General Information of the Compound
Compound ID
CP0372832
Compound Name
8-(bis(2-chlorophenyl)methyl)-N-(2-methoxyethyl)-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide
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Structure
Formula
C30H32Cl2N2O2
Molecular Weight
523.504
Canonical SMILES
COCCNC(=O)C1(CC2CCC(C1)N2C(c1ccccc1Cl)c1ccccc1Cl)c1ccccc1
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InChI
InChI=1S/C30H32Cl2N2O2/c1-36-18-17-33-29(35)30(21-9-3-2-4-10-21)19-22-15-16-23(20-30)34(22)28(24-11-5-7-13-26(24)31)25-12-6-8-14-27(25)32/h2-14,22-23,28H,15-20H2,1H3,(H,33,35)
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InChIKey
RYSIREMKKVFZGH-UHFFFAOYSA-N
Physicochemical Property
logP
6.4102
Rotatable Bonds
8
Heavy Atom Count
36
Polar Areas
41.57
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44574962
ChEMBL ID
CHEMBL466693
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 60 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 8.2 nM
   TI
   LI
   LO
   TS