General Information of the Protein
Protein ID
PT02333
Protein Name
Cannabinoid receptor 2
Gene Name
CNR2
Sequence
MAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Cannabinoid receptor
Function
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis (By similarity).
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Uniprot ID
Primary ID:
Q9QZN9

Secondarily ID:
Q9EP74
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Ensembl ID
ENSG00000188822
Subcellular Location
Cell membrane
Cell projection
Dendrite
Perikaryon
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0420845
 Compound Info 
3-(3-(2-Cyano-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(9-ethyl-9H-carbazol-3-yl)propanamide
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C26H20FN5O2
  1
1
EC50 = 0.13 nM
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CP0388577
 Compound Info 
N-(9-ethylcarbazol-3-yl)-3-[3-(4-fluoro-2-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide
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C26H23FN4O2
  1
1
EC50 = 0.27 nM
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CP0048192
 Compound Info 
2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)-5-(2-methyloctan-2-yl)phenol
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C24H40O3
  1
1
EC50 = 0.34 nM
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CP0388675
 Compound Info 
N-(9-ethylcarbazol-3-yl)-3-[3-(oxan-4-yl)-1,2,4-oxadiazol-5-yl]propanamide
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C24H26N4O3
  1
1
EC50 = 0.38 nM
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CP0379014
 Compound Info 
3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(6-chloro-1,8-naphthyridin-3-yl)propanamide
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C19H12Cl2FN5O2
  1
1
EC50 = 0.4 nM
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CP0423248
 Compound Info 
N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propanamide
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C18H18ClFN4O3
  1
1
EC50 = 0.4 nM
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CP0423249
 Compound Info 
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(9-ethyl-9H-carbazol-3-yl)propanamide
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C25H20ClFN4O2
  1
1
EC50 = 0.4 nM
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CP0437003
 Compound Info 
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(5-(piperidin-1-yl)-1,3,4-thiadiazol-2-yl)propanamide
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C18H18ClFN6O2S
  1
1
EC50 = 1.1 nM
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CP0381508
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-[1-(hydroxymethyl)cyclopentyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C20H21F2N3O2
  1
1
EC50 = 1.2 nM
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CP0388581
 Compound Info 
N-[3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propyl]-3-(trifluoromethoxy)quinolin-6-amine
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C21H15ClF4N4O2
  1
1
EC50 = 1.3 nM
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CP0388583
 Compound Info 
N-(2-tert-butylpyrimidin-5-yl)-3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propanamide
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C19H19ClFN5O2
  1
1
EC50 = 1.3 nM
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CP0423247
 Compound Info 
3-(3-(3-Cyanopyridin-4-yl)-1,2,4-oxadiazol-5-yl)-N-(9-ethyl-9Hcarbazol-3-yl)propanamide
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C25H20N6O2
  1
1
EC50 = 1.3 nM
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CP0437500
 Compound Info 
6-Chloro-N-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propyl)quinolin-3-amine
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C20H15Cl2FN4O
  1
1
EC50 = 1.3 nM
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CP0396919
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-(2-pyridin-3-ylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C22H20F2N4O
  1
1
EC50 = 1.5 nM
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CP0410712
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-(2-methyl-1-morpholin-4-ylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C22H26F2N4O2
  1
1
EC50 = 2.9 nM
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CP0388584
 Compound Info 
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(5-cyano-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propanamide
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C19H12ClF4N5O3
  1
1
EC50 = 3.1 nM
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CP0379010
 Compound Info 
N-(9-ethylcarbazol-3-yl)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propanamide
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C25H21FN4O2
  1
1
EC50 = 3.2 nM
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CP0474269
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-[(1R)-2-hydroxy-1-phenylethyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C22H19F2N3O2
  1
1
EC50 = 4.4 nM
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CP0397078
 Compound Info 
(2R,4R)-N-tert-butyl-9-(2,4-difluorophenyl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H19F2N3O
  1
1
EC50 = 4.8 nM
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CP0379011
 Compound Info 
6-Chloro-3-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propoxy)quinoline
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C20H14Cl2FN3O2
  1
1
EC50 = 5.1 nM
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CP0397077
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-(1-phenylcyclopropyl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C23H19F2N3O
  1
1
EC50 = 5.7 nM
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CP0375333
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-(2-pyridin-2-ylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C22H20F2N4O
  1
1
EC50 = 6.2 nM
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CP0474275
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-[1-(hydroxymethyl)cyclobutyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C19H19F2N3O2
  1
1
EC50 = 6.7 nM
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CP0388576
 Compound Info 
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)propanamide
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C19H11ClF4N4O3S
  1
1
EC50 = 6.9 nM
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CP0375336
 Compound Info 
(2R,4R)-9-(2,5-difluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H19F2N3O2
  1
1
EC50 = 7.9 nM
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CP0396918
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-(oxan-4-ylmethyl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C20H21F2N3O2
  1
1
EC50 = 10.4 nM
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CP0388674
 Compound Info 
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(6-chloroquinolin-3-yl)propanamide
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C20H13Cl2FN4O2
  1
1
EC50 = 11 nM
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CP0381504
 Compound Info 
(2S,4S)-N-tert-butyl-9-(2,4-difluorophenyl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H19F2N3O
  1
1
EC50 = 11.9 nM
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CP0155571
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H19F2N3O2
  1
1
EC50 = 12.8 nM
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CP0423250
 Compound Info 
2-tert-Butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propoxy)pyrimidine
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C19H20ClFN4O2
  1
1
EC50 = 16 nM
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CP0410476
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-(oxan-4-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C19H19F2N3O2
  1
1
EC50 = 17.5 nM
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CP0483740
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-(1-fluoro-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H18F3N3O
  1
1
EC50 = 18.1 nM
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CP0396921
 Compound Info 
(2R,4R)-9-(2-fluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H20FN3O2
  1
1
EC50 = 32.4 nM
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CP0388568
 Compound Info 
N-(9-ethylcarbazol-3-yl)-3-[3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl]propanamide
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C25H21FN4O2
  1
1
EC50 = 33 nM
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CP0410471
 Compound Info 
(2R,4R)-9-(3-fluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H20FN3O2
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1
EC50 = 34.3 nM
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CP0410473
 Compound Info 
(2R,4R)-9-(4-fluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H20FN3O2
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1
EC50 = 34.8 nM
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CP0379970
 Compound Info 
(2S,4S)-9-(2,4-difluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H19F2N3O2
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1
EC50 = 38.7 nM
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CP0379012
 Compound Info 
N-[3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propyl]quinolin-6-amine
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C20H16ClFN4O
  1
1
EC50 = 45 nM
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CP0483738
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-[1-(hydroxymethyl)cyclopropyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H17F2N3O2
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1
EC50 = 47 nM
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CP0487953
 Compound Info 
(2R,4R)-N-(1-hydroxy-2-methylpropan-2-yl)-9-pyrazin-2-yl-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C16H19N5O2
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1
EC50 = 50.3 nM
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CP0375332
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-(2-phenylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C23H21F2N3O
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1
EC50 = 52 nM
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CP0388585
 Compound Info 
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(4-(trifluoromethyl)phenyl)propanamide
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C18H12ClF4N3O2
  1
1
EC50 = 58 nM
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CP0381505
 Compound Info 
(2S,4S)-9-(2,4-difluorophenyl)-N-(oxan-4-ylmethyl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C20H21F2N3O2
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1
EC50 = 67.3 nM
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CP0397080
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-[(1S)-2-hydroxy-1-phenylethyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C22H19F2N3O2
  1
1
EC50 = 69.3 nM
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CP0379009
 Compound Info 
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)propanamide
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C17H11ClF4N4O2
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1
EC50 = 73 nM
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CP0457650
 Compound Info 
3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-[3-chloro-4-(trifluoromethyl)phenyl]propanamide
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C18H11Cl2F4N3O2
  1
1
EC50 = 79 nM
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CP0397081
 Compound Info 
(2S,4S)-9-(2,4-difluorophenyl)-N-[1-(hydroxymethyl)cyclopropyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H17F2N3O2
  1
1
EC50 = 88.3 nM
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CP0423239
 Compound Info 
N-(9-ethylcarbazol-3-yl)-3-[5-(2-fluorophenyl)tetrazol-2-yl]propanamide
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C24H21FN6O
  1
1
EC50 = 97 nM
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CP0474274
 Compound Info 
(2R,4R)-9-(2,4-dichlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H19Cl2N3O2
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1
EC50 = 99.7 nM
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CP0400313
 Compound Info 
(2R,4R)-N-(1-hydroxy-2-methylpropan-2-yl)-9-pyridin-2-yl-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C17H20N4O2
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1
EC50 = 100 nM
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CP0423243
 Compound Info 
5-(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propylamino)-2-(2,2,2-trifluoroethoxy)nicotinonitrile
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C19H14ClF4N5O2
  1
1
EC50 = 130 nM
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CP0379951
 Compound Info 
(2S,4S)-9-(2,4-difluorophenyl)-N-(oxan-4-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C19H19F2N3O2
  1
1
EC50 = 183 nM
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CP0388582
 Compound Info 
5-tert-Butyl-N-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propyl)isoxazol-3-amine
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C18H20ClFN4O2
  1
1
EC50 = 190 nM
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CP0437503
 Compound Info 
6-Chloro-N-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propyl)benzo[d]thiazol-2-amine
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C18H13Cl2FN4OS
  1
1
EC50 = 290 nM
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CP0375335
 Compound Info 
(2R,4R)-N-(1-hydroxy-2-methylpropan-2-yl)-9-phenyl-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H21N3O2
  1
1
EC50 = 326 nM
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CP0406642
 Compound Info 
(2R,4R)-N-(1-hydroxy-2-methylpropan-2-yl)-9-pyrimidin-4-yl-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C16H19N5O2
  1
1
EC50 = 376.4 nM
 Bioactivity Info 
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CP0379008
 Compound Info 
3-(4-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)butyl)quinoline
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C21H17ClFN3O
  1
1
EC50 = 380 nM
 Bioactivity Info 
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CP0396917
 Compound Info 
(2R,4R)-9-(2,4-difluorophenyl)-N-[(1R,2R,4S)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C24H27F2N3O
  1
1
EC50 = 591 nM
 Bioactivity Info 
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CP0396920
 Compound Info 
(2R,4R)-9-(2,6-difluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C18H19F2N3O2
  1
1
EC50 = 2800 nM
 Bioactivity Info 
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CP0456395
 Compound Info 
(2R,4R)-N-(1-hydroxy-2-methylpropan-2-yl)-9-pyridin-3-yl-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
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C17H20N4O2
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0442068
 Compound Info 
((4S,4aR,8aS)-4-hydroxy-4-phenyloctahydroquinolin-1(2H)-yl)(6-methylpyridin-3-yl)methanone
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C22H26N2O2
  1
1
IC50 = 6.3 nM
 Bioactivity Info 
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CP0456330
 Compound Info 
(2,3-dichlorophenyl)(1-(morpholinomethyl)imidazo[1,5-a]pyridin-3-yl)methanone
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C19H17Cl2N3O2
  1
1
IC50 = 11 nM
 Bioactivity Info 
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CP0436035
 Compound Info 
N-[[1-(hydroxymethyl)cyclopentyl]methyl]-3-morpholin-4-ylimidazo[1,5-a]pyridine-1-carboxamide
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C19H26N4O3
  1
1
IC50 = 58 nM
 Bioactivity Info 
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CP0436298
 Compound Info 
((4S,4aR,8aS)-4-hydroxy-4-phenyloctahydroquinolin-1(2H)-yl)((S)-4-methylmorpholin-3-yl)methanone
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C21H30N2O3
  1
1
IC50 = 81 nM
 Bioactivity Info 
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Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01998 Cannabinoid receptor 2 Mus musculus, Mouse
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT00834 Cannabinoid receptor 2 Homo sapiens, Human
 Protein Info