General Information of the Protein
Protein ID
PT05074
Protein Name
NADPH oxidase 4
Secondarily
Protein Name
Kidney oxidase-1
Kidney superoxide-producing NADPH oxidase
Renal NAD(P)H-oxidase
Gene Name
NOX4
Secondarily
Gene Name
RENOX
Sequence
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (PubMed:15356101, PubMed:14966267, PubMed:15927447, PubMed:25062272, PubMed:21343298). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (PubMed:10869423, PubMed:11032835, PubMed:15155719, PubMed:15572675, PubMed:16230378, PubMed:16179589, PubMed:16324151, PubMed:15927447, PubMed:16019190, PubMed:25062272). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity (PubMed:16019190). May regulate insulin signaling cascade (PubMed:14966267). May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (PubMed:15572675, PubMed:15356101). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation (PubMed:16324151).
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Uniprot ID
Primary ID:
Q9NPH5

Secondarily ID:
A8K715
B7Z520
E7EMD7
Q5K3R4
Q5K3R5
Q5K3R6
Q5K3R8
Q7Z7G3
Q86V92
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HGNC ID
HGNC:7891
Subcellular Location
Endoplasmic reticulum membrane
Cell membrane
Cell junction
Focal adhesion
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0931898
 Compound Info 
2-(2-Chlorophenyl)-10-(pyridin-2-ylmethyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C22H21Cl2N5O2
  1
1
Ki = 67 nM
 Bioactivity Info 
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CP0676506
 Compound Info 
10-benzyl-2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C23H22Cl2N4O2
  1
1
Ki = 72 nM
 Bioactivity Info 
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CP0891668
 Compound Info 
10-(2-Chlorobenzyl)-2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C23H21Cl3N4O2
  1
1
Ki = 76 nM
 Bioactivity Info 
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CP0931896
 Compound Info 
2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C16H16Cl2N4O2
  1
1
Ki = 87 nM
 Bioactivity Info 
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CP0910838
 Compound Info 
2-(2-Methoxyphenyl)-10-(pyridin-2-ylmethyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C23H24ClN5O3
  1
1
Ki = 93 nM
 Bioactivity Info 
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CP0937033
 Compound Info 
2-(2-Chlorophenyl)-10-(pyridin-3-ylmethyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C22H21Cl2N5O2
  1
1
Ki = 94 nM
 Bioactivity Info 
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CP0855809
 Compound Info 
10-(3-Chlorobenzyl)-2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C23H21Cl3N4O2
  1
1
Ki = 101 nM
 Bioactivity Info 
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CP0459997
 Compound Info 
tert-butyl 4-(2-chlorophenyl)-3,8-dioxo-4,5,9,13-tetrazatricyclo[7.5.0.02,6]tetradeca-1,6-diene-13-carboxylate
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C21H23ClN4O4
  1
1
Ki = 103 nM
 Bioactivity Info 
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CP0917567
 Compound Info 
10-(4-Chlorobenzyl)-2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C23H21Cl3N4O2
  1
1
Ki = 103 nM
 Bioactivity Info 
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CP0853723
 Compound Info 
2-(2-Chlorophenyl)-10-(2-methoxybenzyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C24H24Cl2N4O3
  1
1
Ki = 111 nM
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CP0943839
 Compound Info 
2-(2-Chlorophenyl)-10-(furan-3-ylmethyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C21H20Cl2N4O3
  1
1
Ki = 111 nM
 Bioactivity Info 
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CP0868711
 Compound Info 
2-(2-Chloro-phenyl)-9-(3-methoxy-benzyl)-2,3,7,8,9,10-hexahydro-6H-2,3,5a,9-tetraaza-cyclohepta[e]indene-1,5-dione hydrochloride
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C24H24Cl2N4O3
  1
1
Ki = 112 nM
 Bioactivity Info 
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CP0855810
 Compound Info 
2-(2-Chlorophenyl)-10-(4-methoxybenzyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C24H24Cl2N4O3
  1
1
Ki = 116 nM
 Bioactivity Info 
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CP0931897
 Compound Info 
10-(3-Methoxybenzyl)-2-(2-methoxyphenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C25H27ClN4O4
  1
1
Ki = 131 nM
 Bioactivity Info 
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CP0859309
 Compound Info 
9-benzyl-2-(2-chlorophenyl)-2,3,7,8,9,10-hexahydropyrazolo[4',3':3,4]pyrido[1,2-a]pyrazine-1,5-dione hydrochloride
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C22H20Cl2N4O2
  1
1
Ki = 142 nM
 Bioactivity Info 
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CP0919256
 Compound Info 
10-Benzyl-2-(2-methoxyphenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
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C24H25ClN4O3
  1
1
Ki = 144 nM
 Bioactivity Info 
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CP0525079
 Compound Info 
4-(2-chlorophenyl)-12-oxa-4,5,9-triazatricyclo[7.4.0.02,6]trideca-1,6-diene-3,8-dione
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C15H12ClN3O3
  1
1
Ki = 156 nM
 Bioactivity Info 
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Cell Line ID: CL000880 , COS
 Cell Line Info 
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( NADPH oxidase 4 (NOX4) )
Target Type Clinical trial Target