General Information of the Compound
Compound ID
CP0399661
Compound Name
(E)-3-[3-(2-Ethoxy-3,5-diisopropyl-phenyl)-imidazo[1,2-a]pyridin-6-yl]-but-2-enoic acid
    Show/Hide
Structure
Formula
C25H30N2O3
Molecular Weight
406.526
Canonical SMILES
CCOc1c(cc(cc1-c1cnc2ccc(cn12)C(\C)=C\C(O)=O)C(C)C)C(C)C
    Show/Hide
InChI
InChI=1S/C25H30N2O3/c1-7-30-25-20(16(4)5)11-19(15(2)3)12-21(25)22-13-26-23-9-8-18(14-27(22)23)17(6)10-24(28)29/h8-16H,7H2,1-6H3,(H,28,29)/b17-10+
    Show/Hide
InChIKey
CZIPWDFUYKXIJA-LICLKQGHSA-N
Physicochemical Property
logP
6.1347
Rotatable Bonds
7
Heavy Atom Count
30
Polar Areas
63.83
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 10223041
SID: 15224013
ChEMBL ID
CHEMBL328072
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01806, Retinoic acid receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01930, Retinoic acid receptor RXR-alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  1
1
Ki = 2078.3 nM
   TI
   LI
   LO
   TS