General Information of the Protein
Protein ID
PT02225
Protein Name
Tyrosine-protein phosphatase non-receptor type 1
Secondarily
Protein Name
Protein-tyrosine phosphatase 1B
Protein-tyrosine phosphatase HA2
Gene Name
PTPN1
Sequence
MEMEKEFEEIDKAGNWAAIYQDIRHEASDFPCKVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQYWPQQEEKEMVFDDTGLKLTLISEDVKSYYTVRQLELENLTTKETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSLEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSREDLDLPPEHVPPPPRPPKRTLEPHNGKCKELFSSHQWVSEETCGDEDSLAREEGRAQSSAMHSVSSMSPDTEVRRRMVGGGLQSAQASVPTEEELSSTEEEHKAHWPSHWKPFLVNVCMATLLATGAYLCYRVCFH
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Phosphatase
>
Protein Phosphatase
>
Tyrosine protein phosphatase
Function
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity).
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Uniprot ID
Primary ID:
P35821

Secondarily ID:
Q60840
Q62131
Q64498
Q99JS1
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Ensembl ID
ENSG00000196396
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0254995
 Compound Info 
5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]prop-1-en-1-yl]phenyl}-4-(hydroxymethyl)-1,2-oxazole-3-carboxylic acid
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C22H19NO8
  1
1
Ki = 920 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0151260
 Compound Info 
4-amino-5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]prop-1-en-1-yl]phenyl}-1,2-oxazole-3-carboxylic acid
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C21H18N2O7
  1
1
Ki = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036444
 Compound Info 
5-{2-fluoro-5-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]prop-1-en-1-yl]phenyl}-1,2-oxazole-3-carboxylic acid
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C21H16FNO7
  1
1
Ki = 6900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036443
 Compound Info 
12-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]prop-1-en-1-yl]-3-oxa-4-azatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),4,10,12-pentaene-5-carboxylic acid
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C23H19NO7
  1
1
Ki = 11500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0883934
 Compound Info 
5-{3-[3-(3-Hydroxy-2-methoxycarbonyl-phenoxy)-propyl]-phenyl}-isoxazole-3-carboxylic acid
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C21H19NO7
  1
1
Ki = 23000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0317539
 Compound Info 
5-[3-({2-[3-hydroxy-2-(methoxycarbonyl)phenoxy]ethyl}amino)phenyl]-1,2-oxazole-3-carboxylic acid
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C20H18N2O7
  1
1
Ki = 60300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01158 Tyrosine-protein phosphatase non-receptor type 1 Homo sapiens, Human
 Protein Info