Protein Information

General Information of the Protein

Protein ID	PT05434
Protein Name	P2Y purinoceptor 14
Secondarily Protein Name	G-protein coupled receptor 105 UDP-glucose receptor
Gene Name	P2RY14
Secondarily Gene Name	GPR105 KIAA0001
Sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Nucleotide-like receptor (family A GPCR) > Purine receptor
Function	Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP. Show/Hide
Uniprot ID	Primary ID: Q15391 Secondarily ID: Q8IYT7 Show/Hide
Ensembl ID	ENSG00000174944
HGNC ID	HGNC:16442
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000053 , COS-7

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0469840 Compound Info	[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate Show/Hide	C15H24N2O16P2S	1
1	EC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0452617 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate Show/Hide	C14H22N2O16P2	1
1	EC50 = 238 nM Bioactivity Info	TI LI LO TS
CP0385875 Compound Info	UDP-alpha-D-glucose Show/Hide	C15H24N2O17P2	2
1	EC50 = 261 nM Bioactivity Info	TI LI LO TS
2	EC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0401576 Compound Info	[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-oxo-4-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate Show/Hide	C15H24N2O16P2S	2
1	EC50 = 290 nM Bioactivity Info	TI LI LO TS
2	EC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0504583 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4S,5R)-3,4,5-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl hydrogen phosphate Show/Hide	C15H24N2O17P2	1
1	EC50 = 323 nM Bioactivity Info	TI LI LO TS
CP0421299 Compound Info	(2S,3S,4S,5R,6R)-6-[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Show/Hide	C15H22N2O18P2	1
1	EC50 = 370 nM Bioactivity Info	TI LI LO TS
CP0463374 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxan-2-yl]methyl hydrogen phosphate Show/Hide	C15H24N2O17P2	1
1	EC50 = 373 nM Bioactivity Info	TI LI LO TS
CP0541808 Compound Info	(2S,3S,4S,5R,6R)-6-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Show/Hide	C15H22N2O17P2S	1
1	EC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0477667 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4S,5S)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate Show/Hide	C14H22N2O16P2	1
1	EC50 = 460 nM Bioactivity Info	TI LI LO TS
CP0401575 Compound Info	[(2R,3R,4S,5S,6S)-6-(2-acetamidoethylcarbamoyl)-3,4,5-trihydroxyoxan-2-yl] [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate Show/Hide	C19H30N4O18P2	1
1	EC50 = 496 nM Bioactivity Info	TI LI LO TS
CP0470265 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl] hydrogen phosphate Show/Hide	C15H24N2O16P2	1
1	EC50 = 562 nM Bioactivity Info	TI LI LO TS
CP0470264 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate Show/Hide	C15H24N2O17P2	1
1	EC50 = 588 nM Bioactivity Info	TI LI LO TS
CP0470266 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4S,5S,6S)-3,4,5,6-tetrahydroxyoxan-2-yl]methyl hydrogen phosphate Show/Hide	C15H24N2O17P2	1
1	EC50 = 658 nM Bioactivity Info	TI LI LO TS
CP0278982 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate Show/Hide	C15H24N2O17P2	1
1	EC50 = 670 nM Bioactivity Info	TI LI LO TS
CP0499300 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl hydrogen phosphate Show/Hide	C15H24N2O17P2	1
1	EC50 = 880 nM Bioactivity Info	TI LI LO TS
CP0383614 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate Show/Hide	C15H24N2O17P2	1
1	EC50 = 910 nM Bioactivity Info	TI LI LO TS
CP0390310 Compound Info	tert-butyl N-[2-[[(2S,3S,4S,5R,6R)-6-[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-3,4,5-trihydroxyoxane-2-carbonyl]amino]ethyl]carbamate Show/Hide	C22H36N4O19P2	1
1	EC50 = 951 nM Bioactivity Info	TI LI LO TS
CP0554705 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2S,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl] hydrogen phosphate Show/Hide	C15H24N2O17P2	1
1	EC50 = 1880 nM Bioactivity Info	TI LI LO TS
CP0429834 Compound Info	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,5R,6R)-2,3,4,5,6-pentahydroxycyclohexyl] hydrogen phosphate Show/Hide	C15H24N2O17P2	1
1	EC50 = 1880 nM Bioactivity Info	TI LI LO TS
CP0499299 Compound Info	[(2R,3R,4S,5S,6S)-6-(2-aminoethylcarbamoyl)-3,4,5-trihydroxyoxan-2-yl] [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate Show/Hide	C17H28N4O17P2	1
1	EC50 = 2590 nM Bioactivity Info	TI LI LO TS
CP0427215 Compound Info	[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methylsulfanyl-2-oxo-1,6-dihydropyrimidin-3-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate Show/Hide	C16H28N2O16P2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0032210 Compound Info	4-(4-piperidin-4-ylphenyl)-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid Show/Hide	C29H24F3NO2	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000049 , C6

Cell Line Info

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000040 , THP-1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0032210 Compound Info	4-(4-piperidin-4-ylphenyl)-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid Show/Hide	C29H24F3NO2	3
1	IC50 ~ 0.5 nM
2	Ki ~ 2.3 nM
3	Ki ~ 35 nM
CP0339301 Compound Info	4-[4-[1-[4-[1-[6-[[4-(3-amino-6-imino-4,5-disulfoxanthen-9-yl)-3-carboxybenzoyl]amino]hexyl]triazol-4-yl]butyl]piperidin-4-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid Show/Hide	C62H58F3N7O12S2	1
1	Ki = 0.08 nM

Clinical Information about the Protein

Target 1 ( P2Y purinoceptor 14 (P2RY14) )

Target Type	Literature-reported Target

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT00635	Purinergic receptor P2Y14	Pan troglodytes, Chimpanzee	Protein Info

50% Identity

Protein ID	Protein Name	Protein Organism
PT05244	P2Y purinoceptor 14	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han