Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrate;hydrochloride
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 PubChem ID
CID: 6005
SID: 14823961
Canonical SMILES
CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31
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Compound Formula C17H17NO2
Compound Structure
Protein Name
 Protein Info 
D(2) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P61169
Gene Name
DRD2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6
 Cell Line Info 
Rattus norvegicus (Rat)  2
1
Kd = 200 nM
   TI
   LI
   LO
   TS
2
Kd = 600 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
2
EC50 = 53 nM
   TI
   LI
   LO
   TS
3
Ki = 11.5 nM
   TI
   LI
   LO
   TS
4
Ki = 32 nM
   TI
   LI
   LO
   TS
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  2
1
IC50 = 118 nM
   TI
   LI
   LO
   TS
2
IC50 = 135 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 0.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.6 nM
2 IC50 = 21 nM
3 IC50 = 24 nM
4 Ki = 1.8 nM
5 Ki = 2.2 nM
6 Ki = 11.1 nM
7 Ki = 13 nM
8 Ki = 17.3 nM
9 Ki = 98 nM