General Information of the Protein
Protein ID
PT04161
Protein Name
Disintegrin and metalloproteinase domain-containing protein 8
Secondarily
Protein Name
Cell surface antigen MS2
Gene Name
ADAM8
Secondarily
Gene Name
MS2
Sequence
MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Metallo protease
>
Metallo protease MAM clan
>
Metallo protease M12B subfamily
Function
Possible involvement in extravasation of leukocytes.
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Uniprot ID
Primary ID:
P78325

Secondarily ID:
B4DVM6
H0YL36
H0YLR0
H0YN39
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Ensembl ID
ENSG00000151651
HGNC ID
HGNC:215
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0415537
 Compound Info 
2-[(2S,5S,8S,11S,14S,17R)-2,8-bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-17-(hydroxymethyl)-14-(3-methylbutyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C33H61N11O9
  1
1
IC50 = 142 nM
 Bioactivity Info 
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CP0570900
 Compound Info 
2-[(2S,5S,8S,11S,14S,17R)-2,8-bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-17-(hydroxymethyl)-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C32H59N11O9
  1
1
IC50 = 157 nM
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CP0566166
 Compound Info 
2-[(2S,5S,8S,11S,14R,17S)-5,17-bis(4-aminobutyl)-8-[3-(diaminomethylideneamino)propyl]-14-(hydroxymethyl)-11-(2-methylpropyl)-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexazacyclooctadec-2-yl]acetic acid
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C31H57N11O9
  1
1
IC50 = 182 nM
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CP0551381
 Compound Info 
2-[(2S,5S,8S,11S,14S,17R)-2,8-bis(4-aminobutyl)-11-[3-(carbamoylamino)propyl]-17-(hydroxymethyl)-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C32H58N10O10
  1
1
IC50 = 192 nM
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CP0447767
 Compound Info 
2-[(2S,5S,8S,11S,14S)-2,8-bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-14-(3-methylbutyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C32H59N11O8
  1
1
IC50 = 220 nM
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CP0563598
 Compound Info 
2-[(2S,5S,8S,11S,14S,17S)-5,17-bis(4-aminobutyl)-8-[3-(diaminomethylideneamino)propyl]-14-(hydroxymethyl)-11-(2-methylpropyl)-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexazacyclooctadec-2-yl]acetic acid
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C31H57N11O9
  1
1
IC50 = 240 nM
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CP0566169
 Compound Info 
2-[(2S,5S,8S,11S,14S)-2,8-bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2,2-dimethylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C32H59N11O8
  1
1
IC50 = 256 nM
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CP0567657
 Compound Info 
2-[(2S,5S,8S,11S,14S,17R)-2,8-bis(4-aminobutyl)-11-[4-(diaminomethylideneamino)butyl]-17-(hydroxymethyl)-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C33H61N11O9
  1
1
IC50 = 368 nM
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CP0566170
 Compound Info 
2-[(2S,5S,8S,11S,14S)-2,8-bis(4-aminobutyl)-14-butyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C31H57N11O8
  1
1
IC50 = 378 nM
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CP0567656
 Compound Info 
(2S,5S,8S,11S,14S,17S)-2,8-bis(4-aminobutyl)-5-(carboxymethyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadecane-17-carboxylic acid
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C32H57N11O10
  1
1
IC50 = 420 nM
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CP0447768
 Compound Info 
2-[(2S,5S,8S,11S,14S)-2,8-bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15,19-hexaoxo-14-propyl-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C30H55N11O8
  1
1
IC50 = 452 nM
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CP0386318
 Compound Info 
2-[(2S,5S,8S,11S,14S)-2,8-bis(4-aminobutyl)-11-[3-(carbamoylamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C31H56N10O9
  1
1
IC50 = 890 nM
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CP0570902
 Compound Info 
2-[(2S,5S,8S,11S,14S,17R)-2,8-bis(4-aminobutyl)-11-[3-[[amino(nitramido)methylidene]amino]propyl]-17-(hydroxymethyl)-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C32H58N12O11
  1
1
IC50 = 1245 nM
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CP0566167
 Compound Info 
2-[(2S,5S,8S,11S,14S)-2,8-bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C31H57N11O8
  1
1
IC50 = 1645 nM
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CP0566168
 Compound Info 
2-[(2S,5S,8S,11S,14S)-2,8-bis(4-aminobutyl)-11-[3-[[amino(nitramido)methylidene]amino]propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C31H56N12O10
  1
1
IC50 = 2345 nM
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CP0551380
 Compound Info 
4-[(2S,5S,8S,11S,14S)-2-(4-aminobutyl)-5-(carboxymethyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-8-yl]butyl-trimethylazanium
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C34H64N11O8+
  1
1
IC50 > 10000 nM
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CP0386319
 Compound Info 
2-[(2S,5S,8S,11S,14S)-2-(4-aminobutyl)-8-(3-aminopropyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C30H55N11O8
  1
1
IC50 > 5000 nM
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CP0445909
 Compound Info 
2-[(2S,5S,8S,11S,14S)-2-(4-aminobutyl)-8-(aminomethyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C28H51N11O8
  1
1
IC50 > 5000 nM
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CP0570901
 Compound Info 
2-[(2S,5S,8S,11S,14S)-2-(4-aminobutyl)-8-(2-aminoethyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid
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C29H53N11O8
  1
1
IC50 > 5000 nM
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Clinical Information about the Protein
Target 1 ( Cell surface antigen MS2 (ADAM8) )
Target Type Literature-reported Target