General Information of the Compound
Compound ID
CP0520032
Compound Name
(6R,8S)-6-(((3R,4R)-4-(4-fluoro-2-methylphenyl)-3-hydroxypiperidin-1-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-ol
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Structure
Formula
C22H27FN2O2
Molecular Weight
370.468
Canonical SMILES
Cc1cc(F)ccc1[C@H]1CCN(C[C@H]2C[C@H](O)c3ncccc3C2)C[C@@H]1O
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InChI
InChI=1S/C22H27FN2O2/c1-14-9-17(23)4-5-18(14)19-6-8-25(13-21(19)27)12-15-10-16-3-2-7-24-22(16)20(26)11-15/h2-5,7,9,15,19-21,26-27H,6,8,10-13H2,1H3/t15-,19-,20+,21+/m1/s1
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InChIKey
JTAMWNPJYHNWBD-IDCXYZFESA-N
Physicochemical Property
logP
2.97532
Rotatable Bonds
3
Heavy Atom Count
27
Polar Areas
56.59
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24894533
ChEMBL ID
CHEMBL487457
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 21 nM
   TI
   LI
   LO
   TS