General Information of the Protein
Protein ID
PT01998
Protein Name
Cannabinoid receptor 2
Gene Name
CNR2
Sequence
MEGCRETEVTNGSNGGLEFNPMKEYMILSSGQQIAVAVLCTLMGLLSALENMAVLYIILSSRRLRRKPSYLFISSLAGADFLASVIFACNFVIFHVFHGVDSNAIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALCVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHRHVATLAEHQDRQVPGIARMRLDVRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDQVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLIGWKKYLQGLGPEGKEEGPRSSVTETEADVKTT
    Show/Hide
Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Cannabinoid receptor
Function
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
    Show/Hide
Uniprot ID
Primary ID:
P47936

Secondarily ID:
Q544H5
    Show/Hide
Ensembl ID
ENSG00000188822
Subcellular Location
Cell membrane
Cell projection
Dendrite
Perikaryon
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0155571
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H19F2N3O2
  1
1
EC50 = 28700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0479894
 Compound Info 
(NE)-N-[amino-(2,4-difluorophenyl)methylidene]-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C29H21Cl2F2N5O2S
  1
1
Ki = 106 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483593
 Compound Info 
(NE)-N-[amino-(2-fluorophenyl)methylidene]-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C29H22Cl2FN5O2S
  1
1
Ki = 107 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483591
 Compound Info 
(NE)-N-[amino-(4-chlorophenyl)methylidene]-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C29H22Cl3N5O2S
  1
1
Ki = 158 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0492771
 Compound Info 
(NE)-N-[amino-(3-methoxyphenyl)methylidene]-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C30H25Cl2N5O3S
  1
1
Ki = 161 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483590
 Compound Info 
(NE)-N-[amino-(4-fluorophenyl)methylidene]-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C29H22Cl2FN5O2S
  1
1
Ki = 173 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413329
 Compound Info 
(NE)-N-[amino-(3-bromophenyl)methylidene]-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C29H22BrCl2N5O2S
  1
1
Ki = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0492770
 Compound Info 
(NZ)-N-[amino-(2,3,4,5-tetrahydropyridin-6-ylamino)methylidene]-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C28H27Cl2N7O2S
  1
1
Ki = 836 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483589
 Compound Info 
US10787419, Compound 8
   Show/Hide
C29H23Cl2N5O2S
  1
1
Ki = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413324
 Compound Info 
methyl N'-[(E)-C-[5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-N-naphthalen-2-ylsulfonylcarbonimidoyl]carbamimidothioate
   Show/Hide
C28H24ClN5O2S2
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413325
 Compound Info 
ethyl N'-[(E)-C-[5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-N-(4-chlorophenyl)sulfonylcarbonimidoyl]carbamimidothioate
   Show/Hide
C25H23Cl2N5O2S2
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413326
 Compound Info 
methyl N'-[(E)-C-[5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-N-[4-(trifluoromethyl)phenyl]sulfonylcarbonimidoyl]carbamimidothioate
   Show/Hide
C25H21ClF3N5O2S2
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413327
 Compound Info 
US10787419, Compound 2
   Show/Hide
C24H21Cl2N5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413328
 Compound Info 
(NE)-N-[1-adamantyl(amino)methylidene]-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C33H33Cl2N5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413330
 Compound Info 
(NE)-N-[amino(thiophen-2-yl)methylidene]-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C27H21Cl2N5O2S2
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413333
 Compound Info 
2-phenylethyl N'-[(E)-C-[5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-N-(4-chlorophenyl)sulfonylcarbonimidoyl]carbamimidothioate
   Show/Hide
C31H27Cl2N5O2S2
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413334
 Compound Info 
(NE)-N-(1-amino-2-phenoxyethylidene)-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C30H25Cl2N5O3S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0464071
 Compound Info 
(NE)-N-[amino-(4-bromophenyl)methylidene]-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C29H22BrCl2N5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475901
 Compound Info 
(NE)-N-(1-aminoethylidene)-N'-(4-bromophenyl)sulfonyl-5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C24H21BrClN5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475902
 Compound Info 
(NE)-N-(1-aminoethylidene)-5-(4-chlorophenyl)-N'-naphthalen-2-ylsulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C28H24ClN5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475903
 Compound Info 
(NE)-N-(1-aminoethylidene)-5-(4-chlorophenyl)-4-phenyl-N'-[4-(trifluoromethyl)phenyl]sulfonyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C25H21ClF3N5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0479893
 Compound Info 
US10787419, Compound 3
   Show/Hide
C27H27Cl2N5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0480976
 Compound Info 
(NE)-N-(1-aminoethylidene)-5-(4-chlorophenyl)-N'-(4-iodophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C24H21ClIN5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0480977
 Compound Info 
US10787419, Compound 4
   Show/Hide
C26H23Cl2N5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0480978
 Compound Info 
3-phenylpropyl N'-[(E)-C-[5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-N-(4-chlorophenyl)sulfonylcarbonimidoyl]carbamimidothioate
   Show/Hide
C32H29Cl2N5O2S2
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0480996
 Compound Info 
(NE)-N-(1-aminoethylidene)-5-(4-chlorophenyl)-N'-(4-methoxyphenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C25H24ClN5O3S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0480997
 Compound Info 
(NE)-N-(1-aminoethylidene)-5-(4-chlorophenyl)-4-phenyl-N'-[4-(trifluoromethoxy)phenyl]sulfonyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C25H21ClF3N5O3S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483586
 Compound Info 
methyl N'-[(E)-C-[5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-N-(4-iodophenyl)sulfonylcarbonimidoyl]carbamimidothioate
   Show/Hide
C24H21ClIN5O2S2
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483587
 Compound Info 
(NE)-N-(1-aminoethylidene)-5-(4-chlorophenyl)-N'-(4-methylphenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C25H24ClN5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483588
 Compound Info 
(NZ)-N-(1-aminoethylidene)-N'-(benzenesulfonyl)-5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C24H22ClN5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483592
 Compound Info 
US10787419, Compound 12
   Show/Hide
C28H22Cl2N6O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483594
 Compound Info 
benzyl N'-[(E)-C-[5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-N-(4-chlorophenyl)sulfonylcarbonimidoyl]carbamimidothioate
   Show/Hide
C30H25Cl2N5O2S2
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0489176
 Compound Info 
methyl N'-[C-[5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-N-(4-chlorophenyl)sulfonylcarbonimidoyl]carbamimidothioate
   Show/Hide
C24H21Cl2N5O2S2
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0492772
 Compound Info 
(NE)-N-(1-amino-2-methylpropylidene)-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C26H25Cl2N5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0513716
 Compound Info 
(NE)-N-(1-aminoethylidene)-5-(4-chlorophenyl)-4-phenyl-N'-(4-propan-2-ylphenyl)sulfonyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C27H28ClN5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0540250
 Compound Info 
propan-2-yl N'-[(E)-C-[5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-N-(4-chlorophenyl)sulfonylcarbonimidoyl]carbamimidothioate
   Show/Hide
C26H25Cl2N5O2S2
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547350
 Compound Info 
(NE)-N-(1-aminoethylidene)-5-(4-chlorophenyl)-N'-(4-fluorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C24H21ClFN5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0566949
 Compound Info 
(NE)-N-(1-aminoethylidene)-N'-(4-tert-butylphenyl)sulfonyl-5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
   Show/Hide
C28H30ClN5O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0567160
 Compound Info 
N'-[(E)-C-[5-(4-chlorophenyl)-4-phenyl-3,4-dihydropyrazol-2-yl]-N-(4-chlorophenyl)sulfonylcarbonimidoyl]pyridine-2-carboximidamide
   Show/Hide
C28H22Cl2N6O2S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0045801
 Compound Info 
(10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
   Show/Hide
C21H30O2
  1
1 Ki = 9.2 nM
CP0037364
 Compound Info 
(-)-(6aR-trans)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
   Show/Hide
C21H30O2
  1
1 Ki = 39.6 nM
CP0038524
 Compound Info 
(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((R)-2-hydroxy-1-methyl-ethyl)-amide
   Show/Hide
C23H39NO2
  1
1 Ki = 815 nM
CP0037555
 Compound Info 
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
   Show/Hide
C22H37NO2
  1
1 Ki = 1926 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02333 Cannabinoid receptor 2 Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT00834 Cannabinoid receptor 2 Homo sapiens, Human
 Protein Info