General Information of the Compound
Compound ID
CP0396234
Compound Name
1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-indol-2-one
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Structure
Formula
C20H22N2O
Molecular Weight
306.409
Canonical SMILES
O=C1Cc2ccccc2N1C1CCN(Cc2ccccc2)CC1
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InChI
InChI=1S/C20H22N2O/c23-20-14-17-8-4-5-9-19(17)22(20)18-10-12-21(13-11-18)15-16-6-2-1-3-7-16/h1-9,18H,10-15H2
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InChIKey
ZRIOIQJUIUJPED-UHFFFAOYSA-N
Physicochemical Property
logP
3.2403
Rotatable Bonds
3
Heavy Atom Count
23
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 3655995
SID: 16475076
ChEMBL ID
CHEMBL320874
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 < 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 84.5 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 1981 nM
   TI
   LI
   LO
   TS
2
Ki = 91.1 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  3
1
EC50 = 174 nM
   TI
   LI
   LO
   TS
2
Ki = 201 nM
   TI
   LI
   LO
   TS
3
Ki = 201.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 201 nM