General Information of the Compound
Compound ID
CP0915535
Compound Name
cyclo [Asp6,Lys10]N/OFQ(1-13)NH2
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Synonyms
CHEMBL1162357
Cyclo-[Asp6,Lys10]N/OFQ(1-13)NH2
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Structure
Formula
C66H107N23O15
Molecular Weight
1462.728
Canonical SMILES
C[C@H](NC(=O)[C@@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccccc2)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(N)=O
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InChI
InChI=1S/C66H107N23O15/c1-37(55(95)84-46(25-16-30-76-65(71)72)59(99)83-43(54(70)94)22-10-13-27-67)80-58(98)44-24-12-15-29-75-50(91)34-49(62(102)81-38(2)56(96)85-47(26-17-31-77-66(73)74)61(101)87-45(60(100)86-44)23-11-14-28-68)88-64(104)53(39(3)90)89-63(103)48(33-41-20-8-5-9-21-41)82-52(93)36-78-51(92)35-79-57(97)42(69)32-40-18-6-4-7-19-40/h4-9,18-21,37-39,42-49,53,90H,10-17,22-36,67-69H2,1-3H3,(H2,70,94)(H,75,91)(H,78,92)(H,79,97)(H,80,98)(H,81,102)(H,82,93)(H,83,99)(H,84,95)(H,85,96)(H,86,100)(H,87,101)(H,88,104)(H,89,103)(H4,71,72,76)(H4,73,74,77)/t37-,38-,39+,42-,43-,44-,45-,46-,47-,48-,49-,53-/m0/s1
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InChIKey
QRTPPIOAYQKBJN-WYNMOEERSA-N
Physicochemical Property
logP
-7.73986
Rotatable Bonds
38
Heavy Atom Count
104
Polar Areas
643.48
Hydrogen Bond Donor Count
24
Hydrogen Bond Acceptor Count
20
Complexity
104

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25084507
SID: 56247460
ChEMBL ID
CHEMBL1162357
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 4.12 nM
   TI
   LI
   LO
   TS
2
Ki = 0.34 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Cyclo-[Asp6,Lys10]N/OFQ(1-13)NH2 )
Drug Name Cyclo-[Asp6,Lys10]N/OFQ(1-13)NH2
Target(s)
Nociceptin receptor (OPRL1)
Inhibitor