| Compound ID |
Compound Name |
Compound Formula |
|
CP0872620
|
[(pF)Phe4Aib7Arg14Lys15]N/OFQ-NH2
Show/Hide
|
C83H139FN32O21
|
2
|
| 1 |
EC50 = 0.02818 nM
|
|
|
| 2 |
Ki = 0.02818 nM
|
|
|
|
CP0378860
|
(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]pentanediamide
Show/Hide
|
C79H129FN28O21
|
3
|
| 1 |
EC50 = 0.06607 nM
|
|
|
| 2 |
EC50 = 0.309 nM
|
|
|
| 3 |
Ki = 0.02188 nM
|
|
|
|
CP0393127
|
(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-N-[(2S)-5-(diaminoamino)-1-hydrazinyl-1,5-dioxopentan-2-yl]butanediamide
Show/Hide
|
C82H140FN35O21
|
2
|
| 1 |
EC50 = 0.06761 nM
|
|
|
| 2 |
EC50 = 0.07586 nM
|
|
|
|
CP0038350
|
(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-{2-[(2S,3R)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-phenylpropanamido]acetamido}acetamido)-3-phenylpropanamido]-3-hydroxybutanamido]acetamido}propanamido]-5-carbamimidamidopentanamido]hexanamido]-3-hydroxypropanamido]propanamido]-5-carbamimidamidopentanamido]hexanamido]-4-methylpentanamido]propanamido]butanediamido]-4-carbamoylbutanoic acid
Show/Hide
|
C79H129N27O22
|
14
|
| 1 |
EC50 = 0.08 nM
|
|
|
| 2 |
EC50 = 0.1148 nM
|
|
|
| 3 |
EC50 = 0.2089 nM
|
|
|
| 4 |
EC50 = 0.4266 nM
|
|
|
| 5 |
EC50 = 0.912 nM
|
|
|
| 6 |
EC50 = 1.047 nM
|
|
|
| 7 |
EC50 = 3.6 nM
|
|
|
| 8 |
EC50 = 8.1 nM
|
|
|
| 9 |
Ki = 0.04898 nM
|
|
|
| 10 |
Ki = 0.06 nM
|
|
|
| 11 |
Ki = 0.08 nM
|
|
|
| 12 |
Ki = 0.12 nM
|
|
|
| 13 |
Ki = 0.214 nM
|
|
|
| 14 |
Ki = 0.3162 nM
|
|
|
|
CP0378862
|
(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-N-[(2S)-5-(diaminoamino)-1-hydrazinyl-1,5-dioxopentan-2-yl]butanediamide
Show/Hide
|
C82H141N35O21
|
2
|
| 1 |
EC50 = 0.1 nM
|
|
|
| 2 |
EC50 = 0.1413 nM
|
|
|
|
CP0496294
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-nitrophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H99N23O17
|
1
|
| 1 |
EC50 = 0.1349 nM
|
|
|
|
CP0460886
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H99FN22O15
|
1
|
| 1 |
EC50 = 0.1585 nM
|
|
|
|
CP0872618
|
[Phe1psi(CH2-NH)Gly2(pF)Phe4Aib7Arg14Lys15]N/OFQ-NH2
Show/Hide
|
C84H142FN33O21
|
2
|
| 1 |
EC50 = 0.1905 nM
|
|
|
| 2 |
Ki = 0.05495 nM
|
|
|
|
CP0377625
|
(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropyl]amino]acetyl]amino]acetyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-N-[(2S)-5-(diaminoamino)-1-hydrazinyl-1,5-dioxopentan-2-yl]butanediamide
Show/Hide
|
C82H142FN35O20
|
3
|
| 1 |
EC50 = 0.2089 nM
|
|
|
| 2 |
EC50 = 0.302 nM
|
|
|
| 3 |
Ki = 0.01995 nM
|
|
|
|
CP0405523
|
(4S)-5-amino-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]-5-oxopentanoic acid
Show/Hide
|
C79H128N26O23
|
1
|
| 1 |
EC50 = 0.2188 nM
|
|
|
|
CP0394046
|
(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-N-[(2S)-5-(diaminoamino)-1-hydrazinyl-1,5-dioxopentan-2-yl]butanediamide
Show/Hide
|
C82H143N35O20
|
3
|
| 1 |
EC50 = 0.2399 nM
|
|
|
| 2 |
EC50 = 0.9333 nM
|
|
|
| 3 |
Ki = 0.03162 nM
|
|
|
|
CP0484526
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(3-fluorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H99FN22O15
|
1
|
| 1 |
EC50 = 0.2512 nM
|
|
|
|
CP0488133
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H99ClN22O15
|
1
|
| 1 |
EC50 = 0.2692 nM
|
|
|
|
CP0424016
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-cyanophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C62H99N23O15
|
1
|
| 1 |
EC50 = 0.302 nM
|
|
|
|
CP0181125
|
Demethyl-AMPA
Show/Hide
|
C61H100N22O15
|
4
|
| 1 |
EC50 = 0.3236 nM
|
|
|
| 2 |
EC50 = 0.5129 nM
|
|
|
| 3 |
EC50 = 7.82 nM
|
|
|
| 4 |
Ki = 0.62 nM
|
|
|
|
CP0393233
|
(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[2-(benzylamino)acetyl]amino]acetyl]amino]acetyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-N-[(2S)-5-(diaminoamino)-1-hydrazinyl-1,5-dioxopentan-2-yl]butanediamide
Show/Hide
|
C82H140FN35O21
|
3
|
| 1 |
EC50 = 0.4074 nM
|
|
|
| 2 |
EC50 = 4.898 nM
|
|
|
| 3 |
Ki = 0.02512 nM
|
|
|
|
CP0377639
|
(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropyl]amino]acetyl]amino]acetyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]pentanediamide
Show/Hide
|
C79H131FN28O20
|
3
|
| 1 |
EC50 = 0.4786 nM
|
|
|
| 2 |
EC50 = 0.8128 nM
|
|
|
| 3 |
Ki = 0.04786 nM
|
|
|
|
CP0573321
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H100N22O16
|
1
|
| 1 |
EC50 = 0.5888 nM
|
|
|
|
CP0394043
|
(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]pentanediamide
Show/Hide
|
C79H132N28O20
|
3
|
| 1 |
EC50 = 0.7586 nM
|
|
|
| 2 |
EC50 = 5.248 nM
|
|
|
| 3 |
Ki = 0.1288 nM
|
|
|
|
CP0484527
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(2-fluorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H99FN22O15
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0438945
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-bromophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H99BrN22O15
|
1
|
| 1 |
EC50 = 1.413 nM
|
|
|
|
CP0874940
|
cyclo[DAsp7,Lys10]N/OFQ(1-13)NH2
Show/Hide
|
C65H105N23O15
|
2
|
| 1 |
EC50 = 1.6 nM
|
|
|
| 2 |
Ki = 0.27 nM
|
|
|
|
CP0427577
|
2-[3-[1-[(1R)-1,2-dihydroacenaphthylen-1-yl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-methylacetamide
Show/Hide
|
C27H28N4O2
|
2
|
| 1 |
EC50 = 1.6 nM
|
|
|
| 2 |
Ki = 0.336 nM
|
|
|
|
CP0543953
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C63H104N22O15
|
1
|
| 1 |
EC50 = 1.698 nM
|
|
|
|
CP0540304
|
(2S)-N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]butanediamide
Show/Hide
|
C61H99N23O16
|
1
|
| 1 |
EC50 = 1.995 nM
|
|
|
|
CP0542327
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C62H102N22O15
|
1
|
| 1 |
EC50 = 1.995 nM
|
|
|
|
CP0573548
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-phenylbutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C67H104N22O15
|
1
|
| 1 |
EC50 = 1.995 nM
|
|
|
|
CP0559435
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C63H104N22O16
|
1
|
| 1 |
EC50 = 2.692 nM
|
|
|
|
CP0543952
|
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-6-acetamido-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-6-aminohexanamide
Show/Hide
|
C65H107N23O16
|
1
|
| 1 |
EC50 = 2.818 nM
|
|
|
|
CP0543958
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]pentanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C62H102N22O15
|
1
|
| 1 |
EC50 = 3.715 nM
|
|
|
|
CP0544072
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C70H110N22O16
|
2
|
| 1 |
EC50 = 4.074 nM
|
|
|
| 2 |
EC50 = 19.5 nM
|
|
|
|
CP0915535
|
cyclo [Asp6,Lys10]N/OFQ(1-13)NH2
Show/Hide
|
C66H107N23O15
|
2
|
| 1 |
EC50 = 4.12 nM
|
|
|
| 2 |
Ki = 0.34 nM
|
|
|
|
CP0377638
|
(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[2-(benzylamino)acetyl]amino]acetyl]amino]acetyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]pentanediamide
Show/Hide
|
C79H129FN28O21
|
3
|
| 1 |
EC50 = 5.888 nM
|
|
|
| 2 |
EC50 = 54.95 nM
|
|
|
| 3 |
Ki = 0.2399 nM
|
|
|
|
CP0397617
|
1-(1-cyclooctylpiperidin-4-yl)-3-ethyl-3H-indol-2-one
Show/Hide
|
C23H34N2O
|
2
|
| 1 |
EC50 = 6.8 nM
|
|
|
| 2 |
Ki = 8.67 nM
|
|
|
|
CP0549725
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]butanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H100N22O15
|
1
|
| 1 |
EC50 = 7.079 nM
|
|
|
|
CP0487354
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-iodophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H99IN22O15
|
1
|
| 1 |
EC50 = 7.244 nM
|
|
|
|
CP0397614
|
3-ethyl-1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C24H36N2O
|
2
|
| 1 |
EC50 = 8.5 nM
|
|
|
| 2 |
Ki = 5.22 nM
|
|
|
|
CP0542551
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C63H104N22O15
|
1
|
| 1 |
EC50 = 9.333 nM
|
|
|
|
CP0372295
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-methylphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C62H102N22O15
|
1
|
| 1 |
EC50 = 10.96 nM
|
|
|
|
CP0543954
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-methoxyphenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C67H104N22O16
|
1
|
| 1 |
EC50 = 13.18 nM
|
|
|
|
CP0543956
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C68H106N22O16
|
1
|
| 1 |
EC50 = 17.78 nM
|
|
|
|
CP0547724
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C66H102N22O15
|
1
|
| 1 |
EC50 = 19.05 nM
|
|
|
|
CP0127782
|
2-[exo-8-[Bis(2-chlorophenyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl]-1-piperidineacetonitrile
Show/Hide
|
C27H31Cl2N3
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0297485
|
(1S,5S)-8-[bis(2-chlorophenyl)methyl]-3-piperidin-2-yl-8-azabicyclo[3.2.1]octane
Show/Hide
|
C25H30Cl2N2
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0316578
|
2-[exo-8-[Bis(2-chlorophenyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl]-1-piperidineethanol
Show/Hide
|
C27H34Cl2N2O
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0805996
|
exo-8-[Bis(2-chlorophenyl)methyl]-3-(1-methyl-2-piperidinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C26H32Cl2N2
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0328913
|
1-(1-Cyclooctyl-piperidin-4-yl)-1,3-dihydro-indol-2-one
Show/Hide
|
C21H30N2O
|
2
|
| 1 |
EC50 = 20.8 nM
|
|
|
| 2 |
Ki = 1.39 nM
|
|
|
|
CP0375818
|
8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C26H31N3O
|
2
|
| 1 |
EC50 = 21 nM
|
|
|
| 2 |
Ki = 1.12 nM
|
|
|
|
CP0380888
|
1-[1-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]piperidin-4-yl]-3-ethyl-3H-indol-2-one
Show/Hide
|
C28H34N2O
|
2
|
| 1 |
EC50 = 21.7 nM
|
|
|
| 2 |
Ki = 3.16 nM
|
|
|
|
CP0400917
|
(3S)-4-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoic acid
Show/Hide
|
C66H109N23O16
|
2
|
| 1 |
EC50 = 22.3 nM
|
|
|
| 2 |
Ki = 0.54 nM
|
|
|
|
CP0847400
|
4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol
Show/Hide
|
C25H28ClNO
|
2
|
| 1 |
EC50 = 23 nM
|
|
|
| 2 |
Ki = 0.7 nM
|
|
|
|
CP0377250
|
1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C20H22ClN3O
|
3
|
| 1 |
EC50 = 25 nM
|
|
|
| 2 |
IC50 = 5.9 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0377404
|
1-((2-methoxyphenyl)(phenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C25H27NO2
|
2
|
| 1 |
EC50 = 26 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0495412
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-aminophenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C68H107N23O15
|
1
|
| 1 |
EC50 = 26.3 nM
|
|
|
|
CP0857914
|
1-(1-(4-isopropylcyclohexyl)piperidin-4-yl)indolin-2-one
Show/Hide
|
C22H32N2O
|
2
|
| 1 |
EC50 = 26.5 nM
|
|
|
| 2 |
Ki = 3.96 nM
|
|
|
|
CP0559432
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-2-phenylacetyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C65H100N22O15
|
1
|
| 1 |
EC50 = 26.92 nM
|
|
|
|
CP0403744
|
3-ethyl-1-[1-(1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C25H30N2O
|
2
|
| 1 |
EC50 = 27.9 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0795316
|
exo-8-[Bis(2-chlorophenyl)methyl]-3-(2-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C25H24Cl2N2
|
2
|
| 1 |
EC50 = 28 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0397620
|
1-(1-Bicyclo[3.3.1]non-9-yl-piperidin-4-yl)-1,3-dihydro-indol-2-one
Show/Hide
|
C22H30N2O
|
2
|
| 1 |
EC50 = 28.7 nM
|
|
|
| 2 |
Ki = 7.49 nM
|
|
|
|
CP0431954
|
4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol
Show/Hide
|
C25H27NO
|
2
|
| 1 |
EC50 = 29 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0411391
|
1-(1-cyclooctylpiperidin-4-yl)-3-methyl-3H-indol-2-one
Show/Hide
|
C22H32N2O
|
2
|
| 1 |
EC50 = 30.2 nM
|
|
|
| 2 |
Ki = 12.65 nM
|
|
|
|
CP0573209
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-aminophenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C66H103N23O15
|
1
|
| 1 |
EC50 = 30.2 nM
|
|
|
|
CP0446183
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-[4-(trifluoromethyl)phenyl]propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C62H99F3N22O15
|
1
|
| 1 |
EC50 = 31.62 nM
|
|
|
|
CP0966184
|
(S)-2-((2S,5S,11S,14S,23S)-11-((1H-imidazol-5-yl)methyl)-23-amino-14-benzyl-2-(3-guanidinopropyl)-24-(4-hydroxyphenyl)-5-methyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-6-amino-N-((S)-1-((S)-1-((S)-1-((S)-1,6-diamino-1-oxohexan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-yl)hexanamide
Show/Hide
|
C63H100N24O15
|
1
|
| 1 |
EC50 = 40.74 nM
|
|
|
|
CP0411660
|
1-[1-[(1R,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]piperidin-4-yl]-3-ethyl-3H-indol-2-one
Show/Hide
|
C28H34N2O
|
2
|
| 1 |
EC50 = 40.9 nM
|
|
|
| 2 |
Ki = 2.99 nM
|
|
|
|
CP0849181
|
(R)-8-(Chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrogenoxalate hemihydrate
Show/Hide
|
C24H29N3O7
|
1
|
| 1 |
EC50 = 45.71 nM
|
|
|
|
CP0397613
|
1-[1-[(3aR)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C26H30N2O
|
2
|
| 1 |
EC50 = 46.1 nM
|
|
|
| 2 |
Ki = 11.43 nM
|
|
|
|
CP0488750
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C66H101FN22O15
|
1
|
| 1 |
EC50 = 48.98 nM
|
|
|
|
CP0545578
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-nitrophenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C66H101N23O17
|
1
|
| 1 |
EC50 = 48.98 nM
|
|
|
|
CP0380887
|
3-ethyl-1-[1-(1,2,3,4-tetrahydronaphthalen-1-yl)piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C25H30N2O
|
2
|
| 1 |
EC50 = 50.2 nM
|
|
|
| 2 |
Ki = 8.63 nM
|
|
|
|
CP0380885
|
1-[1-[(1R,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C26H30N2O
|
2
|
| 1 |
EC50 = 52.7 nM
|
|
|
| 2 |
Ki = 3.41 nM
|
|
|
|
CP0967407
|
(S)-2-((2S,5S,11S,14S,23S)-11-((1H-indol-3-yl)methyl)-23-amino-14-benzyl-2-(3-guanidinopropyl)-24-(4-hydroxyphenyl)-5-methyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-6-amino-N-((S)-1-((S)-1-((S)-1-((S)-1,6-diamino-1-oxohexan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-yl)hexanamide
Show/Hide
|
C68H103N23O15
|
1
|
| 1 |
EC50 = 53.7 nM
|
|
|
|
CP0489521
|
1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]-2,3-dihydroindole
Show/Hide
|
C22H34N2
|
2
|
| 1 |
EC50 = 54.5 nM
|
|
|
| 2 |
Ki = 10.3 nM
|
|
|
|
CP0396228
|
3-methyl-1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C23H34N2O
|
2
|
| 1 |
EC50 = 54.9 nM
|
|
|
| 2 |
Ki = 6.53 nM
|
|
|
|
CP0488749
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C63H105N23O15
|
1
|
| 1 |
EC50 = 54.95 nM
|
|
|
|
CP0571190
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C68H106N22O15
|
1
|
| 1 |
EC50 = 56.23 nM
|
|
|
|
CP0543957
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-naphthalen-1-ylpropanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C72H108N22O15
|
1
|
| 1 |
EC50 = 60.26 nM
|
|
|
|
CP0406389
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-methoxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C62H102N22O16
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0577370
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-3-amino-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C60H99N23O15
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0420681
|
(NZ)-N-[[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methylidene]hydroxylamine
Show/Hide
|
C23H33N3O
|
2
|
| 1 |
EC50 = 67 nM
|
|
|
| 2 |
Ki = 2.17 nM
|
|
|
|
CP0575906
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-naphthalen-1-ylpropanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C70H104N22O15
|
1
|
| 1 |
EC50 = 67.61 nM
|
|
|
|
CP0380889
|
3-ethyl-1-[1-(3-phenylpropyl)piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C24H30N2O
|
2
|
| 1 |
EC50 = 72.2 nM
|
|
|
| 2 |
Ki = 188.7 nM
|
|
|
|
CP0425378
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2R)-2-hydroxy-3,3-dimethylpentan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C30H43NO4
|
2
|
| 1 |
EC50 = 78.6 nM
|
|
|
| 2 |
Ki = 8.46 nM
|
|
|
|
CP0391686
|
3-ethyl-1-[1-(1H-indol-4-ylmethyl)piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C24H27N3O
|
2
|
| 1 |
EC50 = 82 nM
|
|
|
| 2 |
Ki = 11.1 nM
|
|
|
|
CP0396233
|
1-[1-(1-cyclohexylethyl)piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C21H30N2O
|
2
|
| 1 |
EC50 = 82.3 nM
|
|
|
| 2 |
Ki = 9.98 nM
|
|
|
|
CP0403915
|
CHEMBL2387189
Show/Hide
|
C24H36N2O
|
2
|
| 1 |
EC50 = 83 nM
|
|
|
| 2 |
Ki = 15.26 nM
|
|
|
|
CP0391685
|
1-[1-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C26H30N2O
|
2
|
| 1 |
EC50 = 84.9 nM
|
|
|
| 2 |
Ki = 2.1 nM
|
|
|
|
CP0540305
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C66H102N22O16
|
1
|
| 1 |
EC50 = 85.11 nM
|
|
|
|
CP0433076
|
1-(1-cyclooctylpiperidin-4-yl)-4-methyl-3,4-dihydroquinolin-2-one
Show/Hide
|
C23H34N2O
|
2
|
| 1 |
EC50 = 94.7 nM
|
|
|
| 2 |
Ki = 40.28 nM
|
|
|
|
CP0452693
|
1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]-3-(pyrrolidin-1-ylmethyl)indole
Show/Hide
|
C27H41N3
|
2
|
| 1 |
EC50 = 97.4 nM
|
|
|
| 2 |
Ki = 1.47 nM
|
|
|
|
CP0396229
|
1-(1-cyclooctylpiperidin-4-yl)-3,4-dihydroquinolin-2-one
Show/Hide
|
C22H32N2O
|
2
|
| 1 |
EC50 = 101 nM
|
|
|
| 2 |
Ki = 18.66 nM
|
|
|
|
CP0400916
|
(3R)-4-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-oxobutanoic acid
Show/Hide
|
C65H107N23O16
|
2
|
| 1 |
EC50 = 106 nM
|
|
|
| 2 |
Ki = 1.79 nM
|
|
|
|
CP0397622
|
1-[1-(4-propylcyclohexyl)piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C22H32N2O
|
2
|
| 1 |
EC50 = 107 nM
|
|
|
| 2 |
Ki = 7.63 nM
|
|
|
|
CP0384549
|
(1S,2S,6R,14R,15R,16R)-16-[(2R)-1-(2-bicyclo[2.2.1]heptanyl)-2-hydroxypropan-2-yl]-5-(cyclopropylmethyl)-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C33H45NO4
|
2
|
| 1 |
EC50 = 111 nM
|
|
|
| 2 |
Ki = 16 nM
|
|
|
|
CP0528135
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-2-phenylacetyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C67H104N22O15
|
1
|
| 1 |
EC50 = 112.2 nM
|
|
|
|
CP0435891
|
1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C26H29NO
|
2
|
| 1 |
EC50 = 114 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0072627
|
BUPRENORPHINE
Show/Hide
|
C29H41NO4
|
3
|
| 1 |
EC50 = 116 nM
|
|
|
| 2 |
Ki = 77 nM
|
|
|
| 3 |
Ki = 77.4 nM
|
|
|
|
CP0431955
|
1-(bis(2-methoxyphenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C26H29NO3
|
2
|
| 1 |
EC50 = 117 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0470739
|
[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methanol
Show/Hide
|
C23H34N2O
|
2
|
| 1 |
EC50 = 117 nM
|
|
|
| 2 |
Ki = 44.7 nM
|
|
|
|
CP0540306
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-phenylphenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanamide
Show/Hide
|
C72H106N22O15
|
1
|
| 1 |
EC50 = 117.49 nM
|
|
|
|
CP0375813
|
methyl 2-[8-(naphthalen-1-ylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetate
Show/Hide
|
C27H29N3O3
|
2
|
| 1 |
EC50 = 121 nM
|
|
|
| 2 |
Ki = 12.9 nM
|
|
|
|
CP0455165
|
[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methanamine
Show/Hide
|
C23H35N3
|
2
|
| 1 |
EC50 = 121 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0562484
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C68H106N22O16
|
1
|
| 1 |
EC50 = 123.03 nM
|
|
|
|
CP0411661
|
1-[1-(3,3-diphenylpropyl)piperidin-4-yl]-3-ethyl-3H-indol-2-one
Show/Hide
|
C30H34N2O
|
2
|
| 1 |
EC50 = 123.5 nM
|
|
|
| 2 |
Ki = 76.6 nM
|
|
|
|
CP0914262
|
(rel)-(3-(4-fluorobenzyl)-8-(bis(2-chlorophenyl)methyl)-8-aza-bicyclo[3.2.1]octan-3-yl)methanamine
Show/Hide
|
C28H29Cl2FN2
|
2
|
| 1 |
EC50 = 124 nM
|
|
|
| 2 |
Ki = 34 nM
|
|
|
|
CP0396226
|
1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]-3,4-dihydroquinolin-2-one
Show/Hide
|
C23H34N2O
|
2
|
| 1 |
EC50 = 127 nM
|
|
|
| 2 |
Ki = 20.4 nM
|
|
|
|
CP0854482
|
(rel)-N-((3-(4-fluorobenzyl)-8-(bis(2-chlorophenyl)methyl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C30H31Cl2FN2O
|
2
|
| 1 |
EC50 = 129 nM
|
|
|
| 2 |
Ki = 15 nM
|
|
|
|
CP0465292
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H100N22O16
|
1
|
| 1 |
EC50 = 134.9 nM
|
|
|
|
CP0407576
|
1-[1-(1-phenylethyl)piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C21H24N2O
|
2
|
| 1 |
EC50 = 138 nM
|
|
|
| 2 |
Ki = 26.9 nM
|
|
|
|
CP0485583
|
CHEMBL4465668
Show/Hide
|
C24H39Cl2N3
|
2
|
| 1 |
EC50 = 139 nM
|
|
|
| 2 |
Ki = 2.27 nM
|
|
|
|
CP0543951
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C70H104N22O15
|
1
|
| 1 |
EC50 = 151.36 nM
|
|
|
|
CP0906681
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(pyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)-N,N-dimethylmethanamine
Show/Hide
|
C28H31Cl2N3
|
2
|
| 1 |
EC50 = 156 nM
|
|
|
| 2 |
Ki = 7 nM
|
|
|
|
CP0850583
|
(rac)-8-(Chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrogenoxalate hemihydrate
Show/Hide
|
C24H29N3O7
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0492059
|
1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indole
Show/Hide
|
C22H32N2
|
2
|
| 1 |
EC50 = 160 nM
|
|
|
| 2 |
Ki = 9.8 nM
|
|
|
|
CP0396234
|
1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-indol-2-one
Show/Hide
|
C20H22N2O
|
3
|
| 1 |
EC50 = 174 nM
|
|
|
| 2 |
Ki = 201 nM
|
|
|
| 3 |
Ki = 201.3 nM
|
|
|
|
CP0489538
|
3-[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]propylthiourea
Show/Hide
|
C26H40N4S
|
2
|
| 1 |
EC50 = 175 nM
|
|
|
| 2 |
Ki = 31.8 nM
|
|
|
|
CP0866900
|
(S)-8-(Chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrogenoxalate hemihydrate
Show/Hide
|
C24H29N3O7
|
1
|
| 1 |
EC50 = 208.93 nM
|
|
|
|
CP0377393
|
1-(bis(2-chlorophenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C24H23Cl2NO
|
2
|
| 1 |
EC50 = 222 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0543955
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3,3-diphenylpropanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanamide
Show/Hide
|
C72H106N22O15
|
1
|
| 1 |
EC50 = 245.47 nM
|
|
|
|
CP0435482
|
3-[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]propan-1-amine;dihydrochloride
Show/Hide
|
C25H41Cl2N3
|
2
|
| 1 |
EC50 = 249 nM
|
|
|
| 2 |
Ki = 20.9 nM
|
|
|
|
CP0475602
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-3-(4-aminophenyl)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H101N23O15
|
1
|
| 1 |
EC50 = 257.04 nM
|
|
|
|
CP0869825
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C29H30Cl2N2O
|
2
|
| 1 |
EC50 = 269 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0455155
|
2-(ethylamino)-N-[[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methyl]acetamide
Show/Hide
|
C27H42N4O
|
2
|
| 1 |
EC50 = 277 nM
|
|
|
| 2 |
Ki = 15.9 nM
|
|
|
|
CP0850584
|
Spiroxatrine oxalate
Show/Hide
|
C24H27N3O7
|
1
|
| 1 |
EC50 = 323.59 nM
|
|
|
|
CP0847398
|
4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol
Show/Hide
|
C25H28BrNO
|
2
|
| 1 |
EC50 = 331 nM
|
|
|
| 2 |
Ki = 23 nM
|
|
|
|
CP0435480
|
[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methylthiourea
Show/Hide
|
C24H36N4S
|
2
|
| 1 |
EC50 = 343 nM
|
|
|
| 2 |
Ki = 10.5 nM
|
|
|
|
CP0562481
|
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-4-amino-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]butanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Show/Hide
|
C61H101N23O15
|
1
|
| 1 |
EC50 = 371.54 nM
|
|
|
|
CP0852668
|
8-(5-fluorochroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one oxalate
Show/Hide
|
C24H26FN3O6
|
1
|
| 1 |
EC50 = 426.58 nM
|
|
|
|
CP0431569
|
1-[[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methyl]piperidin-4-ol
Show/Hide
|
C28H43N3O
|
2
|
| 1 |
EC50 = 446 nM
|
|
|
| 2 |
Ki = 64 nM
|
|
|
|
CP0492061
|
6-amino-N-[[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methyl]hexanamide
Show/Hide
|
C29H46N4O
|
2
|
| 1 |
EC50 = 464 nM
|
|
|
| 2 |
Ki = 23.1 nM
|
|
|
|
CP0854481
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-aza-bicyclo[3.2.1]octan-3-yl)-N,N-dimethylmethanamine
Show/Hide
|
C29H32Cl2N2
|
2
|
| 1 |
EC50 = 483 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0530058
|
N,N-dimethyl-1-[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methanamine
Show/Hide
|
C25H39N3
|
2
|
| 1 |
EC50 = 532 nM
|
|
|
| 2 |
Ki = 43.8 nM
|
|
|
|
CP0435483
|
(3R)-1-[[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methyl]pyrrolidin-3-ol
Show/Hide
|
C27H41N3O
|
2
|
| 1 |
EC50 = 575 nM
|
|
|
| 2 |
Ki = 9.46 nM
|
|
|
|
CP0531587
|
1-[[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methyl]azetidin-3-ol
Show/Hide
|
C26H39N3O
|
2
|
| 1 |
EC50 = 1559 nM
|
|
|
| 2 |
Ki = 23.6 nM
|
|
|
|
CP0384546
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2R)-2-hydroxy-4-methyl-4-phenylpentan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C35H45NO4
|
2
|
| 1 |
EC50 = 2380 nM
|
|
|
| 2 |
Ki = 22 nM
|
|
|
|
CP0266826
|
1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C19H21N3O
|
3
|
| 1 |
EC50 = 6900 nM
|
|
|
| 2 |
IC50 = 200 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0371873
|
1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-piperidin-4-yl)-3-ethyl-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C24H37N3O2
|
6
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1.5 nM
|
|
|
| 3 |
IC50 = 2.3 nM
|
|
|
| 4 |
IC50 = 2.4 nM
|
|
|
| 5 |
IC50 = 5.6 nM
|
|
|
| 6 |
Ki = 0.403 nM
|
|
|
|
CP0448402
|
1-((3S,4S)-1-Cyclooctylmethyl-3-hydroxymethyl-piperidin-4-yl)-3-ethyl-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C24H37N3O2
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 820 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0377461
|
1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C21H31N3O
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 6.8 nM
|
|
|
| 3 |
IC50 = 20 nM
|
|
|
|
CP0445356
|
1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C23H35N3O
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 6.8 nM
|
|
|
| 3 |
IC50 = 20 nM
|
|
|
|
CP0419606
|
1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide
Show/Hide
|
C28H37N3O
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 42 nM
|
|
|
| 3 |
IC50 = 47 nM
|
|
|
|
CP0422203
|
2-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)benzamide
Show/Hide
|
C29H32N2O
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 8.3 nM
|
|
|
| 3 |
IC50 = 10 nM
|
|
|
|
CP0428295
|
2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]benzamide
Show/Hide
|
C29H32N2O2
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
| 3 |
IC50 = 8.2 nM
|
|
|
|
CP0428305
|
2-Benzyloxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]benzamide
Show/Hide
|
C30H34N2O2
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 83 nM
|
|
|
| 3 |
IC50 = 110 nM
|
|
|
|
CP0460201
|
(2S)-2-hydroxy-3-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)propanamide
Show/Hide
|
C25H32N2O2
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 7.5 nM
|
|
|
| 3 |
IC50 = 12 nM
|
|
|
|
CP0431571
|
2-[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]ethylthiourea
Show/Hide
|
C25H38N4S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 24.4 nM
|
|
|
|
CP0431674
|
(2S)-2-amino-5-(diaminomethylideneamino)-N-[[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methyl]pentanamide
Show/Hide
|
C29H47N7O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
|
CP0419604
|
1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-D-prolineamide
Show/Hide
|
C28H37N3O
|
3
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 0.12 nM
|
|
|
| 3 |
IC50 = 0.22 nM
|
|
|
|
CP0422204
|
(R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-1-benzylpyrrolidine-2-carboxamide
Show/Hide
|
C27H35N3O2
|
4
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 0.15 nM
|
|
|
| 3 |
IC50 = 0.27 nM
|
|
|
| 4 |
Ki = 0.2399 nM
|
|
|
|
CP0322413
|
arylpyrazole, 31
Show/Hide
|
C21H22ClF2N5
|
1
|
| 1 |
IC50 = 0.31 nM
|
|
|
|
CP0294580
|
benzimidazole analogue, 7j
Show/Hide
|
C24H34ClN5OS
|
1
|
| 1 |
IC50 = 0.55 nM
|
|
|
|
CP0086801
|
benzimidazole analogue, 7p
Show/Hide
|
C22H29ClN6OS
|
1
|
| 1 |
IC50 = 0.59 nM
|
|
|
|
CP0128713
|
2-[(3R)-4-(2-tert-butylsulfanyl-6-chloro-1H-benzimidazol-5-yl)-3-methylpiperazin-1-yl]ethanol
Show/Hide
|
C18H27ClN4OS
|
1
|
| 1 |
IC50 = 0.65 nM
|
|
|
|
CP0345095
|
2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benzo[d]imidazol-5-yl)piperazin-1-yl)ethanol
Show/Hide
|
C19H29ClN4OS
|
2
|
| 1 |
IC50 = 0.66 nM
|
|
|
| 2 |
IC50 = 1.2 nM
|
|
|
|
CP0070284
|
benzimidazole analogue, 7e
Show/Hide
|
C22H32ClN5O2S
|
1
|
| 1 |
IC50 = 0.72 nM
|
|
|
|
CP0334660
|
benzimidazole analogue, 7m
Show/Hide
|
C22H31ClN8S
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0316879
|
benzimidazole analogue, 7o
Show/Hide
|
C23H31ClN6OS
|
1
|
| 1 |
IC50 = 0.91 nM
|
|
|
|
CP0281459
|
arylpyrazole, 28
Show/Hide
|
C21H23ClFN5
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0197693
|
benzimidazole analogue, 7k
Show/Hide
|
C22H32ClN5OS
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0299304
|
benzimidazole analogue, 7c
Show/Hide
|
C22H32ClN5O2S
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0299306
|
benzimidazole analogue, 7g
Show/Hide
|
C22H32ClN5OS
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0230628
|
arylpyrazole, 30
Show/Hide
|
C21H23ClFN5
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0305800
|
benzimidazole analogue, 7h
Show/Hide
|
C23H34ClN5OS
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0439366
|
(1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-isopropyl-1-(6-methylpyridin-3-yl)-1H-imidazol-4-yl)methyl)-3-fluorocyclopentanamine
Show/Hide
|
C23H27ClFN5
|
2
|
| 1 |
IC50 = 1.4 nM
|
|
|
| 2 |
IC50 = 2.3 nM
|
|
|
|
CP0444664
|
(7R,9S)-7-((4-(2,6-dichlorophenyl)piperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C22H26Cl2N2O
|
2
|
| 1 |
IC50 = 1.6 nM
|
|
|
| 2 |
Ki = 0.47 nM
|
|
|
|
CP0094117
|
benzimidazole analogue, 7i
Show/Hide
|
C21H32ClN5O2S2
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0433652
|
2-[4-[6-chloro-2-(1-methylcyclohexyl)sulfanyl-1H-benzimidazol-5-yl]piperazin-1-yl]ethanol
Show/Hide
|
C20H29ClN4OS
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0299305
|
benzimidazole analogue, 7d
Show/Hide
|
C22H32ClN5O2S
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0486495
|
6-chloro-2-pentan-3-ylsulfanyl-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C16H23ClN4S
|
2
|
| 1 |
IC50 = 2.1 nM
|
|
|
| 2 |
IC50 = 9.1 nM
|
|
|
|
CP0421937
|
(1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-ethyl-1-(6-methylpyridin-3-yl)-1H-imidazol-4-yl)methyl)-3-fluorocyclopentanamine
Show/Hide
|
C22H25ClFN5
|
2
|
| 1 |
IC50 = 2.3 nM
|
|
|
| 2 |
IC50 = 3.2 nM
|
|
|
|
CP0433651
|
2-[4-[6-chloro-2-(2-methylbutan-2-ylsulfanyl)-1H-benzimidazol-5-yl]piperazin-1-yl]ethanol
Show/Hide
|
C18H27ClN4OS
|
2
|
| 1 |
IC50 = 2.5 nM
|
|
|
| 2 |
IC50 = 5.6 nM
|
|
|
|
CP0364199
|
2-(3-(1-((1s,4s)-4-isopropylcyclohexyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C24H36N4O2
|
2
|
| 1 |
IC50 = 2.6 nM
|
|
|
| 2 |
Ki = 0.7 nM
|
|
|
|
CP0316877
|
benzimidazole analogue, 5a
Show/Hide
|
C18H27ClN4S
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0262654
|
2-(4-(6-chloro-2-(pentan-3-ylthio)-3H-benzo[d]imidazol-5-yl)piperazin-1-yl)ethanol
Show/Hide
|
C18H27ClN4OS
|
2
|
| 1 |
IC50 = 3.3 nM
|
|
|
| 2 |
IC50 = 9.7 nM
|
|
|
|
CP0316878
|
benzimidazole analogue, 7n
Show/Hide
|
C22H31ClN8S
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0496483
|
(1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-methyl-1-(6-methylpyridin-3-yl)-1H-imidazol-4-yl)methyl)-3-fluorocyclopentanamine
Show/Hide
|
C21H23ClFN5
|
2
|
| 1 |
IC50 = 3.7 nM
|
|
|
| 2 |
IC50 = 9.1 nM
|
|
|
|
CP0437280
|
6-chloro-5-(4-ethylpiperazin-1-yl)-2-pentan-3-ylsulfanyl-1H-benzimidazole
Show/Hide
|
C18H27ClN4S
|
2
|
| 1 |
IC50 = 3.9 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0297824
|
benzimidazole analogue, 7l
Show/Hide
|
C21H31ClN4O2S2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0230627
|
arylpyrazole, 29
Show/Hide
|
C21H22ClF2N5
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0431068
|
(1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-methyl-1H-imidazol-4-yl)methyl)-3-fluorocyclopentanamine
Show/Hide
|
C19H24F3N3
|
2
|
| 1 |
IC50 = 4.5 nM
|
|
|
| 2 |
IC50 = 8.6 nM
|
|
|
|
CP0423319
|
(7R,9S)-7-(((3S,4S)-4-(4-fluoro-2-methylphenyl)-3-hydroxypiperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C23H29FN2O2
|
2
|
| 1 |
IC50 = 4.5 nM
|
|
|
| 2 |
Ki = 3.7 nM
|
|
|
|
CP0230623
|
arylpyrazole, 19
Show/Hide
|
C21H24ClN5
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0511526
|
6-fluoro-2-pentan-3-ylsulfanyl-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C16H23FN4S
|
2
|
| 1 |
IC50 = 4.7 nM
|
|
|
| 2 |
IC50 = 690 nM
|
|
|
|
CP0506345
|
N-[[2-(3-chloropyridin-2-yl)-1-(6-methylpyridin-3-yl)-5-propan-2-ylimidazol-4-yl]methyl]cyclopentanamine
Show/Hide
|
C23H28ClN5
|
2
|
| 1 |
IC50 = 4.7 nM
|
|
|
| 2 |
IC50 = 9.6 nM
|
|
|
|
CP0431539
|
(7R,9S)-7-(((3R,4R)-4-(2-chloro-4-fluorophenyl)-3-hydroxypiperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C22H26ClFN2O2
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
Ki = 4.4 nM
|
|
|
|
CP0498920
|
2-[1-(1-Cyclodecyl-piperidin-4-yl)-2,2-dioxo-1,4-dihydro-2H-2lambda*6*-benzo[1,2,6]thiadiazin-3-yl]-N-methyl-acetamide
Show/Hide
|
C25H40N4O3S
|
2
|
| 1 |
IC50 = 5.2 nM
|
|
|
| 2 |
Ki = 0.6 nM
|
|
|
|
CP0427035
|
(1S,3R)-N-((5-(4-chlorophenyl)-1-isopropyl-4-(2-methoxyethyl)-1H-imidazol-2-yl)methyl)-3-fluorocyclopentanamine
Show/Hide
|
C21H29ClFN3O
|
2
|
| 1 |
IC50 = 5.6 nM
|
|
|
| 2 |
IC50 = 7.6 nM
|
|
|
|
CP0440519
|
(7R,9S)-7-(((3S,4R)-3-methyl-4-o-tolylpiperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C24H32N2O
|
2
|
| 1 |
IC50 = 5.7 nM
|
|
|
| 2 |
Ki = 3.5 nM
|
|
|
|
CP0399587
|
2-[(2,3-dichlorophenyl)methylsulfanyl]-6-fluoro-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C18H17Cl2FN4S
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 140 nM
|
|
|
|
CP0280634
|
benzimidazole analogue, 5e
Show/Hide
|
C19H26ClN5S
|
1
|
| 1 |
IC50 = 6.4 nM
|
|
|
|
CP0334661
|
benzimidazole analogue, 7q
Show/Hide
|
C23H31ClN6OS
|
1
|
| 1 |
IC50 = 7.1 nM
|
|
|
|
CP0399222
|
(7R,9S)-7-(((3S,4R)-3-(hydroxymethyl)-4-o-tolylpiperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C24H32N2O2
|
2
|
| 1 |
IC50 = 7.3 nM
|
|
|
| 2 |
Ki = 4.3 nM
|
|
|
|
CP0411109
|
2-[3-(1-Cyclodecyl-piperidin-4-yl)-2,2-dioxo-2,3-dihydro-2lambda*6*-benzo[1,2,5]thiadiazol-1-yl]-N-methyl-acetamide
Show/Hide
|
C24H38N4O3S
|
2
|
| 1 |
IC50 = 7.5 nM
|
|
|
| 2 |
Ki = 2.5 nM
|
|
|
|
CP0296905
|
1-methanesulfinylmethyl-3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzimidazol-2-one
Show/Hide
|
C28H39N3O4S
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0201513
|
benzimidazole analogue, 7b
Show/Hide
|
C20H30ClN5O2S
|
1
|
| 1 |
IC50 = 8.6 nM
|
|
|
|
CP0439808
|
(-)-(7R,9S)-7-{[4-(2-Methylphenyl)piperidin-1-yl]methyl}-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C23H30N2O
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0402032
|
2-(8-cyclodecyl-1-oxo-4-phenyl-2,3,8-triazaspiro[4.5]dec-3-en-2-yl)-N-methylacetamide
Show/Hide
|
C26H38N4O2
|
2
|
| 1 |
IC50 = 9.6 nM
|
|
|
| 2 |
Ki = 2.3 nM
|
|
|
|
CP0423317
|
(5S,7R)-1-methyl-7-[[4-(2-methylphenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol
Show/Hide
|
C25H33NO
|
3
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 6 nM
|
|
|
|
CP0281458
|
arylpyrazole, 27
Show/Hide
|
C21H23ClFN5
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0431067
|
N-[[5-(4-chlorophenyl)-4-methyl-1-propan-2-ylimidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C19H26ClN3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0281457
|
arylpyrazole, 18
Show/Hide
|
C20H21Cl2N5
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0422074
|
2-{3-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-2,2-dioxo-2,3-dihydro-2lambda*6*-benzo[1,2,5]thiadiazol-1-yl}-N-methyl-acetamide
Show/Hide
|
C24H36N4O3S
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
Ki = 7.1 nM
|
|
|
|
CP0493718
|
(-)-(3R,4R)-4-(2-Chloro-4-fluorophenyl)-3-hydroxy-1-{[(6R,8S)-8-hydroxy-5,6,7,8-tetrahydroquinolin-6-yl]methyl}piperidinium Chloride
Show/Hide
|
C21H24ClFN2O2
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
|
CP0338887
|
1-methanesulfonylmethyl-3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzimidazol-2-one
Show/Hide
|
C28H39N3O5S
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0433649
|
2-pentan-3-ylsulfanyl-6-piperazin-1-yl-3H-benzimidazole-5-carbonitrile
Show/Hide
|
C17H23N5S
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 78 nM
|
|
|
|
CP0498922
|
2-{1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2,2-dioxo-1,4-dihydro-2H-2lambda*6*-benzo[1,2,6]thiadiazin-3-yl}-N-methyl-acetamide
Show/Hide
|
C24H38N4O3S
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
Ki = 2.9 nM
|
|
|
|
CP0136050
|
2-{8-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl}-N-methyl-acetamide
Show/Hide
|
C30H42N4O4
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0311381
|
2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]imidazol-5-yl)piperazin-1-yl)ethanol
Show/Hide
|
C17H25ClN4OS
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 21 nM
|
|
|
|
CP0437281
|
2-(cyclohexylmethylsulfanyl)-6-fluoro-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C18H25FN4S
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 930 nM
|
|
|
|
CP0402030
|
2-(8-(decahydronaphthalen-2-yl)-1-oxo-4-phenyl-2,3,8-triazaspiro[4.5]dec-3-en-2-yl)-N-methylacetamide
Show/Hide
|
C26H36N4O2
|
2
|
| 1 |
IC50 = 18 nM
|
|
|
| 2 |
Ki = 7.7 nM
|
|
|
|
CP0439767
|
(7R,9S)-7-(((3S,4S)-3-hydroxy-4-o-tolylpiperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C23H30N2O2
|
2
|
| 1 |
IC50 = 18 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0493342
|
2-[4-(6-chloro-2-cyclohexylsulfanyl-1H-benzimidazol-5-yl)piperazin-1-yl]ethanol
Show/Hide
|
C19H27ClN4OS
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0496826
|
2-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)benzamide
Show/Hide
|
C30H34N2O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0463344
|
2-{3-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2,2-dioxo-2,3-dihydro-2lambda*6*-benzo[1,2,5]thiadiazol-1-yl}-N-methyl-acetamide
Show/Hide
|
C23H36N4O3S
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
Ki = 6.4 nM
|
|
|
|
CP0490528
|
2-[(2-chlorophenyl)methylsulfanyl]-6-fluoro-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C18H18ClFN4S
|
2
|
| 1 |
IC50 = 23 nM
|
|
|
| 2 |
IC50 = 380 nM
|
|
|
|
CP0439436
|
(4R)-3-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-2-oxo-1,3-oxazolidine-4-carboxamide
Show/Hide
|
C27H33N3O3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0504118
|
N-[[2-(3-chloropyridin-2-yl)-5-methyl-1-(6-methylpyridin-3-yl)imidazol-4-yl]methyl]cyclopentanamine
Show/Hide
|
C21H24ClN5
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0440520
|
(7R,9S)-7-((4-(2-chlorophenyl)piperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C22H27ClN2O
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
Ki = 1.1 nM
|
|
|
|
CP0163450
|
arylpyrazole, 13
Show/Hide
|
C22H22Cl3N3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0422846
|
N-[[1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-methylimidazol-4-yl]methyl]cyclopentanamine
Show/Hide
|
C22H22Cl3N3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0469633
|
2-{1-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-2,2-dioxo-1,4-dihydro-2H-2lambda*6*-benzo[1,2,6]thiadiazin-3-yl}-N-methyl-acetamide
Show/Hide
|
C25H38N4O3S
|
2
|
| 1 |
IC50 = 28 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0491911
|
(4S,5S)-4-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-2-oxo-1,3-oxazolidine-5-carboxamide
Show/Hide
|
C27H33N3O3
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0542824
|
6-fluoro-2-[(4-methylphenyl)methylsulfanyl]-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C19H21FN4S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0296906
|
2-(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-acetamide
Show/Hide
|
C28H38N4O4
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0051440
|
1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-3-methylsulfanylmethyl-1,3-dihydro-benzimidazol-2-one
Show/Hide
|
C28H39N3O3S
|
2
|
| 1 |
IC50 = 33 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0431064
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-propan-2-ylimidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C24H26Cl3N3
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0145421
|
1-(1-(3-(5-methoxy-2-methylphenoxy)-4-methylpentyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
Show/Hide
|
C26H35N3O3
|
2
|
| 1 |
IC50 = 38 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0853355
|
2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-4-(4-methylpiperazin-1-yl)-1H-pyrrolo[3,2-c]pyridine
Show/Hide
|
C22H23ClN6O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0464210
|
N-cyclopropyl-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C31H42N4O4
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0731080
|
(+/-)-1-(4-(2-(tert-butylthio)-5-chloro-1H-benzo[d]imidazol-6-yl)-3-methylpiperazin-1-yl)propan-2-one
Show/Hide
|
C19H27ClN4OS
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0335783
|
1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-3-(2-methylsulfanyl-ethyl)-1,3-dihydro-benzimidazol-2-one
Show/Hide
|
C29H41N3O3S
|
2
|
| 1 |
IC50 = 42 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0145420
|
1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-3-(2-oxo-butyl)-1,3-dihydro-benzimidazol-2-one
Show/Hide
|
C30H41N3O4
|
2
|
| 1 |
IC50 = 44 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0816827
|
(+/-)-methyl 3-(5-chloro-6-(4-ethylpiperazin-1-yl)-1H-benzo[d]imidazol-2-ylthio)-3-methylcyclopentylcarbamate
Show/Hide
|
C21H30ClN5O2S
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0526239
|
2-(2-(3-(4-(trifluoromethyl)phenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C23H23F3N4O
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0436582
|
(2R)-1-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-5-oxopyrrolidine-2-carboxamide
Show/Hide
|
C28H35N3O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0463352
|
2-(8-(4-isopropylcyclohexyl)-1-oxo-4-phenyl-2,3,8-triazaspiro[4.5]dec-3-en-2-yl)-N-methylacetamide
Show/Hide
|
C25H36N4O2
|
2
|
| 1 |
IC50 = 53 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
|
CP0440575
|
2-[(2,6-dichlorophenyl)methylsulfanyl]-6-fluoro-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C18H17Cl2FN4S
|
2
|
| 1 |
IC50 = 55 nM
|
|
|
| 2 |
IC50 = 2700 nM
|
|
|
|
CP0145418
|
8-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C27H37N3O3
|
2
|
| 1 |
IC50 = 56 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0542413
|
2-(2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N-ethyl-N-methylethanamine
Show/Hide
|
C23H25ClN4O
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0500235
|
2-(3-(1-((1r,4r)-4-isopropylcyclohexyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C24H36N4O2
|
2
|
| 1 |
IC50 = 59 nM
|
|
|
| 2 |
Ki = 31 nM
|
|
|
|
CP0376136
|
(2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylmethanamine
Show/Hide
|
C21H21ClN4O
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0456473
|
2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-4-(1-methylpiperidin-4-yl)-1H-indole
Show/Hide
|
C24H25ClN4O
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0535157
|
6-fluoro-2-[(4-fluorophenyl)methylsulfanyl]-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C18H18F2N4S
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0381677
|
2-(2-(3-(3-cyclohexylpropyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C23H32N4O
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0051361
|
1-(2-hydroxy-ethyl)-3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydrobenzimidazol-2-one
Show/Hide
|
C28H39N3O4
|
2
|
| 1 |
IC50 = 77 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0486498
|
6-fluoro-2-[(2-methylphenyl)methylsulfanyl]-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C19H21FN4S
|
2
|
| 1 |
IC50 = 78 nM
|
|
|
| 2 |
IC50 = 1700 nM
|
|
|
|
CP0378302
|
1-{1-[3-(2-Chloro-5-methoxy-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H32ClN3O3
|
2
|
| 1 |
IC50 = 80 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0371947
|
N-ethyl-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C30H42N4O4
|
2
|
| 1 |
IC50 = 90 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0309394
|
1-ethoxymethyl-3-{1-[3-(5-methoxy-2-methylphenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydrobenzimidazol-2-one
Show/Hide
|
C29H41N3O4
|
2
|
| 1 |
IC50 = 92 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0542407
|
2-(2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C22H23ClN4O
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0439365
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-(1,3-difluoropropan-2-yl)imidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C24H24Cl3F2N3
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0395368
|
2-(2-(2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)ethoxy)-N,N-dimethylethanamine
Show/Hide
|
C24H27ClN4O2
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0221376
|
1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-3-(2-methylamino-ethyl)-1,3-dihydro-benzimidazol-2-one
Show/Hide
|
C29H42N4O3
|
2
|
| 1 |
IC50 = 99 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0399718
|
N-(2-hydroxyethyl)-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C30H42N4O5
|
2
|
| 1 |
IC50 = 103 nM
|
|
|
| 2 |
Ki = 15 nM
|
|
|
|
CP0463351
|
2-(1'-cyclodecyl-2-oxospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1(2H)-yl)-N-methylacetamide
Show/Hide
|
C25H37N3O3
|
2
|
| 1 |
IC50 = 103 nM
|
|
|
| 2 |
Ki = 28 nM
|
|
|
|
CP0221377
|
2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]ethyl acetate
Show/Hide
|
C30H41N3O5
|
2
|
| 1 |
IC50 = 104 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
|
CP0542412
|
2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-4-(4-methylpiperazin-1-yl)-1H-indole
Show/Hide
|
C23H24ClN5O
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0486494
|
2-[4-(6-chloro-2-propan-2-ylsulfanyl-1H-benzimidazol-5-yl)piperazin-1-yl]ethanol
Show/Hide
|
C16H23ClN4OS
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0309392
|
(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-acetic acid methyl ester
Show/Hide
|
C29H39N3O5
|
2
|
| 1 |
IC50 = 123 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0332957
|
3-(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-propionic acid methyl ester
Show/Hide
|
C30H41N3O5
|
2
|
| 1 |
IC50 = 123 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0378297
|
1-{1-[3-(5-Amino-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H34N4O2
|
2
|
| 1 |
IC50 = 128 nM
|
|
|
| 2 |
Ki = 14 nM
|
|
|
|
CP0496482
|
N-[[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)pyrazol-3-yl]methyl]cyclopentanamine
Show/Hide
|
C21H20Cl3N3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0378298
|
1-{1-[3-(2,5-Dimethyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C26H35N3O2
|
2
|
| 1 |
IC50 = 131 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
|
CP0449596
|
benzyl (4R)-4-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropylcarbamoyl)-1,3-oxazolidine-3-carboxylate
Show/Hide
|
C28H35N3O4
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0443074
|
2-(2-(3-(2-cyclohexylethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C22H30N4O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0530527
|
2-benzylsulfanyl-6-fluoro-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C18H19FN4S
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0371609
|
3-(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-N-methyl-propionamide
Show/Hide
|
C30H42N4O4
|
2
|
| 1 |
IC50 = 158 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0431063
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-ethylimidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C23H24Cl3N3
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0502180
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-pentan-3-ylimidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C26H30Cl3N3
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0545601
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-(2-fluoroethyl)imidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C23H23Cl3FN3
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0392531
|
1-{1-[4-Methyl-3-(5-methyl-2-nitro-phenoxy)-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H32N4O4
|
2
|
| 1 |
IC50 = 165 nM
|
|
|
| 2 |
Ki = 39 nM
|
|
|
|
CP0371958
|
2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-prop-2-enylacetamide
Show/Hide
|
C31H42N4O4
|
2
|
| 1 |
IC50 = 166 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0392170
|
2-phenylsulfanyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C24H30N2OS
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0484089
|
6-fluoro-2-[(3-methylphenyl)methylsulfanyl]-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C19H21FN4S
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0506343
|
N-[[5-(4-chlorophenyl)-1-cyclopropyl-4-(2,4-dichlorophenyl)imidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C24H24Cl3N3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0547516
|
N-[[1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-2-methylpyrrol-3-yl]methyl]cyclopentanamine
Show/Hide
|
C23H23Cl3N2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0551848
|
3-(2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylpropan-1-amine
Show/Hide
|
C23H25ClN4O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0541690
|
N,N-dimethyl-2-[2-[3-[2-(4-methylphenyl)ethyl]-1,2,4-oxadiazol-5-yl]-1H-indol-4-yl]ethanamine
Show/Hide
|
C23H26N4O
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0486946
|
2-anilino-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)benzamide
Show/Hide
|
C29H33N3O
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0486497
|
2-[(2,3-dichlorophenyl)methylsulfonyl]-6-fluoro-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C18H17Cl2FN4O2S
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0392330
|
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-3-phenyl-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C28H30ClN3O2
|
2
|
| 1 |
IC50 = 240 nM
|
|
|
| 2 |
Ki = 8.3 nM
|
|
|
|
CP0496810
|
1-{1-[3-(2-Fluoro-5-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H32FN3O2
|
2
|
| 1 |
IC50 = 244 nM
|
|
|
| 2 |
Ki = 25 nM
|
|
|
|
CP0449600
|
2-(1,3-benzothiazol-2-ylsulfanyl)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)acetamide
Show/Hide
|
C25H29N3OS2
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0484072
|
2-pentan-3-ylsulfanyl-6-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C16H24N4S
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0444889
|
N-cyclobutyl-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C32H44N4O4
|
2
|
| 1 |
IC50 = 328 nM
|
|
|
| 2 |
Ki = 23 nM
|
|
|
|
CP0539501
|
2-(1H-indol-3-yl)-2-oxo-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C26H29N3O2
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0422119
|
2-[3-(1-Cycloheptyl-piperidin-4-yl)-2,2-dioxo-2,3-dihydro-2lambda*6*-benzo[1,2,5]thiadiazol-1-yl]-N-methyl-acetamide
Show/Hide
|
C21H32N4O3S
|
2
|
| 1 |
IC50 = 339 nM
|
|
|
| 2 |
Ki = 111 nM
|
|
|
|
CP0449597
|
2-(3-phenoxyphenyl)-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C30H34N2O2
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0496809
|
4-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)butanamide
Show/Hide
|
C26H34N2O
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0371610
|
2-(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-N,N-dimethyl-acetamide
Show/Hide
|
C30H42N4O4
|
2
|
| 1 |
IC50 = 358 nM
|
|
|
| 2 |
Ki = 22 nM
|
|
|
|
CP0496823
|
3-(1H-indol-3-yl)-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)propanamide
Show/Hide
|
C27H33N3O
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0500573
|
2-(2-(3-((4-chlorophenoxy)methyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C21H21ClN4O2
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0426963
|
N-(2-methoxyethyl)-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C31H44N4O5
|
2
|
| 1 |
IC50 = 436 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0428266
|
2-(2-(3-(cyclohexylmethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C21H28N4O
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0532330
|
2-(2-(3-(2-(bicyclo[2.2.1]heptan-2-yl)ethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C23H30N4O
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0497282
|
2-(1'-(4-isopropylcyclohexyl)-2-oxospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1(2H)-yl)-N-methylacetamide
Show/Hide
|
C24H35N3O3
|
2
|
| 1 |
IC50 = 448 nM
|
|
|
| 2 |
Ki = 106 nM
|
|
|
|
CP0408329
|
2-(2-(3-(4-fluorophenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C22H23FN4O
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0526242
|
2-(2-(3-(4-chlorobenzyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C21H21ClN4O
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0281454
|
arylpyrazole, 1
Show/Hide
|
C20H20Cl3N3
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0547517
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-(2,2-difluoroethyl)imidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C23H22Cl3F2N3
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0548891
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-methylimidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C22H22Cl3N3
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0506344
|
N-[[5-(4-chlorophenyl)-1-cyclobutyl-4-(2,4-dichlorophenyl)imidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C25H26Cl3N3
|
1
|
| 1 |
IC50 = 530 nM
|
|
|
|
CP0510865
|
(E)-3-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)prop-2-enamide
Show/Hide
|
C25H30N2O
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0548888
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-(2-methylpropyl)imidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C25H28Cl3N3
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0497183
|
2-(2-(3-(4-methoxyphenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C23H26N4O2
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0500597
|
2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-4-(2-(pyrrolidin-1-yl)ethyl)-1H-indole
Show/Hide
|
C24H25ClN4O
|
1
|
| 1 |
IC50 = 568 nM
|
|
|
|
CP0382639
|
N-benzyl-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C35H44N4O4
|
2
|
| 1 |
IC50 = 569 nM
|
|
|
| 2 |
Ki = 29 nM
|
|
|
|
CP0464332
|
2-(2-(3-(2-cyclopentylethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C21H28N4O
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0394698
|
2-[hydroxy(phenyl)methyl]-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)benzamide
Show/Hide
|
C30H34N2O2
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0456472
|
2-(2-(5-(4-chlorophenethyl)-1,2,4-oxadiazol-3-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C22H23ClN4O
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0427031
|
N-[[2-(4-chlorophenyl)-1-(2,4-dichlorophenyl)imidazol-4-yl]methyl]cyclopentanamine
Show/Hide
|
C21H20Cl3N3
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0497426
|
1-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)cyclohexane-1-carboxamide
Show/Hide
|
C29H38N2O
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0498921
|
2-(8-(4-tert-butylcyclohexyl)-1-oxo-4-phenyl-2,3,8-triazaspiro[4.5]dec-3-en-2-yl)-N-methylacetamide
Show/Hide
|
C26H38N4O2
|
2
|
| 1 |
IC50 = 685 nM
|
|
|
| 2 |
Ki = 44 nM
|
|
|
|
CP0439434
|
(2E)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-3-phenylprop-2-enamide
Show/Hide
|
C25H32N2O
|
1
|
| 1 |
IC50 = 730 nM
|
|
|
|
CP0392312
|
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-3-phenyl-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C28H30ClN3O3
|
1
|
| 1 |
IC50 = 797 nM
|
|
|
|
CP0157527
|
1-(2-dimethylamino-ethyl)-3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzimidazol-2-one
Show/Hide
|
C30H44N4O3
|
2
|
| 1 |
IC50 = 810 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0515194
|
N-[[4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C22H22Cl3N3
|
1
|
| 1 |
IC50 = 850 nM
|
|
|
|
CP0554326
|
2-(4-chlorophenoxy)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-2-methylpropanamide
Show/Hide
|
C26H33ClN2O2
|
1
|
| 1 |
IC50 = 870 nM
|
|
|
|
CP0496827
|
2-phenoxy-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)propanamide
Show/Hide
|
C25H32N2O2
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0511515
|
6-fluoro-2-[(4-fluorophenyl)methylsulfanyl]-5-(4-methylpiperazin-1-yl)-1H-benzimidazole
Show/Hide
|
C19H20F2N4S
|
1
|
| 1 |
IC50 = 910 nM
|
|
|
|
CP0420149
|
1-(1-{2-[1-(2-Chloro-5-methyl-phenoxy)-cyclohexyl]-2-hydroxy-ethyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C27H34ClN3O3
|
2
|
| 1 |
IC50 = 957 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0490616
|
2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-propan-2-ylacetamide
Show/Hide
|
C31H44N4O4
|
2
|
| 1 |
IC50 = 1028 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0449374
|
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-hexyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H32ClN3O3
|
2
|
| 1 |
IC50 = 1058 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0483214
|
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-5-methyl-hexyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C26H34ClN3O3
|
2
|
| 1 |
IC50 = 1081 nM
|
|
|
| 2 |
Ki = 28 nM
|
|
|
|
CP0505592
|
2-(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-N-propyl-acetamide
Show/Hide
|
C31H44N4O4
|
2
|
| 1 |
IC50 = 1219 nM
|
|
|
| 2 |
Ki = 19 nM
|
|
|
|
CP0449371
|
1-{1-[3-(4-Fluoro-3-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H32FN3O2
|
2
|
| 1 |
IC50 = 1532 nM
|
|
|
| 2 |
Ki = 52 nM
|
|
|
|
CP0436481
|
1-{1-[4-Methyl-3-(2-trifluoromethyl-phenoxy)-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H30F3N3O2
|
2
|
| 1 |
IC50 = 1730 nM
|
|
|
| 2 |
Ki = 24 nM
|
|
|
|
CP0371949
|
N-(cyclopropylmethyl)-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C32H44N4O4
|
2
|
| 1 |
IC50 = 2034 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0509961
|
6-fluoro-2-methylsulfanyl-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C12H15FN4S
|
1
|
| 1 |
IC50 = 2900 nM
|
|
|
|
CP0551950
|
2-[(2,3-dichlorophenyl)methylsulfinyl]-6-fluoro-5-piperazin-1-yl-1H-benzimidazole
Show/Hide
|
C18H17Cl2FN4OS
|
1
|
| 1 |
IC50 = 2900 nM
|
|
|
|
CP0486496
|
1-(2-pentan-3-ylsulfanyl-6-piperazin-1-yl-3H-benzimidazol-5-yl)ethanone
Show/Hide
|
C18H26N4OS
|
1
|
| 1 |
IC50 = 3100 nM
|
|
|
|
CP0496902
|
1-{1-[3-(2-Chloro-5-fluoro-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C24H29ClFN3O2
|
2
|
| 1 |
IC50 = 5179 nM
|
|
|
| 2 |
Ki = 126 nM
|
|
|
|
CP0530529
|
5-(4-benzylpiperazin-1-yl)-6-fluoro-2-[(4-fluorophenyl)methylsulfanyl]-1H-benzimidazole
Show/Hide
|
C25H24F2N4S
|
1
|
| 1 |
IC50 = 8200 nM
|
|
|
|
CP0461954
|
1-{1-[3-(4-Fluoro-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H32FN3O2
|
2
|
| 1 |
IC50 = 9837 nM
|
|
|
| 2 |
Ki = 32 nM
|
|
|
|
CP0530528
|
5-[4-(cyclooctylmethyl)piperazin-1-yl]-6-fluoro-2-[(4-fluorophenyl)methylsulfanyl]-1H-benzimidazole
Show/Hide
|
C27H34F2N4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0374838
|
2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-4,5-bis(1-methylpyrrolidin-2-yl)-1H-indole
Show/Hide
|
C28H32ClN5O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0376140
|
2-(2-(3-butyl-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C18H24N4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0376269
|
N,N-dimethyl-2-[2-[3-[2-(oxan-4-yl)ethyl]-1,2,4-oxadiazol-5-yl]-1H-indol-4-yl]ethanamine
Show/Hide
|
C21H28N4O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0381745
|
4-(2-(5-(4-(2-(dimethylamino)ethyl)-1H-indol-2-yl)-1,2,4-oxadiazol-3-yl)ethyl)-N,N-dimethylbenzenamine
Show/Hide
|
C24H29N5O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0391017
|
2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-4-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C22H23ClN6O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0394249
|
2-(2-(5-(4-chlorophenethyl)oxazol-2-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C23H24ClN3O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0394258
|
2-(2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-5-yl)-N,N-dimethylethanamine
Show/Hide
|
C22H23ClN4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0395346
|
2-(2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-7-yl)-N,N-dimethylethanamine
Show/Hide
|
C22H23ClN4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0428244
|
2-(2-(3-(2-cyclopropylethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C19H24N4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0433521
|
2-(2-(3-(3,3-dimethylbutyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C20H28N4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0443061
|
2-(2-(5-(4-chlorophenethyl)-1,3,4-oxadiazol-2-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C22H23ClN4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0443080
|
2-(2-(3-isopentyl-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C19H26N4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0449481
|
N,N-dimethyl-2-[2-[3-(3-pyrrolidin-1-ylpropyl)-1,2,4-oxadiazol-5-yl]-1H-indol-4-yl]ethanamine
Show/Hide
|
C21H29N5O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0453078
|
N-[3-(4-chlorophenyl)propyl]-4-[2-(dimethylamino)ethyl]-1H-indole-2-carboxamide
Show/Hide
|
C22H26ClN3O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0453090
|
N,N-dimethyl-2-[2-[3-(2-pyridin-4-ylethyl)-1,2,4-oxadiazol-5-yl]-1H-indol-4-yl]ethanamine
Show/Hide
|
C21H23N5O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0453091
|
N,N-dimethyl-2-[2-[3-(2-pyridin-3-ylethyl)-1,2,4-oxadiazol-5-yl]-1H-indol-4-yl]ethanamine
Show/Hide
|
C21H23N5O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0461470
|
N,N-dimethyl-2-[2-[3-(2-phenylethyl)-1,2,4-oxadiazol-5-yl]-1H-indol-4-yl]ethanamine
Show/Hide
|
C22H24N4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0496032
|
N,N-dimethyl-2-[2-(3-propyl-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl]ethanamine
Show/Hide
|
C17H22N4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0497174
|
2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-4-(2-morpholinoethyl)-1H-indole
Show/Hide
|
C24H25ClN4O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0500680
|
N-[2-(4-chlorophenyl)ethyl]-4-[2-(dimethylamino)ethyl]-1H-indole-2-carboxamide
Show/Hide
|
C21H24ClN3O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0501099
|
N,N-dimethyl-2-[2-[3-(2-pyridin-2-ylethyl)-1,2,4-oxadiazol-5-yl]-1H-indol-4-yl]ethanamine
Show/Hide
|
C21H23N5O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0502054
|
2-(2-(3-(3-(4-chlorophenyl)propyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C23H25ClN4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0505670
|
2-(2-(3-(3-methoxy-3-methylbutyl)-1,2,4-oxadiazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C20H28N4O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0505671
|
2-(2-(3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)-1H-indol-6-yl)-N,N-dimethylethanamine
Show/Hide
|
C22H23ClN4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0515800
|
2-(2-(2-(4-chlorophenethyl)-2H-tetrazol-5-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Show/Hide
|
C21H23ClN6
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0394717
|
5-methyl-3-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)-1,2-oxazole-4-carboxamide
Show/Hide
|
C27H31N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0422202
|
N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)-1,2,3,4-tetrahydronaphthalene-2-carboxamide
Show/Hide
|
C27H34N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0428298
|
2-(2,3-dihydro-1H-inden-2-yl)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)acetamide
Show/Hide
|
C27H34N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0428299
|
2-naphthalen-2-yl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C28H32N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0428304
|
2-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C24H30N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0436580
|
1-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)cyclopentane-1-carboxamide
Show/Hide
|
C28H36N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0436581
|
(2R)-2-hydroxy-3-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)propanamide
Show/Hide
|
C25H32N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0436583
|
3-oxo-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)-1,2-dihydroindene-1-carboxamide
Show/Hide
|
C26H30N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0439432
|
N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)-2,3-dihydro-1H-indene-2-carboxamide
Show/Hide
|
C26H32N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0449593
|
(2S,3R)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-3-hydroxy-2-(phenylformamido)butanamide
Show/Hide
|
C27H35N3O3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0449595
|
3-phenoxy-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)pyridine-2-carboxamide
Show/Hide
|
C28H31N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0449598
|
tert-butyl N-[1-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropylcarbamoyl)cyclohexyl]carbamate
Show/Hide
|
C28H43N3O3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0449599
|
1-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-2-N-phenylcyclohexane-1,2-dicarboxamide
Show/Hide
|
C30H39N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0449602
|
1-pyrimidin-2-yl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)piperidine-4-carboxamide
Show/Hide
|
C26H35N5O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0449603
|
(2Z)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-3-(2-methoxyphenyl)prop-2-enamide
Show/Hide
|
C26H32N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0460171
|
2-(6-methoxy-3-oxo-1,2-dihydroinden-2-yl)-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C28H34N2O3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0460177
|
N-[1-oxo-1-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropylamino)propan-2-yl]benzamide
Show/Hide
|
C26H33N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0460204
|
2-methoxy-2-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C25H32N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0460205
|
N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide
Show/Hide
|
C25H30N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0483467
|
2-oxo-3-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)propanamide
Show/Hide
|
C25H30N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0486947
|
N-[(1S,2S)-2-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropylcarbamoyl)cyclohexyl]benzamide
Show/Hide
|
C30H39N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0486948
|
2-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-3,3-dimethylbutanamide
Show/Hide
|
C29H40N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0491912
|
2-naphthalen-1-yl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C28H32N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0491913
|
2-cyclohexyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-2-hydroxy-2-phenylacetamide
Show/Hide
|
C30H40N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0496582
|
3-(2H-1,3-benzodioxol-5-yl)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-2-oxopropanamide
Show/Hide
|
C26H30N2O4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0496824
|
2-(2,4-dichlorophenoxy)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)propanamide
Show/Hide
|
C25H30Cl2N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0496828
|
4-oxo-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)chromene-2-carboxamide
Show/Hide
|
C26H28N2O3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0496829
|
(2E)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-4-(4-methylphenyl)-4-oxobut-2-enamide
Show/Hide
|
C27H32N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0496830
|
2-methyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)-1H-indene-1-carboxamide
Show/Hide
|
C27H32N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0496831
|
N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)-9H-fluorene-1-carboxamide
Show/Hide
|
C30H32N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0497185
|
N-[(1S,2R)-2-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropylcarbamoyl)cyclohexyl]benzamide
Show/Hide
|
C30H39N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0497186
|
N-methyl-N-[2-oxo-2-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropylamino)ethyl]benzamide
Show/Hide
|
C26H33N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0500669
|
3-[hydroxy(phenyl)methyl]-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)pyridine-2-carboxamide
Show/Hide
|
C29H33N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0509355
|
(2S)-1-benzoyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)pyrrolidine-2-carboxamide
Show/Hide
|
C28H35N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0509546
|
2,3-diphenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)propanamide
Show/Hide
|
C31H36N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0514215
|
3-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)pyridine-2-carboxamide
Show/Hide
|
C28H31N3O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0514216
|
1-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)-2,3-dihydroindole-2-carboxamide
Show/Hide
|
C31H35N3O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0514217
|
5-(4-chlorophenyl)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)furan-2-carboxamide
Show/Hide
|
C27H29ClN2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0515838
|
(2Z)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-2-acetamido-3-phenylprop-2-enamide
Show/Hide
|
C27H33N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0515839
|
(2E)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-3-(1H-indol-3-yl)prop-2-enamide
Show/Hide
|
C27H31N3O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0554325
|
(2R)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-2-hydroxy-3-phenylpropanamide
Show/Hide
|
C29H32N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0562434
|
2-oxo-2-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C28H29F3N4O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0562444
|
2-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)cyclopropane-1-carboxamide
Show/Hide
|
C26H32N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0382055
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C21H19Cl3N2S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0427037
|
N-[[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1,2,4-triazol-3-yl]methyl]cyclopentanamine
Show/Hide
|
C20H19Cl3N4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0431065
|
N-[[5-(4-chlorophenyl)-1-cyclopentyl-4-(2,4-dichlorophenyl)imidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C26H28Cl3N3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0439367
|
N-[[5-(4-chlorophenyl)-1-cyclohexyl-4-(2,4-dichlorophenyl)imidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C27H30Cl3N3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0439489
|
N-[[1-(3,4-difluorophenyl)-5-methyltriazol-4-yl]methyl]cyclopentanamine
Show/Hide
|
C15H18F2N4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0505770
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1,3-oxazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C21H19Cl3N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0505771
|
N-[[4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-3-methylfuran-2-yl]methyl]cyclopentanamine
Show/Hide
|
C23H22Cl3NO
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0505773
|
N-[[5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C23H21Cl3F3N3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0507991
|
N-[(3,5-dimethyl-1-phenylpyrazol-4-yl)methyl]cyclopentanamine
Show/Hide
|
C17H23N3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0509263
|
N-[[5-(3,5-difluorophenyl)-4-methyl-1,2,4-triazol-3-yl]methyl]cyclopentanamine
Show/Hide
|
C15H18F2N4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0509264
|
N-[[1-tert-butyl-5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)imidazol-2-yl]methyl]cyclopentanamine
Show/Hide
|
C25H28Cl3N3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0452007
|
(2R)-1-benzyl-N-[3-[4-(2,6-dichlorophenyl)piperidin-1-yl]propyl]pyrrolidine-2-carboxamide
Show/Hide
|
C26H33Cl2N3O
|
2
|
| 1 |
Kd = 0.123 nM
|
|
|
| 2 |
Ki = 0.7244 nM
|
|
|
|
CP0871631
|
[Nphe1Aib7Arg14Lys15]N/OFQ-NH2
Show/Hide
|
C83H140N32O21
|
2
|
| 1 |
Kd = 2.089 nM
|
|
|
| 2 |
Ki = 0.1778 nM
|
|
|
|
CP0386706
|
2-[(2-chlorophenyl)methyl]-3-(2-chlorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanamide
Show/Hide
|
C21H24Cl2N2O2S
|
1
|
| 1 |
Ki = 0.0373 nM
|
|
|
|
CP0476075
|
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanamide
Show/Hide
|
C51H73N17O9
|
1
|
| 1 |
Ki = 0.04 nM
|
|
|
|
CP0419962
|
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanamide
Show/Hide
|
C49H68FN17O8
|
1
|
| 1 |
Ki = 0.05 nM
|
|
|
|
CP0411715
|
2,3-dihydroxybutanedioic acid;1-[3-fluoro-2-[4-[(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]phenyl]-N,N-dimethylmethanamine
Show/Hide
|
C25H30F2N4OS
|
1
|
| 1 |
Ki = 0.0648 nM
|
|
|
|
CP0386702
|
N-cyclopropyl-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide
Show/Hide
|
C25H30F2N2O2S
|
1
|
| 1 |
Ki = 0.0672 nM
|
|
|
|
CP0541377
|
1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]methyl]-2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine];2,3-dihydroxybutanedioic acid
Show/Hide
|
C26H28F3N3O7S
|
1
|
| 1 |
Ki = 0.0711 nM
|
|
|
|
CP0851387
|
(+)2-Fluorophenylmethyl-3-(2-chlorospiro[4,5-dihydrothieno[2,3-c]-pyran-7,4'-piperidine]-1'-yl)-N,N-dimethylpropanamide L-tatrtaric acid salt
Show/Hide
|
C27H34ClFN2O8S
|
1
|
| 1 |
Ki = 0.0892 nM
|
|
|
|
CP0500933
|
(2S)-2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide
Show/Hide
|
C22H26ClFN2O2S
|
1
|
| 1 |
Ki = 0.09 nM
|
|
|
|
CP0908351
|
(-)2-(2-chlorobenzyl)-3-(2'-fluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)-N-methylpropanamide
Show/Hide
|
C22H26ClFN2O2S
|
1
|
| 1 |
Ki = 0.0902 nM
|
|
|
|
CP0541376
|
2-chloro-1'-[[1-[3-(methoxymethyl)pyridin-2-yl]-3-methylpyrazol-4-yl]methyl]spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine];2,3-dihydroxybutanedioic acid
Show/Hide
|
C23H27ClN4O2S
|
1
|
| 1 |
Ki = 0.0908 nM
|
|
|
|
CP0411713
|
2-chloro-4,4-difluoro-1'-[[1-[3-(1H-imidazol-2-yl)pyridin-2-yl]-3-methylpyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]
Show/Hide
|
C24H23ClF2N6OS
|
1
|
| 1 |
Ki = 0.0916 nM
|
|
|
|
CP0457150
|
2,3-dihydroxybutanedioic acid;2-fluoro-1'-[[1-[3-(methoxymethyl)pyridin-2-yl]-3-methylpyrazol-4-yl]methyl]spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]
Show/Hide
|
C23H27FN4O2S
|
1
|
| 1 |
Ki = 0.0939 nM
|
|
|
|
CP0457149
|
2,3-dihydroxybutanedioic acid;3-fluoro-2-[4-[(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]benzamide
Show/Hide
|
C27H30F2N4O8S
|
1
|
| 1 |
Ki = 0.0954 nM
|
|
|
|
CP0411718
|
1-[2-[4-[(2-chloro-4,4-difluorospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]-3-fluorophenyl]-N-methylmethanamine;2,3-dihydroxybutanedioic acid
Show/Hide
|
C28H32ClF3N4O7S
|
1
|
| 1 |
Ki = 0.097 nM
|
|
|
|
CP0459239
|
(2S)-2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanamide
Show/Hide
|
C21H24ClFN2O2S
|
1
|
| 1 |
Ki = 0.101 nM
|
|
|
|
CP0482591
|
[2-[4-[(2-chloro-4,4-difluorospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]pyridin-3-yl]methanol;2,3-dihydroxybutanedioic acid
Show/Hide
|
C26H29ClF2N4O8S
|
1
|
| 1 |
Ki = 0.105 nM
|
|
|
|
CP0427578
|
(2S)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanamide
Show/Hide
|
C21H24F2N2O2S
|
1
|
| 1 |
Ki = 0.106 nM
|
|
|
|
CP0877758
|
(S)(-)3-(2'-Fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]-pyran]-1-yl)2-(2-Fluorobenzyl)-N,N-dimethylpropanamide L-tatrtaric acid salt
Show/Hide
|
C27H34F2N2O8S
|
1
|
| 1 |
Ki = 0.114 nM
|
|
|
|
CP0419950
|
[2-[4-[(2-chloro-4,4-difluorospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]-3-fluorophenyl]methanol;2,3-dihydroxybutanedioic acid
Show/Hide
|
C27H29ClF3N3O8S
|
1
|
| 1 |
Ki = 0.114 nM
|
|
|
|
CP0411711
|
1-[2-[4-[(2-chlorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]-3-fluorophenyl]-N,N-dimethylmethanamine;2,3-dihydroxybutanedioic acid
Show/Hide
|
C25H30ClFN4OS
|
1
|
| 1 |
Ki = 0.122 nM
|
|
|
|
CP0526716
|
2-[(2-chlorophenyl)methyl]-3-(2-chlorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide
Show/Hide
|
C22H26Cl2N2O2S
|
1
|
| 1 |
Ki = 0.124 nM
|
|
|
|
CP0481496
|
2-[(2-chlorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-(2-fluorophenyl)-N-methylpropanamide
Show/Hide
|
C22H26ClFN2O2S
|
1
|
| 1 |
Ki = 0.127 nM
|
|
|
|
CP0422699
|
(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[2-(benzylamino)acetyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-N-[(2S)-5-(diaminoamino)-1-hydrazinyl-1,5-dioxopentan-2-yl]butanediamide
Show/Hide
|
C82H141N35O21
|
1
|
| 1 |
Ki = 0.1288 nM
|
|
|
|
CP0386700
|
2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N,N-dimethylpropanamide
Show/Hide
|
C23H28ClFN2O2S
|
1
|
| 1 |
Ki = 0.134 nM
|
|
|
|
CP0386701
|
(2S)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methyl-N-propan-2-ylpropanamide
Show/Hide
|
C25H32F2N2O2S
|
1
|
| 1 |
Ki = 0.137 nM
|
|
|
|
CP0419951
|
2,3-dihydroxybutanedioic acid;2-fluoro-1'-[[1-(3-fluoropyridin-2-yl)-3-methylpyrazol-4-yl]methyl]spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]
Show/Hide
|
C25H28F2N4O7S
|
1
|
| 1 |
Ki = 0.139 nM
|
|
|
|
CP0411717
|
1-[2-[4-[(2-chloro-4,4-difluorospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]-3-fluorophenyl]-N,N-dimethylmethanamine;2,3-dihydroxybutanedioic acid
Show/Hide
|
C25H28ClF3N4OS
|
1
|
| 1 |
Ki = 0.145 nM
|
|
|
|
CP0375814
|
(2S)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide
Show/Hide
|
C22H26F2N2O2S
|
2
|
| 1 |
Ki = 0.15 nM
|
|
|
| 2 |
Ki = 0.174 nM
|
|
|
|
CP0846655
|
(-)2-Chlorophenylmethyl-3-(2-chlorospiro[4,5-dihydrothieno[2,3-c]-pyran-7,4'-piperidine]-1'-yl)-N,N-dimethylpropanamide L-tatrtaric acid salt
Show/Hide
|
C27H34Cl2N2O8S
|
1
|
| 1 |
Ki = 0.169 nM
|
|
|
|
CP0411712
|
2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]methyl]-4,4-difluorospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine];2,3-dihydroxybutanedioic acid
Show/Hide
|
C22H20ClF4N3OS
|
1
|
| 1 |
Ki = 0.172 nM
|
|
|
|
CP0411716
|
2-chloro-4,4-difluoro-1'-[[1-(3-fluoropyridin-2-yl)-3-methylpyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine];2,3-dihydroxybutanedioic acid
Show/Hide
|
C21H20ClF3N4OS
|
1
|
| 1 |
Ki = 0.176 nM
|
|
|
|
CP0411714
|
2-chloro-4,4-difluoro-1'-[[1-[3-(methoxymethyl)pyridin-2-yl]-3-methylpyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine];2,3-dihydroxybutanedioic acid
Show/Hide
|
C27H31ClF2N4O8S
|
1
|
| 1 |
Ki = 0.185 nM
|
|
|
|
CP0435919
|
2-[(2-chlorophenyl)methyl]-N-cyclopropyl-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide
Show/Hide
|
C25H30ClFN2O2S
|
1
|
| 1 |
Ki = 0.194 nM
|
|
|
|
CP0463349
|
2-(3-(1-cyclodecylpiperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C25H38N4O2
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0459238
|
(2S)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-propan-2-ylpropanamide
Show/Hide
|
C24H30F2N2O2S
|
1
|
| 1 |
Ki = 0.231 nM
|
|
|
|
CP0920434
|
(+)3-(2'-Fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]-pyran]-1-yl)2-(1H-pyrazol-1-ylmethyl)-N,N-dimethylpropanamide L-tatrtaric acid salt
Show/Hide
|
C24H33FN4O8S
|
1
|
| 1 |
Ki = 0.248 nM
|
|
|
|
CP0873332
|
(5S,7S)-7-((4-(2,6-dichlorophenyl)piperidin-1-yl)methyl)-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol
Show/Hide
|
C24H29Cl2NO
|
1
|
| 1 |
Ki = 0.253 nM
|
|
|
|
CP0387899
|
8-(dio-tolylmethyl)-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C28H31NO
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0464699
|
8-(8-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26FN3O
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0419949
|
1-[2-[4-[(2-chloro-4,4-difluorospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]pyridin-3-yl]-N,N-dimethylmethanamine;2,3-dihydroxybutanedioic acid
Show/Hide
|
C24H28ClF2N5OS
|
1
|
| 1 |
Ki = 0.371 nM
|
|
|
|
CP0386703
|
2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N,N-dimethylpropanamide
Show/Hide
|
C23H28F2N2O2S
|
1
|
| 1 |
Ki = 0.396 nM
|
|
|
|
CP0421763
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-{2-[(3-methylbutyl)amino]ethyl}-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C32H46N4O
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0472065
|
3-[2-(butylamino)ethyl]-8-[(2,6-dichlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C26H34Cl2N4O
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0457952
|
4-(2-(aminomethyl)phenyl)-1-(1-phenylpentyl)piperidin-4-ol
Show/Hide
|
C23H32N2O
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0528546
|
2-cyclobutyl-1-[8-(dimethylamino)-8-phenyl-2-azaspiro[4.5]decan-2-yl]ethanone
Show/Hide
|
C23H34N2O
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0393275
|
(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[2-(benzylamino)acetyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]pentanediamide
Show/Hide
|
C79H130N28O21
|
1
|
| 1 |
Ki = 0.4169 nM
|
|
|
|
CP0403795
|
1'-(4-isopropylcyclohexyl)-2-methyl-5-phenyl-(3aR,6aR)-spiro[perhydrocyclopenta[c]pyrrole-4,4'-(hexahydropyridine)]
Show/Hide
|
C27H42N2
|
1
|
| 1 |
Ki = 0.49 nM
|
|
|
|
CP0231166
|
3-[2-(butylamino)ethyl]-8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H44N4O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0401323
|
3-{2-[(cyclopropylmethyl)amino]ethyl}-8-[(2,6-dichlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C26H32Cl2N4O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0421769
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-{2-[(2-methylpropyl)amino]ethyl}-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H44N4O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0439569
|
3-[2-(cyclobutylamino)ethyl]-8-[(2,6-dichlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C26H32Cl2N4O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0450457
|
8-[(2,6-dichlorophenyl)methyl]-3-{2-[(2-methylpropyl)amino]ethyl}-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C26H34Cl2N4O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0428519
|
4-(2-(aminomethyl)phenyl)-1-(1-phenylhexyl)piperidin-4-ol
Show/Hide
|
C24H34N2O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0433317
|
4-(2-(aminomethyl)phenyl)-1-(bis(2-chlorophenyl)methyl)piperidin-4-ol
Show/Hide
|
C25H26Cl2N2O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0457956
|
4-(2-(aminomethyl)phenyl)-1-(bis(2-fluorophenyl)methyl)piperidin-4-ol
Show/Hide
|
C25H26F2N2O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0465183
|
4-(2-(aminomethyl)phenyl)-1-((2-chlorophenyl)(phenyl)methyl)piperidin-4-ol
Show/Hide
|
C25H27ClN2O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0501501
|
4-(2-(aminomethyl)phenyl)-1-(dio-tolylmethyl)piperidin-4-ol
Show/Hide
|
C27H32N2O
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0433735
|
2-[3-[1-[(3S)-3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-methylacetamide
Show/Hide
|
C29H40N4O4
|
1
|
| 1 |
Ki = 0.5012 nM
|
|
|
|
CP0439565
|
3-[2-(butylamino)ethyl]-8-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H43ClN4O
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0450456
|
8-[(2,6-dichlorophenyl)methyl]-1-phenyl-3-[2-(propylamino)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C25H32Cl2N4O
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0445680
|
1-((2-ethylphenyl)(phenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C26H29NO
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0465215
|
1-(bis(2-chlorophenyl)methyl)-4-(2-((4-(isopropylsulfonyl)piperazin-1-yl)methyl)phenyl)piperidin-4-ol
Show/Hide
|
C32H39Cl2N3O3S
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0417444
|
8-[(2,6-dichlorophenyl)methyl]-3-[2-(ethylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C24H30Cl2N4O
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0472268
|
3-{2-[(cyclohexylmethyl)amino]ethyl}-8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C34H48N4O
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0491349
|
8-[(2,6-dichlorophenyl)methyl]-1-phenyl-3-[2-(propan-2-ylamino)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C25H32Cl2N4O
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0436537
|
4-(2-(aminomethyl)phenyl)-1-(phenyl(o-tolyl)methyl)piperidin-4-ol
Show/Hide
|
C26H30N2O
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0437915
|
1-(bis(2-chlorophenyl)methyl)-4-(2-((methylamino)methyl)phenyl)piperidin-4-ol
Show/Hide
|
C26H28Cl2N2O
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0556855
|
1-[2-[8-(dimethylamino)-8-phenyl-2-azaspiro[4.5]decan-2-yl]-2-oxoethyl]cyclobutane-1-carbonitrile
Show/Hide
|
C24H33N3O
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0421768
|
8-[(2,6-dichlorophenyl)methyl]-3-[2-(methylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C23H28Cl2N4O
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0510046
|
3-{2-[(cyclopropylmethyl)amino]ethyl}-8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H42N4O
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0445014
|
8-(5-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26FN3O
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0559603
|
2-(cyclopentylmethyl)-N,N-dimethyl-8-thiophen-2-yl-2-azaspiro[4.5]decan-8-amine
Show/Hide
|
C21H34N2S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0372851
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-3-[2-(prop-2-en-1-ylamino)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C30H40N4O
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0372861
|
3-[2-(cyclohexylamino)ethyl]-8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C33H46N4O
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0431370
|
3-[2-(cyclopentylamino)ethyl]-8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C32H44N4O
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0428114
|
8-(7-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26FN3O
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0437198
|
1-(bis(2-chlorophenyl)methyl)-4-(2-((4-(ethylsulfonyl)piperazin-1-yl)methyl)phenyl)piperidin-4-ol
Show/Hide
|
C31H37Cl2N3O3S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0421771
|
8-[(2,6-dichlorophenyl)methyl]-3-[2-(diethylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C26H34Cl2N4O
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0472274
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-3-[2-(propylamino)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C30H42N4O
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0035232
|
(+)-2-(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-N-methyl-acetamide
Show/Hide
|
C29H40N4O4
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0454020
|
1-phenyl-8-(1-phenyl-pentyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H31N3O
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0433321
|
4-(2-(aminomethyl)phenyl)-1-((2-bromophenyl)(phenyl)methyl)piperidin-4-ol
Show/Hide
|
C25H27BrN2O
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0427873
|
8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C22H25N3O
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0409536
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(1,3-thiazol-4-ylmethyl)benzimidazol-2-one
Show/Hide
|
C30H38N4O3S
|
1
|
| 1 |
Ki = 1.202 nM
|
|
|
|
CP0417446
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C25H31N3O
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0489530
|
N-methyl-2-[2-oxo-3-(1-spiro[5.5]undecan-4-ylpiperidin-4-yl)benzimidazol-1-yl]acetamide
Show/Hide
|
C26H38N4O2
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0401327
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-3-[2-(pyrrolidin-1-yl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H42N4O
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0450476
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-3-[2-(propan-2-ylamino)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C30H42N4O
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0384913
|
1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H27N3O
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0427872
|
8-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H30ClN3O
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0461171
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(thiophen-2-ylmethyl)benzimidazol-2-one
Show/Hide
|
C31H39N3O3S
|
1
|
| 1 |
Ki = 1.413 nM
|
|
|
|
CP0401324
|
3-[2-(cyclobutylamino)ethyl]-8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H42N4O
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0382634
|
8-(4-methyl-1-phenyl-pentyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H33N3O
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0394324
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(thiophen-3-ylmethyl)benzimidazol-2-one
Show/Hide
|
C31H39N3O3S
|
1
|
| 1 |
Ki = 1.514 nM
|
|
|
|
CP0450475
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-[2-(ethylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C29H40N4O
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0437102
|
4-(2-(aminomethyl)phenyl)-1-benzhydrylpiperidin-4-ol
Show/Hide
|
C25H28N2O
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0430177
|
1-[2-[8-(dimethylamino)-3-oxo-8-phenyl-2-azaspiro[4.5]decan-2-yl]ethyl]cyclobutane-1-carbonitrile
Show/Hide
|
C24H33N3O
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0423876
|
2-[(5-fluorospiro[1H-2-benzofuran-3,4'-piperidine]-1'-yl)methyl]-N,N-dimethyl-3-(1,3-thiazol-4-yl)propanamide
Show/Hide
|
C21H26FN3O2S
|
1
|
| 1 |
Ki = 1.64 nM
|
|
|
|
CP0433738
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(1,2,4-thiadiazol-3-ylmethyl)benzimidazol-2-one
Show/Hide
|
C29H37N5O3S
|
1
|
| 1 |
Ki = 1.698 nM
|
|
|
|
CP0421761
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(2-hydroxyethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C27H35N3O2
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0070437
|
8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C27H26Cl2N2O
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0945715
|
2-(3-(1-(4-isopropylcyclohexyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C24H36N4O2
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0479565
|
3-[2-(butylamino)ethyl]-8-(5-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C29H39ClN4O
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0480308
|
4-(2-(aminomethyl)phenyl)-1-(bis(2-bromophenyl)methyl)piperidin-4-ol
Show/Hide
|
C25H26Br2N2O
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0375812
|
2-[(2-chlorophenyl)methyl]-N,N-dimethyl-3-spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-ylpropanamide
Show/Hide
|
C23H29ClN2O2S
|
1
|
| 1 |
Ki = 1.84 nM
|
|
|
|
CP0394297
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(1,2,4-triazol-1-ylmethyl)benzimidazol-2-one
Show/Hide
|
C29H38N6O3
|
1
|
| 1 |
Ki = 1.862 nM
|
|
|
|
CP0399270
|
8-((2-chloro-4-methylphenyl)(2-chlorophenyl)methyl)-3-cyclopentyl-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C26H31Cl2NO
|
1
|
| 1 |
Ki = 1.9 nM
|
|
|
|
CP0461908
|
1-(bis(2-chlorophenyl)methyl)-4-(2-(piperazin-1-ylmethyl)phenyl)piperidin-4-ol
Show/Hide
|
C29H33Cl2N3O
|
1
|
| 1 |
Ki = 1.9 nM
|
|
|
|
CP0471368
|
1-(2-methoxyethyl)-3-[1-[(3S)-3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]benzimidazol-2-one
Show/Hide
|
C29H41N3O4
|
1
|
| 1 |
Ki = 1.995 nM
|
|
|
|
CP0399273
|
1-(8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octan-3-yl)-3-methylurea
Show/Hide
|
C28H29Cl2N3O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0382638
|
8-(5-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0433756
|
1-(2-(1-(bis(2-chlorophenyl)methyl)-4-hydroxypiperidin-4-yl)benzyl)-3-methylurea
Show/Hide
|
C27H29Cl2N3O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0450727
|
8-[bis(2-chlorophenyl)methyl]-3-[2-(ethylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C30H34Cl2N4O
|
1
|
| 1 |
Ki = 2.1 nM
|
|
|
|
CP0491353
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-[2-(methylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C28H38N4O
|
1
|
| 1 |
Ki = 2.1 nM
|
|
|
|
CP0439563
|
8-[bis(2-chlorophenyl)methyl]-3-[2-(butylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C32H38Cl2N4O
|
1
|
| 1 |
Ki = 2.15 nM
|
|
|
|
CP0437199
|
1-(bis(2-chlorophenyl)methyl)-4-(2-((4-methylpiperazin-1-yl)methyl)phenyl)piperidin-4-ol
Show/Hide
|
C30H35Cl2N3O
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0372850
|
8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(pyrrolidin-1-yl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C32H36Cl2N4O
|
1
|
| 1 |
Ki = 2.25 nM
|
|
|
|
CP0382623
|
8-[(2,6-dichlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C20H21Cl2N3O
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0491352
|
8-[(2,6-dichlorophenyl)methyl]-1-phenyl-3-[2-(pyrrolidin-1-yl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C26H32Cl2N4O
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0511844
|
8-benzhydryl-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C26H27NO
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0549304
|
1-[2-[8-(dimethylamino)-8-phenyl-2-azaspiro[4.5]decan-2-yl]ethyl]cyclobutane-1-carbonitrile
Show/Hide
|
C24H35N3
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0433622
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(1,2,4-oxadiazol-3-ylmethyl)benzimidazol-2-one
Show/Hide
|
C29H37N5O4
|
1
|
| 1 |
Ki = 2.399 nM
|
|
|
|
CP0409409
|
1-phenyl-8-(1-phenyl-butyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H29N3O
|
1
|
| 1 |
Ki = 2.4 nM
|
|
|
|
CP0428050
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(1,3-oxazol-4-ylmethyl)benzimidazol-2-one
Show/Hide
|
C30H38N4O4
|
1
|
| 1 |
Ki = 2.512 nM
|
|
|
|
CP0461274
|
8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(propan-2-ylamino)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H36Cl2N4O
|
1
|
| 1 |
Ki = 2.55 nM
|
|
|
|
CP0382625
|
8-(8-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 2.6 nM
|
|
|
|
CP0475112
|
8-((2-chloro-4-methylphenyl)(2-chlorophenyl)methyl)-3-(3-fluorophenyl)-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C27H26Cl2FNO
|
1
|
| 1 |
Ki = 2.7 nM
|
|
|
|
CP0506548
|
N-methyl-2-[3-[1-[(4-methylnaphthalen-1-yl)methyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C27H30N4O2
|
1
|
| 1 |
Ki = 2.7 nM
|
|
|
|
CP0401321
|
8-[bis(2-chlorophenyl)methyl]-3-{2-[(2-methylpropyl)amino]ethyl}-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C32H38Cl2N4O
|
1
|
| 1 |
Ki = 2.75 nM
|
|
|
|
CP0430176
|
2-butyl-N,N-dimethyl-8-thiophen-2-yl-2-azaspiro[4.5]decan-8-amine
Show/Hide
|
C19H32N2S
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0675515
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(4-fluorobenzyl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C28H27Cl2FN2O
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0858738
|
endo-2-(8-(bis(2-chlorophenyl)methyl)-3-(4-fluorobenzyl)-8-azabicyclo[3.2.1]octan-3-yl)acetamide
Show/Hide
|
C29H29Cl2FN2O
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0858739
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(pyridin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H25Cl2N3O
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0399269
|
8-(bis(2-chlorophenyl)methyl)-3-(pyridin-3-yl)-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C25H24Cl2N2O
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0428368
|
8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxylic acid
Show/Hide
|
C27H25Cl2NO2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0475115
|
8-((2-chloro-4-methylphenyl)(2-chlorophenyl)methyl)-3-(1,4,5,6-tetrahydropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C25H29Cl2N3O
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0377402
|
4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol
Show/Hide
|
C25H27NO
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0417457
|
8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[3-(pyrrolidin-1-yl)propyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C33H38Cl2N4O
|
1
|
| 1 |
Ki = 3.2 nM
|
|
|
|
CP0464696
|
8-(2-chloro-benzyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C20H22ClN3O
|
1
|
| 1 |
Ki = 3.2 nM
|
|
|
|
CP0461168
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(pyrazol-1-ylmethyl)benzimidazol-2-one
Show/Hide
|
C30H39N5O3
|
1
|
| 1 |
Ki = 3.311 nM
|
|
|
|
CP0375404
|
8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C26H25Cl2NO
|
1
|
| 1 |
Ki = 3.4 nM
|
|
|
|
CP0417456
|
8-[bis(2-chlorophenyl)methyl]-3-[2-(dimethylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C30H34Cl2N4O
|
1
|
| 1 |
Ki = 3.5 nM
|
|
|
|
CP0464700
|
1-phenyl-8-(1-phenyl-ethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C21H25N3O
|
1
|
| 1 |
Ki = 3.5 nM
|
|
|
|
CP0498942
|
2-(3-(1-(decahydronaphthalen-2-yl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C25H36N4O2
|
1
|
| 1 |
Ki = 3.5 nM
|
|
|
|
CP0433736
|
1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]benzimidazol-2-one
Show/Hide
|
C32H42N4O4
|
1
|
| 1 |
Ki = 3.548 nM
|
|
|
|
CP0453865
|
3-[2-(benzylamino)ethyl]-8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C34H42N4O
|
1
|
| 1 |
Ki = 3.6 nM
|
|
|
|
CP0493785
|
3-(8-((2-chloro-4-methylphenyl)(2-chlorophenyl)methyl)-3-hydroxy-8-azabicyclo[3.2.1]octan-3-yl)pyrrolidin-2-one
Show/Hide
|
C25H28Cl2N2O2
|
1
|
| 1 |
Ki = 3.6 nM
|
|
|
|
CP0431363
|
8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclopropylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H34Cl2N4O
|
1
|
| 1 |
Ki = 3.7 nM
|
|
|
|
CP0449142
|
1-(1H-imidazol-5-ylmethyl)-3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]benzimidazol-2-one
Show/Hide
|
C30H39N5O3
|
1
|
| 1 |
Ki = 3.715 nM
|
|
|
|
CP0453855
|
8-[bis(2-chlorophenyl)methyl]-3-{2-[(cyclohexylmethyl)amino]ethyl}-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C35H42Cl2N4O
|
1
|
| 1 |
Ki = 3.8 nM
|
|
|
|
CP0461170
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(1,3-oxazol-2-ylmethyl)benzimidazol-2-one
Show/Hide
|
C30H38N4O4
|
1
|
| 1 |
Ki = 3.89 nM
|
|
|
|
CP0497876
|
1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-dihydro-indol-2-one
Show/Hide
|
C22H32N2O
|
1
|
| 1 |
Ki = 3.96 nM
|
|
|
|
CP0870525
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(pyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H25Cl2N3O
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0493793
|
8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octan-3-amine
Show/Hide
|
C26H26Cl2N2
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0431947
|
1-((2-chlorophenyl)(phenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C24H24ClNO
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0949691
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(6-methoxypyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C29H31Cl2N3O2
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0479566
|
8-[bis(2-chlorophenyl)methyl]-3-[2-(methylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C29H32Cl2N4O
|
1
|
| 1 |
Ki = 4.05 nM
|
|
|
|
CP0221378
|
(+)-1-(2-methoxy-ethyl)-3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzimidazol-2-one
Show/Hide
|
C29H41N3O4
|
1
|
| 1 |
Ki = 4.074 nM
|
|
|
|
CP0430049
|
N-[[2-[1-[bis(2-chlorophenyl)methyl]-4-hydroxypiperidin-4-yl]phenyl]methyl]propane-2-sulfonamide
Show/Hide
|
C28H32Cl2N2O3S
|
1
|
| 1 |
Ki = 4.1 nM
|
|
|
|
CP0449144
|
1-(imidazol-1-ylmethyl)-3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]benzimidazol-2-one
Show/Hide
|
C30H39N5O3
|
1
|
| 1 |
Ki = 4.169 nM
|
|
|
|
CP0461515
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(2-oxopropyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C28H35N3O2
|
1
|
| 1 |
Ki = 4.5 nM
|
|
|
|
CP0481495
|
(2R)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-propan-2-ylpropanamide
Show/Hide
|
C24H30F2N2O2S
|
2
|
| 1 |
Ki = 4.51 nM
|
|
|
| 2 |
Ki = 4.54 nM
|
|
|
|
CP0445058
|
8-(cyclopentyl-phenyl-methyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H31N3O
|
1
|
| 1 |
Ki = 4.6 nM
|
|
|
|
CP0435294
|
4-(2-(aminomethyl)phenyl)-1-(cycloheptylmethyl)piperidin-4-ol
Show/Hide
|
C20H32N2O
|
1
|
| 1 |
Ki = 4.6 nM
|
|
|
|
CP0415483
|
1-[(R)-1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-1,3-dihydro-indol-2-one
Show/Hide
|
C23H32N2O
|
1
|
| 1 |
Ki = 4.67 nM
|
|
|
|
CP0504638
|
N-methyl-2-[2-oxo-3-[1-(2,2,4,4-tetramethylcyclohexyl)piperidin-4-yl]benzimidazol-1-yl]acetamide
Show/Hide
|
C25H38N4O2
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0394298
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-[(2-methylimidazol-1-yl)methyl]benzimidazol-2-one
Show/Hide
|
C31H41N5O3
|
1
|
| 1 |
Ki = 4.898 nM
|
|
|
|
CP0428046
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(pyridin-2-ylmethyl)benzimidazol-2-one
Show/Hide
|
C32H40N4O3
|
1
|
| 1 |
Ki = 4.898 nM
|
|
|
|
CP0502162
|
8-(bis(2-chlorophenyl)methyl)-N-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C28H28Cl2N2O
|
1
|
| 1 |
Ki = 4.9 nM
|
|
|
|
CP0439566
|
8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclohexylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C34H40Cl2N4O
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0377400
|
1-((2-fluorophenyl)(phenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C24H24FNO
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0431949
|
4-phenyl-1-(1-phenylpentyl)piperidin-4-ol
Show/Hide
|
C22H29NO
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0906680
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(pyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C28H29Cl2N3O
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0726947
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-(3-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C25H24Cl2N2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0423875
|
2-[(2-fluorophenyl)methyl]-N,N-dimethyl-3-spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-ylpropanamide
Show/Hide
|
C23H29FN2O2S
|
1
|
| 1 |
Ki = 5.16 nM
|
|
|
|
CP0372613
|
8-((2-chloro-4-methylphenyl)(2-chlorophenyl)methyl)-3-(pyrimidin-4-yl)-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C25H25Cl2N3O
|
1
|
| 1 |
Ki = 5.2 nM
|
|
|
|
CP0469635
|
2-(3-(1-(4,4-dimethylcyclohexyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C23H34N4O2
|
1
|
| 1 |
Ki = 5.2 nM
|
|
|
|
CP0432390
|
8-(bis(2-chlorophenyl)methyl)-3-phenyl-3-(1H-1,2,4-triazol-3-yl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C28H26Cl2N4
|
1
|
| 1 |
Ki = 5.3 nM
|
|
|
|
CP0915767
|
(+)3-(2'-fluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide
Show/Hide
|
C22H26F2N2O2S
|
1
|
| 1 |
Ki = 5.32 nM
|
|
|
|
CP0481270
|
(2R)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide
Show/Hide
|
C22H26F2N2O2S
|
1
|
| 1 |
Ki = 5.32 nM
|
|
|
|
CP0439567
|
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-3-propyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C28H37N3O
|
1
|
| 1 |
Ki = 5.4 nM
|
|
|
|
CP0457954
|
4-(2-(aminomethyl)phenyl)-1-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)piperidin-4-ol
Show/Hide
|
C24H32N2O
|
1
|
| 1 |
Ki = 5.5 nM
|
|
|
|
CP0489528
|
2-(3-(1-(4-tert-butylcyclohexyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C25H38N4O2
|
1
|
| 1 |
Ki = 5.5 nM
|
|
|
|
CP0427579
|
(2R)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanamide
Show/Hide
|
C21H24F2N2O2S
|
1
|
| 1 |
Ki = 5.61 nM
|
|
|
|
CP0448267
|
1-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-1,3-dihydro-indol-2-one
Show/Hide
|
C23H32N2O
|
1
|
| 1 |
Ki = 5.64 nM
|
|
|
|
CP0376083
|
1-((2R,6S,9aR)-6-Phenyl-octahydro-quinolizin-2-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C22H25N3O
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0485881
|
1-[8-(dimethylamino)-8-phenyl-2-azaspiro[4.5]decan-2-yl]butan-1-one
Show/Hide
|
C21H32N2O
|
1
|
| 1 |
Ki = 5.8 nM
|
|
|
|
CP0461169
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(pyrazin-2-ylmethyl)benzimidazol-2-one
Show/Hide
|
C31H39N5O3
|
1
|
| 1 |
Ki = 5.888 nM
|
|
|
|
CP0471377
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-[(5-oxo-1,4-dihydro-1,2,4-triazol-3-yl)methyl]benzimidazol-2-one
Show/Hide
|
C29H38N6O4
|
1
|
| 1 |
Ki = 5.888 nM
|
|
|
|
CP0461924
|
1-(bis(2-chlorophenyl)methyl)-4-(2-(morpholinomethyl)phenyl)piperidin-4-ol
Show/Hide
|
C29H32Cl2N2O2
|
1
|
| 1 |
Ki = 5.9 nM
|
|
|
|
CP0755483
|
endo-N-(8-(bis(2-chlorophenyl)methyl)-3-(pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)acetamide
Show/Hide
|
C27H27Cl2N3O
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0920160
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-methylpyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C27H27Cl2N3O
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0428369
|
(8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octan-3-yl)methanol
Show/Hide
|
C27H27Cl2NO
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0445414
|
methyl N-[8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-yl]carbamate
Show/Hide
|
C28H28Cl2N2O2
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0432003
|
1-(bis(2-fluorophenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C24H23F2NO
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0914260
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(pyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)ethanamine
Show/Hide
|
C28H31Cl2N3
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0914296
|
(rel)-8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octan-3-yl)methanamine
Show/Hide
|
C27H28Cl2N2
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0790865
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-(2-pyrimidinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C24H23Cl2N3
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0090072
|
1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-indol-2-one
Show/Hide
|
C22H32N2O
|
1
|
| 1 |
Ki = 6.04 nM
|
|
|
|
CP0428099
|
8-[bis-(2-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H25F2N3O
|
1
|
| 1 |
Ki = 6.3 nM
|
|
|
|
CP0439568
|
3-{2-[bis(propan-2-yl)amino]ethyl}-8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C33H48N4O
|
1
|
| 1 |
Ki = 6.7 nM
|
|
|
|
CP0434491
|
8-[bis(2-chlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C26H25Cl2N3O
|
1
|
| 1 |
Ki = 6.8 nM
|
|
|
|
CP0675517
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-fluoropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H24Cl2FN3O
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0891915
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-fluoropyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-amine
Show/Hide
|
C25H24Cl2FN3
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0504014
|
8-(bis(2-chlorophenyl)methyl)-N-ethyl-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C29H30Cl2N2O
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0918898
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(pyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methanamine
Show/Hide
|
C26H27Cl2N3
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0869859
|
exo-8-[Bis(2-chlorophenyl)methyl]-3-[3-(1-piperidinylmethyl)-2-pyridinyl]-8-azabicyclo[3.2.1]octane
Show/Hide
|
C31H35Cl2N3
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0475107
|
8-((2-chloro-4-methylphenyl)(2-chlorophenyl)methyl)-3-(4-methylpyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C27H28Cl2N2O
|
1
|
| 1 |
Ki = 7.3 nM
|
|
|
|
CP0375819
|
N,N-dimethyl-2-(pyrazol-1-ylmethyl)-3-spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-ylpropanamide
Show/Hide
|
C20H28N4O2S
|
1
|
| 1 |
Ki = 7.37 nM
|
|
|
|
CP0500772
|
8-((2-chloro-4-methylphenyl)(2-chlorophenyl)methyl)-3-(3-hydroxypropyl)-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C24H29Cl2NO2
|
1
|
| 1 |
Ki = 7.4 nM
|
|
|
|
CP0521465
|
9-benzhydryl-3-phenyl-9-azabicyclo[3.3.1]nonan-3-ol
Show/Hide
|
C27H29NO
|
1
|
| 1 |
Ki = 7.5 nM
|
|
|
|
CP0458028
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(2H-triazol-4-ylmethyl)benzimidazol-2-one
Show/Hide
|
C29H38N6O3
|
1
|
| 1 |
Ki = 7.943 nM
|
|
|
|
CP0417451
|
8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(piperidin-1-yl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C33H38Cl2N4O
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0500773
|
8-(bis(2-chlorophenyl)methyl)-3-methoxy-3-phenyl-8-azabicyclo[3.2.1]octane
Show/Hide
|
C27H27Cl2NO
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0372832
|
8-(bis(2-chlorophenyl)methyl)-N-(2-methoxyethyl)-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C30H32Cl2N2O2
|
1
|
| 1 |
Ki = 8.2 nM
|
|
|
|
CP0382636
|
8-(6-fluoro-4,4-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H30FN3O
|
1
|
| 1 |
Ki = 8.4 nM
|
|
|
|
CP0421764
|
8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclopentylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C33H38Cl2N4O
|
1
|
| 1 |
Ki = 8.65 nM
|
|
|
|
CP0882779
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(4,5-difluoropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H23Cl2F2N3O
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0412726
|
8-di-o-tolylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C28H31N3O
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0432031
|
8-[(2-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H26ClN3O
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0377391
|
1-(4-methyl-1-phenylpentyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C23H31NO
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0377399
|
1-((2-(hydroxymethyl)phenyl)(phenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C25H27NO2
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0706577
|
Exo-8-[bis(2-chorophenyl)methyl]-3-(6-methoxy-2-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C26H26Cl2N2O
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0795317
|
Exo-8-[bis(2-chorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane
Show/Hide
|
C26H25Cl2N
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0391308
|
(2R)-2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide
Show/Hide
|
C22H26ClFN2O2S
|
1
|
| 1 |
Ki = 9.08 nM
|
|
|
|
CP0375817
|
2-benzyl-N,N-dimethyl-3-spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-ylpropanamide
Show/Hide
|
C23H30N2O2S
|
1
|
| 1 |
Ki = 9.4 nM
|
|
|
|
CP0394323
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(pyridin-3-ylmethyl)benzimidazol-2-one
Show/Hide
|
C32H40N4O3
|
1
|
| 1 |
Ki = 9.55 nM
|
|
|
|
CP0461910
|
4-(2-(aminomethyl)phenyl)-1-(bis(3-fluorophenyl)methyl)piperidin-4-ol
Show/Hide
|
C25H26F2N2O
|
1
|
| 1 |
Ki = 9.6 nM
|
|
|
|
CP0709542
|
endo-methyl 8-(bis(2-chlorophenyl)methyl)-3-(pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-ylcarbamate
Show/Hide
|
C27H27Cl2N3O2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0858737
|
endo-N-(8-(bis(2-chlorophenyl)methyl)-3-(5-fluoropyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)acetamide
Show/Hide
|
C27H26Cl2FN3O
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0858741
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-amine
Show/Hide
|
C25H25Cl2N3
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0858743
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(6-fluoropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H24Cl2FN3O
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0904369
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(4-chlorobenzyl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C28H27Cl3N2O
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0522060
|
8-(bis(2-chlorophenyl)methyl)-N-isopropyl-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C30H32Cl2N2O
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0879969
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-aza-bicyclo[3.2.1]octan-3-yl)-N-methylmethanamine
Show/Hide
|
C28H30Cl2N2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0777560
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-(6-methyl-2-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C26H26Cl2N2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0488138
|
(2R)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methyl-N-propan-2-ylpropanamide
Show/Hide
|
C25H32F2N2O2S
|
1
|
| 1 |
Ki = 10.2 nM
|
|
|
|
CP0445013
|
8-(7-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 10.8 nM
|
|
|
|
CP0464698
|
8-[(2-fluoro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H26FN3O
|
1
|
| 1 |
Ki = 10.8 nM
|
|
|
|
CP0417441
|
8-(bis(2-chlorophenyl)methyl)-N-(2-hydroxypropyl)-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C30H32Cl2N2O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0502161
|
N-[8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-yl]cyclopropanecarboxamide
Show/Hide
|
C30H30Cl2N2O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0409403
|
8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C20H23N3O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0432000
|
1-((2-bromophenyl)(phenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C24H24BrNO
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0465197
|
1-benzhydryl-4-o-tolylpiperidin-4-ol
Show/Hide
|
C25H27NO
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0859623
|
(rel)-(3-benzyl-8-(bis(2-chlorophenyl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)methanamine
Show/Hide
|
C28H30Cl2N2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0946802
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(6-methoxypyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methanamine
Show/Hide
|
C27H29Cl2N3O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0399223
|
(6R,8S)-6-((4-o-tolylpiperidin-1-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-ol
Show/Hide
|
C22H28N2O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0409407
|
1-phenyl-8-(phenyl-o-tolyl-methyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C27H29N3O
|
1
|
| 1 |
Ki = 11.5 nM
|
|
|
|
CP0374668
|
1-[1-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-piperidin-4-yl]-1,3-dihydro-indol-2-one
Show/Hide
|
C23H26N2O
|
1
|
| 1 |
Ki = 11.7 nM
|
|
|
|
CP0394327
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-[(2-methyl-1,2,4-triazol-3-yl)methyl]benzimidazol-2-one
Show/Hide
|
C30H40N6O3
|
1
|
| 1 |
Ki = 11.75 nM
|
|
|
|
CP0423619
|
methyl N-[(1R,5R)-8-[bis(2-chlorophenyl)methyl]-3-(5-fluoropyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl]carbamate
Show/Hide
|
C27H26Cl2FN3O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0858740
|
endo-methyl 8-(bis(2-chlorophenyl)methyl)-3-(5-chloropyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-ylcarbamate
Show/Hide
|
C27H26Cl3N3O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0377401
|
4-phenyl-1-(phenyl(2-(trifluoromethyl)phenyl)methyl)piperidin-4-ol
Show/Hide
|
C25H24F3NO
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0458953
|
1-(2-(1-(bis(2-chlorophenyl)methyl)-4-hydroxypiperidin-4-yl)benzyl)-3-ethylurea
Show/Hide
|
C28H31Cl2N3O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0921386
|
(rel)-N-((3-benzyl-8-(bis(2-chlorophenyl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C30H32Cl2N2O
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0461275
|
8-[bis(2-chlorophenyl)methyl]-3-{2-[bis(propan-2-yl)amino]ethyl}-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C34H42Cl2N4O
|
1
|
| 1 |
Ki = 12.1 nM
|
|
|
|
CP0506372
|
3-[2-(butylamino)ethyl]-8-(6,7-dichloro-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H42Cl2N4O
|
1
|
| 1 |
Ki = 12.2 nM
|
|
|
|
CP0867901
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(6-bromopyridin-3-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H24BrCl2N3O
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0377403
|
1-benzhydryl-4-phenylpiperidin-4-ol
Show/Hide
|
C24H25NO
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0423620
|
8-((2-chloro-4-methylphenyl)(2-chlorophenyl)methyl)-3-((5-methoxypyridin-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C28H30Cl2N2O2
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0445417
|
3-(1-benzylpyrrolidin-2-yl)-8-((2-chloro-4-methylphenyl)(2-chlorophenyl)methyl)-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C32H36Cl2N2O
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0445009
|
1-phenyl-8-thiophen-3-ylmethyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C18H21N3OS
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0394214
|
4-phenyl-1-(1-phenylhexyl)piperidin-4-ol
Show/Hide
|
C23H31NO
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0442425
|
1-benzhydryl-4-(4-fluorophenyl)piperidin-4-ol
Show/Hide
|
C24H24FNO
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0869856
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-(5-methyl-2-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C26H26Cl2N2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0454021
|
1-phenyl-8-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H29N3O
|
1
|
| 1 |
Ki = 14.5 nM
|
|
|
|
CP0675516
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-chloropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H24Cl3N3O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0918780
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(4,6-difluoropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H23Cl2F2N3O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0433309
|
1-benzhydryl-4-(3-methylthiophen-2-yl)piperidin-4-ol
Show/Hide
|
C23H25NOS
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0437886
|
N-[[2-[1-[bis(2-chlorophenyl)methyl]-4-hydroxypiperidin-4-yl]phenyl]methyl]propane-1-sulfonamide
Show/Hide
|
C28H32Cl2N2O3S
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0498944
|
2-(3-(1-cyclooctylpiperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C23H34N4O2
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0412722
|
8-(6,7-dichloro-4,4-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H29Cl2N3O
|
1
|
| 1 |
Ki = 15.1 nM
|
|
|
|
CP0403743
|
1-[1-(6,6-Dimethyl-bicyclo[3.1.1]hept-2-ylmethyl)-piperidin-4-yl]-1,3-dihydro-indol-2-one
Show/Hide
|
C23H32N2O
|
1
|
| 1 |
Ki = 15.5 nM
|
|
|
|
CP0485883
|
1-[8-(dimethylamino)-8-(3-methylthiophen-2-yl)-2-azaspiro[4.5]decan-2-yl]butan-1-one
Show/Hide
|
C20H32N2OS
|
1
|
| 1 |
Ki = 15.5 nM
|
|
|
|
CP0414804
|
1-[1-(Decahydro-naphthalen-1-yl)-piperidin-4-yl]-1,3-dihydro-indol-2-one
Show/Hide
|
C23H32N2O
|
1
|
| 1 |
Ki = 15.6 nM
|
|
|
|
CP0372852
|
3-[2-(butylamino)ethyl]-8-(7-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C29H39ClN4O
|
1
|
| 1 |
Ki = 15.9 nM
|
|
|
|
CP0858742
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(3,6-difluoropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H23Cl2F2N3O
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0387900
|
8-(bis(2-chlorophenyl)methyl)-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C27H25Cl2FN2O
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0377390
|
1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C25H27NO
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0424327
|
1-benzhydryl-4-(2-(hydroxymethyl)phenyl)piperidin-4-ol
Show/Hide
|
C25H27NO2
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0504637
|
2-(3-(1-(biphenyl-2-ylmethyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C28H30N4O2
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0417478
|
(1R,5R)-8-[bis(2-chlorophenyl)methyl]-3-piperidin-2-yl-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H31Cl2N3O
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0867895
|
endo-2-(8-(bis(2-chlorophenyl)methyl)-3-(4-hydroxybenzyl)-8-azabicyclo[3.2.1]octan-3-yl)acetamide
Show/Hide
|
C29H30Cl2N2O2
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0412641
|
1-phenyl-8-(1-phenyl-propyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C22H27N3O
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0442423
|
1-benzhydryl-4-cyclohexylpiperidin-4-ol
Show/Hide
|
C24H31NO
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0904420
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(piperidin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methanamine
Show/Hide
|
C26H33Cl2N3
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0488457
|
(2R)-2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanamide
Show/Hide
|
C21H24ClFN2O2S
|
1
|
| 1 |
Ki = 17.1 nM
|
|
|
|
CP0449143
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-[(2-methyl-1,3-thiazol-4-yl)methyl]benzimidazol-2-one
Show/Hide
|
C31H40N4O3S
|
1
|
| 1 |
Ki = 17.38 nM
|
|
|
|
CP0432002
|
4-phenyl-1-(1-phenylheptyl)piperidin-4-ol
Show/Hide
|
C24H33NO
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0806432
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-(4-methyl-2-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C26H26Cl2N2
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0463345
|
2-(3-(1-((4-methoxynaphthalen-1-yl)methyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C27H30N4O3
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0510052
|
8-[bis(2-chlorophenyl)methyl]-3-(2-hydroxyethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C28H29Cl2N3O2
|
1
|
| 1 |
Ki = 18.5 nM
|
|
|
|
CP0384545
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2R)-2-hydroxy-4,4-dimethylpentan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C30H43NO4
|
1
|
| 1 |
Ki = 18.5 nM
|
|
|
|
CP0920159
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-fluoro-4-(fluoromethyl)pyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C27H25Cl2F2N3O
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0432001
|
4-phenyl-1-(1-phenylbutyl)piperidin-4-ol
Show/Hide
|
C21H27NO
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0417450
|
methyl 2-{8-[bis(2-chlorophenyl)methyl]-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl}acetate
Show/Hide
|
C29H29Cl2N3O3
|
1
|
| 1 |
Ki = 19.5 nM
|
|
|
|
CP0375935
|
1-Ethyl-3-((2R,6S,9aR)-6-phenyl-octahydro-quinolizin-2-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C24H29N3O
|
1
|
| 1 |
Ki = 19.6 nM
|
|
|
|
CP0675514
|
endo-N-((8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C29H30Cl2N2O
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0904372
|
8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octane-3-carbaldehyde oxime
Show/Hide
|
C27H26Cl2N2O
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0859621
|
(rel)-methyl (8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-aza-bicyclo[3.2.1]octan-3-yl)methylcarbamate
Show/Hide
|
C29H30Cl2N2O2
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0904418
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(6-methoxypyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)ethanamine
Show/Hide
|
C29H33Cl2N3O
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0423320
|
(7R,9S)-7-((4-o-tolylpiperazin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C22H29N3O
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0433970
|
1-(bis(2-bromophenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C24H23Br2NO
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0497582
|
2-(1-(1-(4-isopropylcyclohexyl)piperidin-4-yl)-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-methylacetamide
Show/Hide
|
C25H38N4O2
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0520032
|
(6R,8S)-6-(((3R,4R)-4-(4-fluoro-2-methylphenyl)-3-hydroxypiperidin-1-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-ol
Show/Hide
|
C22H27FN2O2
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0464243
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-[(5-methyl-1,2-oxazol-3-yl)methyl]benzimidazol-2-one
Show/Hide
|
C31H40N4O4
|
1
|
| 1 |
Ki = 21.88 nM
|
|
|
|
CP0867902
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-methoxypyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C27H27Cl2N3O2
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0480474
|
8-(bis(2-chlorophenyl)methyl)-3-(4-methoxyphenyl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C28H28Cl2N2O2
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0403722
|
1-[1-[[(2S)-2-bicyclo[2.2.1]heptanyl]methyl]piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C21H28N2O
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0793160
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-(5-bromo-2-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C25H23BrCl2N2
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0489674
|
N-methyl-2-[1-[1-[(4-methylnaphthalen-1-yl)methyl]piperidin-4-yl]-2-oxo-4H-quinazolin-3-yl]acetamide
Show/Hide
|
C28H32N4O2
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0372854
|
8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C26H27N3O
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0435292
|
1-benzhydryl-4-(3-fluorophenyl)piperidin-4-ol
Show/Hide
|
C24H24FNO
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0438968
|
1-benzhydryl-4-butylpiperidin-4-ol
Show/Hide
|
C22H29NO
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0919391
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-[5-(methylthio)-2-pyridinyl]-8-azabicyclo[3.2.1]octane
Show/Hide
|
C26H26Cl2N2S
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0436539
|
1-benzhydryl-4-(4-chlorophenyl)piperidin-4-ol
Show/Hide
|
C24H24ClNO
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0869822
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(6-fluoropyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C28H28Cl2FN3O
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0874932
|
exo-6-[8-[Bis(2-chlorophenyl)-methyl]-8-azabicyclo[3.2.1]oct-3-yl]-3-pyridinol
Show/Hide
|
C25H24Cl2N2O
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0776928
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-(6-fluoro-2-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C25H23Cl2FN2
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0503267
|
(3R)-3-{[4-(2-methylphenyl)piperidin-1-yl]methyl}-2,3,4,5-tetrahydrospiro[cyclohepta[b]pyridine-1,2'-[1,3]dioxolane]
Show/Hide
|
C25H32N2O2
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0453866
|
8-[bis(2-chlorophenyl)methyl]-3-(2-methoxyethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C29H31Cl2N3O2
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0377427
|
1-((3-chlorophenyl)(phenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C24H24ClNO
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0433310
|
1-benzhydryl-4-m-tolylpiperidin-4-ol
Show/Hide
|
C25H27NO
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0859722
|
7-[(R)-2-((S)-2-Acetylamino-5-guanidino-pentanoylamino)-3-cyclohexyl-propionylamino]-6-oxo-octahydro-quinolizine-4-carboxylic acid {(R)-1-[1-carbamoyl-2-((R)-4-chloro-phenyl)-ethylcarbamoyl]-4-guanidino-butyl}-amide
Show/Hide
|
C42H66ClN13O7
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0879970
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(5-bromopyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C28H28BrCl2N3O
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0906684
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(piperidin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C28H35Cl2N3O
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0485872
|
1-[8-(dimethylamino)-8-(3-methylthiophen-2-yl)-2-azaspiro[4.5]decan-2-yl]-3-methylbutan-1-one
Show/Hide
|
C21H34N2OS
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0408704
|
1-[1-[[(2R)-2-bicyclo[2.2.1]heptanyl]methyl]piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C21H28N2O
|
1
|
| 1 |
Ki = 27.9 nM
|
|
|
|
CP0422132
|
1-((2R,6S,9aR)-6-Cyclohexyl-octahydro-quinolizin-2-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C22H31N3O
|
1
|
| 1 |
Ki = 28.7 nM
|
|
|
|
CP0409537
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(pyridin-4-ylmethyl)benzimidazol-2-one
Show/Hide
|
C32H40N4O3
|
1
|
| 1 |
Ki = 28.84 nM
|
|
|
|
CP0709541
|
8-(bis(2-chlorophenyl)methyl)-3-(5-bromopyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H24BrCl2N3O
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0421844
|
N-butyl-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C32H46N4O4
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0914261
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(6-fluoropyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methanamine
Show/Hide
|
C26H26Cl2FN3
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0793147
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-(3-methyl-2-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C26H26Cl2N2
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0506549
|
N-methyl-2-[3-[1-(naphthalen-1-ylmethyl)piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C26H28N4O2
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0430572
|
1-[1-(1,2,3,4-Tetrahydro-naphthalen-2-yl)-piperidin-4-yl]-1,3-dihydro-indol-2-one
Show/Hide
|
C23H26N2O
|
1
|
| 1 |
Ki = 29.3 nM
|
|
|
|
CP0549302
|
1-[8-cyclopentyl-8-(dimethylamino)-2-azaspiro[4.5]decan-2-yl]-2-cyclopropylethanone
Show/Hide
|
C21H36N2O
|
1
|
| 1 |
Ki = 29.5 nM
|
|
|
|
CP0394329
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]benzimidazol-2-one
Show/Hide
|
C30H39N5O4
|
1
|
| 1 |
Ki = 29.51 nM
|
|
|
|
CP0517519
|
(7R,9S)-7-((4-phenylpiperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C22H28N2O
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0522180
|
8-(diphenylmethyl)-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C27H29N3O
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0906802
|
endo-3-(5-aminopyridin-2-yl)-8-(bis(2-chlorophenyl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H26Cl2N4O
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0399286
|
8-(bis(2-chlorophenyl)methyl)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C27H25Cl3N2O
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0919292
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(4-fluorophenyl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C29H29Cl2FN2O
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0479563
|
8-(diphenylmethyl)-1-phenyl-3-propyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C29H33N3O
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0433319
|
1-benzhydryl-4-(2-fluorophenyl)piperidin-4-ol
Show/Hide
|
C24H24FNO
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0858298
|
6-[2-((2S,3R)-2-Acetylamino-5-guanidino-pentanoylamino)-3-cyclohexyl-propionylamino]-5-oxo-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid {(R)-1-[1-carbamoyl-2-(4-chloro-phenyl)-ethylcarbamoyl]-4-guanidino-butyl}-amide
Show/Hide
|
C40H62ClN13O7S
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0920419
|
exo-8-[Bis(2-chlorophenyl)methyl]-3-(5-fluoro-2-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C25H23Cl2FN2
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0383411
|
4-phenyl-1-(phenyl(thiophen-2-yl)methyl)piperidin-4-ol
Show/Hide
|
C22H23NOS
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0869824
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(pyridin-3-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C28H29Cl2N3O
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0489531
|
2-(3-(1-cycloheptylpiperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C22H32N4O2
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0921774
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(4-chlorobenzyl)-8-azabicyclo[3.2.1]octan-3-amine
Show/Hide
|
C27H27Cl3N2
|
1
|
| 1 |
Ki = 36 nM
|
|
|
|
CP0409408
|
8-(5H-dibenzo[a,d]cyclohepten-5-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C28H27N3O
|
1
|
| 1 |
Ki = 36.5 nM
|
|
|
|
CP0432831
|
1-{1-[3-(2-Ethyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C26H35N3O2
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0433623
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]benzimidazol-2-one
Show/Hide
|
C30H39N5O4
|
1
|
| 1 |
Ki = 37.15 nM
|
|
|
|
CP0859622
|
(rel)-8-(bis(2-chlorophenyl)methyl)-5'-fluoro-8-azaspiro[bicyclo[3.2.1]octane-3,3'-indoline]
Show/Hide
|
C27H25Cl2FN2
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0880183
|
(rel)-N-((3-benzyl-8-(bis(2-chlorophenyl)methyl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)ethanamine
Show/Hide
|
C30H34Cl2N2
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0418983
|
8-(bis(2-chlorophenyl)methyl)-3-(4-bromophenyl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C27H25BrCl2N2O
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0431948
|
1-(cyclopentyl(phenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C23H29NO
|
1
|
| 1 |
Ki = 41 nM
|
|
|
|
CP0471378
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-[(5-methyl-1H-1,2,4-triazol-3-yl)methyl]benzimidazol-2-one
Show/Hide
|
C30H40N6O3
|
1
|
| 1 |
Ki = 41.69 nM
|
|
|
|
CP0915063
|
endo-8-(bis(2-chlorophenyl)methyl)-N,N-dimethyl-3-(pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-amine
Show/Hide
|
C27H29Cl2N3
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0497242
|
1-[1-(4-Methyl-3-o-tolyloxy-pentyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H33N3O2
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0433966
|
1-(bis(4-fluorophenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C24H23F2NO
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0854212
|
7-[(R)-3-Cyclohexyl-2-((R)-5-guanidino-pentanoylamino)-1-oxo-propylamino]-6-oxo-octahydro-quinolizine-4-carboxylic acid {(R)-1-[1-carbamoyl-2-((R)-4-chloro-phenyl)-ethylcarbamoyl]-4-ureido-butyl}-amide
Show/Hide
|
C40H62ClN11O7
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0051438
|
1-[2-(benzyl-methyl-amino)-ethyl]-3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzimidazol-2-one
Show/Hide
|
C36H48N4O3
|
1
|
| 1 |
Ki = 46 nM
|
|
|
|
CP0918778
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(3,5-difluoropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H23Cl2F2N3O
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0453869
|
3-(2-aminoethyl)-8-[bis(2-chlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C28H30Cl2N4O
|
1
|
| 1 |
Ki = 47.8 nM
|
|
|
|
CP0449777
|
1-benzhydryl-4-(thiophen-2-yl)piperidin-4-ol
Show/Hide
|
C22H23NOS
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0372859
|
8-[bis(2-chlorophenyl)methyl]-3-butyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C30H33Cl2N3O
|
1
|
| 1 |
Ki = 48.7 nM
|
|
|
|
CP0532446
|
N-[[(2R)-1-benzylpyrrolidin-2-yl]methyl]-3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropan-1-amine
Show/Hide
|
C27H37N3O
|
1
|
| 1 |
Ki = 48.98 nM
|
|
|
|
CP0464697
|
8-[bis-(4-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H25F2N3O
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0514705
|
(R)-7-((4-o-tolylpiperidin-1-yl)methyl)-5,6,7,8-tetrahydrocyclohepta[b]pyridin-9-one
Show/Hide
|
C23H28N2O
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0906679
|
(rel)-(1S,5S)-8-(bis(2-chlorophenyl)methyl)-8-azaspiro[bicyclo[3.2.1]octane-3,3'-indoline]
Show/Hide
|
C27H26Cl2N2
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0906682
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(3-methylpyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methanamine
Show/Hide
|
C27H29Cl2N3
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0428524
|
1-benzhydryl-4-(4-bromophenyl)piperidin-4-ol
Show/Hide
|
C24H24BrNO
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0541213
|
(6R,8S)-6-(((3R,4R)-3-hydroxy-4-o-tolylpiperidin-1-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-ol
Show/Hide
|
C22H28N2O2
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0450477
|
3-(cyclobutylmethyl)-8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H35N3O
|
1
|
| 1 |
Ki = 53 nM
|
|
|
|
CP0377395
|
4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol
Show/Hide
|
C25H27NO
|
1
|
| 1 |
Ki = 53 nM
|
|
|
|
CP0467042
|
1-benzhydryl-4-methoxy-4-phenylpiperidine
Show/Hide
|
C25H27NO
|
1
|
| 1 |
Ki = 54 nM
|
|
|
|
CP0440372
|
1-benzhydryl-4-p-tolylpiperidin-4-ol
Show/Hide
|
C25H27NO
|
1
|
| 1 |
Ki = 55 nM
|
|
|
|
CP0859624
|
(rel)-(3-benzyl-8-(bis(2-chlorophenyl)methyl)-8-aza-bicyclo[3.2.1]octan-3-yl)-N,N-dimethylmethanamine
Show/Hide
|
C30H34Cl2N2
|
1
|
| 1 |
Ki = 55 nM
|
|
|
|
CP0514425
|
8-[bis(2-chlorophenyl)methyl]-3-(3-methylbutyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C31H35Cl2N3O
|
1
|
| 1 |
Ki = 56 nM
|
|
|
|
CP0675518
|
endo-methyl 8-(bis(2-chlorophenyl)methyl)-3-(4-chlorobenzyl)-8-azabicyclo[3.2.1]octan-3-ylcarbamate
Show/Hide
|
C29H29Cl3N2O2
|
1
|
| 1 |
Ki = 56 nM
|
|
|
|
CP0479564
|
3-butyl-8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C30H35N3O
|
1
|
| 1 |
Ki = 57 nM
|
|
|
|
CP0949689
|
(rel)-3-(4-fluorobenzyl)-8-(bis(2-chlorophenyl)methyl)-3-(pyrrolidin-1-ylmethyl)-8-aza-bicyclo[3.2.1]octane
Show/Hide
|
C32H35Cl2FN2
|
1
|
| 1 |
Ki = 58 nM
|
|
|
|
CP0493717
|
(7R,9S)-7-((4-methyl-4-phenylpiperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol
Show/Hide
|
C23H30N2O
|
1
|
| 1 |
Ki = 58 nM
|
|
|
|
CP0441387
|
(2S)-2-amino-3-phenyl-N-(3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl)propanamide
Show/Hide
|
C24H31N3O2
|
1
|
| 1 |
Ki = 58.88 nM
|
|
|
|
CP0460743
|
(2R)-2-amino-3-phenyl-N-(3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl)propanamide
Show/Hide
|
C24H31N3O2
|
1
|
| 1 |
Ki = 58.88 nM
|
|
|
|
CP0377392
|
1-benzhydryl-4-ethoxy-4-phenylpiperidine
Show/Hide
|
C26H29NO
|
1
|
| 1 |
Ki = 59 nM
|
|
|
|
CP0483213
|
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C24H30ClN3O3
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0452006
|
2-(benzylamino)-N-(3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl)acetamide
Show/Hide
|
C24H31N3O2
|
1
|
| 1 |
Ki = 60.26 nM
|
|
|
|
CP0445010
|
8-cyclohexylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C20H29N3O
|
1
|
| 1 |
Ki = 61.2 nM
|
|
|
|
CP0399977
|
1-benzhydryl-4-tert-butylpiperidin-4-ol
Show/Hide
|
C22H29NO
|
1
|
| 1 |
Ki = 62 nM
|
|
|
|
CP0869823
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(5-methoxypyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C29H31Cl2N3O2
|
1
|
| 1 |
Ki = 62 nM
|
|
|
|
CP0463347
|
2-(3-(1-(2,2-dimethylcyclopentyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C22H32N4O2
|
1
|
| 1 |
Ki = 62 nM
|
|
|
|
CP0417449
|
8-(diphenylmethyl)-1-phenyl-3-(propan-2-yl)-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C29H33N3O
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0384550
|
(1S,2S,6R,14R,15R,16R)-9-chloro-5-(cyclopropylmethyl)-16-[(2R)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8,10,12(20)-trien-11-ol
Show/Hide
|
C29H40ClNO4
|
1
|
| 1 |
Ki = 67.8 nM
|
|
|
|
CP0880182
|
(rel)-1-((8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)pyrrolidin-2-one
Show/Hide
|
C31H32Cl2N2O
|
1
|
| 1 |
Ki = 68 nM
|
|
|
|
CP0920868
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-(4-pyridinyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C25H24Cl2N2
|
1
|
| 1 |
Ki = 69 nM
|
|
|
|
CP0878844
|
(rel)-8-(bis(2-chlorophenyl)methyl)-3-phenyl-3-(pyrrolidin-1-ylmethyl)-8-aza-bicyclo[3.2.1]octane
Show/Hide
|
C31H34Cl2N2
|
1
|
| 1 |
Ki = 70 nM
|
|
|
|
CP0322328
|
1-Acetyl-2-[exo-8-[bis(2-chlorophenyl)methyl]-8-azabicyclo[3.2.1]-oct-3-yl]piperidine
Show/Hide
|
C27H32Cl2N2O
|
1
|
| 1 |
Ki = 71 nM
|
|
|
|
CP0463753
|
1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-dihydro-indol-2-one
Show/Hide
|
C22H32N2O
|
1
|
| 1 |
Ki = 71.2 nM
|
|
|
|
CP0891916
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-hydroxypyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H25Cl2N3O2
|
1
|
| 1 |
Ki = 72 nM
|
|
|
|
CP0377398
|
1-benzhydryl-4-phenyl-4-propoxypiperidine
Show/Hide
|
C27H31NO
|
1
|
| 1 |
Ki = 72 nM
|
|
|
|
CP0916461
|
7-[(R)-2-((S)-2-Acetylamino-5-ureido-pentanoylamino)-3-cyclohexyl-propionylamino]-6-oxo-octahydro-quinolizine-4-carboxylic acid {(R)-1-[1-carbamoyl-2-((R)-4-chloro-phenyl)-ethylcarbamoyl]-4-guanidino-butyl}-amide
Show/Hide
|
C42H65ClN12O8
|
1
|
| 1 |
Ki = 72 nM
|
|
|
|
CP0906855
|
(rel)-8-(bis(2-chlorophenyl)methyl)-5'-methyl-8-azaspiro[bicyclo[3.2.1]octane-3,3'-indoline]
Show/Hide
|
C28H28Cl2N2
|
1
|
| 1 |
Ki = 74 nM
|
|
|
|
CP0928359
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-cyanopyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C27H24Cl2N4O
|
1
|
| 1 |
Ki = 75 nM
|
|
|
|
CP0867899
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(pyridin-4-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C26H25Cl2N3O
|
1
|
| 1 |
Ki = 79 nM
|
|
|
|
CP0906683
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(pyridin-3-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methanamine
Show/Hide
|
C26H27Cl2N3
|
1
|
| 1 |
Ki = 82 nM
|
|
|
|
CP0431362
|
3-(cyclopropylmethyl)-8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C30H33N3O
|
1
|
| 1 |
Ki = 83 nM
|
|
|
|
CP0524749
|
(2S)-1-benzyl-N-[3-[4-(2,6-dichlorophenyl)piperidin-1-yl]propyl]pyrrolidine-2-carboxamide
Show/Hide
|
C26H33Cl2N3O
|
1
|
| 1 |
Ki = 83.18 nM
|
|
|
|
CP0431361
|
8-(diphenylmethyl)-3-ethyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C28H31N3O
|
1
|
| 1 |
Ki = 84 nM
|
|
|
|
CP0424328
|
1-benzhydryl-4-(2-methoxyphenyl)piperidin-4-ol
Show/Hide
|
C25H27NO2
|
1
|
| 1 |
Ki = 85 nM
|
|
|
|
CP0372858
|
3-(cyclohexylmethyl)-8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C33H39N3O
|
1
|
| 1 |
Ki = 89 nM
|
|
|
|
CP0394326
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]benzimidazol-2-one
Show/Hide
|
C30H40N6O3
|
1
|
| 1 |
Ki = 95.5 nM
|
|
|
|
CP0922733
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(5-(piperidin-1-yl)pyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C33H38Cl2N4O
|
1
|
| 1 |
Ki = 99 nM
|
|
|
|
CP0428367
|
8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octane-3-carbonitrile
Show/Hide
|
C27H24Cl2N2
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0928832
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(6-fluoropyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)-N,N-dimethylmethanamine
Show/Hide
|
C28H30Cl2FN3
|
1
|
| 1 |
Ki = 104 nM
|
|
|
|
CP0440869
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(3S)-3-hydroxy-2,2-dimethylpentan-3-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C30H43NO4
|
1
|
| 1 |
Ki = 105 nM
|
|
|
|
CP0478452
|
3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl (2R)-1-benzylpyrrolidine-2-carboxylate
Show/Hide
|
C27H34N2O3
|
1
|
| 1 |
Ki = 107.15 nM
|
|
|
|
CP0392311
|
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H32ClN3O3
|
1
|
| 1 |
Ki = 108 nM
|
|
|
|
CP0399976
|
4-(2-(aminomethyl)phenyl)-1-(dip-tolylmethyl)piperidin-4-ol
Show/Hide
|
C27H32N2O
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0497243
|
1-{1-[3-(2-Isopropyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C27H37N3O2
|
1
|
| 1 |
Ki = 113 nM
|
|
|
|
CP0854480
|
(rel)-3-benzyl-8-(bis(2-chlorophenyl)methyl)-3-(pyrrolidin-1-ylmethyl)-8-aza-bicyclo[3.2.1]octane
Show/Hide
|
C32H36Cl2N2
|
1
|
| 1 |
Ki = 116 nM
|
|
|
|
CP0859605
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(4-methoxyphenyl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C30H32Cl2N2O2
|
1
|
| 1 |
Ki = 118 nM
|
|
|
|
CP0428115
|
1-phenyl-8-pyridin-2-ylmethyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C19H22N4O
|
1
|
| 1 |
Ki = 119 nM
|
|
|
|
CP0920436
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-(trifluoromethyl)pyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C27H24Cl2F3N3O
|
1
|
| 1 |
Ki = 122 nM
|
|
|
|
CP0434413
|
1-((4-bromophenyl)(phenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C24H24BrNO
|
1
|
| 1 |
Ki = 125 nM
|
|
|
|
CP0452694
|
CHEMBL4473383
Show/Hide
|
C23H33N3O
|
1
|
| 1 |
Ki = 129 nM
|
|
|
|
CP0377394
|
1-((4-chlorophenyl)(phenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C24H24ClNO
|
1
|
| 1 |
Ki = 132 nM
|
|
|
|
CP0428097
|
1-phenyl-8-pyridin-3-ylmethyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C19H22N4O
|
1
|
| 1 |
Ki = 133 nM
|
|
|
|
CP0455501
|
(1S,2S,6R,14R,15R,16R)-16-[(1R)-1-(4-tert-butylphenyl)-1-hydroxyethyl]-5-(cyclopropylmethyl)-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C35H45NO4
|
1
|
| 1 |
Ki = 133 nM
|
|
|
|
CP0434416
|
1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C21H27NO2
|
1
|
| 1 |
Ki = 134 nM
|
|
|
|
CP0377397
|
4-phenyl-1-(1-phenylpropyl)piperidin-4-ol
Show/Hide
|
C20H25NO
|
1
|
| 1 |
Ki = 135 nM
|
|
|
|
CP0465214
|
1-{1-[1-(9H-Fluoren-2-yl)-ethyl]-piperidin-4-yl}-1,3-dihydro-indol-2-one
Show/Hide
|
C28H28N2O
|
1
|
| 1 |
Ki = 135 nM
|
|
|
|
CP0457953
|
1-benzhydryl-4-(furan-2-yl)piperidin-4-ol
Show/Hide
|
C22H23NO2
|
1
|
| 1 |
Ki = 136 nM
|
|
|
|
CP0435484
|
CHEMBL4518220
Show/Hide
|
C25H39N3O
|
1
|
| 1 |
Ki = 136 nM
|
|
|
|
CP0445059
|
8-[(4-chloro-phenyl)-phenyl-methyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H26ClN3O
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0388338
|
(3R,4S)-1-benzhydryl-3-methyl-4-phenylpiperidin-4-ol
Show/Hide
|
C25H27NO
|
1
|
| 1 |
Ki = 142 nM
|
|
|
|
CP0399720
|
N-tert-butyl-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C32H46N4O4
|
1
|
| 1 |
Ki = 155 nM
|
|
|
|
CP0524748
|
1'-[3-[[(2R)-1-benzylpyrrolidin-2-yl]methoxy]propyl]spiro[1H-2-benzofuran-3,4'-piperidine]
Show/Hide
|
C27H36N2O2
|
1
|
| 1 |
Ki = 158.49 nM
|
|
|
|
CP0384548
|
(1S,2S,6R,14R,15R,16R)-10-bromo-5-(cyclopropylmethyl)-16-[(2R)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8,10,12(20)-trien-11-ol
Show/Hide
|
C29H40BrNO4
|
1
|
| 1 |
Ki = 159 nM
|
|
|
|
CP0434481
|
1-benzhydryl-4-(benzyloxy)-4-phenylpiperidine
Show/Hide
|
C31H31NO
|
1
|
| 1 |
Ki = 162 nM
|
|
|
|
CP0530878
|
8-benzyl-2-butyl-N,N-dimethyl-2-azaspiro[4.5]decan-8-amine
Show/Hide
|
C22H36N2
|
1
|
| 1 |
Ki = 170 nM
|
|
|
|
CP0844983
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(3-methylpyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C29H31Cl2N3O
|
1
|
| 1 |
Ki = 173 nM
|
|
|
|
CP0440371
|
1-benzhydryl-4-(3-methoxyphenyl)piperidin-4-ol
Show/Hide
|
C25H27NO2
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0500257
|
2-(3-(1-(3,3-dimethylbutyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C21H32N4O2
|
1
|
| 1 |
Ki = 186 nM
|
|
|
|
CP0395433
|
(1R,2S,6R,14R,15R,19R)-5-(cyclopropylmethyl)-19-[(3S)-3-hydroxy-2,2-dimethylpentan-3-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,16-tetraen-11-ol
Show/Hide
|
C30H41NO4
|
1
|
| 1 |
Ki = 187 nM
|
|
|
|
CP0391136
|
1-((2S,6S,9aR)-6-Cyclohexyl-octahydro-quinolizin-2-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C22H31N3O
|
1
|
| 1 |
Ki = 189 nM
|
|
|
|
CP0395435
|
(1R,2S,6R,14R,15R,19R)-5-(cyclopropylmethyl)-19-[(1S)-1-hydroxy-1-phenylpropyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,16-tetraen-11-ol
Show/Hide
|
C32H37NO4
|
1
|
| 1 |
Ki = 197 nM
|
|
|
|
CP0493139
|
8-(diphenylmethyl)-1-phenyl-3-(prop-2-en-1-yl)-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C29H31N3O
|
1
|
| 1 |
Ki = 203 nM
|
|
|
|
CP0869821
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-phenyl-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)-N-methylacetamide
Show/Hide
|
C30H32Cl2N2O
|
1
|
| 1 |
Ki = 210 nM
|
|
|
|
CP0411392
|
1-[1-(cyclohexylmethyl)piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C20H28N2O
|
1
|
| 1 |
Ki = 212.8 nM
|
|
|
|
CP0377388
|
4-phenyl-1-(phenyl(pyridin-2-yl)methyl)piperidin-4-ol
Show/Hide
|
C23H24N2O
|
1
|
| 1 |
Ki = 214 nM
|
|
|
|
CP0447825
|
1-[[1-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]indol-3-yl]methyl]piperidin-4-amine
Show/Hide
|
C28H44N4
|
1
|
| 1 |
Ki = 216 nM
|
|
|
|
CP0883408
|
1-{1-[4-Methyl-3-(2-methyl-5-nitro-phenoxy)-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C25H32N4O4
|
1
|
| 1 |
Ki = 218 nM
|
|
|
|
CP0412727
|
8-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C28H29N3O
|
1
|
| 1 |
Ki = 225 nM
|
|
|
|
CP0383418
|
4-phenyl-1-(phenyl(4-(trifluoromethyl)phenyl)methyl)piperidin-4-ol
Show/Hide
|
C25H24F3NO
|
1
|
| 1 |
Ki = 225 nM
|
|
|
|
CP0489675
|
2-(8-cycloheptyl-1-oxo-4-phenyl-2,3,8-triazaspiro[4.5]dec-3-en-2-yl)-N-methylacetamide
Show/Hide
|
C23H32N4O2
|
1
|
| 1 |
Ki = 227 nM
|
|
|
|
CP0500258
|
2-(3-(1-cyclohexylpiperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C21H30N4O2
|
1
|
| 1 |
Ki = 227 nM
|
|
|
|
CP0453868
|
8-(diphenylmethyl)-1-phenyl-3-(prop-2-yn-1-yl)-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C29H29N3O
|
1
|
| 1 |
Ki = 234 nM
|
|
|
|
CP0384547
|
(1S,2S,6R,14R,15R,16R)-9-bromo-5-(cyclopropylmethyl)-16-[(2R)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8,10,12(20)-trien-11-ol
Show/Hide
|
C29H40BrNO4
|
1
|
| 1 |
Ki = 237 nM
|
|
|
|
CP0904419
|
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(3-(piperidin-1-ylmethyl)pyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methanamine
Show/Hide
|
C32H38Cl2N4
|
1
|
| 1 |
Ki = 245 nM
|
|
|
|
CP0412724
|
8-[bis-(3-chloro-phenyl)-methyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H25Cl2N3O
|
1
|
| 1 |
Ki = 249 nM
|
|
|
|
CP0428101
|
8-[bis-(3-fluoro-phenyl)-methyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H25F2N3O
|
1
|
| 1 |
Ki = 250 nM
|
|
|
|
CP0009545
|
1-{1-[1-(4-Cyclohexyl-phenyl)-ethyl]-piperidin-4-yl}-1,3-dihydro-indol-2-one
Show/Hide
|
C27H34N2O
|
1
|
| 1 |
Ki = 253 nM
|
|
|
|
CP0498928
|
N-methyl-2-[2-oxo-3-[1-(4-phenylcyclohexyl)piperidin-4-yl]benzimidazol-1-yl]acetamide
Show/Hide
|
C27H34N4O2
|
1
|
| 1 |
Ki = 253 nM
|
|
|
|
CP0506550
|
2-(3-(1-(cyclohexylmethyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C22H32N4O2
|
1
|
| 1 |
Ki = 259 nM
|
|
|
|
CP0777561
|
exo-8-[Bis(2-chlorophenyl)methyl]-3-(5-oxazolyl)-8-azabicyclo-[3.2.1]octane
Show/Hide
|
C23H22Cl2N2O
|
1
|
| 1 |
Ki = 272 nM
|
|
|
|
CP0491851
|
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C22H26ClN3O2
|
1
|
| 1 |
Ki = 282 nM
|
|
|
|
CP0375405
|
8-(bis(2-chlorophenyl)methyl)-3-(4-(trifluoromethoxy)phenyl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C28H25Cl2F3N2O2
|
1
|
| 1 |
Ki = 285 nM
|
|
|
|
CP0434411
|
1-(2-methoxy-1-phenylethyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C20H25NO2
|
1
|
| 1 |
Ki = 295 nM
|
|
|
|
CP0469634
|
2-(1'-(4-tert-butylcyclohexyl)-2-oxospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1(2H)-yl)-N-methylacetamide
Show/Hide
|
C25H37N3O3
|
1
|
| 1 |
Ki = 295 nM
|
|
|
|
CP0437108
|
1-benzhydryl-4-(pyridin-2-yl)piperidin-4-ol
Show/Hide
|
C23H24N2O
|
1
|
| 1 |
Ki = 313 nM
|
|
|
|
CP0383414
|
4-phenyl-1-(1-phenylethyl)piperidin-4-ol
Show/Hide
|
C19H23NO
|
1
|
| 1 |
Ki = 323 nM
|
|
|
|
CP0394141
|
4-phenyl-1-(phenyl(pyridin-3-yl)methyl)piperidin-4-ol
Show/Hide
|
C23H24N2O
|
1
|
| 1 |
Ki = 323 nM
|
|
|
|
CP0949688
|
(rel)-1-((3-benzyl-8-(bis(2-chlorophenyl)methyl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)pyrrolidin-2-one
Show/Hide
|
C32H34Cl2N2O
|
1
|
| 1 |
Ki = 336 nM
|
|
|
|
CP0383410
|
4-phenyl-1-(phenyl(3-(trifluoromethyl)phenyl)methyl)piperidin-4-ol
Show/Hide
|
C25H24F3NO
|
1
|
| 1 |
Ki = 357 nM
|
|
|
|
CP0424326
|
1-benzhydryl-4-cyclopropylpiperidin-4-ol
Show/Hide
|
C21H25NO
|
1
|
| 1 |
Ki = 376 nM
|
|
|
|
CP0475113
|
3-(bis(2-chlorophenyl)methyl)-8-(4-methylpyridin-2-yl)-3-azabicyclo[3.2.1]octan-8-ol
Show/Hide
|
C26H26Cl2N2O
|
1
|
| 1 |
Ki = 385 nM
|
|
|
|
CP0434692
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(1S)-1-hydroxy-1-phenylpropyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C32H39NO4
|
1
|
| 1 |
Ki = 396 nM
|
|
|
|
CP0882777
|
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-carbamoylpyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C27H26Cl2N4O2
|
1
|
| 1 |
Ki = 401 nM
|
|
|
|
CP0435624
|
1-benzhydryl-4-isopropylpiperidin-4-ol
Show/Hide
|
C21H27NO
|
1
|
| 1 |
Ki = 433 nM
|
|
|
|
CP0445682
|
1-(bis(4-methoxyphenyl)methyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C26H29NO3
|
1
|
| 1 |
Ki = 439 nM
|
|
|
|
CP0422120
|
N-methyl-2-[3-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C26H28N4O2
|
1
|
| 1 |
Ki = 454 nM
|
|
|
|
CP0433322
|
4-(2-(aminomethyl)phenyl)-1-benzylpiperidin-4-ol
Show/Hide
|
C19H24N2O
|
1
|
| 1 |
Ki = 455 nM
|
|
|
|
CP0505500
|
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-3-cyclohexyl-2-hydroxy-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C28H36ClN3O3
|
1
|
| 1 |
Ki = 462 nM
|
|
|
|
CP0844203
|
Exo-8-[bis(2-chlorophenyl)methyl]-3-[3-bromo-2-pyridinyl]-8-azabicyclo[3.2.1]octane
Show/Hide
|
C25H23BrCl2N2
|
1
|
| 1 |
Ki = 467 nM
|
|
|
|
CP0402035
|
2-(3-(1-cyclopentylpiperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C20H28N4O2
|
1
|
| 1 |
Ki = 470 nM
|
|
|
|
CP0463346
|
N-methyl-2-[3-[1-(4-methylpentyl)piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
Show/Hide
|
C21H32N4O2
|
1
|
| 1 |
Ki = 471 nM
|
|
|
|
CP0489676
|
2-(3-(1-(bicyclo[2.2.1]heptan-2-yl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C22H30N4O2
|
1
|
| 1 |
Ki = 487 nM
|
|
|
|
CP0053492
|
8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C29H31F2N3O
|
1
|
| 1 |
Ki = 500 nM
|
|
|
|
CP0392313
|
1-(1-{2-[1-(2-Chloro-5-methyl-phenoxy)-cyclohexyl]-2-imidazol-1-yl-ethyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C30H36ClN5O2
|
1
|
| 1 |
Ki = 509 nM
|
|
|
|
CP0410108
|
1-Ethyl-3-((2S,6S,9aR)-6-phenyl-octahydro-quinolizin-2-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C24H29N3O
|
1
|
| 1 |
Ki = 535 nM
|
|
|
|
CP0433313
|
1-benzhydryl-4-(4-methoxyphenyl)piperidin-4-ol
Show/Hide
|
C25H27NO2
|
1
|
| 1 |
Ki = 588 nM
|
|
|
|
CP0460621
|
2-butyl-8-(dimethylamino)-8-thiophen-2-yl-2-azaspiro[4.5]decan-1-one
Show/Hide
|
C19H30N2OS
|
1
|
| 1 |
Ki = 600 nM
|
|
|
|
CP0536325
|
1-(3,3-diphenylpropyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C26H29NO
|
1
|
| 1 |
Ki = 613 nM
|
|
|
|
CP0524476
|
1-[1-(2-Cyclohexyl-2-hydroxy-ethyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C20H29N3O2
|
1
|
| 1 |
Ki = 620 nM
|
|
|
|
CP0922732
|
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(3-(piperidin-1-ylmethyl)pyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
Show/Hide
|
C34H40Cl2N4O
|
1
|
| 1 |
Ki = 670 nM
|
|
|
|
CP0425723
|
4-(2-(aminomethyl)phenyl)-1-(bis(4-chlorophenyl)methyl)piperidin-4-ol
Show/Hide
|
C25H26Cl2N2O
|
1
|
| 1 |
Ki = 674 nM
|
|
|
|
CP0417436
|
8-(bis(2-chlorophenyl)methyl)-3-(4-carbamoylphenyl)-8-azabicyclo[3.2.1]octane-3-carboxamide
Show/Hide
|
C28H27Cl2N3O2
|
1
|
| 1 |
Ki = 678 nM
|
|
|
|
CP0497038
|
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-4-phenyl-butyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C29H32ClN3O3
|
1
|
| 1 |
Ki = 768 nM
|
|
|
|
CP0421308
|
1-((2S,6S,9aR)-6-Phenyl-octahydro-quinolizin-2-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C22H25N3O
|
1
|
| 1 |
Ki = 786 nM
|
|
|
|
CP0491996
|
1-(1-{2-[1-(2-Chloro-5-methyl-phenoxy)-cyclohexyl]-2-dimethylamino-ethyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C29H39ClN4O2
|
1
|
| 1 |
Ki = 815 nM
|
|
|
|
CP0445012
|
1-phenyl-8-pyridin-4-ylmethyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C19H22N4O
|
1
|
| 1 |
Ki = 824 nM
|
|
|
|
CP0392310
|
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-butyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C23H28ClN3O3
|
1
|
| 1 |
Ki = 838 nM
|
|
|
|
CP0411757
|
(1S,2S,10R,18R)-8-(cyclohexylmethyl)-19-(cyclopropylmethyl)-2,13-dihydroxy-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),12,14,16(22)-tetraen-7-one
Show/Hide
|
C30H38N2O4
|
1
|
| 1 |
Ki = 880 nM
|
|
|
|
CP0486415
|
1-{1-[3-((S)-2-Chloro-5-methyl-phenoxy)-2-hydroxy-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C22H26ClN3O3
|
1
|
| 1 |
Ki = 905 nM
|
|
|
|
CP0522059
|
3-(bis(2-chlorophenyl)methyl)-8-(pyridin-3-yl)-3-azabicyclo[3.2.1]octan-8-ol
Show/Hide
|
C25H24Cl2N2O
|
1
|
| 1 |
Ki = 908 nM
|
|
|
|
CP0526992
|
1-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(2H-tetrazol-5-ylmethyl)benzimidazol-2-one
Show/Hide
|
C28H37N7O3
|
1
|
| 1 |
Ki = 912.01 nM
|
|
|
|
CP0500240
|
2-(3-(1-(isoquinolin-1-ylmethyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C25H27N5O2
|
1
|
| 1 |
Ki = 1050 nM
|
|
|
|
CP0499031
|
1-(1-{2-[1-(2-Chloro-5-methyl-phenoxy)-cyclohexyl]-ethyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C27H34ClN3O2
|
1
|
| 1 |
Ki = 1115 nM
|
|
|
|
CP0463348
|
2-(3-(1-isopentylpiperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C20H30N4O2
|
1
|
| 1 |
Ki = 1118 nM
|
|
|
|
CP0437919
|
1-benzhydryl-4-hexylpiperidin-4-ol
Show/Hide
|
C24H33NO
|
1
|
| 1 |
Ki = 1147 nM
|
|
|
|
CP0505811
|
(2R)-1-benzyl-N-methyl-N-(3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl)pyrrolidine-2-carboxamide
Show/Hide
|
C28H37N3O2
|
1
|
| 1 |
Ki = 1148.15 nM
|
|
|
|
CP0458026
|
1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]-3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]benzimidazol-2-one
Show/Hide
|
C33H45N5O4
|
1
|
| 1 |
Ki = 1174.9 nM
|
|
|
|
CP0440369
|
1-benzhydryl-4-(2H-1lambda*4*-thiazol-2-yl)-piperidin-4-ol
Show/Hide
|
C21H22N2OS
|
1
|
| 1 |
Ki = 1273 nM
|
|
|
|
CP0399975
|
1-benzhydryl-4-(4-ethylphenyl)piperidin-4-ol
Show/Hide
|
C26H29NO
|
1
|
| 1 |
Ki = 1281 nM
|
|
|
|
CP0426771
|
(1S,2S,10R,18R)-8-benzyl-19-(cyclopropylmethyl)-2,13-dihydroxy-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),12,14,16(22)-tetraen-7-one
Show/Hide
|
C30H32N2O4
|
1
|
| 1 |
Ki = 1300 nM
|
|
|
|
CP0440367
|
4-(1-benzhydryl-4-hydroxypiperidin-4-yl)benzonitrile
Show/Hide
|
C25H24N2O
|
1
|
| 1 |
Ki = 1449 nM
|
|
|
|
CP0426817
|
(1S,2S,10R,18R)-19-(cyclopropylmethyl)-2,13-dihydroxy-8-(2-phenylethyl)-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),12,14,16(22)-tetraen-7-one
Show/Hide
|
C31H34N2O4
|
1
|
| 1 |
Ki = 1500 nM
|
|
|
|
CP0549303
|
8-benzyl-2-butyl-8-(dimethylamino)-2-azaspiro[4.5]decan-1-one
Show/Hide
|
C22H34N2O
|
1
|
| 1 |
Ki = 1510 nM
|
|
|
|
CP0479514
|
(3S,4S)-1-benzhydryl-3-methyl-4-phenylpiperidin-4-ol
Show/Hide
|
C25H27NO
|
1
|
| 1 |
Ki = 1571 nM
|
|
|
|
CP0112287
|
(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-acetic acid
Show/Hide
|
C28H37N3O5
|
1
|
| 1 |
Ki = 1595 nM
|
|
|
|
CP0437917
|
1-benzhydryl-4-(3-phenylpropyl)piperidin-4-ol
Show/Hide
|
C27H31NO
|
1
|
| 1 |
Ki = 1667 nM
|
|
|
|
CP0425717
|
1-benzhydryl-4-(4-propylphenyl)piperidin-4-ol
Show/Hide
|
C27H31NO
|
1
|
| 1 |
Ki = 1745 nM
|
|
|
|
CP0377406
|
methyl 2-(4-hydroxy-4-phenylpiperidin-1-yl)-2-phenylacetate
Show/Hide
|
C20H23NO3
|
1
|
| 1 |
Ki = 1887 nM
|
|
|
|
CP0439839
|
1-{1-[3-((R)-2-Chloro-5-methyl-phenoxy)-2-hydroxy-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Show/Hide
|
C22H26ClN3O3
|
1
|
| 1 |
Ki = 1920 nM
|
|
|
|
CP0383412
|
1-benzyl-4-phenylpiperidin-4-ol
Show/Hide
|
C18H21NO
|
1
|
| 1 |
Ki = 1983 nM
|
|
|
|
CP0500259
|
2-(1'-cycloheptyl-2-oxospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1(2H)-yl)-N-methylacetamide
Show/Hide
|
C22H31N3O3
|
1
|
| 1 |
Ki = 2152 nM
|
|
|
|
CP0471064
|
1-[8-benzyl-8-(dimethylamino)-2-azaspiro[4.5]decan-2-yl]ethanone
Show/Hide
|
C20H30N2O
|
1
|
| 1 |
Ki = 2160 nM
|
|
|
|
CP0435623
|
1-benzhydryl-4-benzylpiperidin-4-ol
Show/Hide
|
C25H27NO
|
1
|
| 1 |
Ki = 2176 nM
|
|
|
|
CP0506551
|
2-(3-(1-(cyclobutylmethyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide
Show/Hide
|
C20H28N4O2
|
1
|
| 1 |
Ki = 2560 nM
|
|
|
|
CP0399272
|
8-(bis(2-chlorophenyl)methyl)-3-(fluoromethyl)-3-phenyl-8-azabicyclo[3.2.1]octane
Show/Hide
|
C27H26Cl2FN
|
1
|
| 1 |
Ki = 3151 nM
|
|
|
|
CP0377389
|
1-(2-hydroxy-1-phenylethyl)-4-phenylpiperidin-4-ol
Show/Hide
|
C19H23NO2
|
1
|
| 1 |
Ki = 4035 nM
|
|
|
|
CP0489673
|
N-methyl-2-[2-oxo-3-[1-(quinolin-2-ylmethyl)piperidin-4-yl]benzimidazol-1-yl]acetamide
Show/Hide
|
C25H27N5O2
|
1
|
| 1 |
Ki = 4082 nM
|
|
|
|
CP0435775
|
1-benzhydryl-4-(4-(dimethylamino)phenyl)piperidin-4-ol
Show/Hide
|
C26H30N2O
|
1
|
| 1 |
Ki = 4544 nM
|
|
|
|
CP0431950
|
2-((4-hydroxy-4-phenylpiperidin-1-yl)(phenyl)methyl)benzoic acid
Show/Hide
|
C25H25NO3
|
1
|
| 1 |
Ki = 6753 nM
|
|
|
|
CP0377396
|
N-(2,6-difluorophenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-2-phenylacetamide
Show/Hide
|
C25H24F2N2O2
|
1
|
| 1 |
Ki = 8183 nM
|
|
|
|
CP0433314
|
1-benzhydryl-4-(4-butylphenyl)piperidin-4-ol
Show/Hide
|
C28H33NO
|
1
|
| 1 |
Ki = 9155 nM
|
|
|
|
CP0377405
|
2-(4-hydroxy-4-phenylpiperidin-1-yl)-2-phenylacetonitrile
Show/Hide
|
C19H20N2O
|
1
|
| 1 |
Ki = 10000 nM
|
|
|
|
CP0375095
|
1-(1-Dicyclohexylmethyl-piperidin-4-yl)-1,3-dihydro-indol-2-one
Show/Hide
|
C26H38N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0478453
|
1'-[5-[(2R)-1-benzylpyrrolidin-2-yl]pent-4-enyl]spiro[1,2-dihydroisoindole-3,4'-piperidine]
Show/Hide
|
C28H37N3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0509315
|
(2R)-1-benzyl-N-[3-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propyl]pyrrolidine-2-carboxamide
Show/Hide
|
C28H37N5O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0532447
|
(2R)-1-benzyl-N-[3-[4-(3-ethyl-2-oxobenzimidazol-1-yl)piperidin-1-yl]propyl]pyrrolidine-2-carboxamide
Show/Hide
|
C29H39N5O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0035617
|
N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl]acetamide
Show/Hide
|
C22H32N2O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0038418
|
13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid
Show/Hide
|
C30H39N5O7S2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0043301
|
(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide
Show/Hide
|
C26H35N5O6
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0380884
|
3-ethyl-1-[1-[4-(4-phenylphenyl)butyl]piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C31H36N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0380886
|
3-ethyl-1-[1-[(E)-3-phenylprop-2-enyl]piperidin-4-yl]-3H-indol-2-one
Show/Hide
|
C24H28N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0435385
|
1-[1-(4,4-diphenylbutan-2-yl)piperidin-4-yl]-3-ethyl-3H-indol-2-one
Show/Hide
|
C31H36N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0375815
|
N,N-dimethyl-2-(pyridin-2-ylmethyl)-3-spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-ylpropanamide
Show/Hide
|
C22H29N3O2S
|
1
|
| 1 |
Ki > 10 nM
|
|
|
|
CP0423871
|
2-[(2,6-difluorophenyl)methyl]-N,N-dimethyl-3-spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-ylpropanamide
Show/Hide
|
C23H28F2N2O2S
|
1
|
| 1 |
Ki > 10 nM
|
|
|
|
CP0427576
|
2-[(2-methoxyphenyl)methyl]-N,N-dimethyl-3-spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-ylpropanamide
Show/Hide
|
C24H32N2O3S
|
1
|
| 1 |
Ki > 10 nM
|
|
|
|
CP0495388
|
1'-[2-[(2-chlorophenyl)methyl]-3-fluoropropyl]spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]
Show/Hide
|
C21H25ClFNOS
|
1
|
| 1 |
Ki > 10 nM
|
|
|
|
CP0386704
|
1'-[2-[(2-chlorophenyl)methyl]-3-methoxypropyl]spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]
Show/Hide
|
C22H28ClNO2S
|
1
|
| 1 |
Ki > 40 nM
|
|
|
|
CP0435923
|
2-[(2-chlorophenyl)methyl]-3-spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-ylpropanenitrile
Show/Hide
|
C21H23ClN2OS
|
1
|
| 1 |
Ki > 40 nM
|
|
|
|
CP0544597
|
1'-[2-(chloromethyl)-3-(2-chlorophenyl)propyl]spiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]
Show/Hide
|
C21H25Cl2NOS
|
1
|
| 1 |
Ki > 40 nM
|
|
|
|
CP0891914
|
endo-methyl 6-(8-(bis(2-chlorophenyl)methyl)-3-carbamoyl-8-azabicyclo[3.2.1]octan-3-yl)nicotinate
Show/Hide
|
C28H27Cl2N3O3
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0914952
|
endo-2-(8-(bis(2-chlorophenyl)methyl)-3-carbamoyl-8-azabicyclo[3.2.1]octan-3-yl)-5-fluoroisonicotinic acid
Show/Hide
|
C27H24Cl2FN3O3
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0850391
|
7-[(S)-2-((R)-Acetylamino)-5-guanidino-pentanoylamino]-6-oxo-octahydro-quinolizine-4-carboxylic acid {(R)-1-[1-carbamoyl-2-((R)-4-chloro-phenyl)-ethylcarbamoyl]-4-ureido-butyl}-amide
Show/Hide
|
C33H50ClN11O7
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0858294
|
7-[(R)-2-((S)-2-Acetylamino-5-guanidino-pentanoylamino)-3-cyclohexyl-propionylamino]-6-oxo-octahydro-quinolizine-4-carboxylic acid {(R)-1-[1-carbamoyl-2-((R)-4-chloro-phenyl)-ethylcarbamoyl]-4-ureido-butyl}-amide
Show/Hide
|
C42H65ClN12O8
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0881022
|
7-((R)-2-Acetylamino-3-cyclohexyl-propionylamino)-6-oxo-octahydro-quinolizine-4-carboxylic acid ((R)-1-carbamoyl-4-ureido-butyl)-amide
Show/Hide
|
C27H45N7O6
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
|
CP0930340
|
7-[2-((S)-2-Acetylamino-5-(R)-guanidino-pentanoylamino)-3-cyclohexyl-propionylamino]-6-oxo-octahydro-quinolizine-4-carboxylic acid ((R)-1-carbamoyl-4-ureido-butyl)-amide
Show/Hide
|
C33H57N11O7
|
1
|
| 1 |
Ki > 5000 nM
|
|
|
