General Information of the Protein
| Protein ID |
PT01871
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| Protein Name |
Proteinase-activated receptor 1
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| Secondarily Protein Name |
Coagulation factor II receptor
Thrombin receptor
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| Gene Name |
F2R
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| Secondarily Gene Name |
CF2R
PAR1
TR
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| Sequence |
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Protease-activated receptor
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Protease-activated receptor
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| Function |
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Cell membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000023 , BTI-Tn-5B1-4
Cell Line ID: CL000011 , CHO
Cell Line ID: CL000812 , CHRF
Cell Line ID: CL000053 , COS-7
Cell Line ID: CL000213 , EA.hy 926
Cell Line ID: CL000006 , HEK293
Cell Line ID: CL000902 , HEK293/Galpha15
Cell Line ID: CL000667 , KNRK
Cell Line ID: CL000111 , MDA-MB-231
Biochemical Assays
Clinical Information about the Protein
Target 1 ( Proteinase activated receptor 1 (F2R) )
| Target Type | Successful Target | ||||
|---|---|---|---|---|---|
| Disease | 5 Target-related Diseases | 5 | |||
| 1 | Myocardial infarction [ICD-11: BA41-BA43] | ||||
| 2 | Acute coronary syndrome [ICD-11: BA41] | ||||
| 3 | Artery stenosis [ICD-11: BD52] | ||||
| 4 | Thrombosis [ICD-11: DB61-GB90] | ||||
| 5 | Arteriosclerosis [ICD-11: BD40] | ||||
| Approved Drug(s) | 1 Approved Drug | 1 | |||
| 1 | Vorapaxar | Approved | |||
| Clinical Trial Drug(s) | 1 Clinical Trial Drug | 1 | |||
| 1 | E5555 | Phase 2 | |||
| Discontinued Drug(s) | 1 Discontinued Drug | 1 | |||
| 1 | RWJ-58259 | Terminated | |||
| Investigative Drug(s) | 2 Investigative Drugs | 2 | |||
| 1 | SCH-205831 | Investigative | |||
| 2 | SCH-602539 | Investigative | |||