General Information of the Protein
Protein ID
PT01806
Protein Name
Retinoic acid receptor gamma
Secondarily
Protein Name
Nuclear receptor subfamily 1 group B member 3
Gene Name
RARG
Secondarily
Gene Name
NR1B3
Sequence
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 1
>
Nuclear hormone receptor subfamily 1 group B
>
Nuclear hormone receptor subfamily 1 group B member 3
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
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Uniprot ID
Primary ID:
P13631

Secondarily ID:
B7Z492
B7Z4F1
B7ZAE4
J3KNP6
P22932
Q15281
Q52LZ8
Q9BYX8
Q9H1I3
Q9UJ38
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Ensembl ID
ENSG00000172819
HGNC ID
HGNC:9866
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0718144
 Compound Info 
4-[3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-4,5-dihydro-isoxazol-5-yl]-benzoic acid
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C25H29NO3
  1
1
AC50 < 1 nM
 Bioactivity Info 
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CP0742222
 Compound Info 
4'-Methyl-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-biphenyl-4-carboxylic acid
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C28H30O2
  1
1
AC50 < 1 nM
 Bioactivity Info 
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CP0742480
 Compound Info 
4'-Methyl-3'-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-biphenyl-4-carboxylic acid
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C29H32O2
  1
1
AC50 = 1 nM
 Bioactivity Info 
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CP0723268
 Compound Info 
3'-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-biphenyl-4-carboxylic acid
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C27H28O2
  1
1
AC50 = 2.3 nM
 Bioactivity Info 
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CP0042977
 Compound Info 
9-cis retinoic acid
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C20H28O2
  3
1
AC50 = 3 nM
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2
EC50 = 45 nM
 Bioactivity Info 
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3
EC50 = 50 nM
 Bioactivity Info 
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CP0041093
 Compound Info 
(E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-enyl)benzoic acid
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C24H28O2
  2
1
AC50 = 26 nM
 Bioactivity Info 
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2
EC50 = 2 nM
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CP0042771
 Compound Info 
5',5',8',8'-Tetramethyl-5',6',7',8'-tetrahydro-[2,2']binaphthalenyl-6-carboxylic acid
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C25H26O2
  1
1
AC50 = 68 nM
 Bioactivity Info 
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CP0715557
 Compound Info 
4-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-thiazol-5-yl]-benzoic acid
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C25H27NO2S
  1
1
AC50 = 220 nM
 Bioactivity Info 
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CP0806169
 Compound Info 
4-[6-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-pyridin-2-yl]-benzoic acid
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C27H29NO2
  1
1
AC50 = 1000 nM
 Bioactivity Info 
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CP0041422
 Compound Info 
4-[2-Methyl-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C25H30O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0049341
 Compound Info 
4-[2-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C26H32O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0299470
 Compound Info 
4-[Cyclopropylidene-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C26H30O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0730002
 Compound Info 
5',5',8',8'-Tetramethyl-5',6',7',8'-tetrahydro-[1,2']binaphthalenyl-6-carboxylic acid
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C25H26O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0734985
 Compound Info 
4-[(Z)-3-Methyl-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-but-1-enyl]-benzoic acid
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C26H32O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0756887
 Compound Info 
4-[Cyclopropylidene-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C25H28O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0648950
 Compound Info 
4-[6-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-pyridin-2-yl]-benzoic acid
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C26H27NO2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
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C20H28O2
  3
1
EC50 = 0.7 nM
 Bioactivity Info 
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2
EC50 = 10 nM
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3
EC50 = 19 nM
 Bioactivity Info 
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CP0372864
 Compound Info 
(2E,4E,6E)-7-(3,3-Dimethyl-2,3-dihydro-benzo[b]thiophen-5-yl)-3-methyl-octa-2,4,6-trienoic acid
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C19H22O2S
  1
1
EC50 = 8 nM
 Bioactivity Info 
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CP0377408
 Compound Info 
(2E,4E,6E)-7-(4,4-Dimethyl-thiochroman-6-yl)-3-methyl-octa-2,4,6-trienoic acid
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C20H24O2S
  1
1
EC50 = 12 nM
 Bioactivity Info 
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CP0061828
 Compound Info 
4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C26H32O2
  1
1
EC50 = 23 nM
 Bioactivity Info 
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CP0042976
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
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C24H32O2
  1
1
EC50 = 24 nM
 Bioactivity Info 
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CP0403151
 Compound Info 
4-[(E)-2-(3,3-Dimethyl-2,3-dihydro-benzo[b]thiophen-5-yl)-propenyl]-benzoic acid
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C20H20O2S
  1
1
EC50 = 30 nM
 Bioactivity Info 
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CP0414842
 Compound Info 
(2E,4E,6E)-7-(4,4-Dimethyl-chroman-6-yl)-3-methyl-octa-2,4,6-trienoic acid
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C20H24O3
  1
1
EC50 = 39 nM
 Bioactivity Info 
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CP0377308
 Compound Info 
4-[(E)-2-(4,4-Dimethyl-thiochroman-6-yl)-propenyl]-benzoic acid methyl ester
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C22H24O2S
  1
1
EC50 = 84 nM
 Bioactivity Info 
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CP0112883
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
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C24H32O2
  1
1
EC50 = 144 nM
 Bioactivity Info 
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CP0073370
 Compound Info 
4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C25H30O2
  1
1
EC50 = 180 nM
 Bioactivity Info 
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CP0493334
 Compound Info 
4-[(E)-2-(4,4-Dimethyl-chroman-6-yl)-propenyl]-benzoic acid
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C21H22O3
  1
1
EC50 = 200 nM
 Bioactivity Info 
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CP0756593
 Compound Info 
3-Methyl-5-[5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-bicyclo[3.1.0]hex-1-yl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 209 nM
 Bioactivity Info 
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CP0449565
 Compound Info 
(2E,4E,6E)-7-(3,3-Dimethyl-2,3-dihydro-benzofuran-5-yl)-3-methyl-octa-2,4,6-trienoic acid
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C19H22O3
  1
1
EC50 = 230 nM
 Bioactivity Info 
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CP0047977
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O2
  1
1
EC50 = 266 nM
 Bioactivity Info 
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CP0148476
 Compound Info 
4-[(E)-2-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C27H34O2
  1
1
EC50 = 270 nM
 Bioactivity Info 
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CP0448523
 Compound Info 
4-[(E)-2-(4,4-Dimethyl-chroman-6-yl)-propenyl]-benzoic acid methyl ester
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C22H24O3
  1
1
EC50 = 330 nM
 Bioactivity Info 
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CP0102521
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 355 nM
 Bioactivity Info 
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CP0063990
 Compound Info 
(2E,4E)-6-[1-(3,5-Di-tert-butyl-phenyl)-cyclopropyl]-3-methyl-hexa-2,4-dienoic acid
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C24H34O2
  1
1
EC50 = 391 nM
 Bioactivity Info 
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CP0149843
 Compound Info 
4-[1-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25FO2
  1
1
EC50 = 397 nM
 Bioactivity Info 
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CP0150625
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
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C23H30O2
  1
1
EC50 = 399 nM
 Bioactivity Info 
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CP0449634
 Compound Info 
4-[(E)-2-(3,3-Dimethyl-2,3-dihydro-benzofuran-5-yl)-propenyl]-benzoic acid methyl ester
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C21H22O3
  1
1
EC50 = 400 nM
 Bioactivity Info 
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CP0377756
 Compound Info 
4-[(E)-2-(3,3-Dimethyl-2,3-dihydro-benzofuran-5-yl)-propenyl]-benzoic acid
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C20H20O3
  1
1
EC50 = 460 nM
 Bioactivity Info 
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CP0004259
 Compound Info 
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
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C24H28O2
  2
1
EC50 = 648 nM
 Bioactivity Info 
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2
EC50 > 10000 nM
 Bioactivity Info 
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CP0184156
 Compound Info 
4-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23FO3
  1
1
EC50 = 1016 nM
 Bioactivity Info 
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CP0059678
 Compound Info 
3-Methyl-5-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
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C25H32O2
  1
1
EC50 = 1146 nM
 Bioactivity Info 
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CP0135295
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 1291 nM
 Bioactivity Info 
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CP0111163
 Compound Info 
4-[1-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25ClO2
  1
1
EC50 = 1446 nM
 Bioactivity Info 
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CP0092667
 Compound Info 
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O3
  2
1
EC50 = 1604 nM
 Bioactivity Info 
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2
EC50 > 10000 nM
 Bioactivity Info 
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CP0092680
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 1779 nM
 Bioactivity Info 
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CP0059698
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 1779 nM
 Bioactivity Info 
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CP0049287
 Compound Info 
4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H24O3
  1
1
EC50 = 2043 nM
 Bioactivity Info 
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CP0041092
 Compound Info 
4-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H24O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0063697
 Compound Info 
4-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C24H28O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0063793
 Compound Info 
4-[1-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C26H32O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0063958
 Compound Info 
4-[1-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25BrO2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0076318
 Compound Info 
4-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C25H30O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0100503
 Compound Info 
4-[1-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0100726
 Compound Info 
4-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C25H30O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0105911
 Compound Info 
4-[1-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C24H28O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0123457
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C26H32O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0144133
 Compound Info 
4-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23ClO3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0149955
 Compound Info 
4-[1-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C25H30O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0186182
 Compound Info 
4-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H23BrO3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0209249
 Compound Info 
4-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0134367
 Compound Info 
(E)-3-Methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0215028
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
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C24H32O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0280492
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0000547
 Compound Info 
(2E,4E,6Z)-7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid
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C25H36O3
  1
1
Ki = 8566 nM
 Bioactivity Info 
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CP0420322
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-2'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
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C26H27F3O3
  1
1
Ki = 8764 nM
 Bioactivity Info 
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CP0044243
 Compound Info 
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID
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C24H29NO2
  1
1
Ki = 9901 nM
 Bioactivity Info 
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CP0001933
 Compound Info 
(2E,4E,6E)-7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-8,8,8-trifluoro-3-methyl-octa-2,4,6-trienoic acid
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C25H33F3O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0004953
 Compound Info 
(2E,4E,6E)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
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C25H33F3O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0004965
 Compound Info 
(2Z,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-2-fluoro-3-methyl-octa-2,4,6-trienoic acid
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C25H33F3O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0005671
 Compound Info 
(2E,4Z,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-5-fluoro-3-methyl-octa-2,4,6-trienoic acid
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C25H33F3O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0006755
 Compound Info 
(2E,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid
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C25H34F2O3
  2
1
Ki > 10000 nM
 Bioactivity Info 
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2
Ki > 9513 nM
 Bioactivity Info 
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CP0006760
 Compound Info 
(2E,4E,6Z)-7-(2-Butoxy-3,5-di-tert-butyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
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C27H40O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0006963
 Compound Info 
(2E,4Z,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-4-fluoro-3-methyl-octa-2,4,6-trienoic acid
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C25H33F3O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0006981
 Compound Info 
(2Z,4E,6Z)-7-(2-Butoxy-3,5-di-tert-butyl-phenyl)-3-trifluoromethyl-octa-2,4,6-trienoic acid
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C27H37F3O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0377464
 Compound Info 
(2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-3-isopropyl-5-thiophen-2-yl-phenyl]-3-methyl-octa-2,4,6-trienoic acid
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C24H26F2O3S
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0377687
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-3'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
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C26H27F3O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0384182
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-3',5'-difluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
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C26H26F4O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0394545
 Compound Info 
(2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroethyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
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C22H25F5O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0395224
 Compound Info 
(2E,4E,6E)-7-(2-Butoxy-3,5-diisopropyl-phenyl)-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
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C25H35FO3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0397600
 Compound Info 
(2E,4E,6E)-7-[3,5-Di-tert-butyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
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C25H32F4O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0401559
 Compound Info 
(2E,4E,6E)-7-[2-(2,2-Difluoro-ethoxy)-3,5-bis-(1,1-dimethyl-propyl)-phenyl]-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
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C27H37F3O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0403927
 Compound Info 
(2E,4E,6Z)-7-(2-Butoxy-3-isopropyl-5-pentafluoroethyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
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C24H29F5O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0406456
 Compound Info 
(2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
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C26H28F2O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0448038
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
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C26H27F3O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0395263
 Compound Info 
(2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-5-furan-2-yl-3-isopropyl-phenyl]-3-methyl-octa-2,4,6-trienoic acid
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C24H26F2O4
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0397602
 Compound Info 
(2E,4E,6Z)-7-(5-Isopropyl-3-pentafluoroethyl-2-propoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid
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C23H27F5O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0264302
 Compound Info 
(2E,4E,6Z)-7-(2-Butoxy-3,5-diisopropyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
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C25H36O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0274319
 Compound Info 
(2E,4E,6Z)-7-(2-Ethoxy-3,5-diisopropyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
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C23H32O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0373374
 Compound Info 
(E)-3-[3-(2-Butoxy-3,5-diisopropyl-phenyl)-1H-indol-5-yl]-but-2-enoic acid
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C28H35NO3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0373617
 Compound Info 
(E)-3-{3-[2-(3-Fluoro-propoxy)-3,5-diisopropyl-phenyl]-benzo[b]thiophen-5-yl}-but-2-enoic acid
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C27H31FO3S
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0392826
 Compound Info 
(E)-3-[3-(2-Butoxy-3,5-diisopropyl-phenyl)-1-methyl-1H-indol-5-yl]-but-2-enoic acid
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C29H37NO3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0398941
 Compound Info 
(E)-3-[3-(3,5-Di-tert-butyl-2-propoxy-phenyl)-1H-indol-5-yl]-but-2-enoic acid
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C29H37NO3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0399610
 Compound Info 
(E)-3-[3-(3,5-Diisopropyl-2-methoxy-phenyl)-benzo[b]thiophen-5-yl]-but-2-enoic acid
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C25H28O3S
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0399661
 Compound Info 
(E)-3-[3-(2-Ethoxy-3,5-diisopropyl-phenyl)-imidazo[1,2-a]pyridin-6-yl]-but-2-enoic acid
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C25H30N2O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0399760
 Compound Info 
(2E,4E,6Z)-7-[3,5-Di-tert-butyl-2-(3-fluoro-propoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C26H37FO3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0409539
 Compound Info 
(E)-3-{3-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-1H-indol-5-yl}-but-2-enoic acid
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C28H33F2NO3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0409751
 Compound Info 
(E)-3-[3-(2-Butoxy-3,5-di-tert-butyl-phenyl)-1H-indol-5-yl]-but-2-enoic acid
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C30H39NO3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0409795
 Compound Info 
(E)-3-[3-(2-Hydroxy-3,5-diisopropyl-phenyl)-benzo[b]thiophen-5-yl]-but-2-enoic acid
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C24H26O3S
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0414794
 Compound Info 
(E)-3-[3-(2-Ethoxy-3,5-diisopropyl-phenyl)-benzo[d]isoxazol-5-yl]-but-2-enoic acid
   Show/Hide
C25H29NO4
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0858883
 Compound Info 
(E)-3-[3-(2-Ethoxy-3,5-diisopropyl-phenyl)-1H-indazol-5-yl]-but-2-enoic acid
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C25H30N2O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
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CP0465377
 Compound Info 
(2E,4E,6Z)-7-(3-Isopropyl-5-pentafluoroethyl-2-propoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid
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C23H27F5O3
  1
1
Ki > 1000 nM
 Bioactivity Info 
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Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000017 , HeLa
 Cell Line Info 
Cell Line ID: CL000789 , HG5LN
 Cell Line Info 
Cell Line ID: CL000035 , NIH 3T3
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
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C20H28O2
  20
1 EC50 = 0.5 nM
2 EC50 = 6 nM
3 EC50 = 8 nM
4 EC50 = 10 nM
5 EC50 = 14.7 nM
6 IC50 = 0.5 nM
7 IC50 = 0.62 nM
8 IC50 = 18 nM
9 Kd = 0.2 nM
10 Kd = 0.3 nM
11 Kd = 3 nM
12 Kd = 16 nM
13 Kd = 17 nM
14 Kd = 18 nM
15 Kd = 19 nM
16 Ki = 0.5 nM
17 Ki = 0.6 nM
18 Ki = 0.7 nM
19 Ki = 3 nM
20 Ki = 18.5 nM
CP0041093
 Compound Info 
(E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-enyl)benzoic acid
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C24H28O2
  6
1 EC50 = 2 nM
2 EC50 = 2.4 nM
3 EC50 = 24 nM
4 IC50 = 26 nM
5 Kd = 26 nM
6 Ki = 5 nM
CP0042977
 Compound Info 
9-cis retinoic acid
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C20H28O2
  9
1 EC50 = 6 nM
2 EC50 = 12 nM
3 EC50 = 45 nM
4 IC50 = 17 nM
5 Kd = 0.8 nM
6 Kd = 22 nM
7 Kd = 148 nM
8 Kd = 150 nM
9 Ki = 20 nM
CP0073370
 Compound Info 
4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C25H30O2
  3
1 EC50 = 152 nM
2 IC50 = 645 nM
3 Kd = 645 nM
CP0061828
 Compound Info 
4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
   Show/Hide
C26H32O2
  2
1 EC50 = 195 nM
2 IC50 = 250 nM
CP0004259
 Compound Info 
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
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C24H28O2
  4
1 EC50 > 10000 nM
2 Ki = 130 nM
3 Ki = 3206 nM
4 Ki > 1000 nM
CP0148476
 Compound Info 
4-[(E)-2-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
   Show/Hide
C27H34O2
  1
1 IC50 > 1000 nM
CP0042976
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd = 552 nM
CP0076822
 Compound Info 
4-(1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene-7-carboxamido)benzoic acid
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C22H25NO3
  2
1 Kd = 3800 nM
2 Kd = 3824 nM
CP0095234
 Compound Info 
(E)-3-Methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd = 15900 nM
CP0134367
 Compound Info 
(E)-3-Methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Kd > 1000 nM
CP0215028
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd > 1000 nM
CP0280492
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Kd > 1000 nM
CP0063990
 Compound Info 
(2E,4E)-6-[1-(3,5-Di-tert-butyl-phenyl)-cyclopropyl]-3-methyl-hexa-2,4-dienoic acid
   Show/Hide
C24H34O2
  1
1 Kd > 1000 nM
CP0103897
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd > 10000 nM
CP0042771
 Compound Info 
5',5',8',8'-Tetramethyl-5',6',7',8'-tetrahydro-[2,2']binaphthalenyl-6-carboxylic acid
   Show/Hide
C25H26O2
  1
1 Ki = 40 nM
CP0047520
 Compound Info 
6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-2-carboxylic acid
   Show/Hide
C27H26O3
  1
1 Ki = 77 nM
CP0076073
 Compound Info 
6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid
   Show/Hide
C28H28O3
  1
1 Ki = 130 nM
CP0047977
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H26O2
  1
1 Ki = 887 nM
CP0000547
 Compound Info 
(2E,4E,6Z)-7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H36O3
  1
1 Ki = 10000 nM
CP0006755
 Compound Info 
(2E,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H34F2O3
  1
1 Ki = 10000 nM
CP0044243
 Compound Info 
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID
   Show/Hide
C24H29NO2
  1
1 Ki = 10000 nM
CP0264302
 Compound Info 
(2E,4E,6Z)-7-(2-Butoxy-3,5-diisopropyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H36O3
  1
1 Ki = 10000 nM
CP0274319
 Compound Info 
(2E,4E,6Z)-7-(2-Ethoxy-3,5-diisopropyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C23H32O3
  1
1 Ki = 10000 nM
CP0092680
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C26H36O2
  1
1 Ki > 1000 nM
CP0112883
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
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C24H32O2
  1
1 Ki > 1000 nM
CP0150625
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
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C23H30O2
  1
1 Ki > 1000 nM
CP0059678
 Compound Info 
3-Methyl-5-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
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C25H32O2
  1
1 Ki > 1000 nM
CP0059698
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H36O2
  1
1 Ki > 1000 nM
CP0102521
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1 Ki > 1000 nM
CP0135295
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1 Ki > 1000 nM
CP0756593
 Compound Info 
3-Methyl-5-[5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-bicyclo[3.1.0]hex-1-yl]-penta-2,4-dienoic acid
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C26H34O2
  1
1 Ki > 1000 nM
CP0092667
 Compound Info 
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O3
  1
1 Ki > 10000 nM
Clinical Information about the Protein
Target 1 ( Retinoic acid receptor gamma (RARG) )
Target Type Successful Target
Disease 3 Target-related Diseases  3
1 Kaposi sarcoma [ICD-11: 2B57]
2 Psoriasis vulgaris [ICD-11: EA90]
3 Acne vulgaris [ICD-11: ED80]
Approved Drug(s) 4 Approved Drugs  4
1 Alitretinoin
 Drug Info 
Approved
Kaposi sarcoma
2 Tazarotene
 Drug Info 
Approved
Psoriasis vulgaris
3 Tretinoin
 Drug Info 
Approved
Acne vulgaris
4 Trifarotene
 Drug Info 
Approved
Acne vulgaris