Brief Information of the Cell Line and Protein
Cell Line ID: CL000053 , COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Protein ID: PT01661 , Tyrosine-protein kinase receptor TYRO3
Gene Name TYRO3
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q06418
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000053  Protein ID: PT01661
 
Compound ID Compound Name Compound Formula
CP0545727
2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-((1S,2S)-2-((4′-((4-methylpiperazin-1-yl)methyl)-[1,1′-biphenyl]-4-yl)methoxy)cyclopentyl)nicotinamide
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C34H41N7O2
 1
1
IC50 = 5011.87 nM
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CP0480273
N-[[3-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-6-yl]methyl]-N-methyl-5-[2-methyl-4-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1,3,4-oxadiazol-2-amine
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C31H36N10O
 1
1
IC50 = 12589.25 nM
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CP0514791
N-methyl-N-[[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-6-yl]methyl]-5-[2-methyl-4-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1,3,4-oxadiazol-2-amine
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C28H29N9O
 1
1
IC50 = 12589.25 nM
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CP0480272
N-methyl-5-[2-methyl-4-(1,3,5-trimethylpyrazol-4-yl)phenyl]-N-[(3-phenylimidazo[1,2-a]pyridin-6-yl)methyl]-1,3,4-oxadiazol-2-amine
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C30H29N7O
 1
1
IC50 = 19952.62 nM
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CP0480271
N,N-dimethyl-6-[[methyl-[5-[2-methyl-4-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1,3,4-oxadiazol-2-yl]amino]methyl]imidazo[1,2-a]pyridine-3-carboxamide
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C27H30N8O2
 1
1
IC50 = 25118.86 nM
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CP0245111
N-(imidazo[1,2-a]pyridin-6-ylmethyl)-N-methyl-5-[2-methyl-4-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1,3,4-oxadiazol-2-amine
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C24H25N7O
 1
1
IC50 > 31622.78 nM
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CP0494150
N-methyl-N-[[3-(1-methylpiperidin-4-yl)imidazo[1,2-a]pyridin-6-yl]methyl]-5-[2-methyl-4-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1,3,4-oxadiazol-2-amine
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C30H36N8O
 1
1
IC50 > 31622.78 nM
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CP0494159
N-[[3-[6-[(dimethylamino)methyl]pyridin-3-yl]imidazo[1,2-a]pyridin-6-yl]methyl]-N-methyl-5-[3-methyl-5-(1,3,5-trimethylpyrazol-4-yl)pyridin-2-yl]-1,3,4-oxadiazol-2-amine
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C31H34N10O
 1
1
IC50 > 31622.78 nM
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   TS
CP0514792
N-[[3-[3-[(dimethylamino)methyl]phenyl]imidazo[1,2-a]pyridin-6-yl]methyl]-N-methyl-5-[3-methyl-5-(1,3,5-trimethylpyrazol-4-yl)pyridin-2-yl]-1,3,4-oxadiazol-2-amine
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C32H35N9O
 1
1
IC50 > 31622.78 nM
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CP0527506
N-[[3-[5-[(dimethylamino)methyl]pyridin-2-yl]imidazo[1,2-a]pyridin-6-yl]methyl]-N-methyl-5-[3-methyl-5-(1,3,5-trimethylpyrazol-4-yl)pyridin-2-yl]-1,3,4-oxadiazol-2-amine
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C31H34N10O
 1
1
IC50 > 31622.78 nM
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CP0548059
N-[[3-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-6-yl]methyl]-N-methyl-5-[3-methyl-5-(1,3,5-trimethylpyrazol-4-yl)pyridin-2-yl]-1,3,4-oxadiazol-2-amine
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C30H35N11O
 1
1
IC50 > 31622.78 nM
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CP0552479
N-[[3-[4-[(dimethylamino)methyl]phenyl]imidazo[1,2-a]pyridin-6-yl]methyl]-N-methyl-5-[3-methyl-5-(1,3,5-trimethylpyrazol-4-yl)pyridin-2-yl]-1,3,4-oxadiazol-2-amine
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C32H35N9O
 1
1
IC50 > 31622.78 nM
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CP0554525
N-(imidazo[1,2-a]pyridin-6-ylmethyl)-N-methyl-5-[3-methyl-5-(1,3,5-trimethylpyrazol-4-yl)pyridin-2-yl]-1,3,4-oxadiazol-2-amine
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C23H24N8O
 1
1
IC50 > 31622.78 nM
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