Brief Information of the Cell Line and Protein
Cell Line ID: CL000053 , COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Protein ID: PT01161 , D(4) dopamine receptor
Gene Name DRD4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P21917
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000053  Protein ID: PT01161
 
Compound ID Compound Name Compound Formula
CP0005956
1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-piperazine
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C19H19ClN2O
 1
1
Ki = 0.54 nM
   TI
   LI
   LO
   TS
CP0010829
1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine
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C19H20N2O
 1
1
Ki = 2 nM
   TI
   LI
   LO
   TS
CP0076121
13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,9,12,14-heptaene
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C18H18ClN3O
 1
1
Ki = 4.9 nM
   TI
   LI
   LO
   TS
CP0039958
(risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one
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C23H27FN4O2
 1
1
Ki = 7 nM
   TI
   LI
   LO
   TS
CP0874541
4-Dibenzo[b,f]oxepin-10-yl-1-methyl-piperidine hydrochloride
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C20H22ClNO
 1
1
Ki = 9.5 nM
   TI
   LI
   LO
   TS
CP0183655
1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10-yl)-piperazine
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C21H24N2
 1
1
Ki = 12 nM
   TI
   LI
   LO
   TS
CP0686615
4-(5H-Dibenzo[a,d]cyclohepten-10-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine hydrochloride
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C21H22ClN
 1
1
Ki = 12 nM
   TI
   LI
   LO
   TS
CP0025667
2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone
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C18H19ClN4
 1
1
Ki = 21 nM
   TI
   LI
   LO
   TS
CP0885801
4-Dibenzo[b,f]oxepin-10-yl-1-ethyl-1,2,3,6-tetrahydro-pyridine hydrochloride
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C21H22ClNO
 1
1
Ki = 26 nM
   TI
   LI
   LO
   TS
CP0685158
4-(5H-Dibenzo[a,d]cyclohepten-10-yl)-1-ethyl-1,2,3,6-tetrahydro-pyridine hydrochloride
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C22H24ClN
 1
1
Ki = 28 nM
   TI
   LI
   LO
   TS
CP0391139
4-Dibenzo[b,f]oxepin-10-yl-1-methyl-1,2,3,6-tetrahydro-pyridine
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C20H19NO
 1
1
Ki = 29 nM
   TI
   LI
   LO
   TS
CP0845312
1-Allyl-4-dibenzo[b,f]oxepin-10-yl-1,2,3,6-tetrahydro-pyridine hydrochloride
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C22H22ClNO
 1
1
Ki = 37 nM
   TI
   LI
   LO
   TS
CP0710703
1-Allyl-4-(5H-dibenzo[a,d]cyclohepten-10-yl)-1,2,3,6-tetrahydro-pyridine hydrochloride
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C23H24ClN
 1
1
Ki = 60 nM
   TI
   LI
   LO
   TS
CP0316388
4-(8-Chloro-5-isopropylidene-5H-dibenzo[a,d]cyclohepten-10-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine
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C24H24ClN
 1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0037340
4-(5-Isopropylidene-5H-dibenzo[a,d]cyclohepten-10-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine
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C24H25N
 1
1
Ki = 270 nM
   TI
   LI
   LO
   TS
CP0801575
1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10-yl)-1,2,3,6-tetrahydro-pyridine hydrochloride
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C22H24ClN
 1
1
Ki = 320 nM
   TI
   LI
   LO
   TS