General Information of the Protein
Protein ID
PT05244
Protein Name
P2Y purinoceptor 14
Secondarily
Protein Name
G-protein coupled receptor 105
UDP-glucose receptor
Gene Name
P2RY14
Secondarily
Gene Name
Gpr105
Sequence
MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Nucleotide-like receptor (family A GPCR)
>
Purine receptor
Function
Receptor for UDP-glucose coupled to G-proteins.
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Uniprot ID
Q9ESG6
Ensembl ID
ENSG00000174944
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0337975
 Compound Info 
2-(2-cyanopyrimidin-5-yl)-N-(3-ethylphenyl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C28H25N7O
  1
1
IC50 = 1 nM
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CP0137739
 Compound Info 
2-(4-cyanopyridin-3-yl)-N-(3-ethylphenyl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C29H26N6O
  1
1
IC50 = 3 nM
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CP0137566
 Compound Info 
2-(3,5-dimethylisoxazol-4-yl)-N-(3-ethylphenyl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C28H29N5O2
  1
1
IC50 = 4 nM
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CP0425968
 Compound Info 
(R)-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid
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C26H16F6O3
  1
1
IC50 = 4 nM
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CP0341302
 Compound Info 
(R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid
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C26H17F5O3
  1
1
IC50 = 8 nM
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CP0499006
 Compound Info 
4-(2,6-dimethylphenyl)-N-(3-ethylphenyl)-2-(pyridin-3-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C29H29N5O
  1
1
IC50 = 9 nM
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CP0291744
 Compound Info 
2-(benzo[d][1,3]dioxol-5-yl)-N-(3-ethylphenyl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C30H28N4O3
  1
1
IC50 = 10 nM
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CP0164538
 Compound Info 
N-(3-ethylphenyl)-4-(2-methylphenyl)-2-pyrimidin-5-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C27H26N6O
  1
1
IC50 = 12 nM
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CP0441303
 Compound Info 
N-(3-ethylphenyl)-4-(2-methylphenyl)-2-quinolin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C32H29N5O
  1
1
IC50 = 13 nM
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CP0502633
 Compound Info 
4-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid
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C26H16F6O3
  1
1
IC50 = 13 nM
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CP0261952
 Compound Info 
4-[4-[(1R,4R,5R)-2-azabicyclo[2.2.1]heptan-5-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C30H24F3NO2
  1
1
IC50 = 13.4 nM
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CP0531346
 Compound Info 
7-(4-fluoro-2,6-dimethylbenzyloxy)-4-(thiophen-3-yl)-2-naphthoic acid
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C24H19FO3S
  1
1
IC50 = 14 nM
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CP0571897
 Compound Info 
4-[4-[(1S,5S)-8-hydroxy-3-azabicyclo[3.2.1]octan-8-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C31H26F3NO3
  1
1
IC50 = 15.5 nM
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CP0494428
 Compound Info 
2-(4-cyanophenyl)-N-(3-ethylphenyl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C30H27N5O
  1
1
IC50 = 16 nM
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CP0578708
 Compound Info 
4-[4-[(1S,2S,4S)-4-amino-2-(hydroxymethyl)cyclopentyl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C30H26F3NO3
  1
1
IC50 = 17.9 nM
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CP0551575
 Compound Info 
4-[4-[5-(hydroxymethyl)-1,2-oxazol-3-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C28H18F3NO4
  1
1
IC50 = 18.6 nM
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CP0377820
 Compound Info 
4-(4-(methylsulfonyl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid
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C25H17F3O4S
  1
1
IC50 = 20 nM
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CP0321473
 Compound Info 
4-[4-(1-azabicyclo[2.2.2]octan-4-yl)phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C31H26F3NO2
  1
1
IC50 = 21.4 nM
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CP0032210
 Compound Info 
4-(4-piperidin-4-ylphenyl)-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C29H24F3NO2
  1
1
IC50 = 21.6 nM
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CP0505161
 Compound Info 
N-(3-ethylphenyl)-2-(4-fluorophenyl)-4-(2-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C29H27FN4O
  1
1
IC50 = 25 nM
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CP0438203
 Compound Info 
7-(2,6-dimethylbenzyloxy)-4-(thiophen-3-yl)-2-naphthoic acid
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C24H20O3S
  1
1
IC50 = 26 nM
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CP0496316
 Compound Info 
4-[4-[(1R,4R,5R)-3-oxo-2-azabicyclo[2.2.1]heptan-5-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C30H22F3NO3
  1
1
IC50 = 26.2 nM
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CP0438186
 Compound Info 
N-[3-(1-fluoroethyl)phenyl]-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C28H26FN5O
  1
1
IC50 = 29 nM
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CP0321380
 Compound Info 
4-[4-(1-acetylpiperidin-4-yl)phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C31H26F3NO3
  1
1
IC50 = 29.7 nM
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CP0566036
 Compound Info 
N-(3-ethylphenyl)-2-(3-fluorophenyl)-4-(2-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C29H27FN4O
  1
1
IC50 = 30 nM
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CP0261954
 Compound Info 
4-[4-[(1S,4S,5S)-2-azabicyclo[2.2.1]heptan-5-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C30H24F3NO2
  1
1
IC50 = 33.9 nM
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CP0516553
 Compound Info 
4-[4-(1-propanoylpiperidin-4-yl)phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C32H28F3NO3
  1
1
IC50 = 38 nM
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CP0551528
 Compound Info 
4-[4-[(1S,2S,4S)-4-amino-2-carboxycyclopentyl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C30H24F3NO4
  1
1
IC50 = 40.9 nM
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CP0551526
 Compound Info 
4-[4-[(1R,4R,6S)-3-oxo-2-azabicyclo[2.2.1]heptan-6-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C30H22F3NO3
  1
1
IC50 = 42.9 nM
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CP0524763
 Compound Info 
4-(2-chloro-6-methylphenyl)-N-(3-ethylphenyl)-2-(pyridin-3-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C28H26ClN5O
  1
1
IC50 = 50 nM
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CP0441298
 Compound Info 
4-(2,6-dichlorophenyl)-N-(3-ethylphenyl)-2-(pyridin-3-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C27H23Cl2N5O
  1
1
IC50 = 51 nM
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CP0555636
 Compound Info 
(S)-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid
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C26H16F6O3
  1
1
IC50 = 51 nM
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CP0422868
 Compound Info 
4-(thiophen-3-yl)-7-(4-(trifluoromethoxy)phenyl)-2-naphthoic acid
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C22H13F3O3S
  1
1
IC50 = 54 nM
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CP0548924
 Compound Info 
4-[4-(1-methyl-1-azoniabicyclo[2.2.2]octan-4-yl)phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C32H29F3NO2+
  1
1
IC50 = 56.3 nM
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CP0438187
 Compound Info 
N-(3-ethylphenyl)-4-(2-methylphenyl)-2-(4-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C30H30N4O
  1
1
IC50 = 62 nM
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CP0498999
 Compound Info 
N-(3-ethylphenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C28H27N5O
  1
1
IC50 = 81 nM
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CP0441300
 Compound Info 
N-(3-ethylphenyl)-4-(2-methylphenyl)-2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C29H28N4O
  1
1
IC50 = 87 nM
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CP0345478
 Compound Info 
4-[4-[(1R,4R,6S)-2-azabicyclo[2.2.1]heptan-6-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C30H24F3NO2
  1
1
IC50 = 90.9 nM
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CP0544612
 Compound Info 
4-[4-[(1S,4S,5S)-2-acetyl-2-azabicyclo[2.2.1]heptan-5-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C32H26F3NO3
  1
1
IC50 = 102 nM
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CP0544609
 Compound Info 
4-[4-[(1R,2S,4R)-5-methylsulfonyl-2-bicyclo[2.2.1]heptanyl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C32H27F3O4S
  1
1
IC50 = 103 nM
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CP0503161
 Compound Info 
7-(2,6-dimethylbenzyloxy)-4-phenyl-2-naphthoic acid
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C26H22O3
  1
1
IC50 = 110 nM
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CP0522044
 Compound Info 
4-(benzyloxy)-7-(2,6-dimethylbenzyloxy)-2-naphthoic acid
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C27H24O4
  1
1
IC50 = 110 nM
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CP0414455
 Compound Info 
4-[4-(1-hex-5-ynylpiperidin-4-yl)phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C35H32F3NO2
  1
1
IC50 = 130 nM
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CP0422916
 Compound Info 
2-(3-cyanophenyl)-N-(3-ethylphenyl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C30H27N5O
  1
1
IC50 = 140 nM
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CP0403609
 Compound Info 
3-(4-piperidin-4-ylphenyl)-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid
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C27H23F3N4O2
  1
1
IC50 = 142 nM
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CP0499000
 Compound Info 
4-(2-methylphenyl)-N-(3-propylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C29H29N5O
  1
1
IC50 = 150 nM
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CP0551570
 Compound Info 
3-[4-(piperidine-4-carbonylamino)phenyl]-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid
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C28H24F3N5O3
  1
1
IC50 = 155 nM
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CP0505159
 Compound Info 
N-(3-chloro-5-ethylphenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C28H26ClN5O
  1
1
IC50 = 160 nM
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CP0551572
 Compound Info 
3-[4-[5-(hydroxymethyl)-1,2-oxazol-3-yl]phenyl]-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid
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C26H17F3N4O4
  1
1
IC50 = 184 nM
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CP0441287
 Compound Info 
4-(4-(methylsulfonyl)thiophen-3-yl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid
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C23H15F3O4S2
  1
1
IC50 = 190 nM
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CP0555577
 Compound Info 
7-(2,6-dichlorobenzyloxy)-4-phenyl-2-naphthoic acid
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C24H16Cl2O3
  1
1
IC50 = 190 nM
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CP0139459
 Compound Info 
3-(4-piperidin-4-ylphenyl)-5-[1-[4-(trifluoromethyl)phenyl]triazol-4-yl]benzoic acid
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C27H23F3N4O2
  1
1
IC50 = 246 nM
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CP0566039
 Compound Info 
4-(4-(methylsulfonyl)thiophen-3-yl)-7-(4-(trifluoromethoxy)phenyl)-2-naphthoic acid
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C23H15F3O5S2
  1
1
IC50 = 330 nM
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CP0422869
 Compound Info 
4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)thiophen-3-yl)-7-(4-(trifluoromethoxy)phenyl)-2-naphthoic acid
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C25H13F9O4S
  1
1
IC50 = 350 nM
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CP0551574
 Compound Info 
3-[4-(3-aminoprop-1-ynyl)phenyl]-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid
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C25H17F3N4O2
  1
1
IC50 = 375 nM
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CP0377818
 Compound Info 
3-fluoro-4-(thiophen-3-yl)-7-(4-(trifluoromethoxy)phenyl)-2-naphthoic acid
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C22H12F4O3S
  1
1
IC50 = 380 nM
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CP0424009
 Compound Info 
3-[5-(3-aminopropylcarbamoyl)thiophen-2-yl]-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid
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C24H20F3N5O3S
  1
1
IC50 = 384 nM
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CP0503287
 Compound Info 
4-(2-ethylphenyl)-N-(3-ethylphenyl)-2-(pyridin-3-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C29H29N5O
  1
1
IC50 = 390 nM
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CP0504343
 Compound Info 
N-(3-ethoxyphenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C28H27N5O2
  1
1
IC50 = 420 nM
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CP0502598
 Compound Info 
4-(2-chlorophenyl)-N-(3-ethylphenyl)-2-(pyridin-3-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C27H24ClN5O
  1
1
IC50 = 440 nM
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CP0525562
 Compound Info 
4-[4-[1-[3-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoyl]piperidin-4-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C46H57F3N2O10
  1
1
IC50 = 487 nM
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CP0531880
 Compound Info 
3-(4-piperazin-1-ylphenyl)-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid
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C26H22F3N5O2
  1
1
IC50 = 499 nM
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CP0422785
 Compound Info 
N-(3-chlorophenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C26H22ClN5O
  1
1
IC50 = 580 nM
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CP0494426
 Compound Info 
N-[3-(1,1-difluoroethyl)phenyl]-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C28H25F2N5O
  1
1
IC50 = 620 nM
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CP0524761
 Compound Info 
4-(2-methylphenyl)-N-(3-methylsulfanylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C27H25N5OS
  1
1
IC50 = 630 nM
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CP0133862
 Compound Info 
3-[4-(1-azabicyclo[2.2.2]octan-4-yl)phenyl]-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid
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C29H25F3N4O2
  1
1
IC50 = 845 nM
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CP0441302
 Compound Info 
N-(3-ethylphenyl)-4-(2-methylphenyl)-2-naphthalen-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C33H30N4O
  1
1
IC50 = 880 nM
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CP0437669
 Compound Info 
3-(4-carbamoylphenyl)-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid
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C29H30F3N5O3
  1
1
IC50 = 902 nM
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CP0465945
 Compound Info 
N-(3-ethylphenyl)-4-[2-(hydroxymethyl)phenyl]-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C28H27N5O2
  1
1
IC50 = 1100 nM
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CP0531879
 Compound Info 
3-[4-(3-azabicyclo[4.1.0]heptan-6-yl)phenyl]-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid
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C28H23F3N4O2
  1
1
IC50 = 1160 nM
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CP0499002
 Compound Info 
2-(pyridin-3-yl)-4-o-tolyl-N-(3-vinylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C28H25N5O
  1
1
IC50 = 1200 nM
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CP0499003
 Compound Info 
N-(3-cyclopropylphenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C29H27N5O
  1
1
IC50 = 1200 nM
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CP0465946
 Compound Info 
N-(3-ethylphenyl)-4-(2-methylphenyl)-2-(3-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C30H30N4O
  1
1
IC50 = 1300 nM
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CP0377819
 Compound Info 
3-hydroxy-4-(thiophen-3-yl)-7-(4-(trifluoromethoxy)phenyl)-2-naphthoic acid
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C22H13F3O4S
  1
1
IC50 = 1300 nM
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CP0489797
 Compound Info 
N-(3-ethylphenyl)-4-(2-methylphenyl)-2-pyridin-4-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C28H27N5O
  1
1
IC50 = 1400 nM
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CP0477989
 Compound Info 
4-hydroxy-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C18H11F3O3
  1
1
IC50 = 1600 nM
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CP0524762
 Compound Info 
2-(pyridin-3-yl)-N-m-tolyl-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C27H25N5O
  1
1
IC50 = 1900 nM
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CP0520986
 Compound Info 
7-((2,6-dimethylphenoxy)methyl)-4-phenyl-2-naphthoic acid
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C26H22O3
  1
1
IC50 = 2100 nM
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CP0494427
 Compound Info 
3-(6-(3-ethylphenylcarbamoyl)-4-o-tolyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)pyridine 1-oxide
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C28H27N5O2
  1
1
IC50 = 2800 nM
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CP0499005
 Compound Info 
N-(3-ethylphenyl)-4-(2-methoxyphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C28H27N5O2
  1
1
IC50 = 3300 nM
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CP0522042
 Compound Info 
7-(benzyloxy)-4-phenyl-2-naphthoic acid
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C24H18O3
  1
1
IC50 = 3500 nM
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CP0502599
 Compound Info 
N-(3-ethylphenyl)-4-(2-fluorophenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C27H24FN5O
  1
1
IC50 = 3700 nM
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CP0566035
 Compound Info 
4-(2-methylphenyl)-N-phenyl-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C26H23N5O
  1
1
IC50 = 4900 nM
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CP0441343
 Compound Info 
7-phenoxy-4-phenyl-2-naphthoic acid
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C23H16O3
  1
1
IC50 = 4900 nM
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CP0441295
 Compound Info 
N-(3-methoxyphenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C27H25N5O2
  1
1
IC50 = 5100 nM
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CP0501569
 Compound Info 
N-(4-chlorophenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C26H22ClN5O
  1
1
IC50 = 5800 nM
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CP0441296
 Compound Info 
N-(3-acetylphenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C28H25N5O2
  1
1
IC50 = 6500 nM
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CP0456292
 Compound Info 
N-(3-ethylphenyl)-4-(2-hydroxyphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C27H25N5O2
  1
1
IC50 = 6500 nM
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CP0422915
 Compound Info 
4-(4-chloro-2-methylphenyl)-N-(3-ethylphenyl)-2-(pyridin-3-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C28H26ClN5O
  1
1
IC50 = 7000 nM
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CP0465948
 Compound Info 
N-(3-ethylphenyl)-4-(2-methylphenyl)-2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C30H27F3N4O
  1
1
IC50 = 7500 nM
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CP0499004
 Compound Info 
N-[3-(1-hydroxyethyl)phenyl]-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
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C28H27N5O2
  1
1
IC50 = 8200 nM
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CP0441297
 Compound Info 
4-(3-chlorophenyl)-N-(3-ethylphenyl)-2-(pyridin-3-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
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C27H24ClN5O
  1
1
IC50 = 12000 nM
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CP0441345
 Compound Info 
7-(4-carboxybenzyloxy)-4-phenyl-2-naphthoic acid
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C25H18O5
  1
1
IC50 > 13000 nM
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CP0522043
 Compound Info 
7-(2,6-dimethylbenzyloxy)-2-naphthoic acid
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C20H18O3
  1
1
IC50 = 13000 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0531346
 Compound Info 
7-(4-fluoro-2,6-dimethylbenzyloxy)-4-(thiophen-3-yl)-2-naphthoic acid
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C24H19FO3S
  1
1 IC50 = 14 nM
CP0341302
 Compound Info 
(R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid
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C26H17F5O3
  2
1 Ki = 4 nM
2 Ki = 1290 nM
CP0032210
 Compound Info 
4-(4-piperidin-4-ylphenyl)-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C29H24F3NO2
  1
1 Ki = 35 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00635 Purinergic receptor P2Y14 Pan troglodytes, Chimpanzee
 Protein Info 
PT05434 P2Y purinoceptor 14 Homo sapiens, Human
 Protein Info