| Compound ID |
Compound Name |
Compound Formula |
|
CP0384911
|
ASIMADOLINE HYDROCHLORIDE
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|
C27H30N2O2
|
1
|
| 1 |
EC50 = 0.5 nM
|
|
|
|
CP0399573
|
4-methylsulfanyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-1H-pyrrole-2-carboxamide
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|
C19H23N5OS
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0384912
|
N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-1H-indole-2-carboxamide
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|
C22H23N5O
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0388643
|
3,4-dichloro-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C20H20Cl2N4O
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0418704
|
4-chloranyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C20H21ClN4O
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0397751
|
N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-1H-pyrrole-2-carboxamide
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|
C18H21N5O
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0398002
|
4-chloro-N-[1-[2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl]benzimidazol-2-yl]benzamide
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|
C20H21ClN4O2
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0387028
|
N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-1-benzothiophene-2-carboxamide
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|
C22H22N4OS
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0397753
|
4-methylsulfonyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-1H-pyrrole-2-carboxamide
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|
C19H23N5O3S
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0448321
|
4-fluoro-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C20H21FN4O
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0398003
|
4-chloro-N-[3-(2-pyrrolidin-1-ylethyl)imidazo[4,5-b]pyridin-2-yl]benzamide
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|
C19H20ClN5O
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0326947
|
4-methyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C21H24N4O
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0497946
|
5-methyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]pyridine-2-carboxamide
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|
C20H23N5O
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0462187
|
3-cyano-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C21H21N5O
|
1
|
| 1 |
EC50 = 72 nM
|
|
|
|
CP0537294
|
4-fluoro-2-hydroxy-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C20H21FN4O2
|
1
|
| 1 |
EC50 = 118 nM
|
|
|
|
CP0429396
|
N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-1,3-benzothiazole-2-carboxamide
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|
C21H21N5OS
|
1
|
| 1 |
EC50 = 122 nM
|
|
|
|
CP0451871
|
6-methyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]pyridine-3-carboxamide
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|
C20H23N5O
|
1
|
| 1 |
EC50 = 152 nM
|
|
|
|
CP0456351
|
4-cyano-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C21H21N5O
|
1
|
| 1 |
EC50 = 355 nM
|
|
|
|
CP0448322
|
4-methylsulfonyl-N-[3-(2-pyrrolidin-1-ylethyl)imidazo[4,5-b]pyridin-2-yl]-1H-pyrrole-2-carboxamide
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|
C18H22N6O3S
|
1
|
| 1 |
EC50 = 395 nM
|
|
|
|
CP0537297
|
2-fluoro-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C20H21FN4O
|
1
|
| 1 |
EC50 = 423 nM
|
|
|
|
CP0388644
|
[3-[[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]carbamoyl]phenyl] methanesulfonate
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|
C21H24N4O4S
|
1
|
| 1 |
EC50 = 478 nM
|
|
|
|
CP0494557
|
4-acetyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C22H24N4O2
|
1
|
| 1 |
EC50 = 537 nM
|
|
|
|
CP0497942
|
5-acetyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]thiophene-2-carboxamide
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|
C20H22N4O2S
|
1
|
| 1 |
EC50 = 734 nM
|
|
|
|
CP0555916
|
1-methyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]pyrrole-2-carboxamide
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|
C19H23N5O
|
1
|
| 1 |
EC50 = 765 nM
|
|
|
|
CP0480652
|
4-methyl-N-[1-(3-pyrrolidin-1-ylpropyl)benzimidazol-2-yl]benzamide
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|
C22H26N4O
|
1
|
| 1 |
EC50 = 878 nM
|
|
|
|
CP0388645
|
3-acetyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C22H24N4O2
|
1
|
| 1 |
EC50 = 970 nM
|
|
|
|
CP0480650
|
N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]thiophene-2-carboxamide
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|
C18H20N4OS
|
1
|
| 1 |
EC50 = 1050 nM
|
|
|
|
CP0451874
|
2-cyano-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C21H21N5O
|
1
|
| 1 |
EC50 = 1225 nM
|
|
|
|
CP0445044
|
2-phenyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]acetamide
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|
C21H24N4O
|
1
|
| 1 |
EC50 = 1400 nM
|
|
|
|
CP0553584
|
N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-1H-pyrazole-5-carboxamide
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|
C17H20N6O
|
1
|
| 1 |
EC50 = 1440 nM
|
|
|
|
CP0411628
|
4-chloro-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-3-sulfamoylbenzamide
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|
C20H22ClN5O3S
|
1
|
| 1 |
EC50 = 1550 nM
|
|
|
|
CP0451873
|
methyl 4-[[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]carbamoyl]benzoate
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|
C22H24N4O3
|
1
|
| 1 |
EC50 = 1550 nM
|
|
|
|
CP0456350
|
4-chloro-3-pyrazol-1-yl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]benzamide
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|
C23H23ClN6O
|
1
|
| 1 |
EC50 = 1800 nM
|
|
|
|
CP0434589
|
N-(1H-benzimidazol-2-yl)-4-methylbenzamide
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|
C15H13N3O
|
1
|
| 1 |
EC50 = 2000 nM
|
|
|
|
CP0557907
|
N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]pyrazine-2-carboxamide
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|
C18H20N6O
|
1
|
| 1 |
EC50 = 2050 nM
|
|
|
|
CP0451872
|
N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-3-sulfamoylbenzamide
Show/Hide
|
C20H23N5O3S
|
1
|
| 1 |
EC50 = 2400 nM
|
|
|
|
CP0494556
|
N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-4-sulfamoylbenzamide
Show/Hide
|
C20H23N5O3S
|
1
|
| 1 |
EC50 = 2950 nM
|
|
|
|
CP0445041
|
methyl 3-[[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]carbamoyl]benzoate
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|
C22H24N4O3
|
1
|
| 1 |
EC50 = 4250 nM
|
|
|
|
CP0384910
|
4-[[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]carbamoyl]benzoic acid
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|
C21H22N4O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0411546
|
5-[[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]carbamoyl]thiophene-2-carboxylic acid
Show/Hide
|
C19H20N4O3S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0557908
|
N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]-3-(2H-tetrazol-5-yl)benzamide
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|
C21H22N8O
|
1
|
| 1 |
EC50 = 10000 nM
|
|
|
|
CP0557909
|
2-[3-[[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]carbamoyl]phenoxy]acetic acid
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|
C22H24N4O4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0557910
|
3-[[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]carbamoyl]benzoic acid
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|
C21H22N4O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0041449
|
C18130
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|
C40H43N3O6
|
3
|
| 1 |
Ki = 0.13 nM
|
|
|
| 2 |
Ki = 12.8 nM
|
|
|
| 3 |
Ki = 12.9 nM
|
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CP0072629
|
2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2R,6S,14R,15R,16R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-2-propanol
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|
C26H35NO4
|
3
|
| 1 |
Ki = 0.28 nM
|
|
|
| 2 |
Ki = 0.37 nM
|
|
|
| 3 |
Ki = 0.38 nM
|
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CP0847947
|
17-Methyl-17'-cyclopropylmethyl-3'-hydroxy-6,6',7,7'-tetradehydro-4,5 alpha : 4',5' alpha-diepoxy-6,6'-(imino)[7,7'-bimorphinan]-3,14'-diol
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|
C37H39N3O5
|
3
|
| 1 |
Ki = 0.32 nM
|
|
|
| 2 |
Ki = 39.6 nM
|
|
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| 3 |
Ki = 39.9 nM
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CP0682254
|
17,17'-Bis(cyclopropylmethyl)-3-methoxy-6,6',7,7'-tetradehydro-4,5:4',5'-diepoxy-6,6'-(imino)[7,7'-bimorphinan]-14,14'-diol
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|
C41H45N3O6
|
3
|
| 1 |
Ki = 0.39 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
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| 3 |
Ki = 28 nM
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CP0866792
|
17-Cyclopropylmethyl-17'-guanidinyl-6,6',7,7'-tetradehydro-4,5 alpha : 4',5' alpha-diepoxy-6,6'-(imino)[7,7'-bimorphinan]-3,3',14,14'-tetrol
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|
C37H39N5O6
|
2
|
| 1 |
Ki = 0.57 nM
|
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| 2 |
Ki = 189 nM
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CP0087234
|
(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-dimethyl-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol
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|
C34H35N3O6
|
2
|
| 1 |
Ki = 21.7 nM
|
|
|
| 2 |
Ki > 1000 nM
|
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CP0758384
|
17-(cyclopropylmethyl)-17'-acetyl-6,6',7,7'-tetradehydro-4,5:4',5'-diepoxy-6,6'-imino-7,7'-bimorphinan-3,3',14,14'-tetrol
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|
C38H39N3O7
|
2
|
| 1 |
Ki = 23.6 nM
|
|
|
| 2 |
Ki = 104 nM
|
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CP0858302
|
17-Methyl-17'-cyclopropylmethyl-3'-methoxy-6,6',7,7'-tetradehydro-4,5 alpha : 4',5' alpha-diepoxy-6,6'-(imino)[7,7'-bimorphinan]-3,14,14'-triol
Show/Hide
|
C38H41N3O6
|
2
|
| 1 |
Ki = 36.3 nM
|
|
|
| 2 |
Ki > 1000 nM
|
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