General Information of the Compound
Compound ID
CP0373468
Compound Name
N-[2-[7-[4-[8-[2-(but-3-enoylamino)ethyl]naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]but-3-enamide
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Structure
Formula
C36H40N2O4
Molecular Weight
564.726
Canonical SMILES
C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12
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InChI
InChI=1S/C36H40N2O4/c1-3-9-35(39)37-21-19-29-13-7-11-27-15-17-31(25-33(27)29)41-23-5-6-24-42-32-18-16-28-12-8-14-30(34(28)26-32)20-22-38-36(40)10-4-2/h3-4,7-8,11-18,25-26H,1-2,5-6,9-10,19-24H2,(H,37,39)(H,38,40)
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InChIKey
OLKIGINISJLZQG-UHFFFAOYSA-N
Physicochemical Property
logP
6.7006
Rotatable Bonds
17
Heavy Atom Count
42
Polar Areas
76.66
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9937825
SID: 14911007
ChEMBL ID
CHEMBL1097315
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01843, Melatonin receptor type 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 16.1 nM
   TI
   LI
   LO
   TS
2
Ki = 0.92 nM
   TI
   LI
   LO
   TS
Protein ID: PT02174, Melatonin receptor type 1B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 40.2 nM
   TI
   LI
   LO
   TS
2
Ki = 10.9 nM
   TI
   LI
   LO
   TS