General Information of the Compound
Compound ID
CP0164723
Compound Name
US9266835, 106
    Show/Hide
Structure
Formula
C30H28Cl2N4O3
Molecular Weight
563.485
Canonical SMILES
NC(=O)CC(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
    Show/Hide
InChI
InChI=1S/C30H28Cl2N4O3/c31-21-6-1-18(2-7-21)30(19-3-8-22(32)9-4-19)20-5-10-25-24(15-20)26(16-28(38)35-25)34-23-11-13-36(14-12-23)29(39)17-27(33)37/h1-10,15-16,23,30H,11-14,17H2,(H2,33,37)(H2,34,35,38)
    Show/Hide
InChIKey
PXZDXGPBYQNYGO-UHFFFAOYSA-N
Physicochemical Property
logP
5.2934
Rotatable Bonds
7
Heavy Atom Count
39
Polar Areas
108.29
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 118324032
ChEMBL ID
CHEMBL3905217
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01298, Cannabinoid receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 1550 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 1547 nM
Protein ID: PT00834, Cannabinoid receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 6500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 6500 nM