General Information of the Compound
| Compound ID |
CP0387899
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| Compound Name |
8-(dio-tolylmethyl)-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
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| Synonyms |
NOP agonists (pain, anxiety, cough, urinary incontinence), Merck & Co
NOP receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough
Nociceptin opioid peptide receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough
Nociceptin receptor ligands (pain/anxiety/cough/urinary incontinence)
Nociceptin receptor ligands (pain/anxiety/cough/urinary incontinence), Merck & Co
Nociceptin receptor ligands (pain/anxiety/cough/urinary incontinence),Schering-Plough
ORL1 receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough
Opioid receptor-like 1 receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough
SCH-221510
SCH-225288
SCH-655842
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| Structure |
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| Formula |
C28H31NO
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| Molecular Weight |
397.562
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| Canonical SMILES |
Cc1ccccc1C(N1C2CCC1CC(O)(C2)c1ccccc1)c1ccccc1C
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| InChI |
InChI=1S/C28H31NO/c1-20-10-6-8-14-25(20)27(26-15-9-7-11-21(26)2)29-23-16-17-24(29)19-28(30,18-23)22-12-4-3-5-13-22/h3-15,23-24,27,30H,16-19H2,1-2H3
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| InChIKey |
LOSJNRBXNQTUNT-UHFFFAOYSA-N
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01200, Delta-type opioid receptor
Protein ID: PT00983, Kappa-type opioid receptor
Protein ID: PT01515, Mu-type opioid receptor
Protein ID: PT01360, Nociceptin receptor
Clinical Information about the Compound