General Information of the Compound
Compound ID
CP0449128
Compound Name
4-ethyl-3-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1H-1,2,4-triazole-5-thione
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Structure
Formula
C15H18N4OS
Molecular Weight
302.403
Canonical SMILES
CCn1c(CCc2c[nH]c3ccc(OC)cc23)n[nH]c1=S
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InChI
InChI=1S/C15H18N4OS/c1-3-19-14(17-18-15(19)21)7-4-10-9-16-13-6-5-11(20-2)8-12(10)13/h5-6,8-9,16H,3-4,7H2,1-2H3,(H,18,21)
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InChIKey
DMYOGSLQJSGABR-UHFFFAOYSA-N
Physicochemical Property
logP
3.23569
Rotatable Bonds
5
Heavy Atom Count
21
Polar Areas
58.63
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122178512
ChEMBL ID
CHEMBL3580925
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01843, Melatonin receptor type 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02174, Melatonin receptor type 1B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS