Protein Information

General Information of the Protein

Protein ID	PT02174
Protein Name	Melatonin receptor type 1B
Gene Name	MTNR1B
Sequence	MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine-derivative receptor (family A GPCR) > Melatonin receptor
Function	High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Show/Hide
Uniprot ID	P49286
Ensembl ID	ENSG00000134640
HGNC ID	HGNC:7464
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0396582 Compound Info	N-[3-[5-methoxy-2-[2-(3-methoxyphenyl)ethyl]phenyl]propyl]propanamide Show/Hide	C22H29NO3	2
1	EC50 = 0.024 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.55 nM Bioactivity Info	TI LI LO TS
CP0409354 Compound Info	N-[3-[5-methoxy-2-[(3-methoxyphenyl)methoxy]phenyl]propyl]propanamide Show/Hide	C21H27NO4	3
1	EC50 = 0.05 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.291 nM Bioactivity Info	TI LI LO TS
3	Ki = 1.698 nM Bioactivity Info	TI LI LO TS
CP0444081 Compound Info	N-[2-(2-ethoxy-7,8-dihydrofuro[2,3-g]benzimidazol-1-yl)ethyl]acetamide Show/Hide	C15H19N3O3	2
1	EC50 = 0.05 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.24 nM Bioactivity Info	TI LI LO TS
CP0520740 Compound Info	N-[2-(2-methoxy-7,8-dihydrofuro[2,3-g]benzimidazol-1-yl)ethyl]acetamide Show/Hide	C14H17N3O3	2
1	EC50 = 0.06 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.38 nM Bioactivity Info	TI LI LO TS
CP0034701 Compound Info	N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide Show/Hide	C13H16N2O2	19
1	EC50 = 0.069 nM Bioactivity Info	TI LI LO TS
2	EC50 = 0.07 nM Bioactivity Info	TI LI LO TS
3	EC50 = 0.42 nM Bioactivity Info	TI LI LO TS
4	EC50 = 0.47 nM Bioactivity Info	TI LI LO TS
5	EC50 = 0.49 nM Bioactivity Info	TI LI LO TS
6	EC50 = 0.82 nM Bioactivity Info	TI LI LO TS
7	EC50 = 0.8511 nM Bioactivity Info	TI LI LO TS
8	Ki = 0.12 nM Bioactivity Info	TI LI LO TS
9	Ki = 0.13 nM Bioactivity Info	TI LI LO TS
10	Ki = 0.15 nM Bioactivity Info	TI LI LO TS
11	Ki = 0.21 nM Bioactivity Info	TI LI LO TS
12	Ki = 0.23 nM Bioactivity Info	TI LI LO TS
13	Ki = 0.29 nM Bioactivity Info	TI LI LO TS
14	Ki = 0.35 nM Bioactivity Info	TI LI LO TS
15	Ki = 0.41 nM Bioactivity Info	TI LI LO TS
16	Ki = 0.429 nM Bioactivity Info	TI LI LO TS
17	Ki = 0.52 nM Bioactivity Info	TI LI LO TS
18	Ki = 0.741 nM Bioactivity Info	TI LI LO TS
19	Ki = 0.955 nM Bioactivity Info	TI LI LO TS
CP0178199 Compound Info	Agomelatine Show/Hide	C15H17NO2	7
1	EC50 = 0.06918 nM Bioactivity Info	TI LI LO TS
2	EC50 = 0.1 nM Bioactivity Info	TI LI LO TS
3	EC50 = 0.18 nM Bioactivity Info	TI LI LO TS
4	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
5	Ki = 0.21 nM Bioactivity Info	TI LI LO TS
6	Ki = 0.27 nM Bioactivity Info	TI LI LO TS
7	Ki = 0.3802 nM Bioactivity Info	TI LI LO TS
CP0454903 Compound Info	1-[2-(2-methoxyquinolin-8-yl)ethyl]-3-methylurea Show/Hide	C14H17N3O2	1
1	EC50 = 0.09 nM Bioactivity Info	TI LI LO TS
CP0548271 Compound Info	N-[2-(2-ethoxy-6-methoxybenzimidazol-1-yl)ethyl]butanamide Show/Hide	C16H23N3O3	2
1	EC50 = 0.09 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.28 nM Bioactivity Info	TI LI LO TS
CP0045783 Compound Info	N-[2-(5-methoxy-2-phenyl-1-benzofuran-3-yl)ethyl]acetamide Show/Hide	C19H19NO3	1
1	EC50 = 0.096 nM Bioactivity Info	TI LI LO TS
CP0454899 Compound Info	1-[2-(2-methoxyquinolin-8-yl)ethyl]-3-methylthiourea Show/Hide	C14H17N3OS	1
1	EC50 = 0.1 nM Bioactivity Info	TI LI LO TS
CP0396581 Compound Info	N-[3-[5-methoxy-2-[2-(3-methoxyphenyl)ethynyl]phenyl]propyl]propanamide Show/Hide	C22H25NO3	2
1	EC50 = 0.11 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.073 nM Bioactivity Info	TI LI LO TS
CP0214091 Compound Info	But-3-enoic acid [2-(2-benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-amide Show/Hide	C22H23NO3	1
1	EC50 = 0.17 nM Bioactivity Info	TI LI LO TS
CP0534038 Compound Info	N-[2-(2-ethoxy-6-methoxybenzimidazol-1-yl)ethyl]propanamide Show/Hide	C15H21N3O3	2
1	EC50 = 0.19 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.4 nM Bioactivity Info	TI LI LO TS
CP0417995 Compound Info	N-[3-[5-methoxy-2-(3-methoxyphenyl)phenyl]propyl]propanamide Show/Hide	C20H25NO3	2
1	EC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.339 nM Bioactivity Info	TI LI LO TS
CP0428960 Compound Info	2-(2-methoxyquinolin-8-yl)ethylurea Show/Hide	C13H15N3O2	1
1	EC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0428961 Compound Info	1-ethyl-3-[2-(2-methoxyquinolin-8-yl)ethyl]urea Show/Hide	C15H19N3O2	1
1	EC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0428962 Compound Info	N-[2-(2-methoxyquinolin-8-yl)ethyl]acetamide Show/Hide	C14H16N2O2	1
1	EC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0429915 Compound Info	N-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]acetamide Show/Hide	C18H21NO2	2
1	EC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.1 nM Bioactivity Info	TI LI LO TS
CP0459154 Compound Info	N-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]acetamide Show/Hide	C17H19NO2	2
1	EC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0514069 Compound Info	N-[3-[5-methoxy-2-[(3-methoxyphenyl)methyl]phenyl]propyl]propanamide Show/Hide	C21H27NO3	2
1	EC50 = 0.24 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.39 nM Bioactivity Info	TI LI LO TS
CP0534080 Compound Info	N-[2-(2-ethoxy-6-methoxybenzimidazol-1-yl)ethyl]acetamide Show/Hide	C14H19N3O3	2
1	EC50 = 0.26 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.93 nM Bioactivity Info	TI LI LO TS
CP0419698 Compound Info	US10781182, Compound IA2-121 Show/Hide	C14H18ClN3O3	2
1	EC50 = 0.27 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.93 nM Bioactivity Info	TI LI LO TS
CP0485368 Compound Info	1-ethyl-3-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]urea Show/Hide	C19H24N2O2	2
1	EC50 = 0.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.3 nM Bioactivity Info	TI LI LO TS
CP0419699 Compound Info	US10781182, Compound IA2-142 Show/Hide	C15H20ClN3O3	2
1	EC50 = 0.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.6 nM Bioactivity Info	TI LI LO TS
CP0444082 Compound Info	US10781182, Compound IA2-120 Show/Hide	C15H21N3O3	2
1	EC50 = 0.35 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.5 nM Bioactivity Info	TI LI LO TS
CP0847772 Compound Info	2,2-difluoro-N-(3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl)acetamide Show/Hide	C16H17F2NO3	2
1	EC50 = 0.3715 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.3467 nM Bioactivity Info	TI LI LO TS
CP0192453 Compound Info	But-3-enoic acid {2-[5-methoxy-2-(3-methoxy-benzyl)-benzofuran-3-yl]-ethyl}-amide Show/Hide	C23H25NO4	1
1	EC50 = 0.39 nM Bioactivity Info	TI LI LO TS
CP0454898 Compound Info	methyl N-[2-(2-methoxyquinolin-8-yl)ethyl]carbamate Show/Hide	C14H16N2O3	1
1	EC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0429916 Compound Info	2-methoxy-N-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]acetamide Show/Hide	C18H21NO3	2
1	EC50 = 0.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.1 nM Bioactivity Info	TI LI LO TS
CP0217078 Compound Info	N-[2-[5-methoxy-2-[(2-methoxyphenyl)methyl]-1-benzofuran-3-yl]ethyl]acetamide Show/Hide	C21H23NO4	1
1	EC50 = 0.41 nM Bioactivity Info	TI LI LO TS
CP0418574 Compound Info	N-[2-[7-methoxy-3-[3-(methylamino)phenyl]naphthalen-1-yl]ethyl]acetamide Show/Hide	C22H24N2O2	2
1	EC50 = 0.5 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.51 nM Bioactivity Info	TI LI LO TS
CP0565247 Compound Info	N-[2-(2,6-dimethoxybenzimidazol-1-yl)ethyl]acetamide Show/Hide	C13H17N3O3	2
1	EC50 = 0.52 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.1 nM Bioactivity Info	TI LI LO TS
CP0380668 Compound Info	N-[2-(4-ethyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]acetamide Show/Hide	C15H19N3O2	2
1	EC50 = 0.53 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.42 nM Bioactivity Info	TI LI LO TS
CP0419697 Compound Info	N-[2-(2-ethoxy-6-methoxybenzimidazol-1-yl)ethyl]cyclopropanecarboxamide Show/Hide	C16H21N3O3	2
1	EC50 = 0.56 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.9 nM Bioactivity Info	TI LI LO TS
CP0401351 Compound Info	N-[2-[3-[3-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]butanamide Show/Hide	C24H27NO3	2
1	EC50 = 0.6 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.28 nM Bioactivity Info	TI LI LO TS
CP0877970 Compound Info	rac-2-fluoro-N-(3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl)acetamide Show/Hide	C16H18FNO3	2
1	EC50 = 0.631 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.537 nM Bioactivity Info	TI LI LO TS
CP0424931 Compound Info	N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]acetamide Show/Hide	C18H15F2NOS2	2
1	EC50 = 0.64 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.87 nM Bioactivity Info	TI LI LO TS
CP0452012 Compound Info	N-[2-(5-fluoro-1-benzothiophen-3-yl)ethyl]acetamide Show/Hide	C12H12FNOS	2
1	EC50 = 0.68 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.87 nM Bioactivity Info	TI LI LO TS
CP0401365 Compound Info	N-[2-[3-[3-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]propanamide Show/Hide	C23H25NO3	2
1	EC50 = 0.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.52 nM Bioactivity Info	TI LI LO TS
CP0462764 Compound Info	N-[2-(6-methoxypyrrolo[2,3-b]pyridin-1-yl)ethyl]butanamide Show/Hide	C14H19N3O2	1
1	EC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0121891 Compound Info	N-[2-(8-methoxybenzo[e][1]benzofuran-1-yl)ethyl]acetamide Show/Hide	C17H17NO3	2
1	EC50 = 0.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.09 nM Bioactivity Info	TI LI LO TS
CP0406657 Compound Info	3-(2-methoxyquinolin-8-yl)-N-methylpropanamide Show/Hide	C14H16N2O2	1
1	EC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0414939 Compound Info	1-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]-3-propylurea Show/Hide	C20H26N2O2	2
1	EC50 = 0.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0098513 Compound Info	N-[2-[5-methoxy-2-[(3-methoxyphenyl)methyl]-1-benzofuran-3-yl]ethyl]acetamide Show/Hide	C21H23NO4	2
1	EC50 = 0.72 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.25 nM Bioactivity Info	TI LI LO TS
CP0458570 Compound Info	N-[2-[3-[3-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide Show/Hide	C22H23NO3	2
1	EC50 = 0.76 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.36 nM Bioactivity Info	TI LI LO TS
CP0548268 Compound Info	N-[2-(6-methoxy-2-methylsulfanylbenzimidazol-1-yl)ethyl]acetamide Show/Hide	C13H17N3O2S	2
1	EC50 = 0.76 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.2 nM Bioactivity Info	TI LI LO TS
CP0847771 Compound Info	(R)-2-fluoro-N-(3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl)acetamide Show/Hide	C16H18FNO3	2
1	EC50 = 0.7943 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.9772 nM Bioactivity Info	TI LI LO TS
CP0488406 Compound Info	3-(2-methoxyquinolin-8-yl)-N-methylsulfonylpropanamide Show/Hide	C14H16N2O4S	1
1	EC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0450973 Compound Info	US10781182, Compound IA2-143 Show/Hide	C13H16ClN3O3	2
1	EC50 = 0.86 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.8 nM Bioactivity Info	TI LI LO TS
CP0410497 Compound Info	(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methylurea Show/Hide	C16H18N2O2	2
1	EC50 = 0.9 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.1 nM Bioactivity Info	TI LI LO TS
CP0105645 Compound Info	N-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]cyclopropanecarboxamide Show/Hide	C18H17NO3	2
1	EC50 = 0.98 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.6 nM Bioactivity Info	TI LI LO TS
CP0414625 Compound Info	N-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]acetamide Show/Hide	C16H15NO3	2
1	EC50 = 0.98 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.4 nM Bioactivity Info	TI LI LO TS
CP0433987 Compound Info	N-[2-[3-[3-(bromomethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide Show/Hide	C22H22BrNO2	2
1	EC50 = 1 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.56 nM Bioactivity Info	TI LI LO TS
CP0432632 Compound Info	N-(1-phenyl-3,4-dihydro-2H-quinolin-3-yl)propanamide Show/Hide	C18H20N2O	2
1	EC50 = 1 nM Bioactivity Info	TI LI LO TS
2	Ki = 2 nM Bioactivity Info	TI LI LO TS
CP0405073 Compound Info	N-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]methanesulfonamide Show/Hide	C16H19NO3S	2
1	EC50 = 1 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.1 nM Bioactivity Info	TI LI LO TS
CP0458757 Compound Info	4-azamelatonin Show/Hide	C12H15N3O2	1
1	EC50 = 1.1 nM Bioactivity Info	TI LI LO TS
CP0121949 Compound Info	2-fluoro-N-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]acetamide Show/Hide	C16H14FNO3	2
1	EC50 = 1.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.7 nM Bioactivity Info	TI LI LO TS
CP0474650 Compound Info	1-ethyl-3-[2-(2-methoxyquinolin-8-yl)ethyl]thiourea Show/Hide	C15H19N3OS	1
1	EC50 = 1.1 nM Bioactivity Info	TI LI LO TS
CP0847773 Compound Info	(R)-N-(3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl)propionamide Show/Hide	C17H21NO3	2
1	EC50 = 1.259 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.3162 nM Bioactivity Info	TI LI LO TS
CP0301499 Compound Info	N-[2-[5-methoxy-2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzofuran-3-yl]ethyl]acetamide Show/Hide	C21H20F3NO3	1
1	EC50 = 1.26 nM Bioactivity Info	TI LI LO TS
CP0387872 Compound Info	N-[2-[3-(3-formylphenyl)-7-methoxynaphthalen-1-yl]ethyl]acetamide Show/Hide	C22H21NO3	2
1	EC50 = 1.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.42 nM Bioactivity Info	TI LI LO TS
CP0418572 Compound Info	N-[2-[3-(3-aminophenyl)-7-methoxynaphthalen-1-yl]ethyl]acetamide Show/Hide	C21H22N2O2	2
1	EC50 = 1.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.27 nM Bioactivity Info	TI LI LO TS
CP0486875 Compound Info	N-[2-(2-methoxy-5,6,7,8-tetrahydropyrido[2,3-b]indol-9-yl)ethyl]acetamide Show/Hide	C16H21N3O2	1
1	EC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0377934 Compound Info	N-[2-[7-(cyclohexylmethyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide Show/Hide	C22H29NO2	2
1	EC50 = 1.318 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.012 nM Bioactivity Info	TI LI LO TS
CP0462765 Compound Info	N-[2-(6-methoxypyrrolo[2,3-b]pyridin-1-yl)ethyl]propanamide Show/Hide	C13H17N3O2	1
1	EC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0406180 Compound Info	N-[(8-methoxybenzo[e][1]benzofuran-1-yl)methyl]acetamide Show/Hide	C16H15NO3	2
1	EC50 = 1.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.7 nM Bioactivity Info	TI LI LO TS
CP0435113 Compound Info	N-[2-[3-[3-(dimethylamino)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide Show/Hide	C23H26N2O2	2
1	EC50 = 1.5 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.94 nM Bioactivity Info	TI LI LO TS
CP0469375 Compound Info	1-ethyl-3-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]thiourea Show/Hide	C19H24N2OS	2
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
2	Ki = 3 nM Bioactivity Info	TI LI LO TS
CP0548270 Compound Info	US10781182, Compound IA2-140 Show/Hide	C14H19N3O3	2
1	EC50 = 2.01 nM Bioactivity Info	TI LI LO TS
2	Ki = 11 nM Bioactivity Info	TI LI LO TS
CP0467650 Compound Info	N-[2-(6-methoxypyrrolo[2,3-b]pyridin-1-yl)ethyl]acetamide Show/Hide	C12H15N3O2	1
1	EC50 = 2.1 nM Bioactivity Info	TI LI LO TS
CP0436558 Compound Info	N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]but-3-enamide Show/Hide	C20H17F2NOS2	2
1	EC50 = 2.15 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.24 nM Bioactivity Info	TI LI LO TS
CP0399205 Compound Info	N-[2-(7-methoxy-3-phenylnaphthalen-1-yl)ethyl]acetamide Show/Hide	C21H21NO2	2
1	EC50 = 2.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.37 nM Bioactivity Info	TI LI LO TS
CP0419695 Compound Info	N-[2-(2-ethoxy-6-methoxybenzimidazol-1-yl)ethyl]cyclobutanecarboxamide Show/Hide	C17H23N3O3	2
1	EC50 = 2.49 nM Bioactivity Info	TI LI LO TS
2	Ki = 23 nM Bioactivity Info	TI LI LO TS
CP0877971 Compound Info	rac-N-(1-hydroxy-3-(7-methoxynaphthalen-1-yl)propan-2-yl)propionamide Show/Hide	C17H21NO3	2
1	EC50 = 2.754 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.951 nM Bioactivity Info	TI LI LO TS
CP0385360 Compound Info	3-(5-methoxy-1H-indol-3-yl)-N-prop-2-ynylpropanamide Show/Hide	C15H16N2O2	2
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
2	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0389221 Compound Info	N-[(1-benzyl-3,4-dihydro-2H-quinolin-3-yl)methyl]acetamide Show/Hide	C19H22N2O	2
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
2	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0416460 Compound Info	1-ethyl-3-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]urea Show/Hide	C18H22N2O2	2
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.1 nM Bioactivity Info	TI LI LO TS
CP0429921 Compound Info	1-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]-3-methylthiourea Show/Hide	C18H22N2OS	2
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0121948 Compound Info	N-[2-(8-methoxybenzo[e][1]benzofuran-1-yl)ethyl]cyclopropanecarboxamide Show/Hide	C19H19NO3	2
1	EC50 = 3.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 13.3 nM Bioactivity Info	TI LI LO TS
CP0309822 Compound Info	2-fluoro-N-[(8-methoxybenzo[e][1]benzofuran-1-yl)methyl]acetamide Show/Hide	C16H14FNO3	2
1	EC50 = 3.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.1 nM Bioactivity Info	TI LI LO TS
CP0405083 Compound Info	1-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]-3-propylthiourea Show/Hide	C20H26N2OS	2
1	EC50 = 4 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.3 nM Bioactivity Info	TI LI LO TS
CP0429925 Compound Info	(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methylthiourea Show/Hide	C16H18N2OS	2
1	EC50 = 5 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.4 nM Bioactivity Info	TI LI LO TS
CP0429929 Compound Info	methyl N-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]carbamate Show/Hide	C17H19NO3	2
1	EC50 = 5 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.4 nM Bioactivity Info	TI LI LO TS
CP0381571 Compound Info	5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3H-1,3,4-oxadiazol-2-one Show/Hide	C13H13N3O3	3
1	EC50 = 5.5 nM Bioactivity Info	TI LI LO TS
2	EC50 = 29 nM Bioactivity Info	TI LI LO TS
3	Ki = 4 nM Bioactivity Info	TI LI LO TS
CP0414626 Compound Info	N-[2-(8-methoxybenzo[e][1]benzofuran-2-yl)ethyl]cyclopropanecarboxamide Show/Hide	C19H19NO3	2
1	EC50 = 5.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 11 nM Bioactivity Info	TI LI LO TS
CP0429918 Compound Info	1-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]-3-methylthiourea Show/Hide	C17H20N2OS	1
1	EC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0105646 Compound Info	1-ethyl-3-[2-(8-methoxybenzo[e][1]benzofuran-1-yl)ethyl]urea Show/Hide	C18H20N2O3	2
1	EC50 = 6.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 226 nM Bioactivity Info	TI LI LO TS
CP0426377 Compound Info	N-[(1-ethyl-3,4-dihydro-2H-quinolin-3-yl)methyl]acetamide Show/Hide	C14H20N2O	2
1	EC50 = 7 nM Bioactivity Info	TI LI LO TS
2	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0452013 Compound Info	2-bromo-N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]acetamide Show/Hide	C18H14BrF2NOS2	2
1	EC50 = 7.27 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.21 nM Bioactivity Info	TI LI LO TS
CP0847750 Compound Info	(S)-N-(1-hydroxy-3-(7-methoxynaphthalen-1-yl)propan-2-yl)propionamide Show/Hide	C17H21NO3	2
1	EC50 = 7.413 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.495 nM Bioactivity Info	TI LI LO TS
CP0309821 Compound Info	N-[(8-methoxybenzo[e][1]benzofuran-1-yl)methyl]cyclopropanecarboxamide Show/Hide	C18H17NO3	2
1	EC50 = 8.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0472545 Compound Info	N-[(8-methoxybenzo[e][1]benzofuran-1-yl)methyl]-2-methylpropanamide Show/Hide	C18H19NO3	2
1	EC50 = 8.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 24 nM Bioactivity Info	TI LI LO TS
CP0072976 Compound Info	N-[2-[2-(cyclohexylmethyl)-5-methoxy-1-benzofuran-3-yl]ethyl]acetamide Show/Hide	C20H27NO3	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0436038 Compound Info	N-[2-[6-methoxy-3-(2,2,2-trifluoroacetyl)pyrrolo[2,3-b]pyridin-1-yl]ethyl]acetamide Show/Hide	C14H14F3N3O3	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0443574 Compound Info	1-ethyl-3-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]urea Show/Hide	C17H18N2O3	2
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.2 nM Bioactivity Info	TI LI LO TS
CP0389226 Compound Info	N-[(1-methyl-3,4-dihydro-2H-quinolin-3-yl)methyl]acetamide Show/Hide	C13H18N2O	2
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
2	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0467651 Compound Info	N-[2-(3-iodo-6-methoxypyrrolo[2,3-b]pyridin-1-yl)ethyl]acetamide Show/Hide	C12H14IN3O2	1
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0381574 Compound Info	3-(5-methoxy-1H-indol-3-yl)-N-prop-2-enylpropanamide Show/Hide	C15H18N2O2	2
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.45 nM Bioactivity Info	TI LI LO TS
CP0297769 Compound Info	N-[2-[5-ethyl-2-[(3-methoxyphenyl)methyl]-1-benzofuran-3-yl]ethyl]acetamide Show/Hide	C22H25NO3	1
1	EC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0391337 Compound Info	1-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]-3-propylurea Show/Hide	C19H24N2O2	2
1	EC50 = 20 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0430453 Compound Info	N-[2-[7-[4-[[3-(2-acetamidoethyl)-1-benzothiophen-5-yl]oxy]butoxy]naphthalen-1-yl]ethyl]acetamide Show/Hide	C30H34N2O4S	2
1	EC50 = 20.6 nM Bioactivity Info	TI LI LO TS
2	Ki = 16.9 nM Bioactivity Info	TI LI LO TS
CP0877969 Compound Info	(S)-2-fluoro-N-(3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl)acetamide Show/Hide	C16H18FNO3	2
1	EC50 = 25.12 nM Bioactivity Info	TI LI LO TS
2	Ki = 52.48 nM Bioactivity Info	TI LI LO TS
CP0469064 Compound Info	N-[2-[7-[4-[4-[4-(hydroxymethyl)phenyl]phenoxy]butoxy]naphthalen-1-yl]ethyl]acetamide Show/Hide	C31H33NO4	2
1	EC50 = 26 nM Bioactivity Info	TI LI LO TS
2	Ki = 6.53 nM Bioactivity Info	TI LI LO TS
CP0373468 Compound Info	N-[2-[7-[4-[8-[2-(but-3-enoylamino)ethyl]naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]but-3-enamide Show/Hide	C36H40N2O4	2
1	EC50 = 40.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 10.9 nM Bioactivity Info	TI LI LO TS
CP0405082 Compound Info	1-ethyl-3-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]thiourea Show/Hide	C18H22N2OS	2
1	EC50 = 50 nM Bioactivity Info	TI LI LO TS
2	Ki = 2 nM Bioactivity Info	TI LI LO TS
CP0389326 Compound Info	2-[(5-methoxy-1H-indol-3-yl)methyl]-5-methyl-1,3,4-oxadiazole Show/Hide	C13H13N3O2	2
1	EC50 = 71 nM Bioactivity Info	TI LI LO TS
2	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0432631 Compound Info	N-[[1-(2-phenylethyl)-3,4-dihydro-2H-quinolin-3-yl]methyl]acetamide Show/Hide	C20H24N2O	2
1	EC50 = 80 nM Bioactivity Info	TI LI LO TS
2	Ki = 47 nM Bioactivity Info	TI LI LO TS
CP0382347 Compound Info	2-(5-methoxy-1H-indol-3-yl)-N-prop-2-ynylacetamide Show/Hide	C14H14N2O2	2
1	EC50 = 81 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.8 nM Bioactivity Info	TI LI LO TS
CP0407040 Compound Info	methyl 2-[6-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-2-yl]propanoate Show/Hide	C32H35NO5	2
1	EC50 = 88 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.22 nM Bioactivity Info	TI LI LO TS
CP0401209 Compound Info	N-ethyl-5-[(5-methoxy-1H-indol-3-yl)methyl]-1,3,4-thiadiazol-2-amine Show/Hide	C14H16N4OS	2
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
2	Ki = 17 nM Bioactivity Info	TI LI LO TS
CP0071154 Compound Info	2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamine Show/Hide	C13H18N2O	2
1	EC50 = 112 nM Bioactivity Info	TI LI LO TS
2	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0398561 Compound Info	2-((S)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile Show/Hide	C32H38ClF2N3O2	1
1	EC50 = 115 nM Bioactivity Info	TI LI LO TS
CP0397791 Compound Info	2-(5-methoxy-1H-indol-3-yl)-N-prop-2-enylacetamide Show/Hide	C14H16N2O2	2
1	EC50 = 132 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.9 nM Bioactivity Info	TI LI LO TS
CP0401703 Compound Info	N-[2-[7-[4-[8-[2-(cyclopropanecarbonylamino)ethyl]naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]cyclopropanecarboxamide Show/Hide	C36H40N2O4	2
1	EC50 = 134 nM Bioactivity Info	TI LI LO TS
2	Ki = 13.6 nM Bioactivity Info	TI LI LO TS
CP0378677 Compound Info	N-[3-hydroxy-2-(7-methoxynaphthalen-1-yl)propyl]acetamide Show/Hide	C16H19NO3	2
1	EC50 = 144.54 nM Bioactivity Info	TI LI LO TS
2	Ki = 13.8 nM Bioactivity Info	TI LI LO TS
CP0400794 Compound Info	2-[6-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-2-yl]propanoic acid Show/Hide	C31H33NO5	2
1	EC50 = 161 nM Bioactivity Info	TI LI LO TS
2	Ki = 59.1 nM Bioactivity Info	TI LI LO TS
CP0415246 Compound Info	2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile Show/Hide	C31H36ClF2N3O2	1
1	EC50 = 295 nM Bioactivity Info	TI LI LO TS
CP0382351 Compound Info	5-[(5-methoxy-1H-indol-3-yl)methyl]-3-methyl-1,2,4-oxadiazole Show/Hide	C13H13N3O2	2
1	EC50 = 295 nM Bioactivity Info	TI LI LO TS
2	Ki = 44 nM Bioactivity Info	TI LI LO TS
CP0493345 Compound Info	2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(1-hydroxy-2-methylpropan-2-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile Show/Hide	C32H38ClF2N3O3	1
1	EC50 = 342.9 nM Bioactivity Info	TI LI LO TS
CP0436037 Compound Info	7-azamelatonin Show/Hide	C12H15N3O2	1
1	EC50 = 380 nM Bioactivity Info	TI LI LO TS
CP0400796 Compound Info	N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]acetamide Show/Hide	C32H36N2O4	3
1	EC50 = 405 nM Bioactivity Info	TI LI LO TS
2	Ki = 72.7 nM Bioactivity Info	TI LI LO TS
3	Ki = 167 nM Bioactivity Info	TI LI LO TS
CP0389325 Compound Info	2-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,4-oxadiazole Show/Hide	C13H13N3O2	2
1	EC50 = 457 nM Bioactivity Info	TI LI LO TS
2	Ki = 68 nM Bioactivity Info	TI LI LO TS
CP0398563 Compound Info	2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(pentan-3-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile Show/Hide	C33H40ClF2N3O2	1
1	EC50 = 465 nM Bioactivity Info	TI LI LO TS
CP0415040 Compound Info	2-[2-(5-methoxy-1H-indol-3-yl)ethyl]-5-methyl-1,3-oxazole Show/Hide	C15H16N2O2	2
1	EC50 = 503 nM Bioactivity Info	TI LI LO TS
2	Ki = 498 nM Bioactivity Info	TI LI LO TS
CP0398564 Compound Info	2-((3S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(1-methoxypropan-2-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile Show/Hide	C32H38ClF2N3O3	1
1	EC50 = 615 nM Bioactivity Info	TI LI LO TS
CP0493348 Compound Info	2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile Show/Hide	C34H40ClF2N3O3	1
1	EC50 = 735 nM Bioactivity Info	TI LI LO TS
CP0072131 Compound Info	2-[2-(5-methoxy-1H-indol-3-yl)ethyl]-5-methyl-1,3,4-oxadiazole Show/Hide	C14H15N3O2	3
1	EC50 = 881 nM Bioactivity Info	TI LI LO TS
2	EC50 = 1600 nM Bioactivity Info	TI LI LO TS
3	Ki = 190 nM Bioactivity Info	TI LI LO TS
CP0432491 Compound Info	N-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]ethanesulfonamide Show/Hide	C17H21NO3S	2
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.4 nM Bioactivity Info	TI LI LO TS
CP0398233 Compound Info	5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3H-1,3,4-oxadiazole-2-thione Show/Hide	C13H13N3O2S	2
1	EC50 = 1096 nM Bioactivity Info	TI LI LO TS
2	Ki = 530 nM Bioactivity Info	TI LI LO TS
CP0283823 Compound Info	2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile Show/Hide	C33H38ClF2N3O3	1
1	EC50 = 1697 nM Bioactivity Info	TI LI LO TS
CP0383642 Compound Info	2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile Show/Hide	C28H30ClF2N3O2	1
1	EC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0083725 Compound Info	N-[2-(2-benzyl-5-methoxy-1-benzofuran-3-yl)ethyl]acetamide Show/Hide	C20H21NO3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0095846 Compound Info	N-[2-[5-methoxy-2-[(4-methoxyphenyl)methyl]-1-benzofuran-3-yl]ethyl]acetamide Show/Hide	C21H23NO4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0100122 Compound Info	N-[2-(2-benzyl-1-benzofuran-3-yl)ethyl]acetamide Show/Hide	C19H19NO2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0452010 Compound Info	N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]propanamide Show/Hide	C19H17F2NOS2	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 4.4 nM Bioactivity Info	TI LI LO TS
CP0406181 Compound Info	N-[2-(8-methoxybenzo[e][1]benzofuran-2-yl)ethyl]acetamide Show/Hide	C17H17NO3	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.7 nM Bioactivity Info	TI LI LO TS
CP0389225 Compound Info	N-[(1-phenyl-3,4-dihydro-2H-quinolin-3-yl)methyl]acetamide Show/Hide	C18H20N2O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0432630 Compound Info	N-(1-benzyl-3,4-dihydro-2H-quinolin-3-yl)propanamide Show/Hide	C19H22N2O	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 6 nM Bioactivity Info	TI LI LO TS
CP0393387 Compound Info	1-[(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)methyl]-3-propylthiourea Show/Hide	C19H24N2OS	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 3 nM Bioactivity Info	TI LI LO TS
CP0376623 Compound Info	5-[(5-methoxy-1H-indol-3-yl)methyl]-3H-1,3,4-oxadiazole-2-thione Show/Hide	C12H11N3O2S	2
1	EC50 > 1000 nM Bioactivity Info	TI LI LO TS
2	Ki = 535 nM Bioactivity Info	TI LI LO TS
CP0381569 Compound Info	5-[(5-methoxy-1H-indol-3-yl)methyl]-3H-1,3,4-oxadiazol-2-one Show/Hide	C12H11N3O3	2
1	EC50 > 1000 nM Bioactivity Info	TI LI LO TS
2	Ki = 160 nM Bioactivity Info	TI LI LO TS
CP0381570 Compound Info	3-[(5-methoxy-1H-indol-3-yl)methyl]-4-methyl-1H-1,2,4-triazol-5-one Show/Hide	C13H14N4O2	2
1	EC50 > 1000 nM Bioactivity Info	TI LI LO TS
2	Ki = 560 nM Bioactivity Info	TI LI LO TS
CP0398249 Compound Info	4-ethyl-3-[(5-methoxy-1H-indol-3-yl)methyl]-1H-1,2,4-triazole-5-thione Show/Hide	C14H16N4OS	2
1	EC50 > 1000 nM Bioactivity Info	TI LI LO TS
2	Ki = 220 nM Bioactivity Info	TI LI LO TS
CP0521668 Compound Info	2,2,2-Trifluoro-N-[2-(7-isopropyl-1,6-dihydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]acetamide Show/Hide	C18H20F3NO2	1
1	Ki = 0.01 nM Bioactivity Info	TI LI LO TS
CP0425880 Compound Info	N-[2-(7-propan-2-yl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]propanamide Show/Hide	C19H25NO2	1
1	Ki = 0.011 nM Bioactivity Info	TI LI LO TS
CP0425881 Compound Info	N-[2-[7-(3-propan-2-ylphenyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide Show/Hide	C24H27NO2	1
1	Ki = 0.011 nM Bioactivity Info	TI LI LO TS
CP0377935 Compound Info	N-[2-(7-bromo-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]acetamide Show/Hide	C15H16BrNO2	1
1	Ki = 0.014 nM Bioactivity Info	TI LI LO TS
CP0499108 Compound Info	N-[2-(7-propan-2-yl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]acetamide Show/Hide	C18H23NO2	1
1	Ki = 0.018 nM Bioactivity Info	TI LI LO TS
CP0501489 Compound Info	N-[2-[7-(2-methoxyphenyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide Show/Hide	C22H23NO3	1
1	Ki = 0.02 nM Bioactivity Info	TI LI LO TS
CP0494363 Compound Info	N-[2-(2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]acetamide Show/Hide	C15H17NO2	1
1	Ki = 0.022 nM Bioactivity Info	TI LI LO TS
CP0532363 Compound Info	N-[3-[2-[(3,5-dimethoxyphenyl)methoxy]-5-methoxyphenyl]propyl]acetamide Show/Hide	C21H27NO5	1
1	Ki = 0.0326 nM Bioactivity Info	TI LI LO TS
CP0521667 Compound Info	N-[2-(7-pyridin-3-yl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]acetamide Show/Hide	C20H20N2O2	1
1	Ki = 0.034 nM Bioactivity Info	TI LI LO TS
CP0437994 Compound Info	N-[2-(7-propan-2-yl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]cyclopropanecarboxamide Show/Hide	C20H25NO2	1
1	Ki = 0.035 nM Bioactivity Info	TI LI LO TS
CP0377936 Compound Info	N-[2-[7-(4-methoxyphenyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide Show/Hide	C22H23NO3	1
1	Ki = 0.037 nM Bioactivity Info	TI LI LO TS
CP0504561 Compound Info	N-[3-(5-methoxy-2-phenylmethoxyphenyl)propyl]acetamide Show/Hide	C19H23NO3	1
1	Ki = 0.04705 nM Bioactivity Info	TI LI LO TS
CP0499107 Compound Info	1-ethyl-3-[2-(7-propan-2-yl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]urea Show/Hide	C19H26N2O2	1
1	Ki = 0.084 nM Bioactivity Info	TI LI LO TS
CP0458342 Compound Info	N-[2-(4-phenyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]acetamide Show/Hide	C19H19N3O2	1
1	Ki = 0.085 nM Bioactivity Info	TI LI LO TS
CP0485220 Compound Info	N-[3-(3-methoxyphenyl)-3-naphthalen-2-ylpropyl]acetamide Show/Hide	C22H23NO2	1
1	Ki = 0.11 nM Bioactivity Info	TI LI LO TS
CP0376971 Compound Info	N-[2-(4-cyclopropyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]propanamide Show/Hide	C17H21N3O2	1
1	Ki = 0.14 nM Bioactivity Info	TI LI LO TS
CP0055675 Compound Info	2-Iodomelatonin Show/Hide	C13H15IN2O2	1
1	Ki = 0.15 nM Bioactivity Info	TI LI LO TS
CP0186244 Compound Info	(4-Methoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-6-ylmethyl)-methoxymethyl-amine Show/Hide	C20H23NO2	1
1	Ki = 0.16 nM Bioactivity Info	TI LI LO TS
CP0501182 Compound Info	N-[2-(4-methyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]propanamide Show/Hide	C15H19N3O2	1
1	Ki = 0.19 nM Bioactivity Info	TI LI LO TS
CP0393386 Compound Info	1-[(2-methoxy-8,9-dihydro-7H-cyclopenta[h]quinolin-9-yl)methyl]-3-methylurea Show/Hide	C16H19N3O2	1
1	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0429924 Compound Info	N-[(2-methoxy-8,9-dihydro-7H-cyclopenta[h]quinolin-9-yl)methyl]acetamide Show/Hide	C16H18N2O2	1
1	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0508414 Compound Info	N-[(8-methoxy-1-methyl-2,3-dihydrocyclopenta[a]naphthalen-1-yl)methyl]methanesulfonamide Show/Hide	C17H21NO3S	1
1	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0441548 Compound Info	N-[2-(4-ethyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]propanamide Show/Hide	C16H21N3O2	1
1	Ki = 0.22 nM Bioactivity Info	TI LI LO TS
CP0389224 Compound Info	N-[[(1S,2R)-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl]propanamide Show/Hide	C20H23NO	1
1	Ki = 0.22 nM Bioactivity Info	TI LI LO TS
CP0426376 Compound Info	N-[[(1R,2R)-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl]propanamide Show/Hide	C20H23NO	1
1	Ki = 0.23 nM Bioactivity Info	TI LI LO TS
CP0455738 Compound Info	N-[2-(4-cyclopropyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]acetamide Show/Hide	C16H19N3O2	1
1	Ki = 0.28 nM Bioactivity Info	TI LI LO TS
CP0390104 Compound Info	N-[2-[4-(trifluoromethyl)-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl]ethyl]propanamide Show/Hide	C15H16F3N3O2	1
1	Ki = 0.33 nM Bioactivity Info	TI LI LO TS
CP0509534 Compound Info	N-[2-[7-(2-propan-2-yloxyphenyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide Show/Hide	C24H27NO3	1
1	Ki = 0.34 nM Bioactivity Info	TI LI LO TS
CP0040580 Compound Info	N-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]acetamide Show/Hide	C13H15NO3	1
1	Ki = 0.34 nM Bioactivity Info	TI LI LO TS
CP0384067 Compound Info	N-[2-(2,7-dimethoxynaphthalen-1-yl)ethyl]propanamide Show/Hide	C17H21NO3	1
1	Ki = 0.38 nM Bioactivity Info	TI LI LO TS
CP0429922 Compound Info	1-[(2-methoxy-8,9-dihydro-7H-cyclopenta[h]quinolin-9-yl)methyl]-3-propylurea Show/Hide	C18H23N3O2	1
1	Ki = 0.4 nM Bioactivity Info	TI LI LO TS
CP0474642 Compound Info	N-[2-(6-methoxyquinolin-4-yl)ethyl]butanamide Show/Hide	C16H20N2O2	1
1	Ki = 0.41 nM Bioactivity Info	TI LI LO TS
CP0114370 Compound Info	4-P-PDOT Show/Hide	C19H21NO	1
1	Ki = 0.46 nM Bioactivity Info	TI LI LO TS
CP0475208 Compound Info	N-[[(3R,4S)-1-methyl-4-phenyl-3,4-dihydro-2H-quinolin-3-yl]methyl]propanamide Show/Hide	C20H24N2O	1
1	Ki = 0.48 nM Bioactivity Info	TI LI LO TS
CP0081204 Compound Info	N-[2-(11-methoxy-6,7-dihydro-5H-indolo[2,1-a][2]benzazepin-13-yl)ethyl]butanamide Show/Hide	C24H28N2O2	1
1	Ki = 0.5 nM Bioactivity Info	TI LI LO TS
CP0458343 Compound Info	N-[2-(4-methyl-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl)ethyl]acetamide Show/Hide	C14H17N3O2	1
1	Ki = 0.53 nM Bioactivity Info	TI LI LO TS
CP0456126 Compound Info	3-[4-(2-Acetylaminoethyl)-6-methoxynaphth-2-yl]benzoic acid methyl ester Show/Hide	C23H23NO4	1
1	Ki = 0.64 nM Bioactivity Info	TI LI LO TS
CP0443391 Compound Info	N-[2-[3-[3-(iodomethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide Show/Hide	C22H22INO2	1
1	Ki = 0.71 nM Bioactivity Info	TI LI LO TS
CP0390102 Compound Info	N-[3-(3-methoxyphenyl)propyl]acetamide Show/Hide	C12H17NO2	1
1	Ki = 0.751 nM Bioactivity Info	TI LI LO TS
CP0501488 Compound Info	N-[2-[7-(4-tert-butylphenyl)-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]acetamide Show/Hide	C25H29NO2	1
1	Ki = 0.77 nM Bioactivity Info	TI LI LO TS
CP0420022 Compound Info	1-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]-3-methylthiourea Show/Hide	C16H16N2O2S	1
1	Ki = 0.8 nM Bioactivity Info	TI LI LO TS
CP0416462 Compound Info	N-[2-(2-methoxy-8,9-dihydro-7H-cyclopenta[h]quinolin-9-yl)ethyl]acetamide Show/Hide	C17H20N2O2	1
1	Ki = 0.8 nM Bioactivity Info	TI LI LO TS
CP0399886 Compound Info	N-[2-[(1R,3R)-7-methoxy-3-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]ethyl]cyclobutanecarboxamide Show/Hide	C24H29NO2	1
1	Ki = 0.9 nM Bioactivity Info	TI LI LO TS
CP0441549 Compound Info	N-[2-[4-(trifluoromethyl)-10-oxa-5,6-diazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7-tetraen-3-yl]ethyl]acetamide Show/Hide	C14H14F3N3O2	1
1	Ki = 0.93 nM Bioactivity Info	TI LI LO TS
CP0433988 Compound Info	N-[2-[7-methoxy-3-[3-(methoxymethyl)phenyl]naphthalen-1-yl]ethyl]acetamide Show/Hide	C23H25NO3	1
1	Ki = 0.95 nM Bioactivity Info	TI LI LO TS
CP0518308 Compound Info	N-[2-(6-methoxyquinolin-4-yl)ethyl]propanamide Show/Hide	C15H18N2O2	1
1	Ki = 0.96 nM Bioactivity Info	TI LI LO TS
CP0448964 Compound Info	N-[2-(2-hydroxy-7-methoxynaphthalen-1-yl)ethyl]propanamide Show/Hide	C16H19NO3	1
1	Ki = 1.2 nM Bioactivity Info	TI LI LO TS
CP0510962 Compound Info	N-[2-(2-ethoxy-7-methoxynaphthalen-1-yl)ethyl]propanamide Show/Hide	C18H23NO3	1
1	Ki = 1.2 nM Bioactivity Info	TI LI LO TS
CP0509510 Compound Info	N-[2-[2-(2-hydroxyethoxy)-7-methoxynaphthalen-1-yl]ethyl]propanamide Show/Hide	C18H23NO4	1
1	Ki = 1.3 nM Bioactivity Info	TI LI LO TS
CP0491332 Compound Info	N-[2-(6-methoxyquinolin-4-yl)ethyl]acetamide Show/Hide	C14H16N2O2	1
1	Ki = 1.4 nM Bioactivity Info	TI LI LO TS
CP0430666 Compound Info	N-[3-(2-ethoxy-5-methoxyphenyl)propyl]acetamide Show/Hide	C14H21NO3	1
1	Ki = 1.59 nM Bioactivity Info	TI LI LO TS
CP0430669 Compound Info	N-[3-[5-methoxy-2-(pyridin-2-ylmethoxy)phenyl]propyl]acetamide Show/Hide	C18H22N2O3	1
1	Ki = 1.61 nM Bioactivity Info	TI LI LO TS
CP0390834 Compound Info	methyl 2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]acetate Show/Hide	C31H33NO5	1
1	Ki = 1.84 nM Bioactivity Info	TI LI LO TS
CP0520030 Compound Info	N-[2-[3-[2-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide Show/Hide	C22H23NO3	1
1	Ki = 1.86 nM Bioactivity Info	TI LI LO TS
CP0432490 Compound Info	N-[2-(8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-yl)ethyl]acetamide Show/Hide	C18H21NO2	1
1	Ki = 2 nM Bioactivity Info	TI LI LO TS
CP0470465 Compound Info	N-[3-(5-methoxy-2-propoxyphenyl)propyl]acetamide Show/Hide	C15H23NO3	1
1	Ki = 2.12 nM Bioactivity Info	TI LI LO TS
CP0849416 Compound Info	N-(2-(2-(isoindolin-2-ylmethyl)-5-methoxy-1H-indol-3-yl)ethyl)acetamide Show/Hide	C22H25N3O2	1
1	Ki = 2.239 nM Bioactivity Info	TI LI LO TS
CP0920948 Compound Info	N-[2-(5-Methoxy-2-{[(methyl(phenyl)amino]methyl}-1H-indol-3-yl)ethyl]acetamide Show/Hide	C21H25N3O2	1
1	Ki = 2.291 nM Bioactivity Info	TI LI LO TS
CP0375021 Compound Info	(E)-N-[3-(3-methoxyphenyl)-3-phenyl-2-propenyl]acetamide Show/Hide	C18H19NO2	1
1	Ki = 2.5 nM Bioactivity Info	TI LI LO TS
CP0388318 Compound Info	N-[2-[3-[3-(aminomethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide Show/Hide	C22H24N2O2	1
1	Ki = 3.4 nM Bioactivity Info	TI LI LO TS
CP0866793 Compound Info	N-(2-(2-(isoindolin-2-ylmethyl)-5-methoxy-1H-indol-3-yl)ethyl)propionamide Show/Hide	C23H27N3O2	1
1	Ki = 3.715 nM Bioactivity Info	TI LI LO TS
CP0389223 Compound Info	N-[(1-phenyl-3,4-dihydronaphthalen-2-yl)methyl]propanamide Show/Hide	C20H21NO	1
1	Ki = 3.8 nM Bioactivity Info	TI LI LO TS
CP0458341 Compound Info	N-[2-(2-phenyl-7,8-dihydrofuro[2,3-g]benzimidazol-1-yl)ethyl]acetamide Show/Hide	C19H19N3O2	1
1	Ki = 4.5 nM Bioactivity Info	TI LI LO TS
CP0486794 Compound Info	5-[(E)-2-(7-methoxynaphthalen-1-yl)ethenyl]-3H-1,3,4-oxadiazol-2-one Show/Hide	C15H12N2O3	1
1	Ki = 5.1 nM Bioactivity Info	TI LI LO TS
CP0867260 Compound Info	N-(2-(2-((1H-indol-1-yl)methyl)-5-methoxy-1H-indol-3-yl)ethyl)acetamide Show/Hide	C22H23N3O2	1
1	Ki = 5.754 nM Bioactivity Info	TI LI LO TS
CP0376970 Compound Info	N-[2-(11-phenyl-5-oxa-1,10-diazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-12-yl)ethyl]acetamide Show/Hide	C19H19N3O2	1
1	Ki = 6.1 nM Bioactivity Info	TI LI LO TS
CP0467376 Compound Info	N-[2-(2-butoxy-7-methoxynaphthalen-1-yl)ethyl]propanamide Show/Hide	C20H27NO3	1
1	Ki = 6.7 nM Bioactivity Info	TI LI LO TS
CP0407039 Compound Info	N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]-1,2,3,4-tetrahydronaphthalen-1-yl]ethyl]acetamide Show/Hide	C32H40N2O4	1
1	Ki = 6.79 nM Bioactivity Info	TI LI LO TS
CP0372536 Compound Info	N-[2-(8-methoxy-2-methyl-3,4-dihydro-1H-pyrazino[1,2-a]indol-10-yl)ethyl]butanamide Show/Hide	C19H27N3O2	1
1	Ki = 6.918 nM Bioactivity Info	TI LI LO TS
CP0309824 Compound Info	1-ethyl-3-[(8-methoxybenzo[e][1]benzofuran-2-yl)methyl]thiourea Show/Hide	C17H18N2O2S	1
1	Ki = 7 nM Bioactivity Info	TI LI LO TS
CP0532362 Compound Info	N-[3-(3-methoxyphenyl)propyl]propanamide Show/Hide	C13H19NO2	1
1	Ki = 7.07 nM Bioactivity Info	TI LI LO TS
CP0423453 Compound Info	N-[2-[3-(3-acetamidophenyl)-7-methoxynaphthalen-1-yl]ethyl]acetamide Show/Hide	C23H24N2O3	1
1	Ki = 7.54 nM Bioactivity Info	TI LI LO TS
CP0874931 Compound Info	N-[2-(8-Methoxy-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)ethyl]acetamide Show/Hide	C17H23N3O2	1
1	Ki = 7.762 nM Bioactivity Info	TI LI LO TS
CP0381636 Compound Info	2-((S)-2-Hydroxymethylindolin-1-ylmethyl)-melatonin Show/Hide	C23H27N3O3	1
1	Ki = 7.8 nM Bioactivity Info	TI LI LO TS
CP0474601 Compound Info	ethyl N-[3-[4-(2-acetamidoethyl)-6-methoxynaphthalen-2-yl]phenyl]carbamate Show/Hide	C24H26N2O4	1
1	Ki = 8.3 nM Bioactivity Info	TI LI LO TS
CP0373463 Compound Info	N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]but-3-enamide Show/Hide	C34H38N2O4	1
1	Ki = 8.45 nM Bioactivity Info	TI LI LO TS
CP0111066 Compound Info	N-[[1-[(4-chlorophenyl)methyl]-4-methoxyindol-2-yl]methyl]propanamide Show/Hide	C20H21ClN2O2	1
1	Ki = 9 nM Bioactivity Info	TI LI LO TS
CP0869995 Compound Info	N-(2-(2-(isoindolin-2-ylmethyl)-5-methoxy-1H-indol-3-yl)ethyl)but-3-enamide Show/Hide	C24H27N3O2	1
1	Ki = 9.333 nM Bioactivity Info	TI LI LO TS
CP0486386 Compound Info	N-[2-[2-[2-(dimethylamino)ethoxy]-7-methoxynaphthalen-1-yl]ethyl]propanamide Show/Hide	C20H28N2O3	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0524750 Compound Info	N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]prop-2-enamide Show/Hide	C19H15F2NOS2	1
1	Ki = 10.7 nM Bioactivity Info	TI LI LO TS
CP0400713 Compound Info	N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]cyclopropanecarboxamide Show/Hide	C34H38N2O4	1
1	Ki = 11.1 nM Bioactivity Info	TI LI LO TS
CP0401701 Compound Info	N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]furan-2-carboxamide Show/Hide	C35H36N2O5	1
1	Ki = 11.8 nM Bioactivity Info	TI LI LO TS
CP0869937 Compound Info	5-[1-(5-Methoxy-1H-indol-3-yl)propan-2-yl]-1,3,4-oxadiazol-2(3H)-one Show/Hide	C14H15N3O3	1
1	Ki = 12 nM Bioactivity Info	TI LI LO TS
CP0447593 Compound Info	N-[3-(4-hydroxy-3-methoxyphenyl)propyl]acetamide Show/Hide	C12H17NO3	1
1	Ki = 12.6 nM Bioactivity Info	TI LI LO TS
CP0430667 Compound Info	N-[3-[5-methoxy-2-(2-phenylethoxy)phenyl]propyl]acetamide Show/Hide	C20H25NO3	1
1	Ki = 13.4 nM Bioactivity Info	TI LI LO TS
CP0400793 Compound Info	N-[2-[7-[4-[[3-(2-acetamidoethyl)-1-benzofuran-5-yl]oxy]butoxy]naphthalen-1-yl]ethyl]acetamide Show/Hide	C30H34N2O5	1
1	Ki = 13.9 nM Bioactivity Info	TI LI LO TS
CP0514684 Compound Info	N-[2-(6-methoxy-2-phenylquinazolin-4-yl)ethyl]acetamide Show/Hide	C19H19N3O2	1
1	Ki = 15.6 nM Bioactivity Info	TI LI LO TS
CP0383358 Compound Info	N-[2-(7-methoxy-2-propoxynaphthalen-1-yl)ethyl]propanamide Show/Hide	C19H25NO3	1
1	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0400795 Compound Info	methyl 4-[4-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]phenyl]benzoate Show/Hide	C32H33NO5	1
1	Ki = 19.1 nM Bioactivity Info	TI LI LO TS
CP0947476 Compound Info	N-(2-(2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-5-methoxy-1H-indol-3-yl)ethyl)acetamide Show/Hide	C23H27N3O2	1
1	Ki = 21.38 nM Bioactivity Info	TI LI LO TS
CP0548970 Compound Info	N-[2-(6-hexoxy-3,4-dihydro-2H-chromen-4-yl)ethyl]acetamide Show/Hide	C19H29NO3	1
1	Ki = 21.4 nM Bioactivity Info	TI LI LO TS
CP0047706 Compound Info	N-[3-[2-(4-phenylbutyl)-1,3-benzoxazol-7-yl]propyl]cyclopropanecarboxamide Show/Hide	C24H28N2O2	1
1	Ki = 22 nM Bioactivity Info	TI LI LO TS
CP0907712 Compound Info	{2-[7-Methoxy-1-(2-propionylamino-ethyl)-naphthalen-2-yloxy]-ethyl}-trimethyl-ammonium iodide Show/Hide	C21H31IN2O3	1
1	Ki = 23 nM Bioactivity Info	TI LI LO TS
CP0489804 Compound Info	N-[2-[3-[4-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]acetamide Show/Hide	C22H23NO3	1
1	Ki = 23 nM Bioactivity Info	TI LI LO TS
CP0452009 Compound Info	4-chloro-N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)butanamide Show/Hide	C20H18ClF2NOS2	1
1	Ki = 24.8 nM Bioactivity Info	TI LI LO TS
CP0487668 Compound Info	N-[2-(2-cyclopropyl-6-methoxyquinazolin-4-yl)ethyl]acetamide Show/Hide	C16H19N3O2	1
1	Ki = 25.9 nM Bioactivity Info	TI LI LO TS
CP0400307 Compound Info	N-[3-(2,5-dimethoxyphenyl)propyl]acetamide Show/Hide	C13H19NO3	1
1	Ki = 26.1 nM Bioactivity Info	TI LI LO TS
CP0400306 Compound Info	N-[3-[5-methoxy-2-[(4-methoxyphenyl)methoxy]phenyl]propyl]acetamide Show/Hide	C20H25NO4	1
1	Ki = 27.9 nM Bioactivity Info	TI LI LO TS
CP0499033 Compound Info	(+/-)-2-(2-Hydroxymethyl-5-methoxyindolin-1-ylmethyl)-melatonin Show/Hide	C24H29N3O4	1
1	Ki = 33.6 nM Bioactivity Info	TI LI LO TS
CP0859463 Compound Info	N-(2-(2-(isoindolin-2-ylmethyl)-5-methoxy-1H-indol-3-yl)ethyl)cyclopropanecarboxamide Show/Hide	C24H27N3O2	1
1	Ki = 33.88 nM Bioactivity Info	TI LI LO TS
CP0514746 Compound Info	(+/-)-2-(2-Hydroxymethylindolin-1-ylmethyl)-melatonin Show/Hide	C23H27N3O3	1
1	Ki = 36.2 nM Bioactivity Info	TI LI LO TS
CP0513018 Compound Info	N-[2-(6-methoxyquinazolin-4-yl)ethyl]butanamide Show/Hide	C15H19N3O2	1
1	Ki = 41 nM Bioactivity Info	TI LI LO TS
CP0514689 Compound Info	N-[2-(6-methoxyquinazolin-4-yl)ethyl]propanamide Show/Hide	C14H17N3O2	1
1	Ki = 41.1 nM Bioactivity Info	TI LI LO TS
CP0914470 Compound Info	N-[2-(2-{[(4-Chlorophenyl)(methyl)amino]methyl}-5-methoxy-1H-indol-3-yl)ethyl]acetamide Show/Hide	C21H24ClN3O2	1
1	Ki = 42.66 nM Bioactivity Info	TI LI LO TS
CP0504015 Compound Info	3-(4-(2-Acetylaminoethyl)-6-methoxynaphth-2-yl)benzoic acid Show/Hide	C22H21NO4	1
1	Ki = 43.3 nM Bioactivity Info	TI LI LO TS
CP0400791 Compound Info	2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]acetic acid Show/Hide	C30H31NO5	1
1	Ki = 45.8 nM Bioactivity Info	TI LI LO TS
CP0105647 Compound Info	1-ethyl-3-[2-(8-methoxybenzo[e][1]benzofuran-2-yl)ethyl]urea Show/Hide	C18H20N2O3	1
1	Ki = 46 nM Bioactivity Info	TI LI LO TS
CP0514682 Compound Info	N-[2-[6-methoxy-2-(3-methoxyphenyl)quinazolin-4-yl]ethyl]acetamide Show/Hide	C20H21N3O3	1
1	Ki = 46 nM Bioactivity Info	TI LI LO TS
CP0447591 Compound Info	N-[3-(2-hydroxy-5-methoxyphenyl)propyl]acetamide Show/Hide	C12H17NO3	1
1	Ki = 46.2 nM Bioactivity Info	TI LI LO TS
CP0469724 Compound Info	N-[2-[3-[3-(hydroxymethyl)phenyl]-7-methoxynaphthalen-1-yl]ethyl]cyclobutanecarboxamide Show/Hide	C25H27NO3	1
1	Ki = 48.3 nM Bioactivity Info	TI LI LO TS
CP0415638 Compound Info	N-[2-[5-(3-phenylpropoxy)-1H-indol-3-yl]ethyl]acetamide Show/Hide	C21H24N2O2	1
1	Ki = 49 nM Bioactivity Info	TI LI LO TS
CP0402287 Compound Info	4-[4-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]phenyl]benzoic acid Show/Hide	C31H31NO5	1
1	Ki = 51.3 nM Bioactivity Info	TI LI LO TS
CP0381637 Compound Info	N-[2-(7-methoxy-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4(9),5,7,10,14,16,18-heptaen-10-yl)ethyl]acetamide Show/Hide	C23H25N3O2	2
1	Ki = 64.57 nM Bioactivity Info	TI LI LO TS
2	Ki = 65.2 nM Bioactivity Info	TI LI LO TS
CP0558022 Compound Info	5-[(E)-2-(6,7-dimethoxynaphthalen-1-yl)ethenyl]-3H-1,3,4-oxadiazol-2-one Show/Hide	C16H14N2O4	1
1	Ki = 69 nM Bioactivity Info	TI LI LO TS
CP0477491 Compound Info	N-[3-(3-methoxy-4-phenylmethoxyphenyl)propyl]acetamide Show/Hide	C19H23NO3	1
1	Ki = 69.3 nM Bioactivity Info	TI LI LO TS
CP0430668 Compound Info	N-[3-[5-methoxy-2-(3-phenylpropoxy)phenyl]propyl]acetamide Show/Hide	C21H27NO3	1
1	Ki = 72.2 nM Bioactivity Info	TI LI LO TS
CP0437583 Compound Info	N-[2-[2-(2-iodoethoxy)-7-methoxynaphthalen-1-yl]ethyl]propanamide Show/Hide	C18H22INO3	1
1	Ki = 73 nM Bioactivity Info	TI LI LO TS
CP0849192 Compound Info	N-(2-(2-((1H-indol-1-yl)methyl)-5-methoxy-1H-indol-3-yl)ethyl)cyclobutanecarboxamide Show/Hide	C25H27N3O2	1
1	Ki = 81.28 nM Bioactivity Info	TI LI LO TS
CP0373460 Compound Info	N-[2-[7-[4-[[3-(2-acetamidoethyl)-1H-indol-5-yl]oxy]butoxy]naphthalen-1-yl]ethyl]acetamide Show/Hide	C30H35N3O4	1
1	Ki = 84.3 nM Bioactivity Info	TI LI LO TS
CP0921467 Compound Info	N-[2-(2-Methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)ethyl]butanamide Show/Hide	C18H25N3O	1
1	Ki = 85.11 nM Bioactivity Info	TI LI LO TS
CP0385096 Compound Info	N-[2-[5-(3-phenoxypropoxy)-1H-indol-3-yl]ethyl]acetamide Show/Hide	C21H24N2O3	1
1	Ki = 87 nM Bioactivity Info	TI LI LO TS
CP0510641 Compound Info	N-[3-[2-[(4-bromo-2-fluorophenyl)methoxy]-5-methoxyphenyl]propyl]acetamide Show/Hide	C19H21BrFNO3	1
1	Ki = 102 nM Bioactivity Info	TI LI LO TS
CP0452111 Compound Info	N-[3-[3-methoxy-4-[(3-methoxyphenyl)methoxy]phenyl]propyl]acetamide Show/Hide	C20H25NO4	1
1	Ki = 105 nM Bioactivity Info	TI LI LO TS
CP0558328 Compound Info	N-[2-(7-methoxyphthalazin-1-yl)ethyl]butanamide Show/Hide	C15H19N3O2	1
1	Ki = 108 nM Bioactivity Info	TI LI LO TS
CP0473011 Compound Info	N-(1,2,3,4-tetrahydroquinolin-3-ylmethyl)acetamide Show/Hide	C12H16N2O	1
1	Ki = 110 nM Bioactivity Info	TI LI LO TS
CP0511802 Compound Info	5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-methyl-1,3,4-oxadiazol-2-amine Show/Hide	C14H16N4O2	1
1	Ki = 110 nM Bioactivity Info	TI LI LO TS
CP0479258 Compound Info	N-[2-(6-methoxyquinazolin-4-yl)ethyl]acetamide Show/Hide	C13H15N3O2	1
1	Ki = 115 nM Bioactivity Info	TI LI LO TS
CP0470444 Compound Info	N-[3-(3-methoxy-4-phenylmethoxyphenyl)propyl]propanamide Show/Hide	C20H25NO3	1
1	Ki = 121 nM Bioactivity Info	TI LI LO TS
CP0193528 Compound Info	N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide Show/Hide	C31H34N2O4	2
1	Ki = 149 nM Bioactivity Info	TI LI LO TS
2	Ki = 354.81 nM Bioactivity Info	TI LI LO TS
CP0452008 Compound Info	N-[2-[5-fluoro-2-(4-fluorophenyl)sulfanyl-1-benzothiophen-3-yl]ethyl]cyclobutanecarboxamide Show/Hide	C21H19F2NOS2	1
1	Ki = 194 nM Bioactivity Info	TI LI LO TS
CP0921994 Compound Info	N-(2-(2-(isoindolin-2-ylmethyl)-5-methoxy-1H-indol-3-yl)ethyl)cyclobutanecarboxamide Show/Hide	C25H29N3O2	1
1	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CP0844959 Compound Info	N-[2-(2-{[Ethyl(methyl)amino]methyl}-5-methoxy-1H-indol-3-yl)ethyl]acetamide Show/Hide	C17H25N3O2	1
1	Ki = 223.87 nM Bioactivity Info	TI LI LO TS
CP0258343 Compound Info	3-(cyclobutylmethyl)-5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-one Show/Hide	C18H21N3O3	1
1	Ki = 230 nM Bioactivity Info	TI LI LO TS
CP0375514 Compound Info	N-[2-[7-[8-(2-acetamidoethyl)naphthalen-2-yl]naphthalen-1-yl]ethyl]acetamide Show/Hide	C28H28N2O2	1
1	Ki = 246 nM Bioactivity Info	TI LI LO TS
CP0362932 Compound Info	5-[(E)-2-(7-methoxy-3,4-dihydronaphthalen-1-yl)ethenyl]-3H-1,3,4-oxadiazol-2-one Show/Hide	C15H14N2O3	1
1	Ki = 260 nM Bioactivity Info	TI LI LO TS
CP0511803 Compound Info	3-heptyl-5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-one Show/Hide	C20H27N3O3	1
1	Ki = 300 nM Bioactivity Info	TI LI LO TS
CP0422156 Compound Info	5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3-(3-phenylpropyl)-1,3,4-oxadiazol-2-one Show/Hide	C22H23N3O3	1
1	Ki = 320 nM Bioactivity Info	TI LI LO TS
CP0317553 Compound Info	3-(cyclopentylmethyl)-5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-one Show/Hide	C19H23N3O3	1
1	Ki = 390 nM Bioactivity Info	TI LI LO TS
CP0547557 Compound Info	N-[2-(6-methoxyquinazolin-4-yl)ethyl]cyclopropanecarboxamide Show/Hide	C15H17N3O2	1
1	Ki = 398 nM Bioactivity Info	TI LI LO TS
CP0094726 Compound Info	N-[2-(7,17-dimethoxy-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4(9),5,7,10,14(19),15,17-heptaen-10-yl)ethyl]acetamide Show/Hide	C24H27N3O3	2
1	Ki = 407.38 nM Bioactivity Info	TI LI LO TS
2	Ki = 410 nM Bioactivity Info	TI LI LO TS
CP0514683 Compound Info	N-[2-(7-methoxyphthalazin-1-yl)ethyl]propanamide Show/Hide	C14H17N3O2	1
1	Ki = 414 nM Bioactivity Info	TI LI LO TS
CP0487632 Compound Info	3-hexyl-5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-one Show/Hide	C19H25N3O3	1
1	Ki = 530 nM Bioactivity Info	TI LI LO TS
CP0920290 Compound Info	N-[2-(2-{[(Benzyl(methyl)amino]methyl}-5-methoxy-1H-indol-3-yl)ethyl]acetamide Show/Hide	C22H27N3O2	1
1	Ki = 660.69 nM Bioactivity Info	TI LI LO TS
CP0552037 Compound Info	N-[2-(7-methoxyphthalazin-1-yl)ethyl]acetamide Show/Hide	C13H15N3O2	1
1	Ki = 799 nM Bioactivity Info	TI LI LO TS
CP0914471 Compound Info	N-[2-(9-Methoxy-2-methyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indol-11-yl)ethyl]acetamide Show/Hide	C18H25N3O2	1
1	Ki = 891.25 nM Bioactivity Info	TI LI LO TS
CP0424907 Compound Info	N-[2-(7-methoxyphthalazin-1-yl)ethyl]cyclopropanecarboxamide Show/Hide	C15H17N3O2	1
1	Ki = 1370 nM Bioactivity Info	TI LI LO TS
CP0474655 Compound Info	N-[2-(3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4,6,8,10,14,16,18-heptaen-10-yl)ethyl]acetamide Show/Hide	C22H23N3O	1
1	Ki = 1700 nM Bioactivity Info	TI LI LO TS
CP0498635 Compound Info	N-[3-(5-methoxy-2-phenylmethoxyphenyl)propyl]benzamide Show/Hide	C24H25NO3	1
1	Ki = 2300 nM Bioactivity Info	TI LI LO TS
CP0487667 Compound Info	N-ethyl-4-(6-methoxyquinazolin-4-yl)piperazine-1-carboxamide Show/Hide	C16H21N5O2	1
1	Ki = 2800 nM Bioactivity Info	TI LI LO TS
CP0547559 Compound Info	cyclopropyl-[4-(6-methoxyquinazolin-4-yl)piperazin-1-yl]methanone Show/Hide	C17H20N4O2	1
1	Ki = 3295 nM Bioactivity Info	TI LI LO TS
CP0036921 Compound Info	3-HYDROXYTYRAMINE HYDROCHLORIDE Show/Hide	C8H11NO2	1
1	Ki = 9100 nM Bioactivity Info	TI LI LO TS
CP0549637 Compound Info	5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3-propyl-1,3,4-oxadiazol-2-one Show/Hide	C16H19N3O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0001238 Compound Info	14C-5-hydroxy tryptamine creatinine disulfate Show/Hide	C10H12N2O	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0547558 Compound Info	N-[2-[(6-methoxyquinazolin-4-yl)amino]ethyl]acetamide Show/Hide	C13H16N4O2	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0258344 Compound Info	5-[(E)-2-(5-methoxy-1H-indol-3-yl)ethenyl]-3H-1,3,4-oxadiazol-2-one Show/Hide	C13H11N3O3	1
1	Ki > 100 nM Bioactivity Info	TI LI LO TS
CP0478995 Compound Info	(E)-3-(5-methoxy-1H-indol-3-yl)-N-prop-2-ynylprop-2-enamide Show/Hide	C15H14N2O2	1
1	Ki > 100 nM Bioactivity Info	TI LI LO TS
CP0487486 Compound Info	5-[(E)-2-(5-methoxy-1H-indol-3-yl)ethenyl]-3-prop-2-ynyl-1,3,4-oxadiazol-2-one Show/Hide	C16H13N3O3	1
1	Ki > 100 nM Bioactivity Info	TI LI LO TS
CP0549638 Compound Info	(E)-3-(5-methoxy-1H-indol-3-yl)-N-prop-2-enylprop-2-enamide Show/Hide	C15H16N2O2	1
1	Ki > 100 nM Bioactivity Info	TI LI LO TS
CP0897694 Compound Info	6-Methoxy-1-methyl-4-(2-propionylamino-ethyl)-quinolinium iodide Show/Hide	C16H21IN2O2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0919223 Compound Info	4-(2-Acetylamino-ethyl)-6-methoxy-1-methyl-quinolinium iodide Show/Hide	C15H19IN2O2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0376624 Compound Info	2-[(5-methoxy-1H-indol-3-yl)methyl]-5-methyl-1,3-oxazole Show/Hide	C14H14N2O2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0433770 Compound Info	3-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-methyl-1H-1,2,4-triazol-5-one Show/Hide	C14H16N4O2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0449128 Compound Info	4-ethyl-3-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1H-1,2,4-triazole-5-thione Show/Hide	C15H18N4OS	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0482626 Compound Info	5-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3-methyl-1,2,4-oxadiazole Show/Hide	C14H15N3O2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000035 , NIH 3T3

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0153310 Compound Info	US8552037, 90 Show/Hide	C15H18N2O2	1
1	IC50 = 0.13 nM
CP0034701 Compound Info	N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide Show/Hide	C13H16N2O2	8
1	IC50 = 0.3 nM
2	IC50 = 0.53 nM
3	Kd = 0.15 nM
4	Ki = 0.18 nM
5	Ki = 0.195 nM
6	Ki = 0.2951 nM
7	Ki = 0.3 nM
8	Ki = 0.32 nM
CP0305199 Compound Info	4-((R)-6-Methoxy-indan-1-yl)-piperazine-1-carboxylic acid ethylamide Show/Hide	C17H25N3O2	1
1	IC50 = 1.7 nM
CP0215801 Compound Info	1-[1-(2,2-Diphenyl-ethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone Show/Hide	C27H29NO3	1
1	IC50 = 9.7 nM
CP0283823 Compound Info	2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile Show/Hide	C33H38ClF2N3O3	1
1	IC50 = 1523 nM
CP0171484 Compound Info	5-MCA-NAT Show/Hide	C14H17N3O3	1
1	IC50 = 4000 nM
CP0208351 Compound Info	N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide Show/Hide	C16H21NO2	1
1	Ki = 0.045 nM
CP0060238 Compound Info	N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl]acetamide Show/Hide	C13H15ClN2O2	1
1	Ki = 0.2 nM
CP0110977 Compound Info	N-[2-(5-methoxy-1-methylindol-3-yl)ethyl]acetamide Show/Hide	C14H18N2O2	1
1	Ki = 1.738 nM
CP0089778 Compound Info	N-[2-(1-benzyl-5-methoxyindol-3-yl)ethyl]acetamide Show/Hide	C20H22N2O2	1
1	Ki = 6.457 nM
CP0111066 Compound Info	N-[[1-[(4-chlorophenyl)methyl]-4-methoxyindol-2-yl]methyl]propanamide Show/Hide	C20H21ClN2O2	1
1	Ki = 8.7 nM
CP0047706 Compound Info	N-[3-[2-(4-phenylbutyl)-1,3-benzoxazol-7-yl]propyl]cyclopropanecarboxamide Show/Hide	C24H28N2O2	1
1	Ki = 22 nM
CP0094726 Compound Info	N-[2-(7,17-dimethoxy-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4(9),5,7,10,14(19),15,17-heptaen-10-yl)ethyl]acetamide Show/Hide	C24H27N3O3	1
1	Ki = 410 nM

Clinical Information about the Protein

Target 1 ( Melatonin receptor type 1B (MTNR1B) )

Target Type	Successful Target
Disease	1 Target-related Disease				1
1	Insomnia [ICD-11: 7A00-7A0Z]
Approved Drug(s)	2 Approved Drugs				2
1	Ramelteon	Drug Info	Approved	Insomnia
2	Tasimelteon	Drug Info	Approved	Insomnia

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han