General Information of the Protein
Protein ID
PT05231
Protein Name
Very long chain fatty acid elongase 1
Secondarily
Protein Name
3-keto acyl-CoA synthase ELOVL1
ELOVL fatty acid elongase 1
Elongation of very long chain fatty acids protein 1
Very long chain 3-ketoacyl-CoA synthase 1
Very long chain 3-oxoacyl-CoA synthase 1
Gene Name
ELOVL1
Secondarily
Gene Name
SSC1
CGI-88
Sequence
MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905). Indirectly inhibits RPE65 via production of VLCFAs.
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Uniprot ID
Primary ID:
Q9BW60

Secondarily ID:
B4DP24
Q53HT2
Q5JUY3
Q8WXU3
Q9NVD9
Q9Y396
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Ensembl ID
ENSG00000066322
HGNC ID
HGNC:14418
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0428615
 Compound Info 
6,6-dimethyl-3-{5-methyl-3-oxo-2-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-pyrazol-4-yl}-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
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C28H23F6N3O4
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0857816
 Compound Info 
2-[(1-Methyl-1H-imidazol-4-yl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide
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C21H28N4O4S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000154 , HEK293-EBNA1-6E
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0543584
 Compound Info 
4-[2-(4-fluorophenyl)ethoxy]-6-piperidin-1-ylpyrimidine
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C17H20FN3O
  1
1 IC50 = 220 nM
CP0543009
 Compound Info 
1-(2-fluorophenyl)-N-[1-(1,2,4-thiadiazol-5-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C15H12FN5OS
  1
1 IC50 = 400 nM
CP0543138
 Compound Info 
1-phenyl-N-(1-phenylpyrazol-3-yl)cyclopropane-1-carboxamide
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C19H17N3O
  1
1 IC50 = 500 nM
CP0554500
 Compound Info 
1-(2-fluorophenyl)-N-(1-phenylpyrazol-3-yl)cyclopropane-1-carboxamide
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C19H16FN3O
  1
1 IC50 = 500 nM
CP0578304
 Compound Info 
1-(2,5-difluorophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C18H13F3N4O
  1
1 IC50 = 550 nM
CP0579221
 Compound Info 
N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]-1-phenylcyclopropane-1-carboxamide
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C18H15FN4O
  1
1 IC50 = 560 nM
CP0578846
 Compound Info 
1-(2-fluorophenyl)-N-[1-(6-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C18H14F2N4O
  1
1 IC50 = 800 nM
CP0579544
 Compound Info 
1-(4-fluorophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C18H14F2N4O
  1
1 IC50 = 830 nM
CP0484292
 Compound Info 
2-[2-(4-fluorophenyl)ethoxy]-4-piperidin-1-ylpyridine
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C18H21FN2O
  1
1 IC50 = 860 nM
CP0540391
 Compound Info 
1-(2-fluorophenyl)-N-[1-(2-fluoropyridin-4-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C18H14F2N4O
  1
1 IC50 = 900 nM
CP0543008
 Compound Info 
1-(2-fluorophenyl)-N-(1-pyrimidin-4-ylpyrazol-3-yl)cyclopropane-1-carboxamide
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C17H14FN5O
  1
1 IC50 = 900 nM
CP0577010
 Compound Info 
2,2-difluoro-1-phenyl-N-(1-phenylpyrazol-3-yl)cyclopropane-1-carboxamide
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C19H15F2N3O
  1
1 IC50 = 980 nM
CP0543141
 Compound Info 
1-(2-fluorophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C18H14F2N4O
  1
1 IC50 = 1200 nM
CP0572849
 Compound Info 
1-(2,6-difluorophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C18H13F3N4O
  1
1 IC50 = 1200 nM
CP0577011
 Compound Info 
1-(2-fluorophenyl)-N-[1-(2-methoxypyridin-4-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C19H17FN4O2
  1
1 IC50 = 1200 nM
CP0578303
 Compound Info 
1-(2,3-difluorophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C18H13F3N4O
  1
1 IC50 = 1300 nM
CP0578773
 Compound Info 
1-(2-fluorophenyl)-N-(1-pyridin-4-ylpyrazol-3-yl)cyclopropane-1-carboxamide
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C18H15FN4O
  1
1 IC50 = 1500 nM
CP0579223
 Compound Info 
N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]-1-(3-methoxyphenyl)cyclopropane-1-carboxamide
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C19H17FN4O2
  1
1 IC50 = 1500 nM
CP0568955
 Compound Info 
(2R)-2-phenyl-N-(1-phenylpyrazol-3-yl)propanamide
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C18H17N3O
  1
1 IC50 = 1600 nM
CP0575593
 Compound Info 
2-(2-fluorophenyl)-N-(1-phenylpyrazol-3-yl)acetamide
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C17H14FN3O
  1
1 IC50 = 1600 nM
CP0577012
 Compound Info 
1-(3-fluorophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C18H14F2N4O
  1
1 IC50 = 1600 nM
CP0567969
 Compound Info 
(2S)-2-phenyl-N-(1-phenylpyrazol-3-yl)propanamide
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C18H17N3O
  1
1 IC50 = 2000 nM
CP0543134
 Compound Info 
1-(4-cyanophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C19H14FN5O
  1
1 IC50 = 2200 nM
CP0568820
 Compound Info 
1-(3-cyanophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C19H14FN5O
  1
1 IC50 = 2300 nM
CP0568821
 Compound Info 
1-(4-chlorophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C18H14ClFN4O
  1
1 IC50 = 2400 nM
CP0579218
 Compound Info 
2-methyl-2-phenyl-N-(1-phenylpyrazol-3-yl)propanamide
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C19H19N3O
  1
1 IC50 = 2700 nM
CP0579542
 Compound Info 
2-phenyl-N-(1-phenylpyrazol-3-yl)acetamide
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C17H15N3O
  1
1 IC50 = 2700 nM
CP0578842
 Compound Info 
2-(2-fluorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
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C17H13FN2OS
  1
1 IC50 = 3200 nM
CP0577628
 Compound Info 
N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]-1-(4-methoxyphenyl)cyclopropane-1-carboxamide
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C19H17FN4O2
  1
1 IC50 = 3700 nM
CP0148895
 Compound Info 
2-phenyl-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
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C17H14N2OS
  1
1 IC50 = 4000 nM
CP0551726
 Compound Info 
2,2-dimethyl-1-phenyl-N-(1-phenylpyrazol-3-yl)cyclopropane-1-carboxamide
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C21H21N3O
  1
1 IC50 = 4400 nM
CP0579255
 Compound Info 
1-(2-chlorophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C18H14ClFN4O
  1
1 IC50 = 4500 nM
CP0579222
 Compound Info 
N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]-1-(2-methylphenyl)cyclopropane-1-carboxamide
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C19H17FN4O
  1
1 IC50 = 7500 nM
CP0564366
 Compound Info 
3-phenyl-N-(1-phenylpyrazol-3-yl)oxetane-3-carboxamide
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C19H17N3O2
  1
1 IC50 = 8200 nM
CP0579693
 Compound Info 
(2R)-2-phenyl-N-(1-phenylpyrazol-3-yl)butanamide
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C19H19N3O
  1
1 IC50 = 9500 nM
CP0564595
 Compound Info 
2-[2-(4-fluorophenyl)ethoxy]-5-pyridin-3-ylpyridine
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C18H15FN2O
  1
1 IC50 = 21000 nM
CP0579219
 Compound Info 
1-(2-fluorophenyl)-N-[1-(2-methylpyridin-4-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C19H17FN4O
  1
1 IC50 = 21000 nM
CP0368005
 Compound Info 
1-(2-cyanophenyl)-N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]cyclopropane-1-carboxamide
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C19H14FN5O
  1
1 IC50 = 23000 nM
CP0578843
 Compound Info 
2-(2-fluorophenyl)-N-(2-phenyltriazol-4-yl)acetamide
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C16H13FN4O
  1
1 IC50 > 8000 nM
CP0543007
 Compound Info 
N-[1-(2-aminopyridin-4-yl)pyrazol-3-yl]-1-(2-fluorophenyl)cyclopropane-1-carboxamide
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C18H16FN5O
  1
1 IC50 > 20000 nM
CP0543005
 Compound Info 
2-(2-fluorophenyl)-N-(1-phenylpyrazol-4-yl)acetamide
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C17H14FN3O
  1
1 IC50 > 50000 nM
CP0543006
 Compound Info 
2-(2-fluorophenyl)-N-(4-phenylpyrimidin-2-yl)acetamide
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C18H14FN3O
  1
1 IC50 > 50000 nM
CP0572865
 Compound Info 
2-ethoxy-2-phenyl-N-(1-phenylpyrazol-3-yl)acetamide
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C19H19N3O2
  1
1 IC50 > 50000 nM
CP0577008
 Compound Info 
2-(2-fluorophenyl)-N-(1-phenyl-1,2,4-triazol-3-yl)acetamide
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C16H13FN4O
  1
1 IC50 > 50000 nM
CP0577627
 Compound Info 
N-[1-(5-fluoropyridin-3-yl)pyrazol-3-yl]-1-(2-methoxyphenyl)cyclopropane-1-carboxamide
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C19H17FN4O2
  1
1 IC50 > 50000 nM
CP0578844
 Compound Info 
2-(2-fluorophenyl)-N-(6-phenylpyridin-2-yl)acetamide
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C19H15FN2O
  1
1 IC50 > 50000 nM
CP0578845
 Compound Info 
2-(dimethylamino)-2-phenyl-N-(1-phenylpyrazol-3-yl)acetamide
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C19H20N4O
  1
1 IC50 > 50000 nM
CP0579220
 Compound Info 
1-(2-fluorophenyl)-N-[1-[2-(trifluoromethyl)pyridin-4-yl]pyrazol-3-yl]cyclopropane-1-carboxamide
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C19H14F4N4O
  1
1 IC50 > 50000 nM