General Information of the Protein
Protein ID
PT00984
Protein Name
Intermediate conductance calcium-activated potassium channel protein 4
Secondarily
Protein Name
IKCa1
KCa3.1
KCa4
Putative Gardos channel
Gene Name
KCNN4
Secondarily
Gene Name
IK1
IKCA1
KCA4
SK4
Sequence
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Calcium-activated potassium channel
Function
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580).
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Uniprot ID
Primary ID:
O15554

Secondarily ID:
Q53XR4
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Ensembl ID
ENSG00000104783
HGNC ID
HGNC:6293
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0274224
 Compound Info 
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole
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C22H17ClN2
  1
1
IC50 = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0030899
 Compound Info 
1-[(2-chlorophenyl)-diphenylmethyl]imidazole
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C22H17ClN2
  1
1
IC50 = 70 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398740
 Compound Info 
5-(3-chlorobenzoyl)-5H-dibenzo[b,d]azepin-7(6H)-one
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C21H14ClNO2
  1
1
IC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398739
 Compound Info 
5-(4-chlorophenylsulfonyl)-5H-dibenzo[b,d]azepin-7(6H)-one
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C20H14ClNO3S
  1
1
IC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0417344
 Compound Info 
5-tosyl-5H-dibenzo[b,d]azepin-7(6H)-one
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C21H17NO3S
  1
1
IC50 = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0459507
 Compound Info 
5-(thiophen-2-ylsulfonyl)-5H-dibenzo[b,d]azepin-7(6H)-one
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C18H13NO3S2
  1
1
IC50 = 2400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0153862
 Compound Info 
4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one
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C21H18O5
  1
1
IC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0435122
 Compound Info 
5-(4-methylbenzoyl)-5H-dibenzo[b,d]azepin-7(6H)-one
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C22H17NO2
  1
1
IC50 = 16000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0153862
 Compound Info 
4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one
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C21H18O5
  1
1 EC50 = 10000 nM
CP0274224
 Compound Info 
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole
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C22H17ClN2
  1
1 IC50 = 20 nM
CP0030899
 Compound Info 
1-[(2-chlorophenyl)-diphenylmethyl]imidazole
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C22H17ClN2
  2
1 IC50 = 70 nM
2 IC50 = 360 nM
Clinical Information about the Protein
Target 1 ( Calcium-activated potassium channel KCa3.1 (KCNN4) )
Target Type Clinical trial Target
Disease 2 Target-related Diseases  2
1 Alzheimer disease [ICD-11: 8A20]
2 Conjunctival fibrosis [ICD-11: 9A61.3]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 ICA-17043
 Drug Info 
Phase 2
Alzheimer disease
Investigative Drug(s) 1 Investigative Drug  1
1 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole
 Drug Info 
Investigative
Conjunctival fibrosis