General Information of the Compound
Compound ID
CP0776928
Compound Name
Exo-8-[bis(2-chlorophenyl)methyl]-3-(6-fluoro-2-pyridinyl)-8-azabicyclo[3.2.1]octane
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Formula
C25H23Cl2FN2
Molecular Weight
441.377
Canonical SMILES
Fc1cccc([C@H]2C[C@H]3CC[C@@H](C2)N3C(c2ccccc2Cl)c2ccccc2Cl)n1
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InChI
InChI=1S/C25H23Cl2FN2/c26-21-8-3-1-6-19(21)25(20-7-2-4-9-22(20)27)30-17-12-13-18(30)15-16(14-17)23-10-5-11-24(28)29-23/h1-11,16-18,25H,12-15H2/t16-,17+,18-
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InChIKey
CCSVRAYNXZJMEX-BCDXTJNWSA-N
Physicochemical Property
logP
7.0275
Rotatable Bonds
4
Heavy Atom Count
30
Polar Areas
16.13
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 85282691
ChEMBL ID
CHEMBL3084661
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5420 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 25 nM
   TI
   LI
   LO
   TS