General Information of the Protein
Protein ID
PT05659
Protein Name
Very long chain fatty acid elongase 3
Secondarily
Protein Name
3-keto acyl-CoA synthase ELOVL3
Cold-inducible glycoprotein of 30 kDa
ELOVL fatty acid elongase 3
Elongation of very long chain fatty acids protein 3
Very long chain 3-ketoacyl-CoA synthase 3
Very long chain 3-oxoacyl-CoA synthase 3
Gene Name
ELOVL3
Secondarily
Gene Name
CIG30
Sequence
MVTAMNVSHEVNQLFQPYNFELSKDMRPFFEEYWATSFPIALIYLVLIAVGQNYMKERKGFNLQGPLILWSFCLAIFSILGAVRMWGIMGTVLLTGGLKQTVCFINFIDNSTVKFWSWVFLLSKVIELGDTAFIILRKRPLIFIHWYHHSTVLVYTSFGYKNKVPAGGWFVTMNFGVHAIMYTYYTLKAANVKPPKMLPMLITSLQILQMFVGAIVSILTYIWRQDQGCHTTMEHLFWSFILYMTYFILFAHFFCQTYIRPKVKAKTKSQ
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
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Uniprot ID
Primary ID:
Q9HB03

Secondarily ID:
Q5VZL3
Q8N180
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Ensembl ID
ENSG00000119915
HGNC ID
HGNC:18047
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0504385
 Compound Info 
3-[2-(4-isopropylphenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
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C30H30F3N3O3
  1
1
IC50 = 59 nM
 Bioactivity Info 
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CP0480497
 Compound Info 
3-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
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C27H23ClF3N3O3
  1
1
IC50 = 221 nM
 Bioactivity Info 
   TI
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CP0428615
 Compound Info 
6,6-dimethyl-3-{5-methyl-3-oxo-2-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-pyrazol-4-yl}-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
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C28H23F6N3O4
  1
1
IC50 = 337 nM
 Bioactivity Info 
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CP0495958
 Compound Info 
3-[2-(4-methyllphenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
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C28H26F3N3O3
  1
1
IC50 = 375 nM
 Bioactivity Info 
   TI
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CP0485234
 Compound Info 
3-[2-(4-methoxyphenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
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C28H26F3N3O4
  1
1
IC50 = 503 nM
 Bioactivity Info 
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CP0515764
 Compound Info 
3-[2-(4-cyanophenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
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C28H23F3N4O3
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0857816
 Compound Info 
2-[(1-Methyl-1H-imidazol-4-yl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide
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C21H28N4O4S
  1
1
IC50 = 1510 nM
 Bioactivity Info 
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CP0443407
 Compound Info 
6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
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C27H24F3N3O3
  1
1
IC50 > 10 nM
 Bioactivity Info 
   TI
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Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT05763 Very long chain fatty acid elongase 3 Mus musculus, Mouse
 Protein Info