   LI
   LO
   TS
2
Ki = 2.951 nM
   TI
   LI
   LO
   TS
CP0385360
3-(5-methoxy-1H-indol-3-yl)-N-prop-2-ynylpropanamide
   Show/Hide
C15H16N2O2
 2
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
2
Ki = 1 nM
   TI
   LI
   LO
   TS
CP0389221
N-[(1-benzyl-3,4-dihydro-2H-quinolin-3-yl)methyl]acetamide
   Show/Hide
C19H22N2O
 2
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
2
Ki = 1 nM
   TI
   LI
   LO
   TS
CP0416460
1-ethyl-3-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]urea
   Show/Hide
C18H22N2O2
 2
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
2
Ki = 0.1 nM
   TI
   LI
   LO
   TS
CP0429921
1-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]-3-methylthiourea
   Show/Hide
C18H22N2OS
 2
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
2
Ki = 0.2 nM
   TI
   LI
   LO
   TS
CP0121948
N-[2-(8-methoxybenzo[e][1]benzofuran-1-yl)ethyl]cyclopropanecarboxamide
   Show/Hide
C19H19NO3
 2
1
EC50 = 3.2 nM
   TI
   LI
   LO
   TS
2
Ki = 13.3 nM
   TI
   LI
   LO
   TS
CP0309822
2-fluoro-N-[(8-methoxybenzo[e][1]benzofuran-1-yl)methyl]acetamide
   Show/Hide
C16H14FNO3
 2
1
EC50 = 3.4 nM
   TI
   LI
   LO
   TS
2
Ki = 2.1 nM
   TI
   LI
   LO
   TS
CP0405083
1-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]-3-propylthiourea
   Show/Hide
C20H26N2OS
 2
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
2
Ki = 0.3 nM
   TI
   LI
   LO
   TS
CP0429925
(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methylthiourea
   Show/Hide
C16H18N2OS
 2
1
EC50 = 5 nM
   TI
   LI
   LO
   TS
2
Ki = 0.4 nM
   TI
   LI
   LO
   TS
CP0429929
methyl N-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]carbamate
   Show/Hide
C17H19NO3
 2
1
EC50 = 5 nM
   TI
   LI
   LO
   TS
2
Ki = 0.4 nM
   TI
   LI
   LO
   TS
CP0381571
5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3H-1,3,4-oxadiazol-2-one
   Show/Hide
C13H13N3O3
 3
1
EC50 = 5.5 nM
   TI
   LI
   LO
   TS
2
EC50 = 29 nM
   TI
   LI
   LO
   TS
3
Ki = 4 nM
   TI
   LI
   LO
   TS
CP0414626
N-[2-(8-methoxybenzo[e][1]benzofuran-2-yl)ethyl]cyclopropanecarboxamide
   Show/Hide
C19H19NO3
 2
1
EC50 = 5.8 nM
   TI
   LI
   LO
   TS
2
Ki = 11 nM
   TI
   LI
   LO
   TS
CP0429918
1-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]-3-methylthiourea
   Show/Hide
C17H20N2OS
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0105646
1-ethyl-3-[2-(8-methoxybenzo[e][1]benzofuran-1-yl)ethyl]urea
   Show/Hide
C18H20N2O3
 2
1
EC50 = 6.2 nM
   TI
   LI
   LO
   TS
2
Ki = 226 nM
   TI
   LI
   LO
   TS
CP0426377
N-[(1-ethyl-3,4-dihydro-2H-quinolin-3-yl)methyl]acetamide
   Show/Hide
C14H20N2O
 2
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
2
Ki = 1 nM
   TI
   LI
   LO
   TS
CP0452013
2-bromo-N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]acetamide
   Show/Hide
C18H14BrF2NOS2
 2
1
EC50 = 7.27 nM
   TI
   LI
   LO
   TS
2
Ki = 5.21 nM
   TI
   LI
   LO
   TS
CP0847750
(S)-N-(1-hydroxy-3-(7-methoxynaphthalen-1-yl)propan-2-yl)propionamide
   Show/Hide
C17H21NO3
 2
1
EC50 = 7.413 nM
   TI
   LI
   LO
   TS
2
Ki = 5.495 nM
   TI
   LI
   LO
   TS
CP0309821
N-[(8-methoxybenzo[e][1]benzofuran-1-yl)methyl]cyclopropanecarboxamide
   Show/Hide
C18H17NO3
 2
1
EC50 = 8.8 nM
   TI
   LI
   LO
   TS
2
Ki = 15 nM
   TI
   LI
   LO
   TS
CP0472545
N-[(8-methoxybenzo[e][1]benzofuran-1-yl)methyl]-2-methylpropanamide
   Show/Hide
C18H19NO3
 2
1
EC50 = 8.8 nM
   TI
   LI
   LO
   TS
2
Ki = 24 nM
   TI
   LI
   LO
   TS
CP0072976
N-[2-[2-(cyclohexylmethyl)-5-methoxy-1-benzofuran-3-yl]ethyl]acetamide
   Show/Hide
C20H27NO3
 1
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
CP0436038
N-[2-[6-methoxy-3-(2,2,2-trifluoroacetyl)pyrrolo[2,3-b]pyridin-1-yl]ethyl]acetamide
   Show/Hide
C14H14F3N3O3
 1
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
CP0443574
1-ethyl-3-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]urea
   Show/Hide
C17H18N2O3
 2
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
2
Ki = 4.2 nM
   TI
   LI
   LO
   TS
CP0389226
N-[(1-methyl-3,4-dihydro-2H-quinolin-3-yl)methyl]acetamide
   Show/Hide
C13H18N2O
 2
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
2
Ki = 15 nM
   TI
   LI
   LO
   TS
CP0467651
N-[2-(3-iodo-6-methoxypyrrolo[2,3-b]pyridin-1-yl)ethyl]acetamide
   Show/Hide
C12H14IN3O2
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0381574
3-(5-methoxy-1H-indol-3-yl)-N-prop-2-enylpropanamide
   Show/Hide
C15H18N2O2
 2
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
2
Ki = 0.45 nM
   TI
   LI
   LO
   TS
CP0297769
N-[2-[5-ethyl-2-[(3-methoxyphenyl)methyl]-1-benzofuran-3-yl]ethyl]acetamide
   Show/Hide
C22H25NO3
 1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
CP0391337
1-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]-3-propylurea
   Show/Hide
C19H24N2O2
 2
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
2
Ki = 0.2 nM
   TI
   LI
   LO
   TS
CP0430453
N-[2-[7-[4-[[3-(2-acetamidoethyl)-1-benzothiophen-5-yl]oxy]butoxy]naphthalen-1-yl]ethyl]acetamide
   Show/Hide
C30H34N2O4S
 2
1
EC50 = 20.6 nM
   TI
   LI
   LO
   TS
2
Ki = 16.9 nM
   TI
   LI
   LO
   TS
CP0877969
(S)-2-fluoro-N-(3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl)acetamide
   Show/Hide
C16H18FNO3
 2
1
EC50 = 25.12 nM
   TI
   LI
   LO
   TS
2
Ki = 52.48 nM
   TI
   LI
   LO
   TS
CP0469064
N-[2-[7-[4-[4-[4-(hydroxymethyl)phenyl]phenoxy]butoxy]naphthalen-1-yl]ethyl]acetamide
   Show/Hide
C31H33NO4
 2
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
2
Ki = 6.53 nM
   TI
   LI
   LO
   TS
CP0373468
N-[2-[7-[4-[8-[2-(but-3-enoylamino)ethyl]naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]but-3-enamide
   Show/Hide
C36H40N2O4
 2
1
EC50 = 40.2 nM
   TI
   LI
   LO
   TS
2
Ki = 10.9 nM
   TI
   LI
   LO
   TS
CP0405082
1-ethyl-3-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]thiourea
   Show/Hide
C18H22N2OS
 2
1
EC50 = 50 nM
   TI
   LI
   LO
   TS
2
Ki = 2 nM
   TI
   LI
   LO
   TS
CP0389326
2-[(5-methoxy-1H-indol-3-yl)methyl]-5-methyl-1,3,4-oxadiazole
   Show/Hide
C13H13N3O2
 2
1
EC50 = 71 nM
   TI
   LI
   LO
   TS
2
Ki = 16 nM
   TI
   LI
   LO
   TS
CP0432631
N-[[1-(2-phenylethyl)-3,4-dihydro-2H-quinolin-3-yl]methyl]acetamide
   Show/Hide
C20H24N2O
 2
1
EC50 = 80 nM
   TI
   LI
   LO
   TS
2
Ki = 47 nM
   TI
   LI
   LO
   TS
CP0382347
2-(5-methoxy-1H-indol-3-yl)-N-prop-2-ynylacetamide
   Show/Hide
C14H14N2O2
 2
1
EC50 = 81 nM
   TI
   LI
   LO
   TS
2
Ki = 3.8 nM
   TI
   LI
   LO
   TS
CP0407040
methyl 2-[6-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-2-yl]propanoate
   Show/Hide
C32H35NO5
 2
1
EC50 = 88 nM
   TI
   LI
   LO
   TS
2
Ki = 4.22 nM
   TI
   LI
   LO
   TS
CP0401209
N-ethyl-5-[(5-methoxy-1H-indol-3-yl)methyl]-1,3,4-thiadiazol-2-amine
   Show/Hide
C14H16N4OS
 2
1
EC50 = 110 nM
   TI
   LI
   LO
   TS
2
Ki = 17 nM
   TI
   LI
   LO
   TS
CP0071154
2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamine
   Show/Hide
C13H18N2O
 2
1
EC50 = 112 nM
   TI
   LI
   LO
   TS
2
Ki = 16 nM
   TI
   LI
   LO
   TS
CP0398561
2-((S)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
   Show/Hide
C32H38ClF2N3O2
 1
1
EC50 = 115 nM
   TI
   LI
   LO
   TS
CP0397791
2-(5-methoxy-1H-indol-3-yl)-N-prop-2-enylacetamide
   Show/Hide
C14H16N2O2
 2
1
EC50 = 132 nM
   TI
   LI
   LO
   TS
2
Ki = 4.9 nM
   TI
   LI
   LO
   TS
CP0401703
N-[2-[7-[4-[8-[2-(cyclopropanecarbonylamino)ethyl]naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]cyclopropanecarboxamide
   Show/Hide
C36H40N2O4
 2
1
EC50 = 134 nM
   TI
   LI
   LO
   TS
2
Ki = 13.6 nM
   TI
   LI
   LO
   TS
CP0378677
N-[3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl]acetamide
   Show/Hide
C16H19NO3
 2
1
EC50 = 144.54 nM
   TI
   LI
   LO
   TS
2
Ki = 13.8 nM
   TI
   LI
   LO
   TS
CP0400794
2-[6-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-2-yl]propanoic acid
   Show/Hide
C31H33NO5
 2
1
EC50 = 161 nM
   TI
   LI
   LO
   TS
2
Ki = 59.1 nM
   TI
   LI
   LO
   TS
CP0415246
2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
   Show/Hide
C31H36ClF2N3O2
 1
1
EC50 = 295 nM
   TI
   LI
   LO
   TS
CP0382351
5-[(5-methoxy-1H-indol-3-yl)methyl]-3-methyl-1,2,4-oxadiazole
   Show/Hide
C13H13N3O2
 2
1
EC50 = 295 nM
   TI
   LI
   LO
   TS
2
Ki = 44 nM
   TI
   LI
   LO
   TS
CP0493345
2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(1-hydroxy-2-methylpropan-2-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
   Show/Hide
C32H38ClF2N3O3
 1
1
EC50 = 342.9 nM
   TI
   LI
   LO
   TS
CP0436037
7-azamelatonin
   Show/Hide
C12H15N3O2
 1
1
EC50 = 380 nM
   TI
   LI
   LO
   TS
CP0400796
N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]acetamide
   Show/Hide
C32H36N2O4
 3
1
EC50 = 405 nM
   TI
   LI
   LO
   TS
2
Ki = 72.7 nM
   TI
   LI
   LO
   TS
3
Ki = 167 nM
   TI
   LI
   LO
   TS
CP0389325
2-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,4-oxadiazole
   Show/Hide
C13H13N3O2
 2
1
EC50 = 457 nM
   TI
   LI
   LO
   TS
2
Ki = 68 nM
   TI
   LI
   LO
   TS
CP0398563
2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(pentan-3-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
   Show/Hide
C33H40ClF2N3O2
 1
1
EC50 = 465 nM
   TI
   LI
   LO
   TS
CP0415040
2-[2-(5-methoxy-1H-indol-3-yl)ethyl]-5-methyl-1,3-oxazole
   Show/Hide
C15H16N2O2
 2
1
EC50 = 503 nM
   TI
   LI
   LO
   TS
2
Ki = 498 nM
   TI
   LI
   LO
   TS
CP0398564
2-((3S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(1-methoxypropan-2-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
   Show/Hide
C32H38ClF2N3O3
 1
1
EC50 = 615 nM
   TI
   LI
   LO
   TS
CP0493348
2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
   Show/Hide
C34H40ClF2N3O3
 1
1
EC50 = 735 nM
   TI
   LI
   LO
   TS
CP0072131
2-[2-(5-methoxy-1H-indol-3-yl)ethyl]-5-methyl-1,3,4-oxadiazole
   Show/Hide
C14H15N3O2
 3
1
EC50 = 881 nM
   TI
   LI
   LO
   TS
2
EC50 = 1600 nM
   TI
   LI
   LO
   TS
3
Ki = 190 nM
   TI
   LI
   LO
   TS
CP0432491
N-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]ethanesulfonamide
   Show/Hide
C17H21NO3S
 2
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
2
Ki = 0.4 nM
   TI
   LI
   LO
   TS
CP0398233
5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3H-1,3,4-oxadiazole-2-thione
   Show/Hide
C13H13N3O2S
 2
1
EC50 = 1096 nM
   TI
   LI
   LO
   TS
2
Ki = 530 nM
   TI
   LI
   LO
   TS
CP0283823
2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
   Show/Hide
C33H38ClF2N3O3
 1
1
EC50 = 1697 nM
   TI
   LI
   LO
   TS
CP0383642
2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
   Show/Hide
C28H30ClF2N3O2
 1
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0083725
N-[2-(2-benzyl-5-methoxy-1-benzofuran-3-yl)ethyl]acetamide
   Show/Hide
C20H21NO3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0095846
N-[2-[5-methoxy-2-[(4-methoxyphenyl)methyl]-1-benzofuran-3-yl]ethyl]acetamide
   Show/Hide
C21H23NO4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0100122
N-[2-(2-benzyl-1-benzofuran-3-yl)ethyl]acetamide
   Show/Hide
C19H19NO2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0452010
N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]propanamide
   Show/Hide
C19H17F2NOS2
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 4.4 nM
   TI
   LI
   LO
   TS
CP0406181
N-[2-(8-methoxybenzo[e][1]benzofuran-2-yl)ethyl]acetamide
   Show/Hide
C17H17NO3
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 1.7 nM
   TI
   LI
   LO
   TS
CP0389225
N-[(1-phenyl-3,4-dihydro-2H-quinolin-3-yl)methyl]acetamide
   Show/Hide
C18H20N2O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0432630
N-(1-benzyl-3,4-dihydro-2H-quinolin-3-yl)propanamide
   Show/Hide
C19H22N2O
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 6 nM
   TI
   LI
   LO
   TS
CP0393387
1-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]-3-propylthiourea
   Show/Hide
C19H24N2OS
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 3 nM
   TI
   LI
   LO
   TS
CP0376623
5-[(5-methoxy-1H-indol-3-yl)methyl]-3H-1,3,4-oxadiazole-2-thione
   Show/Hide
C12H11N3O2S
 2
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
2
Ki = 535 nM
   TI
   LI
   LO
   TS
CP0381569
5-[(5-methoxy-1H-indol-3-yl)methyl]-3H-1,3,4-oxadiazol-2-one
   Show/Hide
C12H11N3O3
 2
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
2
Ki = 160 nM
   TI
   LI
   LO
   TS
CP0381570
3-[(5-methoxy-1H-indol-3-yl)methyl]-4-methyl-1H-1,2,4-triazol-5-one
   Show/Hide
C13H14N4O2
 2
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
2
Ki = 560 nM
   TI
   LI
   LO
   TS
CP0398249
4-ethyl-3-[(5-methoxy-1H-indol-3-yl)methyl]-1H-1,2,4-triazole-5-thione
   Show/Hide
C14H16N4OS
 2
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
2
Ki = 220 nM
   TI
   LI
   LO
   TS
CP0521668
2,2,2-Trifluoro-N-[2-(7-isopropyl-1,6-dihydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]acetamide
   Show/Hide
C18H20F3NO2
 1
1
Ki = 0.01 nM
   TI
   LI
   LO
   TS
CP0425880
N-[2-(7-propan-2-yl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]propanamide
   Show/Hide
C19H25NO2
 1
1
Ki = 0.011 nM
   TI
   LI
   LO
   TS
CP0425881
N-[2-[7-(3-propan-2-ylphenyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide
   Show/Hide
C24H27NO2
 1
1
Ki = 0.011 nM
   TI
   LI
   LO
   TS
CP0377935
N-[2-(7-bromo-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]acetamide
   Show/Hide
C15H16BrNO2
 1
1
Ki = 0.014 nM
   TI
   LI
   LO
   TS
CP0499108
N-[2-(7-propan-2-yl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]acetamide
   Show/Hide
C18H23NO2
 1
1
Ki = 0.018 nM
   TI
   LI
   LO
   TS
CP0501489
N-[2-[7-(2-methoxyphenyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide
   Show/Hide
C22H23NO3
 1
1
Ki = 0.02 nM
   TI
   LI
   LO
   TS
CP0494363
N-[2-(2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]acetamide
   Show/Hide
C15H17NO2
 1
1
Ki = 0.022 nM
   TI
   LI
   LO
   TS
CP0532363
N-[3-[2-[(3,5-dimethoxyphenyl)methoxy]-5-methoxyphenyl]propyl]acetamide
   Show/Hide
C21H27NO5
 1
1
Ki = 0.0326 nM
   TI
   LI
   LO
   TS
CP0521667
N-[2-(7-pyridin-3-yl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]acetamide
   Show/Hide
C20H20N2O2
 1
1
Ki = 0.034 nM
   TI
   LI
   LO
   TS
CP0437994
N-[2-(7-propan-2-yl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]cyclopropanecarboxamide
   Show/Hide
C20H25NO2
 1
1
Ki = 0.035 nM
   TI
   LI
   LO
   TS
CP0377936
N-[2-[7-(4-methoxyphenyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide
   Show/Hide
C22H23NO3
 1
1
Ki = 0.037 nM
   TI
   LI
   LO
   TS
CP0504561
N-[3-(5-methoxy-2-phenylmethoxyphenyl)propyl]acetamide
   Show/Hide
C19H23NO3
 1
1
Ki = 0.04705 nM
   TI
   LI
   LO
   TS
CP0499107
1-ethyl-3-[2-(7-propan-2-yl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]urea
   Show/Hide
C19H26N2O2
 1
1
Ki = 0.084 nM
   TI
   LI
   LO
   TS
CP0458342
N-[2-(4-phenyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]acetamide
   Show/Hide
C19H19N3O2
 1
1
Ki = 0.085 nM
   TI
   LI
   LO
   TS
CP0485220
N-[3-(3-methoxyphenyl)-3-naphthalen-2-ylpropyl]acetamide
   Show/Hide
C22H23NO2
 1
1
Ki = 0.11 nM
   TI
   LI
   LO
   TS
CP0376971
N-[2-(4-cyclopropyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]propanamide
   Show/Hide
C17H21N3O2
 1
1
Ki = 0.14 nM
   TI
   LI
   LO
   TS
CP0055675
2-Iodomelatonin
   Show/Hide
C13H15IN2O2
 1
1
Ki = 0.15 nM
   TI
   LI
   LO
   TS
CP0186244
(4-Methoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-6-ylmethyl)-methoxymethyl-amine
   Show/Hide
C20H23NO2
 1
1
Ki = 0.16 nM
   TI
   LI
   LO
   TS
CP0501182
N-[2-(4-methyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]propanamide
   Show/Hide
C15H19N3O2
 1
1
Ki = 0.19 nM
   TI
   LI
   LO
   TS
CP0393386
1-[(2-methoxy-8,9-dihydro-7H-cyclopenta[h]quinolin-9-yl)methyl]-3-methylurea
   Show/Hide
C16H19N3O2
 1
1
Ki = 0.2 nM
   TI
   LI
   LO
   TS
CP0429924
N-[(2-methoxy-8,9-dihydro-7H-cyclopenta[h]quinolin-9-yl)methyl]acetamide
   Show/Hide
C16H18N2O2
 1
1
Ki = 0.2 nM
   TI
   LI
   LO
   TS
CP0508414
N-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]methanesulfonamide
   Show/Hide
C17H21NO3S
 1
1
Ki = 0.2 nM
   TI
   LI
   LO
   TS
CP0441548
N-[2-(4-ethyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]propanamide
   Show/Hide
C16H21N3O2
 1
1
Ki = 0.22 nM
   TI
   LI
   LO
   TS
CP0389224
N-[[(1S,2R)-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl]propanamide
   Show/Hide
C20H23NO
 1
1
Ki = 0.22 nM
   TI
   LI
   LO
   TS
CP0426376
N-[[(1R,2R)-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl]propanamide
   Show/Hide
C20H23NO
 1
1
Ki = 0.23 nM
   TI
   LI
   LO
   TS
CP0455738
N-[2-(4-cyclopropyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]acetamide
   Show/Hide
C16H19N3O2
 1
1
Ki = 0.28 nM
   TI
   LI
   LO
   TS
CP0390104
N-[2-[4-(trifluoromethyl)-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl]ethyl]propanamide
   Show/Hide
C15H16F3N3O2
 1
1
Ki = 0.33 nM
   TI
   LI
   LO
   TS
CP0509534
N-[2-[7-(2-propan-2-yloxyphenyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide
   Show/Hide
C24H27NO3
 1
1
Ki = 0.34 nM
   TI
   LI
   LO
   TS
CP0040580
N-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]acetamide
   Show/Hide
C13H15NO3
 1
1
Ki = 0.34 nM
   TI
   LI
   LO
   TS
CP0384067
N-[2-(2,7-dimethoxynaphthalen-1-yl)ethyl]propanamide
   Show/Hide
C17H21NO3
 1
1
Ki = 0.38 nM
   TI
   LI
   LO
   TS
CP0429922
1-[(2-methoxy-8,9-dihydro-7H-cyclopenta[h]quinolin-9-yl)methyl]-3-propylurea
   Show/Hide
C18H23N3O2
 1
1
Ki = 0.4 nM
   TI
   LI
   LO
   TS
CP0474642
N-[2-(6-methoxyquinolin-4-yl)ethyl]butanamide
   Show/Hide
C16H20N2O2
 1
1
Ki = 0.41 nM
   TI
   LI
   LO
   TS
CP0114370
4-P-PDOT
   Show/Hide
C19H21NO
 1
1
Ki = 0.46 nM
   TI
   LI
   LO
   TS
CP0475208
N-[[(3R,4S)-1-methyl-4-phenyl-3,4-dihydro-2H-quinolin-3-yl]methyl]propanamide
   Show/Hide
C20H24N2O
 1
1
Ki = 0.48 nM
   TI
   LI
   LO
   TS
CP0081204
N-[2-(11-methoxy-6,7-dihydro-5H-indolo[2,1-a][2]benzazepin-13-yl)ethyl]butanamide
   Show/Hide
C24H28N2O2
 1
1
Ki = 0.5 nM
   TI
   LI
   LO
   TS
CP0458343
N-[2-(4-methyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]acetamide
   Show/Hide
C14H17N3O2
 1
1
Ki = 0.53 nM
   TI
   LI
   LO
   TS
CP0456126
3-[4-(2-Acetylaminoethyl)-6-methoxynaphth-2-yl]benzoic acid methyl ester
   Show/Hide
C23H23NO4
 1
1
Ki = 0.64 nM
   TI
   LI
   LO
   TS
CP0443391
N-[2-[3-[3-(iodomethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide
   Show/Hide
C22H22INO2
 1
1
Ki = 0.71 nM
   TI
   LI
   LO
   TS
CP0390102
N-[3-(3-methoxyphenyl)propyl]acetamide
   Show/Hide
C12H17NO2
 1
1
Ki = 0.751 nM
   TI
   LI
   LO
   TS
CP0501488
N-[2-[7-(4-tert-butylphenyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide
   Show/Hide
C25H29NO2
 1
1
Ki = 0.77 nM
   TI
   LI
   LO
   TS
CP0420022
1-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]-3-methylthiourea
   Show/Hide
C16H16N2O2S
 1
1
Ki = 0.8 nM
   TI
   LI
   LO
   TS
CP0416462
N-[2-(2-methoxy-8,9-dihydro-7H-cyclopenta[h]quinolin-9-yl)ethyl]acetamide
   Show/Hide
C17H20N2O2
 1
1
Ki = 0.8 nM
   TI
   LI
   LO
   TS
CP0399886
N-[2-[(1R,3R)-7-methoxy-3-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]ethyl]cyclobutanecarboxamide
   Show/Hide
C24H29NO2
 1
1
Ki = 0.9 nM
   TI
   LI
   LO
   TS
CP0441549
N-[2-[4-(trifluoromethyl)-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl]ethyl]acetamide
   Show/Hide
C14H14F3N3O2
 1
1
Ki = 0.93 nM
   TI
   LI
   LO
   TS
CP0433988
N-[2-[7-methoxy-3-[3-(methoxymethyl)phenyl]naphthalen-1-yl]ethyl]acetamide
   Show/Hide
C23H25NO3
 1
1
Ki = 0.95 nM
   TI
   LI
   LO
   TS
CP0518308
N-[2-(6-methoxyquinolin-4-yl)ethyl]propanamide
   Show/Hide
C15H18N2O2
 1
1
Ki = 0.96 nM
   TI
   LI
   LO
   TS
CP0448964
N-[2-(2-hydroxy-7-methoxynaphthalen-1-yl)ethyl]propanamide
   Show/Hide
C16H19NO3
 1
1
Ki = 1.2 nM
   TI
   LI
   LO
   TS
CP0510962
N-[2-(2-ethoxy-7-methoxynaphthalen-1-yl)ethyl]propanamide
   Show/Hide
C18H23NO3
 1
1
Ki = 1.2 nM
   TI
   LI
   LO
   TS
CP0509510
N-[2-[2-(2-hydroxyethoxy)-7-methoxynaphthalen-1-yl]ethyl]propanamide
   Show/Hide
C18H23NO4
 1
1
Ki = 1.3 nM
   TI
   LI
   LO
   TS
CP0491332
N-[2-(6-methoxyquinolin-4-yl)ethyl]acetamide
   Show/Hide
C14H16N2O2
 1
1
Ki = 1.4 nM
   TI
   LI
   LO
   TS
CP0430666
N-[3-(2-ethoxy-5-methoxyphenyl)propyl]acetamide
   Show/Hide
C14H21NO3
 1
1
Ki = 1.59 nM
   TI
   LI
   LO
   TS
CP0430669
N-[3-[5-methoxy-2-(pyridin-2-ylmethoxy)phenyl]propyl]acetamide
   Show/Hide
C18H22N2O3
 1
1
Ki = 1.61 nM
   TI
   LI
   LO
   TS
CP0390834
methyl 2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]acetate
   Show/Hide
C31H33NO5
 1
1
Ki = 1.84 nM
   TI
   LI
   LO
   TS
CP0520030
N-[2-[3-[2-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide
   Show/Hide
C22H23NO3
 1
1
Ki = 1.86 nM
   TI
   LI
   LO
   TS
CP0432490
N-[2-(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)ethyl]acetamide
   Show/Hide
C18H21NO2
 1
1
Ki = 2 nM
   TI
   LI
   LO
   TS
CP0470465
N-[3-(5-methoxy-2-propoxyphenyl)propyl]acetamide
   Show/Hide
C15H23NO3
 1
1
Ki = 2.12 nM
   TI
   LI
   LO
   TS
CP0849416
N-(2-(2-(isoindolin-2-ylmethyl)-5-methoxy-1H-indol-3-yl)ethyl)acetamide
   Show/Hide
C22H25N3O2
 1
1
Ki = 2.239 nM
   TI
   LI
   LO
   TS
CP0920948
N-[2-(5-Methoxy-2-{[(methyl(phenyl)amino]methyl}-1H-indol-3-yl)ethyl]acetamide
   Show/Hide
C21H25N3O2
 1
1
Ki = 2.291 nM
   TI
   LI
   LO
   TS
CP0375021
(E)-N-[3-(3-methoxyphenyl)-3-phenyl-2-propenyl]acetamide
   Show/Hide
C18H19NO2
 1
1
Ki = 2.5 nM
   TI
   LI
   LO
   TS
CP0388318
N-[2-[3-[3-(aminomethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide
   Show/Hide
C22H24N2O2
 1
1
Ki = 3.4 nM
   TI
   LI
   LO
   TS
CP0866793
N-(2-(2-(isoindolin-2-ylmethyl)-5-methoxy-1H-indol-3-yl)ethyl)propionamide
   Show/Hide
C23H27N3O2
 1
1
Ki = 3.715 nM
   TI
   LI
   LO
   TS
CP0389223
N-[(1-phenyl-3,4-dihydronaphthalen-2-yl)methyl]propanamide
   Show/Hide
C20H21NO
 1
1
Ki = 3.8 nM
   TI
   LI
   LO
   TS
CP0458341
N-[2-(2-phenyl-7,8-dihydrofuro[2,3-g]benzimidazol-1-yl)ethyl]acetamide
   Show/Hide
C19H19N3O2
 1
1
Ki = 4.5 nM
   TI
   LI
   LO
   TS
CP0486794
5-[(E)-2-(7-methoxynaphthalen-1-yl)ethenyl]-3H-1,3,4-oxadiazol-2-one
   Show/Hide
C15H12N2O3
 1
1
Ki = 5.1 nM
   TI
   LI
   LO
   TS
CP0867260
N-(2-(2-((1H-indol-1-yl)methyl)-5-methoxy-1H-indol-3-yl)ethyl)acetamide
   Show/Hide
C22H23N3O2
 1
1
Ki = 5.754 nM
   TI
   LI
   LO
   TS
CP0376970
N-[2-(11-phenyl-5-oxa-1,10-diazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-12-yl)ethyl]acetamide
   Show/Hide
C19H19N3O2
 1
1
Ki = 6.1 nM
   TI
   LI
   LO
   TS
CP0467376
N-[2-(2-butoxy-7-methoxynaphthalen-1-yl)ethyl]propanamide
   Show/Hide
C20H27NO3
 1
1
Ki = 6.7 nM
   TI
   LI
   LO
   TS
CP0407039
N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]-1,2,3,4-tetrahydronaphthalen-1-yl]ethyl]acetamide
   Show/Hide
C32H40N2O4
 1
1
Ki = 6.79 nM
   TI
   LI
   LO
   TS
CP0372536
N-[2-(8-methoxy-2-methyl-3,4-dihydro-1H-pyrazino[1,2-a]indol-10-yl)ethyl]butanamide
   Show/Hide
C19H27N3O2
 1
1
Ki = 6.918 nM
   TI
   LI
   LO
   TS
CP0309824
1-ethyl-3-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]thiourea
   Show/Hide
C17H18N2O2S
 1
1
Ki = 7 nM
   TI
   LI
   LO
   TS
CP0532362
N-[3-(3-methoxyphenyl)propyl]propanamide
   Show/Hide
C13H19NO2
 1
1
Ki = 7.07 nM
   TI
   LI
   LO
   TS
CP0423453
N-[2-[3-(3-acetamidophenyl)-7-methoxynaphthalen-1-yl]ethyl]acetamide
   Show/Hide
C23H24N2O3
 1
1
Ki = 7.54 nM
   TI
   LI
   LO
   TS
CP0874931
N-[2-(8-Methoxy-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)ethyl]acetamide
   Show/Hide
C17H23N3O2
 1
1
Ki = 7.762 nM
   TI
   LI
   LO
   TS
CP0381636
2-((S)-2-Hydroxymethylindolin-1-ylmethyl)-melatonin
   Show/Hide
C23H27N3O3
 1
1
Ki = 7.8 nM
   TI
   LI
   LO
   TS
CP0474601
ethyl N-[3-[4-(2-acetamidoethyl)-6-methoxynaphthalen-2-yl]phenyl]carbamate
   Show/Hide
C24H26N2O4
 1
1
Ki = 8.3 nM
   TI
   LI
   LO
   TS
CP0373463
N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]but-3-enamide
   Show/Hide
C34H38N2O4
 1
1
Ki = 8.45 nM
   TI
   LI
   LO
   TS
CP0111066
N-[[1-[(4-chlorophenyl)methyl]-4-methoxyindol-2-yl]methyl]propanamide
   Show/Hide
C20H21ClN2O2
 1
1
Ki = 9 nM
   TI
   LI
   LO
   TS
CP0869995
N-(2-(2-(isoindolin-2-ylmethyl)-5-methoxy-1H-indol-3-yl)ethyl)but-3-enamide
   Show/Hide
C24H27N3O2
 1
1
Ki = 9.333 nM
   TI
   LI
   LO
   TS
CP0486386
N-[2-[2-[2-(dimethylamino)ethoxy]-7-methoxynaphthalen-1-yl]ethyl]propanamide
   Show/Hide
C20H28N2O3
 1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
CP0524750
N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]prop-2-enamide
   Show/Hide
C19H15F2NOS2
 1
1
Ki = 10.7 nM
   TI
   LI
   LO
   TS
CP0400713
N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]cyclopropanecarboxamide
   Show/Hide
C34H38N2O4
 1
1
Ki = 11.1 nM
   TI
   LI
   LO
   TS
CP0401701
N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]furan-2-carboxamide
   Show/Hide
C35H36N2O5
 1
1
Ki = 11.8 nM
   TI
   LI
   LO
   TS
CP0869937
5-[1-(5-Methoxy-1H-indol-3-yl)propan-2-yl]-1,3,4-oxadiazol-2(3H)-one
   Show/Hide
C14H15N3O3
 1
1
Ki = 12 nM
   TI
   LI
   LO
   TS
CP0447593
N-[3-(4-hydroxy-3-methoxyphenyl)propyl]acetamide
   Show/Hide
C12H17NO3
 1
1
Ki = 12.6 nM
   TI
   LI
   LO
   TS
CP0430667
N-[3-[5-methoxy-2-(2-phenylethoxy)phenyl]propyl]acetamide
   Show/Hide
C20H25NO3
 1
1
Ki = 13.4 nM
   TI
   LI
   LO
   TS
CP0400793
N-[2-[7-[4-[[3-(2-acetamidoethyl)-1-benzofuran-5-yl]oxy]butoxy]naphthalen-1-yl]ethyl]acetamide
   Show/Hide
C30H34N2O5
 1
1
Ki = 13.9 nM
   TI
   LI
   LO
   TS
CP0514684
N-[2-(6-methoxy-2-phenylquinazolin-4-yl)ethyl]acetamide
   Show/Hide
C19H19N3O2
 1
1
Ki = 15.6 nM
   TI
   LI
   LO
   TS
CP0383358
N-[2-(7-methoxy-2-propoxynaphthalen-1-yl)ethyl]propanamide
   Show/Hide
C19H25NO3
 1
1
Ki = 16 nM
   TI
   LI
   LO
   TS
CP0400795
methyl 4-[4-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]phenyl]benzoate
   Show/Hide
C32H33NO5
 1
1
Ki = 19.1 nM
   TI
   LI
   LO
   TS
CP0947476
N-(2-(2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-5-methoxy-1H-indol-3-yl)ethyl)acetamide
   Show/Hide
C23H27N3O2
 1
1
Ki = 21.38 nM
   TI
   LI
   LO
   TS
CP0548970
N-[2-(6-hexoxy-3,4-dihydro-2H-chromen-4-yl)ethyl]acetamide
   Show/Hide
C19H29NO3
 1
1
Ki = 21.4 nM
   TI
   LI
   LO
   TS
CP0047706
N-[3-[2-(4-phenylbutyl)-1,3-benzoxazol-7-yl]propyl]cyclopropanecarboxamide
   Show/Hide
C24H28N2O2
 1
1
Ki = 22 nM
   TI
   LI
   LO
   TS
CP0907712
{2-[7-Methoxy-1-(2-propionylamino-ethyl)-naphthalen-2-yloxy]-ethyl}-trimethyl-ammonium iodide
   Show/Hide
C21H31IN2O3
 1
1
Ki = 23 nM
   TI
   LI
   LO
   TS
CP0489804
N-[2-[3-[4-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide
   Show/Hide
C22H23NO3
 1
1
Ki = 23 nM
   TI
   LI
   LO
   TS
CP0452009
4-chloro-N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)butanamide
   Show/Hide
C20H18ClF2NOS2
 1
1
Ki = 24.8 nM
   TI
   LI
   LO
   TS
CP0487668
N-[2-(2-cyclopropyl-6-methoxyquinazolin-4-yl)ethyl]acetamide
   Show/Hide
C16H19N3O2
 1
1
Ki = 25.9 nM
   TI
   LI
   LO
   TS
CP0400307
N-[3-(2,5-dimethoxyphenyl)propyl]acetamide
   Show/Hide
C13H19NO3
 1
1
Ki = 26.1 nM
   TI
   LI
   LO
   TS
CP0400306
N-[3-[5-methoxy-2-[(4-methoxyphenyl)methoxy]phenyl]propyl]acetamide
   Show/Hide
C20H25NO4
 1
1
Ki = 27.9 nM
   TI
   LI
   LO
   TS
CP0499033
(+/-)-2-(2-Hydroxymethyl-5-methoxyindolin-1-ylmethyl)-melatonin
   Show/Hide
C24H29N3O4
 1
1
Ki = 33.6 nM
   TI
   LI
   LO
   TS
CP0859463
N-(2-(2-(isoindolin-2-ylmethyl)-5-methoxy-1H-indol-3-yl)ethyl)cyclopropanecarboxamide
   Show/Hide
C24H27N3O2
 1
1
Ki = 33.88 nM
   TI
   LI
   LO
   TS
CP0514746
(+/-)-2-(2-Hydroxymethylindolin-1-ylmethyl)-melatonin
   Show/Hide
C23H27N3O3
 1
1
Ki = 36.2 nM
   TI
   LI
   LO
   TS
CP0513018
N-[2-(6-methoxyquinazolin-4-yl)ethyl]butanamide
   Show/Hide
C15H19N3O2
 1
1
Ki = 41 nM
   TI
   LI
   LO
   TS
CP0514689
N-[2-(6-methoxyquinazolin-4-yl)ethyl]propanamide
   Show/Hide
C14H17N3O2
 1
1
Ki = 41.1 nM
   TI
   LI
   LO
   TS
CP0914470
N-[2-(2-{[(4-Chlorophenyl)(methyl)amino]methyl}-5-methoxy-1H-indol-3-yl)ethyl]acetamide
   Show/Hide
C21H24ClN3O2
 1
1
Ki = 42.66 nM
   TI
   LI
   LO
   TS
CP0504015
3-(4-(2-Acetylaminoethyl)-6-methoxynaphth-2-yl)benzoic acid
   Show/Hide
C22H21NO4
 1
1
Ki = 43.3 nM
   TI
   LI
   LO
   TS
CP0400791
2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]acetic acid
   Show/Hide
C30H31NO5
 1
1
Ki = 45.8 nM
   TI
   LI
   LO
   TS
CP0105647
1-ethyl-3-[2-(8-methoxybenzo[e][1]benzofuran-2-yl)ethyl]urea
   Show/Hide
C18H20N2O3
 1
1
Ki = 46 nM
   TI
   LI
   LO
   TS
CP0514682
N-[2-[6-methoxy-2-(3-methoxyphenyl)quinazolin-4-yl]ethyl]acetamide
   Show/Hide
C20H21N3O3
 1
1
Ki = 46 nM
   TI
   LI
   LO
   TS
CP0447591
N-[3-(2-hydroxy-5-methoxyphenyl)propyl]acetamide
   Show/Hide
C12H17NO3
 1
1
Ki = 46.2 nM
   TI
   LI
   LO
   TS
CP0469724
N-[2-[3-[3-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]cyclobutanecarboxamide
   Show/Hide
C25H27NO3
 1
1
Ki = 48.3 nM
   TI
   LI
   LO
   TS
CP0415638
N-[2-[5-(3-phenylpropoxy)-1H-indol-3-yl]ethyl]acetamide
   Show/Hide
C21H24N2O2
 1
1
Ki = 49 nM
   TI
   LI
   LO
   TS
CP0402287
4-[4-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]phenyl]benzoic acid
   Show/Hide
C31H31NO5
 1
1
Ki = 51.3 nM
   TI
   LI
   LO
   TS
CP0381637
N-[2-(7-methoxy-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4(9),5,7,10,14,16,18-heptaen-10-yl)ethyl]acetamide
   Show/Hide
C23H25N3O2
 2
1
Ki = 64.57 nM
   TI
   LI
   LO
   TS
2
Ki = 65.2 nM
   TI
   LI
   LO
   TS
CP0558022
5-[(E)-2-(6,7-dimethoxynaphthalen-1-yl)ethenyl]-3H-1,3,4-oxadiazol-2-one
   Show/Hide
C16H14N2O4
 1
1
Ki = 69 nM
   TI
   LI
   LO
   TS
CP0477491
N-[3-(3-methoxy-4-phenylmethoxyphenyl)propyl]acetamide
   Show/Hide
C19H23NO3
 1
1
Ki = 69.3 nM
   TI
   LI
   LO
   TS
CP0430668
N-[3-[5-methoxy-2-(3-phenylpropoxy)phenyl]propyl]acetamide
   Show/Hide
C21H27NO3
 1
1
Ki = 72.2 nM
   TI
   LI
   LO
   TS
CP0437583
N-[2-[2-(2-iodoethoxy)-7-methoxynaphthalen-1-yl]ethyl]propanamide
   Show/Hide
C18H22INO3
 1
1
Ki = 73 nM
   TI
   LI
   LO
   TS
CP0849192
N-(2-(2-((1H-indol-1-yl)methyl)-5-methoxy-1H-indol-3-yl)ethyl)cyclobutanecarboxamide
   Show/Hide
C25H27N3O2
 1
1
Ki = 81.28 nM
   TI
   LI
   LO
   TS
CP0373460
N-[2-[7-[4-[[3-(2-acetamidoethyl)-1H-indol-5-yl]oxy]butoxy]naphthalen-1-yl]ethyl]acetamide
   Show/Hide
C30H35N3O4
 1
1
Ki = 84.3 nM
   TI
   LI
   LO
   TS
CP0921467
N-[2-(2-Methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)ethyl]butanamide
   Show/Hide
C18H25N3O
 1
1
Ki = 85.11 nM
   TI
   LI
   LO
   TS
CP0385096
N-[2-[5-(3-phenoxypropoxy)-1H-indol-3-yl]ethyl]acetamide
   Show/Hide
C21H24N2O3
 1
1
Ki = 87 nM
   TI
   LI
   LO
   TS
CP0510641
N-[3-[2-[(4-bromo-2-fluorophenyl)methoxy]-5-methoxyphenyl]propyl]acetamide
   Show/Hide
C19H21BrFNO3
 1
1
Ki = 102 nM
   TI
   LI
   LO
   TS
CP0452111
N-[3-[3-methoxy-4-[(3-methoxyphenyl)methoxy]phenyl]propyl]acetamide
   Show/Hide
C20H25NO4
 1
1
Ki = 105 nM
   TI
   LI
   LO
   TS
CP0558328
N-[2-(7-methoxyphthalazin-1-yl)ethyl]butanamide
   Show/Hide
C15H19N3O2
 1
1
Ki = 108 nM
   TI
   LI
   LO
   TS
CP0473011
N-(1,2,3,4-tetrahydroquinolin-3-ylmethyl)acetamide
   Show/Hide
C12H16N2O
 1
1
Ki = 110 nM
   TI
   LI
   LO
   TS
CP0511802
5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-methyl-1,3,4-oxadiazol-2-amine
   Show/Hide
C14H16N4O2
 1
1
Ki = 110 nM
   TI
   LI
   LO
   TS
CP0479258
N-[2-(6-methoxyquinazolin-4-yl)ethyl]acetamide
   Show/Hide
C13H15N3O2
 1
1
Ki = 115 nM
   TI
   LI
   LO
   TS
CP0470444
N-[3-(3-methoxy-4-phenylmethoxyphenyl)propyl]propanamide
   Show/Hide
C20H25NO3
 1
1
Ki = 121 nM
   TI
   LI
   LO
   TS
CP0193528
N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide
   Show/Hide
C31H34N2O4
 2
1
Ki = 149 nM
   TI
   LI
   LO
   TS
2
Ki = 354.81 nM
   TI
   LI
   LO
   TS
CP0452008
N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]cyclobutanecarboxamide
   Show/Hide
C21H19F2NOS2
 1
1
Ki = 194 nM
   TI
   LI
   LO
   TS
CP0921994
N-(2-(2-(isoindolin-2-ylmethyl)-5-methoxy-1H-indol-3-yl)ethyl)cyclobutanecarboxamide
   Show/Hide
C25H29N3O2
 1
1
Ki = 199.53 nM
   TI
   LI
   LO
   TS
CP0844959
N-[2-(2-{[Ethyl(methyl)amino]methyl}-5-methoxy-1H-indol-3-yl)ethyl]acetamide
   Show/Hide
C17H25N3O2
 1
1
Ki = 223.87 nM
   TI
   LI
   LO
   TS
CP0258343
3-(cyclobutylmethyl)-5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-one
   Show/Hide
C18H21N3O3
 1
1
Ki = 230 nM
   TI
   LI
   LO
   TS
CP0375514
N-[2-[7-[8-(2-acetamidoethyl)naphthalen-2-yl]naphthalen-1-yl]ethyl]acetamide
   Show/Hide
C28H28N2O2
 1
1
Ki = 246 nM
   TI
   LI
   LO
   TS
CP0362932
5-[(E)-2-(7-methoxy-3,4-dihydronaphthalen-1-yl)ethenyl]-3H-1,3,4-oxadiazol-2-one
   Show/Hide
C15H14N2O3
 1
1
Ki = 260 nM
   TI
   LI
   LO
   TS
CP0511803
3-heptyl-5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-one
   Show/Hide
C20H27N3O3
 1
1
Ki = 300 nM
   TI
   LI
   LO
   TS
CP0422156
5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3-(3-phenylpropyl)-1,3,4-oxadiazol-2-one
   Show/Hide
C22H23N3O3
 1
1
Ki = 320 nM
   TI
   LI
   LO
   TS
CP0317553
3-(cyclopentylmethyl)-5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-one
   Show/Hide
C19H23N3O3
 1
1
Ki = 390 nM
   TI
   LI
   LO
   TS
CP0547557
N-[2-(6-methoxyquinazolin-4-yl)ethyl]cyclopropanecarboxamide
   Show/Hide
C15H17N3O2
 1
1
Ki = 398 nM
   TI
   LI
   LO
   TS
CP0094726
N-[2-(7,17-dimethoxy-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4(9),5,7,10,14(19),15,17-heptaen-10-yl)ethyl]acetamide
   Show/Hide
C24H27N3O3
 2
1
Ki = 407.38 nM
   TI
   LI
   LO
   TS
2
Ki = 410 nM
   TI
   LI
   LO
   TS
CP0514683
N-[2-(7-methoxyphthalazin-1-yl)ethyl]propanamide
   Show/Hide
C14H17N3O2
 1
1
Ki = 414 nM
   TI
   LI
   LO
   TS
CP0487632
3-hexyl-5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-one
   Show/Hide
C19H25N3O3
 1
1
Ki = 530 nM
   TI
   LI
   LO
   TS
CP0920290
N-[2-(2-{[(Benzyl(methyl)amino]methyl}-5-methoxy-1H-indol-3-yl)ethyl]acetamide
   Show/Hide
C22H27N3O2
 1
1
Ki = 660.69 nM
   TI
   LI
   LO
   TS
CP0552037
N-[2-(7-methoxyphthalazin-1-yl)ethyl]acetamide
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C13H15N3O2
 1
1
Ki = 799 nM
   TI
   LI
   LO
   TS
CP0914471
N-[2-(9-Methoxy-2-methyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indol-11-yl)ethyl]acetamide
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C18H25N3O2
 1
1
Ki = 891.25 nM
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CP0424907
N-[2-(7-methoxyphthalazin-1-yl)ethyl]cyclopropanecarboxamide
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C15H17N3O2
 1
1
Ki = 1370 nM
   TI
   LI
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   TS
CP0474655
N-[2-(3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4,6,8,10,14,16,18-heptaen-10-yl)ethyl]acetamide
   Show/Hide
C22H23N3O
 1
1
Ki = 1700 nM
   TI
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CP0498635
N-[3-(5-methoxy-2-phenylmethoxyphenyl)propyl]benzamide
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C24H25NO3
 1
1
Ki = 2300 nM
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CP0487667
N-ethyl-4-(6-methoxyquinazolin-4-yl)piperazine-1-carboxamide
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C16H21N5O2
 1
1
Ki = 2800 nM
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CP0547559
cyclopropyl-[4-(6-methoxyquinazolin-4-yl)piperazin-1-yl]methanone
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C17H20N4O2
 1
1
Ki = 3295 nM
   TI
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CP0036921
3-HYDROXYTYRAMINE HYDROCHLORIDE
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C8H11NO2
 1
1
Ki = 9100 nM
   TI
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CP0549637
5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3-propyl-1,3,4-oxadiazol-2-one
   Show/Hide
C16H19N3O3
 1
1
Ki > 10000 nM
   TI
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   TS
CP0001238
14C-5-hydroxy tryptamine creatinine disulfate
   Show/Hide
C10H12N2O
 1
1
Ki > 100000 nM
   TI
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CP0547558
N-[2-[(6-methoxyquinazolin-4-yl)amino]ethyl]acetamide
   Show/Hide
C13H16N4O2
 1
1
Ki > 100000 nM
   TI
   LI
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   TS
CP0258344
5-[(E)-2-(5-methoxy-1H-indol-3-yl)ethenyl]-3H-1,3,4-oxadiazol-2-one
   Show/Hide
C13H11N3O3
 1
1
Ki > 100 nM
   TI
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   TS
CP0478995
(E)-3-(5-methoxy-1H-indol-3-yl)-N-prop-2-ynylprop-2-enamide
   Show/Hide
C15H14N2O2
 1
1
Ki > 100 nM
   TI
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   TS
CP0487486
5-[(E)-2-(5-methoxy-1H-indol-3-yl)ethenyl]-3-prop-2-ynyl-1,3,4-oxadiazol-2-one
   Show/Hide
C16H13N3O3
 1
1
Ki > 100 nM
   TI
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CP0549638
(E)-3-(5-methoxy-1H-indol-3-yl)-N-prop-2-enylprop-2-enamide
   Show/Hide
C15H16N2O2
 1
1
Ki > 100 nM
   TI
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CP0897694
6-Methoxy-1-methyl-4-(2-propionylamino-ethyl)-quinolinium iodide
   Show/Hide
C16H21IN2O2
 1
1
Ki > 1000 nM
   TI
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CP0919223
4-(2-Acetylamino-ethyl)-6-methoxy-1-methyl-quinolinium iodide
   Show/Hide
C15H19IN2O2
 1
1
Ki > 1000 nM
   TI
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CP0376624
2-[(5-methoxy-1H-indol-3-yl)methyl]-5-methyl-1,3-oxazole
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C14H14N2O2
 1
1
Ki > 1000 nM
   TI
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   TS
CP0433770
3-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-methyl-1H-1,2,4-triazol-5-one
   Show/Hide
C14H16N4O2
 1
1
Ki > 1000 nM
   TI
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   TS
CP0449128
4-ethyl-3-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1H-1,2,4-triazole-5-thione
   Show/Hide
C15H18N4OS
 1
1
Ki > 1000 nM
   TI
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CP0482626
5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3-methyl-1,2,4-oxadiazole
   Show/Hide
C14H15N3O2
 1
1
Ki > 1000 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0153310
US8552037, 90
   Show/Hide
C15H18N2O2
 1
1 IC50 = 0.13 nM
CP0034701
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
   Show/Hide
C13H16N2O2
 8
1 IC50 = 0.3 nM
2 IC50 = 0.53 nM
3 Kd = 0.15 nM
4 Ki = 0.18 nM
5 Ki = 0.195 nM
6 Ki = 0.2951 nM
7 Ki = 0.3 nM
8 Ki = 0.32 nM
CP0305199
4-((R)-6-Methoxy-indan-1-yl)-piperazine-1-carboxylic acid ethylamide
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C17H25N3O2
 1
1 IC50 = 1.7 nM
CP0215801
1-[1-(2,2-Diphenyl-ethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone
   Show/Hide
C27H29NO3
 1
1 IC50 = 9.7 nM
CP0283823
2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
   Show/Hide
C33H38ClF2N3O3
 1
1 IC50 = 1523 nM
CP0171484
5-MCA-NAT
   Show/Hide
C14H17N3O3
 1
1 IC50 = 4000 nM
CP0208351
N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide
   Show/Hide
C16H21NO2
 1
1 Ki = 0.045 nM
CP0060238
N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl]acetamide
   Show/Hide
C13H15ClN2O2
 1
1 Ki = 0.2 nM
CP0110977
N-[2-(5-methoxy-1-methylindol-3-yl)ethyl]acetamide
   Show/Hide
C14H18N2O2
 1
1 Ki = 1.738 nM
CP0089778
N-[2-(1-benzyl-5-methoxyindol-3-yl)ethyl]acetamide
   Show/Hide
C20H22N2O2
 1
1 Ki = 6.457 nM
CP0111066
N-[[1-[(4-chlorophenyl)methyl]-4-methoxyindol-2-yl]methyl]propanamide
   Show/Hide
C20H21ClN2O2
 1
1 Ki = 8.7 nM
CP0047706
N-[3-[2-(4-phenylbutyl)-1,3-benzoxazol-7-yl]propyl]cyclopropanecarboxamide
   Show/Hide
C24H28N2O2
 1
1 Ki = 22 nM
CP0094726
N-[2-(7,17-dimethoxy-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4(9),5,7,10,14(19),15,17-heptaen-10-yl)ethyl]acetamide
   Show/Hide
C24H27N3O3
 1
1 Ki = 410 nM
Clinical Information about the Protein
Target 1 ( Melatonin receptor type 1B (MTNR1B) )
Target Type Successful Target
Disease 1 Target-related Disease  1
1 Insomnia [ICD-11: 7A00-7A0Z]
Approved Drug(s) 2 Approved Drugs  2
1 Ramelteon Approved
Insomnia
2 Tasimelteon Approved
Insomnia