General Information of the Compound
Compound ID
CP0373374
Compound Name
(E)-3-[3-(2-Butoxy-3,5-diisopropyl-phenyl)-1H-indol-5-yl]-but-2-enoic acid
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Structure
Formula
C28H35NO3
Molecular Weight
433.592
Canonical SMILES
CCCCOc1c(cc(cc1-c1c[nH]c2ccc(cc12)C(\C)=C\C(O)=O)C(C)C)C(C)C
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InChI
InChI=1S/C28H35NO3/c1-7-8-11-32-28-22(18(4)5)14-21(17(2)3)15-24(28)25-16-29-26-10-9-20(13-23(25)26)19(6)12-27(30)31/h9-10,12-18,29H,7-8,11H2,1-6H3,(H,30,31)/b19-12+
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InChIKey
XOYJNOXXJQMGGK-XDHOZWIPSA-N
Physicochemical Property
logP
7.7485
Rotatable Bonds
9
Heavy Atom Count
32
Polar Areas
62.32
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10274512
SID: 15279509
ChEMBL ID
CHEMBL92798
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01806, Retinoic acid receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01930, Retinoic acid receptor RXR-alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  2
1
EC50 = 21.1 nM
   TI
   LI
   LO
   TS
2
Ki = 7.4 nM
   TI
   LI
   LO
   TS