General Information of the Compound
Compound ID
CP0498921
Compound Name
2-(8-(4-tert-butylcyclohexyl)-1-oxo-4-phenyl-2,3,8-triazaspiro[4.5]dec-3-en-2-yl)-N-methylacetamide
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Structure
Formula
C26H38N4O2
Molecular Weight
438.616
Canonical SMILES
CNC(=O)CN1N=C(c2ccccc2)C2(CCN(CC2)C2CCC(CC2)C(C)(C)C)C1=O
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InChI
InChI=1S/C26H38N4O2/c1-25(2,3)20-10-12-21(13-11-20)29-16-14-26(15-17-29)23(19-8-6-5-7-9-19)28-30(24(26)32)18-22(31)27-4/h5-9,20-21H,10-18H2,1-4H3,(H,27,31)
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InChIKey
RGJNSJKRCNTAGB-UHFFFAOYSA-N
Physicochemical Property
logP
3.666
Rotatable Bonds
4
Heavy Atom Count
32
Polar Areas
65.01
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46879667
ChEMBL ID
CHEMBL1079940
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 7.3 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 685 nM
   TI
   LI
   LO
   TS
2
Ki = 44 nM
   TI
   LI
   LO
   TS