Protein Information

General Information of the Protein

Protein ID	PT00834
Protein Name	Cannabinoid receptor 2
Secondarily Protein Name	CX5
Gene Name	CNR2
Secondarily Gene Name	CB2A CB2B
Sequence	MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Lipid-like ligand receptor (family A GPCR) > Cannabinoid receptor
Function	Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Show/Hide
Uniprot ID	Primary ID: P34972 Secondarily ID: C6ES44 Q4VBK8 Q5JRH7 Q6B0G7 Q6NSY0 Show/Hide
Ensembl ID	ENSG00000188822
HGNC ID	HGNC:2160
Subcellular Location	Cell membrane Cell projection Dendrite Perikaryon

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000367 , AtT-20

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0461802 Compound Info	N-(1-adamantyl)-1-pentylindole-3-carboxamide Show/Hide	C24H32N2O	1
1	EC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0461803 Compound Info	1-adamantyl-(1-pentylindol-3-yl)methanone Show/Hide	C24H31NO	1
1	EC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0470521 Compound Info	2-(1-adamantyl)-1-(1-pentylindol-3-yl)ethanone Show/Hide	C25H33NO	1
1	EC50 = 29 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000653 , Chem-4

Cell Line Info

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000076 , CHO/Galpha16

Cell Line Info

Cell Line ID: CL000880 , COS

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000088 , Flp-In-293

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000883 , HTLA

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000102 , U-87MG ATCC

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0461802 Compound Info	N-(1-adamantyl)-1-pentylindole-3-carboxamide Show/Hide	C24H32N2O	1
1	EC50 = 29 nM
CP0058356 Compound Info	(2E,4E,8E,10E,12E)-N-(2-methylpropyl)tetradeca-2,4,8,10,12-pentaenamide Show/Hide	C18H27NO	1
1	EC50 = 41.7 nM
CP0092490 Compound Info	2-(2,4-dichlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid N-(tetrahydropyran-4-ylmethyl)amide Show/Hide	C18H17Cl2F3N4O2	1
1	EC50 = 50 nM
CP0250155 Compound Info	US9266835, 535 Show/Hide	C34H34Cl2F3N3O5S	1
1	EC50 = 60 nM
CP0321874 Compound Info	US9266835, 140 Show/Hide	C32H32Cl2F3N3O4S	1
1	EC50 = 60 nM
CP0190381 Compound Info	US9266835, 100 Show/Hide	C31H31Cl2F3N4O4S	1
1	EC50 = 200 nM
CP0249763 Compound Info	US9266835, 122 Show/Hide	C34H29Cl2N3O5S	1
1	EC50 = 240 nM
CP0250147 Compound Info	US9266835, 108 Show/Hide	C32H31Cl2F3N4O5S	1
1	EC50 = 460 nM
CP0263236 Compound Info	US9266835, 537 Show/Hide	C33H32Cl2F3N3O5S	1
1	EC50 = 2380 nM
CP0326974 Compound Info	US9266835, 63 Show/Hide	C28H27Cl2N3O3S	1
1	EC50 = 2660 nM
CP0279468 Compound Info	US9266835, 95 Show/Hide	C32H31Cl2N3O4	1
1	EC50 = 3650 nM
CP0279480 Compound Info	US9266835, 57 Show/Hide	C31H27Cl2N5O	1
1	EC50 = 4100 nM
CP0219312 Compound Info	US9266835, 44 Show/Hide	C28H24Cl2F3N3O3S	1
1	EC50 = 5230 nM
CP0164723 Compound Info	US9266835, 106 Show/Hide	C30H28Cl2N4O3	1
1	EC50 = 6500 nM
CP0471785 Compound Info	US9266835, 532 Show/Hide	C30H26Cl2F3N3O5S	1
1	EC50 = 6700 nM
CP0119397 Compound Info	US9266835, 538 Show/Hide	C33H33Cl2F3N4O4S	1
1	EC50 = 8630 nM
CP0326975 Compound Info	US9266835, 84 Show/Hide	C34H29Cl2N3O5S	1
1	EC50 = 8960 nM
CP0219426 Compound Info	US9266835, 541 Show/Hide	C28H24Cl2F3N3O3S	1
1	EC50 > 10000 nM
CP0219430 Compound Info	US9266835, 80 Show/Hide	C33H29Cl2N3O3S	1
1	EC50 > 10000 nM
CP0241001 Compound Info	US9266835, 117 Show/Hide	C29H27Cl2N3O3	1
1	EC50 > 10000 nM
CP0241006 Compound Info	US9266835, 141 Show/Hide	C32H34Cl2F3N5O3S	1
1	EC50 > 10000 nM
CP0243591 Compound Info	US9266835, 49 Show/Hide	C29H26Cl2F3N3O3S	1
1	EC50 > 10000 nM
CP0250148 Compound Info	US9266835, 110 Show/Hide	C31H30Cl2F3N3O4S	1
1	EC50 > 10000 nM
CP0266404 Compound Info	US9266835, 96 Show/Hide	C30H27Cl2N3O4	1
1	EC50 > 10000 nM
CP0279473 Compound Info	US9266835, 542 Show/Hide	C32H33Cl2F3N4O3S	1
1	EC50 > 10000 nM
CP0321871 Compound Info	US9266835, 116 Show/Hide	C35H29Cl2N3O4	1
1	EC50 > 10000 nM
CP0324009 Compound Info	US9266835, 127 Show/Hide	C35H31Cl2N3O3	1
1	EC50 > 10000 nM
CP0346676 Compound Info	US9266835, 129 Show/Hide	C35H31Cl2N3O3	1
1	EC50 > 10000 nM
CP0426522 Compound Info	US9266835, 530 Show/Hide	C31H30Cl2F3N3O4S	1
1	EC50 > 10000 nM
CP0022072 Compound Info	1-[1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidin-4-yl]-3-[6-(difluoromethoxy)pyridin-3-yl]urea Show/Hide	C29H24Cl2F2N8O2	2
1	EC50 > 10000 nM
2	IC50 > 10000 nM
CP0051315 Compound Info	6-bromo-1-[(4-fluorophenyl)methyl]-N-(4-methylcyclohexyl)-2-oxo-1,8-naphthyridine-3-carboxamide Show/Hide	C23H23BrFN3O2	2
1	IC50 = 0.72 nM
2	Ki = 0.18 nM
CP0230614 Compound Info	4-(2-{3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-1-yl}ethyl)morpholine Show/Hide	C22H30N2O2	2
1	IC50 = 0.77 nM
2	Ki = 4.4 nM
CP0051372 Compound Info	1-[(4-fluorophenyl)methyl]-N-(4-methylcyclohexyl)-2-oxo-1,8-naphthyridine-3-carboxamide Show/Hide	C23H24FN3O2	2
1	IC50 = 1.37 nM
2	Ki = 0.9 nM
CP0765914 Compound Info	N-(benzo[d][1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-(pentyloxy)-1,2-dihydroquinoline-3-carboxamide Show/Hide	C23H27N3O4	2
1	IC50 = 1.585 nM
2	Ki = 22.3 nM
CP0050487 Compound Info	(11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphthalen-1-ylcarbonyl)-9-oxa-1-azatricyclo[6.3.1.0^{4,12}]dodeca-2,4(12),5,7-tetraene Show/Hide	C27H26N2O3	12
1	IC50 = 2.7 nM
2	Ki = 0.28 nM
3	Ki = 0.3 nM
4	Ki = 1.3 nM
5	Ki = 1.7 nM
6	Ki = 2 nM
7	Ki = 2.2 nM
8	Ki = 2.9 nM
9	Ki = 3.1 nM
10	Ki = 3.73 nM
11	Ki = 9.1 nM
12	Ki = 20 nM
CP0057171 Compound Info	3-[(2-iodo-5-nitrophenyl)carbonyl]-1-[(1-methylpiperidin-2-yl)methyl]-1H-indole Show/Hide	C22H22IN3O3	4
1	IC50 = 3.4 nM
2	Ki = 3.4 nM
3	Ki = 11.5 nM
4	Ki = 15.1 nM
CP0089916 Compound Info	1-(4-fluorobutyl)-N-(4-methylcyclohexyl)-2-oxo-1,8-naphthyridine-3-carboxamide Show/Hide	C20H26FN3O2	2
1	IC50 = 5.35 nM
2	Ki = 1.36 nM
CP0051374 Compound Info	1-(4-hydroxybutyl)-N-(4-methylcyclohexyl)-2-oxo-1,8-naphthyridine-3-carboxamide Show/Hide	C20H27N3O3	2
1	IC50 = 210 nM
2	Ki = 53.3 nM
CP0120450 Compound Info	N-(4-methylcyclohexyl)-1-(2-morpholin-4-ylethyl)-2-oxo-1,8-naphthyridine-3-carboxamide Show/Hide	C22H30N4O3	2
1	IC50 = 210 nM
2	Ki = 1.9 nM
CP0106737 Compound Info	N-[(2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl]-2-methyl-2-[5-(trifluoromethyl)pyridin-2-yl]oxypropanamide Show/Hide	C27H25ClF3N3O2	1
1	IC50 = 290 nM
CP0035515 Compound Info	(2R)-N-[6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-4-yl]-2-hydroxypropanamide Show/Hide	C25H23Cl3N2O3	1
1	IC50 = 2260 nM
CP0193243 Compound Info	(+/-)-SLV319 Show/Hide	C23H20Cl2N4O2S	2
1	IC50 > 5000 nM
2	Ki = 7943.28 nM
CP0045030 Compound Info	(6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6Hdibenzo[b,d]pyran Show/Hide	C22H32O	4
1	Ki = 0.023 nM
2	Ki = 3 nM
3	Ki = 3.4 nM
4	Ki = 20.3 nM
CP0056585 Compound Info	2-methyl-3-(naphthalen-1-ylcarbonyl)-1-propyl-1H-indole Show/Hide	C23H21NO	5
1	Ki = 0.056905 nM
2	Ki = 13.3 nM
3	Ki = 13.8 nM
4	Ki = 14 nM
5	Ki = 36 nM
CP0085438 Compound Info	N-(1,3-benzodioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentoxy-1H-quinoline-3-carboxamide Show/Hide	C24H26N2O6	2
1	Ki = 0.087 nM
2	Ki = 35.9 nM
CP0051866 Compound Info	7-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole Show/Hide	C23H31NO3	1
1	Ki = 0.1 nM
CP0233603 Compound Info	N-(1-adamantyl)-1-(2-morpholin-4-ylethyl)indazole-3-carboxamide Show/Hide	C24H32N4O2	1
1	Ki = 0.15 nM
CP0045801 Compound Info	(10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C21H30O2	7
1	Ki = 0.193125 nM
2	Ki = 3.3 nM
3	Ki = 24 nM
4	Ki = 36 nM
5	Ki = 36.4 nM
6	Ki = 40 nM
7	Ki = 41 nM
CP0206007 Compound Info	3-(1,1-Dimethyl-heptyl)-9-hydroxymethyl-6,6-dimethyl-6H-benzo[c]chromen-1-ol Show/Hide	C25H34O3	1
1	Ki = 0.2 nM
CP0051877 Compound Info	6-methyl-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole Show/Hide	C23H31NO2	1
1	Ki = 0.2 nM
CP0124848 Compound Info	(6aR,10aR)-3(1,1-dimethylheptyl)-9-hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H38O3	3
1	Ki = 0.22 nM
2	Ki = 0.5 nM
3	Ki = 7.3 nM
CP0287055 Compound Info	(6aR,10aR)-6,6,9-trimethyl-3-(2-(thiophen-2-yl)propan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C23H28O2S	2
1	Ki = 0.27 nM
2	Ki = 0.91 nM
CP0048193 Compound Info	5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-pyrazole-3-carboxylic acid (1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amide Show/Hide	C29H34ClN3O	5
1	Ki = 0.28 nM
2	Ki = 0.6 nM
3	Ki = 2.1 nM
4	Ki = 5.4 nM
5	Ki = 51.7 nM
CP0260066 Compound Info	6,6,9-Trimethyl-3-pentyl-6H-benzo[c]chromen-1-ol Show/Hide	C21H26O2	2
1	Ki = 0.296665 nM
2	Ki = 96 nM
CP0054363 Compound Info	1-(oxan-4-ylmethyl)-6-phenyl-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole Show/Hide	C28H33NO2	1
1	Ki = 0.4 nM
CP0037555 Compound Info	(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide Show/Hide	C22H37NO2	3
1	Ki = 0.409933 nM
2	Ki = 180 nM
3	Ki = 371 nM
CP0003146 Compound Info	5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide Show/Hide	C22H21Cl3N4O	7
1	Ki = 0.454845 nM
2	Ki = 313 nM
3	Ki = 398.11 nM
4	Ki = 560 nM
5	Ki = 927 nM
6	Ki = 1569 nM
7	Ki > 1000 nM
CP0155982 Compound Info	N-[[4-(diethylamino)phenyl]methyl]-4-methoxy-N-(4-methylphenyl)benzenesulfonamide Show/Hide	C25H30N2O3S	1
1	Ki = 0.5 nM
CP0109180 Compound Info	2-(6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol Show/Hide	C21H30O2	2
1	Ki = 0.539076 nM
2	Ki = 2860 nM
CP0257214 Compound Info	(6aR,10aR)-3-(2-(3-bromophenyl)propan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H29BrO2	1
1	Ki = 0.54 nM
CP0077457 Compound Info	N-[1-(cyclohexylmethyl)-2-[(5-ethoxypyridin-2-yl)methyl]benzimidazol-5-yl]-N-methylthiophene-2-sulfonamide Show/Hide	C27H32N4O3S2	1
1	Ki = 0.56 nM
CP0048192 Compound Info	2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)-5-(2-methyloctan-2-yl)phenol Show/Hide	C24H40O3	5
1	Ki = 0.6 nM
2	Ki = 0.68 nM
3	Ki = 0.69 nM
4	Ki = 0.7 nM
5	Ki = 15.4 nM
CP0085436 Compound Info	A-836339 Show/Hide	C16H26N2O2S	1
1	Ki = 0.64 nM
CP0122901 Compound Info	(6aR,10aR)-3-(1-Cyclohexyl-1-methyl-ethyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H36O2	1
1	Ki = 0.65 nM
CP0157108 Compound Info	(6aR,10aR)-3-(2-(4-ethylphenyl)propan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C27H34O2	1
1	Ki = 0.67 nM
CP0048140 Compound Info	N-(1-adamantyl)-6-(furan-2-yl)-4-oxo-1-pentylquinoline-3-carboxamide Show/Hide	C29H34N2O3	1
1	Ki = 0.7 nM
CP0150312 Compound Info	6-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-5-ol Show/Hide	C23H31NO4	1
1	Ki = 0.7 nM
CP0399623 Compound Info	N-(1-adamantyl)-1-(2-ethoxyethyl)-8-methoxy-4-oxoquinoline-3-carboxamide Show/Hide	C25H32N2O4	1
1	Ki = 0.7 nM
CP0482925 Compound Info	4-[2-[(3E)-3-[(4-ethylnaphthalen-1-yl)methylidene]inden-1-yl]ethyl]morpholine Show/Hide	C28H29NO	1
1	Ki = 0.79 nM
CP0436996 Compound Info	N-(1-adamantyl)-7-fluoro-4-oxo-1-pentylquinoline-3-carboxamide Show/Hide	C25H31FN2O2	1
1	Ki = 0.8 nM
CP0867688 Compound Info	N-(Adamantan-1-yl)-7-fluoro-4-hydroxy-2-oxo-1-(1-pentyl)-1,4-dihydroquinoline-3-carboxamide Show/Hide	C25H31FN2O3	1
1	Ki = 0.8 nM
CP0272343 Compound Info	(6aR,10aR)-6,6,9-trimethyl-3-(2-p-tolylpropan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C26H32O2	1
1	Ki = 0.88 nM
CP0253788 Compound Info	(6aR,10aR)-3-(2-(3-fluorophenyl)propan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H29FO2	1
1	Ki = 0.9 nM
CP0054364 Compound Info	6-(benzyloxy)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole Show/Hide	C29H35NO3	1
1	Ki = 0.9 nM
CP0042459 Compound Info	(6aR,10aR)-6,6,9-Trimethyl-3-(1-methyl-1-phenyl-ethyl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H30O2	1
1	Ki = 0.91 nM
CP0337138 Compound Info	3-(2-((6aR,10aR)-1-hydroxy-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-3-yl)propan-2-yl)benzonitrile Show/Hide	C26H29NO2	1
1	Ki = 0.91 nM
CP0229055 Compound Info	(S)-N-(1-(4-(4-chloro-2-(2-fluorophenylsulfonyl)phenylsulfonyl)phenyl)ethyl)methanesulfonamide Show/Hide	C21H19ClFNO6S3	1
1	Ki = 1 nM
CP0200883 Compound Info	6-Methoxy-5-(2-morpholin-4-yl-ethyl)-2-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-2,5-dihydro-pyrido[4,3-b]indol-1-one Show/Hide	C28H37N3O3	1
1	Ki = 1 nM
CP0311551 Compound Info	2-(4-ethoxybenzyl)-1-(cyclopentylmethyl)-N,N-diethyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C27H35N3O2	1
1	Ki = 1 nM
CP0207363 Compound Info	4-[2-[(3E)-3-[(4-propylnaphthalen-1-yl)methylidene]inden-1-yl]ethyl]morpholine Show/Hide	C29H31NO	1
1	Ki = 1 nM
CP0286060 Compound Info	(6aR,10aR)-6,6,9-trimethyl-3-(2-m-tolylpropan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C26H32O2	1
1	Ki = 1.13 nM
CP0362820 Compound Info	6-bromo-N-(4-methylcyclohexyl)-1-(2-morpholin-4-ylethyl)-2-oxo-1,8-naphthyridine-3-carboxamide Show/Hide	C22H29BrN4O3	1
1	Ki = 1.26 nM
CP0051325 Compound Info	N-cyclohexyl-1-(3,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide Show/Hide	C23H26Cl2N4O	1
1	Ki = 1.3 nM
CP0353083 Compound Info	5-(benzyloxy)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole Show/Hide	C29H35NO3	1
1	Ki = 1.3 nM
CP0244993 Compound Info	6-(4-methoxyphenyl)-N-(4-methylcyclohexyl)-1-(2-morpholin-4-ylethyl)-2-oxo-1,8-naphthyridine-3-carboxamide Show/Hide	C29H36N4O4	1
1	Ki = 1.47 nM
CP0150228 Compound Info	3-(1',1'-dimethylheptyl)-6,6,9-trimethyl-6H-benzo[c]chromene-1-ol Show/Hide	C25H34O2	2
1	Ki = 1.5 nM
2	Ki = 2.24 nM
CP0286058 Compound Info	(6aR,10aR)-3-(2-(4-bromophenyl)propan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H29BrO2	1
1	Ki = 1.54 nM
CP0199085 Compound Info	2-(4-ethoxybenzyl)-1-(cyclobutylmethyl)-N,N-diethyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C26H33N3O2	1
1	Ki = 1.6 nM
CP0051333 Compound Info	2-Ethyl-5-methyl-1-phenyl-1H-imidazole-4-carboxylic acid adamantan-1-ylamide Show/Hide	C23H29N3O	1
1	Ki = 1.6 nM
CP0353026 Compound Info	(6aR,10aR)-3-(2-(4-chlorophenyl)propan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H29ClO2	1
1	Ki = 1.68 nM
CP0085568 Compound Info	N-cyclohexyl-1-(3,4-dichlorophenyl)-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide Show/Hide	C21H22Cl2N4O	1
1	Ki = 1.7 nM
CP0084893 Compound Info	(6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6H-benzo[c]chromen-9(6aH)-one Show/Hide	C24H36O3	1
1	Ki = 1.84 nM
CP0152977 Compound Info	5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-pyrazole-3-carboxylic acid ((1S,2S,4R)-1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amide Show/Hide	C29H34ClN3O	1
1	Ki = 2.23 nM
CP0195800 Compound Info	4-Oxo-1-pentyl-6-thiophen-2-yl-1,4-dihydro-quinoline-3-carboxylic acidadamantan-1-ylamide Show/Hide	C29H34N2O2S	1
1	Ki = 2.3 nM
CP0257213 Compound Info	3-[1-(4-Cyano-phenyl)-1-methyl-ethyl]-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C26H29NO2	1
1	Ki = 2.53 nM
CP0195805 Compound Info	2,5-Dimethyl-1-phenyl-1H-imidazole-4-carboxylic acid adamantan-1-ylamide Show/Hide	C22H27N3O	1
1	Ki = 2.7 nM
CP0199084 Compound Info	1-adamantan-1-ylmethyl-2-(4-ethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid diethylamide Show/Hide	C32H41N3O2	1
1	Ki = 2.8 nM
CP0316963 Compound Info	2-(4-ethoxybenzyl)-1-(cyclopropylmethyl)-N,N-dipropyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C27H35N3O2	1
1	Ki = 2.8 nM
CP0154091 Compound Info	naphthalen-1-yl-(1-pentylindol-3-yl)methanone Show/Hide	C24H23NO	2
1	Ki = 2.897 nM
2	Ki = 2.9 nM
CP0102159 Compound Info	(1-(2-Methoxyethyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone Show/Hide	C19H25NO2	1
1	Ki = 3.1 nM
CP0297359 Compound Info	(S)-(1-((Tetrahydrofuran-2-yl)methyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone Show/Hide	C21H27NO2	1
1	Ki = 3.3 nM
CP0290316 Compound Info	N-(1-adamantyl)-4-oxo-1-pentyl-6-phenylsulfanylquinoline-3-carboxamide Show/Hide	C31H36N2O2S	1
1	Ki = 3.4 nM
CP0333956 Compound Info	(6aR,10aR)-3-(2-(3-chlorophenyl)propan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H29ClO2	1
1	Ki = 3.54 nM
CP0090914 Compound Info	2-(4-ethoxybenzyl)-1-(cyclohexylmethyl)-N,N-diethyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C28H37N3O2	1
1	Ki = 3.7 nM
CP0195828 Compound Info	N-(1-adamantyl)-4-oxo-1-pentyl-6-phenylquinoline-3-carboxamide Show/Hide	C31H36N2O2	1
1	Ki = 3.8 nM
CP0051329 Compound Info	(2,3-Dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone Show/Hide	C23H24Cl2N2O3	5
1	Ki = 3.8 nM
2	Ki = 3.9 nM
3	Ki = 10 nM
4	Ki = 12 nM
5	Ki = 14 nM
CP0091138 Compound Info	2-(4-ethoxybenzyl)-N,N-diethyl-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C27H35N3O3	1
1	Ki = 3.9 nM
CP0157014 Compound Info	N-[1-(cyclopropylmethyl)-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]-N-methylpiperidine-1-carboxamide Show/Hide	C27H34N4O2	1
1	Ki = 4 nM
CP0291693 Compound Info	N-[1-(cyclopropylmethyl)-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]-N,3-dimethylbutanamide Show/Hide	C26H33N3O2	1
1	Ki = 4 nM
CP0249270 Compound Info	4-[2-[(3E)-3-[(4-methoxynaphthalen-1-yl)methylidene]inden-1-yl]ethyl]morpholine Show/Hide	C27H27NO2	1
1	Ki = 4.07 nM
CP0279387 Compound Info	2-(4-ethoxybenzyl)-1-(cyclopropylmethyl)-N,N-diethyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C25H31N3O2	1
1	Ki = 4.1 nM
CP0085407 Compound Info	6-(4-Hydroxy-phenyl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylicacid adamantan-1-ylamide Show/Hide	C31H36N2O3	1
1	Ki = 4.2 nM
CP0368722 Compound Info	4-[2-[(3E)-3-(1,2-dihydroacenaphthylen-5-ylmethylidene)inden-1-yl]ethyl]morpholine Show/Hide	C28H27NO	1
1	Ki = 4.22 nM
CP0425254 Compound Info	methyl 2-(adamantane-1-carbonylamino)-5-methyl-4-propylthiophene-3-carboxylate Show/Hide	C21H29NO3S	1
1	Ki = 4.3 nM
CP0054397 Compound Info	1-But-3-enyl-6-furan-2-yl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C28H30N2O3	1
1	Ki = 4.4 nM
CP0073069 Compound Info	2-(4-ethoxybenzyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C26H35N3O2	1
1	Ki = 4.5 nM
CP0279388 Compound Info	2-(4-isopropoxybenzyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C27H37N3O2	1
1	Ki = 4.5 nM
CP0225051 Compound Info	5-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole Show/Hide	C23H31NO3	1
1	Ki = 4.6 nM
CP0085406 Compound Info	4-Oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C25H32N2O2	2
1	Ki = 4.7 nM
2	Ki = 16.4 nM
CP0369479 Compound Info	2-(4-phenoxybenzyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C30H35N3O2	1
1	Ki = 4.9 nM
CP0051827 Compound Info	8-Methyl-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C26H34N2O2	1
1	Ki = 4.9 nM
CP0311548 Compound Info	N-[1-(cyclopropylmethyl)-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]-N-methylthiophene-2-carboxamide Show/Hide	C26H27N3O2S	1
1	Ki = 5 nM
CP0089002 Compound Info	N-[2-(4-fluorophenyl)ethyl]-7,8-dimethoxy-2-oxo-1H-quinoline-3-carboxamide Show/Hide	C20H19FN2O4	1
1	Ki = 5 nM
CP0090909 Compound Info	2-(4-ethoxybenzyl)-1-(cyclopropylmethyl)-N,N-bis(2,2,2-trifluoroethyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C25H25F6N3O2	1
1	Ki = 5.6 nM
CP0368718 Compound Info	4-(2-{3-[1-Naphthalen-1-yl-meth-(E)-ylidene]-3H-inden-1-yl}-ethyl)-morpholine Show/Hide	C26H25NO	1
1	Ki = 5.62 nM
CP0316960 Compound Info	1-(2-(4-ethoxybenzyl)-1-(cyclopropylmethyl)-1H-benzo[d]imidazol-5-yl)-3-isopropyl-1-methylurea Show/Hide	C25H32N4O2	1
1	Ki = 5.7 nM
CP0316961 Compound Info	1-(2-(4-ethoxybenzyl)-1-(cyclopropylmethyl)-1H-benzo[d]imidazol-5-yl)-3,3-diethyl-1-methylurea Show/Hide	C26H34N4O2	1
1	Ki = 5.9 nM
CP0116271 Compound Info	1-[[1-(cyclohexylmethyl)-2-oxo-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonyl]amino]cyclooctane-1-carboxylic acid Show/Hide	C28H42N2O4	1
1	Ki = 6.2 nM
CP0195829 Compound Info	6-Isopropyl-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C28H38N2O2	1
1	Ki = 6.3 nM
CP0091635 Compound Info	1-[[1-(cyclohexylmethyl)-2-oxo-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonyl]amino]cyclohexane-1-carboxylic acid Show/Hide	C26H38N2O4	1
1	Ki = 6.7 nM
CP0157009 Compound Info	(2-(4-ethoxybenzyl)-1-(cyclopropylmethyl)-1H-benzo[d]imidazol-5-yl)(piperidin-1-yl)methanone Show/Hide	C26H31N3O2	1
1	Ki = 6.9 nM
CP0096116 Compound Info	7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxylic Acid Phenethylamide Show/Hide	C24H28N2O4	1
1	Ki = 6.92 nM
CP0102146 Compound Info	6-Cyclohexyl-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C31H42N2O2	1
1	Ki = 7.3 nM
CP0139483 Compound Info	(6aR,10aR)-3-(2-(3,5-dimethylphenyl)propan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C27H34O2	1
1	Ki = 7.45 nM
CP0090823 Compound Info	2-(4-ethoxybenzyl)-1-(cyclopropylmethyl)-N-methyl-N-propyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C25H31N3O2	1
1	Ki = 7.6 nM
CP0157114 Compound Info	(6aR,10aR)-6,6,9-trimethyl-3-(2-(4-propylphenyl)propan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C28H36O2	1
1	Ki = 7.83 nM
CP0103197 Compound Info	N-(1-adamantyl)-6-imidazol-1-yl-4-oxo-1-pentylquinoline-3-carboxamide Show/Hide	C28H34N4O2	1
1	Ki = 8 nM
CP0366087 Compound Info	(S)-2-{[7-Methoxy-2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-indole-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester Show/Hide	C27H33N3O5	1
1	Ki = 8 nM
CP0225272 Compound Info	6-Cyclohex-1-enyl-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C31H40N2O2	1
1	Ki = 8.3 nM
CP0353082 Compound Info	1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-6-ol Show/Hide	C22H29NO3	1
1	Ki = 8.3 nM
CP0281047 Compound Info	N-(1-adamantyl)-6-ethynyl-4-oxo-1-pentylquinoline-3-carboxamide Show/Hide	C27H32N2O2	1
1	Ki = 8.8 nM
CP0279328 Compound Info	(R)-2-(4-ethoxybenzyl)-N,N-diethyl-1-((1-methylpiperidin-2-yl)methyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C28H38N4O2	1
1	Ki = 8.9 nM
CP0202992 Compound Info	(Z)-methyl 2-(2-isopropylphenylimino)-5,5-dimethyl-1,3-thiazinane-3-carbodithioate Show/Hide	C17H24N2S3	1
1	Ki = 9 nM
CP0085567 Compound Info	1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-5-amine Show/Hide	C22H30N2O2	1
1	Ki = 9 nM
CP0096117 Compound Info	7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxylic Acid [2-(4-chlorophenyl)-ethyl]amide Show/Hide	C24H27ClN2O4	1
1	Ki = 9.37 nM
CP0298205 Compound Info	5-Butyl-2-methyl-1-phenyl-1H-imidazole-4-carboxylic acid adamantan-1-ylamide Show/Hide	C25H33N3O	1
1	Ki = 9.8 nM
CP0148010 Compound Info	7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxylic Acid (3-phenylpropyl)amide Show/Hide	C25H30N2O4	1
1	Ki = 10.32 nM
CP0302795 Compound Info	(6aR,10aR)-6,6,9-trimethyl-3-(2-o-tolylpropan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C26H32O2	1
1	Ki = 10.65 nM
CP0157013 Compound Info	2-(4-ethoxybenzyl)-N-cyclohexyl-1-(cyclopropylmethyl)-N-methyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C28H35N3O2	1
1	Ki = 11 nM
CP0316965 Compound Info	2-(4-ethoxybenzyl)-N,N-diethyl-1-(furan-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C26H29N3O3	1
1	Ki = 11 nM
CP0139729 Compound Info	cyclopentyl-[1-(oxan-4-ylmethyl)indol-3-yl]methanone Show/Hide	C20H25NO2	1
1	Ki = 11 nM
CP0313817 Compound Info	6-(4-Chloro-phenyl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C31H35ClN2O2	1
1	Ki = 11 nM
CP0139727 Compound Info	N-(1-adamantyl)-4-oxo-1-pentyl-6-(trifluoromethyl)quinoline-3-carboxamide Show/Hide	C26H31F3N2O2	1
1	Ki = 11.6 nM
CP0090827 Compound Info	(S)-2-(4-ethoxybenzyl)-N,N-diethyl-1-((1-methylpyrrolidin-2-yl)methyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C27H36N4O2	1
1	Ki = 12 nM
CP0316966 Compound Info	2-(4-ethoxybenzyl)-1-benzyl-N,N-diethyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C28H31N3O2	1
1	Ki = 12 nM
CP0157111 Compound Info	(6aR,10aR)-3-(2-(4-fluorophenyl)propan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H29FO2	1
1	Ki = 12.4 nM
CP0316962 Compound Info	(2-(4-ethoxybenzyl)-1-(cyclopropylmethyl)-1H-benzo[d]imidazol-5-yl)(pyrrolidin-1-yl)methanone Show/Hide	C25H29N3O2	1
1	Ki = 14 nM
CP0153590 Compound Info	N-(4-chlorophenyl)-N-[[4-(diethylamino)phenyl]methyl]-4-methoxybenzenesulfonamide Show/Hide	C24H27ClN2O3S	1
1	Ki = 14 nM
CP0141726 Compound Info	N-(1-adamantyl)-6-bromo-4-oxo-1-pentylquinoline-3-carboxamide Show/Hide	C25H31BrN2O2	1
1	Ki = 14.3 nM
CP0327684 Compound Info	(S)-2-(4-ethoxybenzyl)-N,N-diethyl-1-((tetrahydrofuran-2-yl)methyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C26H33N3O3	1
1	Ki = 15 nM
CP0266280 Compound Info	5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]pyrrole-3-carboxamide Show/Hide	C30H35ClN2O	1
1	Ki = 15.3 nM
CP0334342 Compound Info	2-(4-ethoxybenzyl)-N,N-diethyl-1-(pyridin-4-ylmethyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C27H30N4O2	1
1	Ki = 16 nM
CP0102143 Compound Info	6-(2,4-Difluoro-phenyl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C31H34F2N2O2	1
1	Ki = 16 nM
CP0088845 Compound Info	1-[[1-[(4-fluorophenyl)methyl]-2-oxo-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonyl]amino]cyclohexane-1-carboxylic acid Show/Hide	C26H31FN2O4	1
1	Ki = 16 nM
CP0195802 Compound Info	N-(1-adamantyl)-6-ethyl-4-oxo-1-pentylquinoline-3-carboxamide Show/Hide	C27H36N2O2	1
1	Ki = 16.9 nM
CP0311552 Compound Info	2-(4-methoxybenzyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C25H33N3O2	1
1	Ki = 17 nM
CP0209931 Compound Info	(6aR,10aR)-6,6,9-Trimethyl-3-(2-phenyl-[1,3]dithiolan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H28O2S2	1
1	Ki = 17.6 nM
CP0203358 Compound Info	(6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methylheptan-2-yl)-6a,7,8,10a-tetrahydro-6H-benzo[c]chromene Show/Hide	C25H38O2	1
1	Ki = 18 nM
CP0256129 Compound Info	naphthalen-1-yl-(4-pentoxynaphthalen-1-yl)methanone Show/Hide	C26H24O2	1
1	Ki = 19 nM
CP0145758 Compound Info	8-Chloro-1-(2,4-dichloro-phenyl)-1,3a,4,5,6,10b-hexahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide Show/Hide	C24H23Cl3N4O	2
1	Ki = 20 nM
2	Ki = 21 nM
CP0102148 Compound Info	1-(3,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide Show/Hide	C20H21Cl2N5O	1
1	Ki = 20 nM
CP0195798 Compound Info	6-Iodo-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C25H31IN2O2	1
1	Ki = 20.6 nM
CP0102145 Compound Info	6-(4-Methoxy-3,5-dimethyl-phenyl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C34H42N2O3	1
1	Ki = 21.5 nM
CP0286987 Compound Info	N-(1-adamantylmethyl)-4-oxo-1-pentylquinoline-3-carboxamide Show/Hide	C26H34N2O2	1
1	Ki = 21.6 nM
CP0048056 Compound Info	((1R,4S,5R)-4-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methanol Show/Hide	C27H42O3	1
1	Ki = 22.7 nM
CP0084895 Compound Info	[(1S,4S,5S)-4-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methanol Show/Hide	C27H42O3	1
1	Ki = 22.7 nM
CP0316964 Compound Info	(R)-2-(4-ethoxybenzyl)-N,N-diethyl-1-((tetrahydrofuran-2-yl)methyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C26H33N3O3	1
1	Ki = 23 nM
CP0037364 Compound Info	(-)-(6aR-trans)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C21H30O2	1
1	Ki = 25 nM
CP0279384 Compound Info	2-(4-(trifluoromethoxy)benzyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C25H30F3N3O2	1
1	Ki = 25 nM
CP0102163 Compound Info	5-(methoxymethyl)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole Show/Hide	C24H33NO3	1
1	Ki = 25 nM
CP0174368 Compound Info	CHEMBL2326307 Show/Hide	C27H35FN2O2S	1
1	Ki = 25 nM
CP0111432 Compound Info	quinolin-8-yl 4-methyl-3-piperidin-1-ylsulfonylbenzoate Show/Hide	C22H22N2O4S	1
1	Ki = 25.12 nM
CP0327685 Compound Info	1-(cyclopropylmethyl)-2-((5-ethoxypyridin-2-yl)methyl)-N,N-diethyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C24H30N4O2	1
1	Ki = 27 nM
CP0316715 Compound Info	(6aS,10aS)-3-(1,1-Dimethyl-heptyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C25H38O2	1
1	Ki = 28.8 nM
CP0227696 Compound Info	5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2R,4S)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]pyrazole-3-carboxamide Show/Hide	C29H34ClN3O	1
1	Ki = 29.1 nM
CP0051337 Compound Info	1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole-5-carbonitrile Show/Hide	C23H28N2O2	1
1	Ki = 30 nM
CP0044659 Compound Info	(6-iodo-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)(4-methoxyphenyl)methanone Show/Hide	C23H25IN2O3	1
1	Ki = 31.2 nM
CP0353084 Compound Info	1-[2-(morpholin-4-yl)ethyl]-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-4-amine Show/Hide	C22H31N3O2	1
1	Ki = 32 nM
CP0090828 Compound Info	(R)-2-(4-ethoxybenzyl)-N,N-diethyl-1-(piperidin-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C27H36N4O2	1
1	Ki = 35 nM
CP0311553 Compound Info	2-(4-ethoxybenzoyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C26H33N3O3	1
1	Ki = 35 nM
CP0167816 Compound Info	2-(4-ethoxybenzyl)-1-(2-(dimethylamino)ethyl)-N,N-diethyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C25H34N4O2	2
1	Ki = 36 nM
2	Ki = 38 nM
CP0110909 Compound Info	1-[[6-ethyl-1-[(4-fluorophenyl)methyl]-5-methyl-2-oxopyridine-3-carbonyl]amino]cyclohexane-1-carboxylic acid Show/Hide	C23H27FN2O4	1
1	Ki = 36 nM
CP0135634 Compound Info	N-(1-adamantyl)-5-(2-pentoxyphenyl)-1,2-oxazole-3-carboxamide Show/Hide	C25H32N2O3	1
1	Ki = 36 nM
CP0093666 Compound Info	N-(1-adamantyl)-6-methyl-4-oxo-1-pentyl-5-pyridin-4-ylpyridine-3-carboxamide Show/Hide	C27H35N3O2	1
1	Ki = 36.5 nM
CP0311550 Compound Info	2-(4-ethoxybenzyl)-N,N-diethyl-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C27H30N4O2	1
1	Ki = 39 nM
CP0224696 Compound Info	8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine Show/Hide	C22H27ClN6O	1
1	Ki = 40 nM
CP0316967 Compound Info	1-(2-(4-ethoxybenzyl)-1-(cyclopropylmethyl)-1H-benzo[d]imidazol-5-yl)-1,3,3-trimethylurea Show/Hide	C24H30N4O2	1
1	Ki = 41 nM
CP0054395 Compound Info	6-(4-Cyano-phenyl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C32H35N3O2	1
1	Ki = 41.9 nM
CP0198990 Compound Info	2-(4-(cyclopentyloxy)benzyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C29H39N3O2	1
1	Ki = 43 nM
CP0198991 Compound Info	2-(4-cyclobutoxybenzyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C28H37N3O2	1
1	Ki = 44 nM
CP0102144 Compound Info	6-(5-Chloro-thiophen-2-yl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C29H33ClN2O2S	1
1	Ki = 44.8 nM
CP0150339 Compound Info	BAY 59-3074 Show/Hide	C18H13F6NO4S	1
1	Ki = 45.5 nM
CP0051324 Compound Info	6-Bromo-4-oxo-1-prop-2-ynyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C23H23BrN2O2	1
1	Ki = 49.8 nM
CP0157015 Compound Info	2-(4-(cyclopropylmethoxy)benzyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C28H37N3O2	1
1	Ki = 53 nM
CP0093178 Compound Info	1-[(1-butyl-2-oxo-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonyl)amino]cyclohexane-1-carboxylic acid Show/Hide	C23H34N2O4	1
1	Ki = 56 nM
CP0170943 Compound Info	1-[[1-(cyclohexylmethyl)-2-oxo-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonyl]amino]cyclopentane-1-carboxylic acid Show/Hide	C25H36N2O4	1
1	Ki = 56 nM
CP0051463 Compound Info	(E)-N-(Adamant-1-yl)-6-[2-(4-methoxyphenyl)vinyl]-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide Show/Hide	C34H40N2O3	1
1	Ki = 56.23 nM
CP0190974 Compound Info	6-(2-Ethyl-phenyl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C33H40N2O2	1
1	Ki = 56.6 nM
CP0090826 Compound Info	2-((4-ethoxyphenyl)(hydroxy)methyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C26H35N3O3	1
1	Ki = 57 nM
CP0323081 Compound Info	2-(4-(2,2,2-trifluoroethoxy)benzyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C26H32F3N3O2	1
1	Ki = 57 nM
CP0316968 Compound Info	2-(4-ethoxybenzyl)-1-(cyclopropylmethyl)-N-ethyl-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C23H27N3O2	1
1	Ki = 63 nM
CP0311549 Compound Info	(S)-2-(4-ethoxybenzyl)-N,N-diethyl-1-(piperidin-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamide Show/Hide	C27H36N4O2	1
1	Ki = 75 nM
CP0184249 Compound Info	(6aR,10aR)-3-Benzyl-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C23H26O2	1
1	Ki = 85.9 nM
CP0771480 Compound Info	N'-[(3Z)-1-Hexyl-6-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide Show/Hide	C22H25N3O3	1
1	Ki = 89.9 nM
CP0055279 Compound Info	5-(4-chloro-3-methylphenyl)-1-phenyl-N-[(1S,2S,4R)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]pyrazole-3-carboxamide Show/Hide	C27H30ClN3O	1
1	Ki = 94.2 nM
CP0418513 Compound Info	6-(3,5-Dimethyl-isoxazol-4-yl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C30H37N3O3	1
1	Ki = 102.33 nM
CP0066503 Compound Info	(2S)-2-cyclohexyl-2-[[1-(cyclohexylmethyl)-2-oxo-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonyl]amino]acetic acid Show/Hide	C27H40N2O4	1
1	Ki = 111 nM
CP0102214 Compound Info	1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide Show/Hide	C22H21Cl2IN4O	2
1	Ki = 112.2 nM
2	Ki = 2290 nM
CP0102470 Compound Info	2,2-dimethyl-N-(4-methyl-3-(morpholinomethyl)phenyl)butanamide Show/Hide	C18H28N2O2	1
1	Ki = 120 nM
CP0257790 Compound Info	1-(3,4-dichlorophenyl)-N-[(3,4-dichlorophenyl)methyl]-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide Show/Hide	C22H16Cl4N4O	1
1	Ki = 151.36 nM
CP0292304 Compound Info	6-Biphenyl-4-yl-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acidadamantan-1-ylamide Show/Hide	C37H40N2O2	1
1	Ki = 177.83 nM
CP0298207 Compound Info	cyclopropanolamide, 11a Show/Hide	C23H37NO2	1
1	Ki = 190.55 nM
CP0051257 Compound Info	(1R,3R)-3-[4-(2-methylheptan-2-yl)phenyl]cyclohexan-1-ol Show/Hide	C20H32O	1
1	Ki = 215 nM
CP0165951 Compound Info	(1R,3S)-3-[4-(1,1-dimethylheptyl)phenyl]cyclohexanol Show/Hide	C21H34O	1
1	Ki = 231 nM
CP0102216 Compound Info	N-(1-adamantyl)-4-oxo-1-pentyl-6-(2-phenylethynyl)quinoline-3-carboxamide Show/Hide	C33H36N2O2	1
1	Ki = 338.84 nM
CP0085437 Compound Info	(3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(piperidin-1-yl)methanone Show/Hide	C22H25NO2	1
1	Ki = 422 nM
CP0216456 Compound Info	(Z)-ethyl 2-(2-isopropylphenylimino)-5,5-dimethyl-1,3-thiazinane-3-carboxylate Show/Hide	C18H26N2O2S	1
1	Ki = 428 nM
CP0294893 Compound Info	5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-3-[(E)-2-[(1S,2S,4R)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]ethenyl]pyrazole Show/Hide	C30H35ClN2	1
1	Ki = 527 nM
CP0175046 Compound Info	N-[2,4-dimethyl-5-(morpholin-4-ylmethyl)phenyl]-2,2-dimethylbutanamide Show/Hide	C19H30N2O2	1
1	Ki = 530 nM
CP0035672 Compound Info	dibenzothiazepine, 12h Show/Hide	C24H20ClFN2OS	1
1	Ki = 1000 nM
CP0334217 Compound Info	2-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-4-[(E)-2-[(1S,2S,4R)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]ethenyl]pyrrole Show/Hide	C31H36ClN	1
1	Ki = 1220 nM
CP0043807 Compound Info	1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate Show/Hide	C23H38O4	1
1	Ki = 1400 nM
CP0073238 Compound Info	1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-N-piperidin-1-yl-1H-pyrazole-4-carboxamide Show/Hide	C21H19Cl2IN4O	1
1	Ki = 1900 nM
CP0158863 Compound Info	2-[((11Z,14Z)-Icosa-5,8,11,14-tetraenyl)oxy]-propane-1,3-diol Show/Hide	C23H40O3	1
1	Ki = 3000 nM
CP0257793 Compound Info	6-(2,4-Dichloro-benzyl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide Show/Hide	C32H36Cl2N2O2	1
1	Ki = 3890.45 nM
CP0170798 Compound Info	(S)-3-(4-chlorophenyl)-N'-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide Show/Hide	C23H20Cl2N4O2S	1
1	Ki = 7943 nM
CP0088635 Compound Info	5-(4-Chlorophenyl)-N-cyclopropyl-1-(2,4-dichlorophenyl)-1H-pyrazole-4-carboxamide Show/Hide	C19H14Cl3N3O	1
1	Ki = 21000 nM
CP0135631 Compound Info	N-(1-adamantyl)-5-(4-pentoxyphenyl)-1,2-oxazole-3-carboxamide Show/Hide	C25H32N2O3	1
1	Ki > 1000 nM
CP0037081 Compound Info	PF-514273 Show/Hide	C21H17Cl2F2N3O2	1
1	Ki > 10000 nM
CP0136518 Compound Info	2-(2-chlorophenyl)-3-(4-chlorophenyl)-5-methyl-6-(2,2,2-trifluoroethyl)pyrazolo[4,3-d]pyrimidin-7-one Show/Hide	C20H13Cl2F3N4O	1
1	Ki > 10000 nM

Clinical Information about the Protein

Target 1 ( Cannabinoid receptor 2 (CB2) )

Target Type	Successful Target
Disease	10 Target-related Diseases				10
1	Attention deficit hyperactivity disorder [ICD-11: 6A05.Z]
2	Insomnia [ICD-11: 7A00-7A0Z]
3	Pain [ICD-11: MG30-MG3Z]
4	Crohn disease [ICD-11: DD70]
5	Atopic dermatitis [ICD-11: EA80]
6	Organ transplant rejection [ICD-11: NE84]
7	Osteoporosis [ICD-11: FB83.0]
8	Prostate cancer [ICD-11: 2C82.0]
9	Neuropathic pain [ICD-11: 8E43.0]
10	Ovarian cancer [ICD-11: 2C73]
Approved Drug(s)	2 Approved Drugs				2
1	Guanfacine extended release	Drug Info	Approved	Attention deficit hyperactivity disorder
2	NABILONE	Drug Info	Approved	Insomnia
Clinical Trial Drug(s)	5 Clinical Trial Drugs				5
1	842166X	Drug Info	Phase 2	Pain
2	APD371	Drug Info	Phase 2	Crohn disease
3	Beta-caryophyllene	Drug Info	Phase 2	Pain
4	S-777469	Drug Info	Phase 2	Atopic dermatitis
5	Tedalinab	Drug Info	Phase 1	Pain
Discontinued Drug(s)	1 Discontinued Drug				1
1	PRS-211375 iv	Drug Info	Discontinued in Phase 2	Pain
Investigative Drug(s)	4 Investigative Drugs				4
1	6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-(HYDROXYMETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX)	Drug Info	Investigative	Ovarian cancer
2	A-796260	Drug Info	Investigative	Pain
3	JWH-051	Drug Info	Investigative	Pain
4	VER-156084	Drug Info	Investigative	Neuropathic pain
Patented Agent(s)	6 Patented Agents				6
1	JWH-015	Drug Info	Patented	Organ transplant rejection
2	N,N-methylenebis-2-phenylacetamide and benzenesulfonamide derivative 1	Drug Info	Patented	Osteoporosis
3	N,N-methylenebis-2-phenylacetamide and benzenesulfonamide derivative 2	Drug Info	Patented	Osteoporosis
4	PMID27215781-Compound-37	Drug Info	Patented	Prostate cancer
5	Tricyclic phytocannabinoid derivative 1	Drug Info	Patented	Neuropathic pain
6	Tricyclic phytocannabinoid derivative 2	Drug Info	Patented	Neuropathic pain

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT01998	Cannabinoid receptor 2	Mus musculus, Mouse	Protein Info
PT02333	Cannabinoid receptor 2	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han