Brief Information of the Cell Line and Protein
Cell Line ID: CL000053 , COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Protein ID: PT00957 , D(2) dopamine receptor
Gene Name DRD2
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID P61169
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000053  Protein ID: PT00957
 
Compound ID Compound Name Compound Formula
CP0162854
(+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
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C16H25NO
 3
1
EC50 = 1.88 nM
   TI
   LI
   LO
   TS
2
IC50 = 180 nM
   TI
   LI
   LO
   TS
3
IC50 = 192 nM
   TI
   LI
   LO
   TS
CP0076352
9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline; compound with methanesulfonic acid
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C19H26N2S
 3
1
EC50 = 7.86 nM
   TI
   LI
   LO
   TS
2
IC50 = 27.5 nM
   TI
   LI
   LO
   TS
3
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0127400
(-)-Pramipexole
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C10H17N3S
 2
1
EC50 = 21.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0389481
S32504 (+)
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C16H22N2O2
 2
1
EC50 = 49.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 406 nM
   TI
   LI
   LO
   TS
CP0078778
4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one
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C16H24N2O
 2
1
EC50 = 75.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 1803 nM
   TI
   LI
   LO
   TS
CP0772206
SID56463240
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C26H32ClN3O2
 2
1
IC50 = 24.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 28.3 nM
   TI
   LI
   LO
   TS
CP0042751
(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrate;hydrochloride
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C17H17NO2
 2
1
IC50 = 118 nM
   TI
   LI
   LO
   TS
2
IC50 = 135 nM
   TI
   LI
   LO
   TS
CP0036921
3-HYDROXYTYRAMINE HYDROCHLORIDE
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C8H11NO2
 3
1
IC50 = 3140 nM
   TI
   LI
   LO
   TS
2
IC50 = 3260 nM
   TI
   LI
   LO
   TS
3
Kd = 17000 nM
   TI
   LI
   LO
   TS
CP0006107
CAS_85760-74-3
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C13H21N3
 2
1
IC50 = 4321 nM
   TI
   LI
   LO
   TS
2
IC50 = 4784 nM
   TI
   LI
   LO
   TS
CP0339664
CHEBI:64217
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C21H26ClN3O2
 2
1
Kd = 0.014 nM
   TI
   LI
   LO
   TS
2
Kd = 0.016 nM
   TI
   LI
   LO
   TS
CP0077311
1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one
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C22H24ClN5O2
 2
1
Ki = 0.52 nM
   TI
   LI
   LO
   TS
2
Ki = 0.57 nM
   TI
   LI
   LO
   TS
CP0008601
4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)
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C21H23ClFNO2
 2
1
Ki = 1.01 nM
   TI
   LI
   LO
   TS
2
Ki = 1.63 nM
   TI
   LI
   LO
   TS
CP0045063
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
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C17H20N4S
 2
1
Ki = 12.6 nM
   TI
   LI
   LO
   TS
2
Ki = 15.3 nM
   TI
   LI
   LO
   TS
CP0025667
2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone
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C18H19ClN4
 2
1
Ki = 63.1 nM
   TI
   LI
   LO
   TS
2
Ki = 64.2 nM
   TI
   LI
   LO
   TS
CP0280047
S33084
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C29H29N3O2
 1
1
Ki = 205 nM
   TI
   LI
   LO
   TS