General Information of the Protein
| Protein ID |
PT05405
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| Protein Name |
Very long chain fatty acid elongase 2
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| Secondarily Protein Name |
3-keto acyl-CoA synthase ELOVL2
ELOVL fatty acid elongase 2
Elongation of very long chain fatty acids protein 2
Very long chain 3-ketoacyl-CoA synthase 2
Very long chain 3-oxoacyl-CoA synthase 2
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| Gene Name |
ELOVL2
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| Secondarily Gene Name |
ELG3
SSC2
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| Sequence |
MEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFFLTVMYLLSIWLGNKYMKNRPALSLRGILTLYNLGITLLSAYMLAELILSTWEGGYNLQCQDLTSAGEADIRVAKVLWWYYFSKSVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTMSAVVKPCGFPFGCLIFQSSYMLTLVILFLNFYVQTYRKKPMKKDMQEPPAGKEVKNGFSKAYFTAANGVMNKKAQ
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
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Transferase
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| Function |
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
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| Uniprot ID |
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| HGNC ID | |||||
| Subcellular Location |
Endoplasmic reticulum membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
