General Information of the Protein
Protein ID
PT02121
Protein Name
Retinoic acid receptor gamma
Secondarily
Protein Name
Nuclear receptor subfamily 1 group B member 3
Gene Name
RARG
Secondarily
Gene Name
Nr1b3
Sequence
MATNKERLFAPGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGGQGKRGQSPQPDQGP
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Organism
Mus musculus, Mouse
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 1
>
Nuclear hormone receptor subfamily 1 group B
>
Nuclear hormone receptor subfamily 1 group B member 3
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.
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Uniprot ID
Primary ID:
P18911

Secondarily ID:
P20787
Q3UG86
Q62149
Q91VK5
Q91YX2
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Ensembl ID
ENSG00000172819
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0101102
 Compound Info 
(2E,4E,6E)-8-[3-Ethyl-2-isopropyl-cyclohex-2-en-(E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid
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C21H30O2
  1
1
EC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0126004
 Compound Info 
(2E,4E,6E,8Z)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid
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C20H28O2
  1
1
EC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0082294
 Compound Info 
(2E,4Z,6Z)-8-[3-Ethyl-2-isopropyl-cyclohex-2-en-(E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid
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C21H30O2
  1
1
EC50 = 190 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0098128
 Compound Info 
(2E,4E,6E)-8-[3,4-Dihydro-2H-naphthalen-(1E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid
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C20H22O2
  1
1
EC50 = 370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
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C20H28O2
  2
1 IC50 = 4 nM
2 Kd = 18 nM
CP0101102
 Compound Info 
(2E,4E,6E)-8-[3-Ethyl-2-isopropyl-cyclohex-2-en-(E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid
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C21H30O2
  1
1 IC50 = 10 nM
CP0098128
 Compound Info 
(2E,4E,6E)-8-[3,4-Dihydro-2H-naphthalen-(1E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid
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C20H22O2
  1
1 IC50 = 55 nM
CP0126004
 Compound Info 
(2E,4E,6E,8Z)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid
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C20H28O2
  1
1 IC50 = 60 nM
CP0082294
 Compound Info 
(2E,4Z,6Z)-8-[3-Ethyl-2-isopropyl-cyclohex-2-en-(E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid
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C21H30O2
  1
1 IC50 > 1000 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT02120 Retinoic acid receptor beta Mus musculus, Mouse
 Protein Info