General Information of the Compound
Compound ID
CP0454021
Compound Name
1-phenyl-8-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
    Show/Hide
Structure
Formula
C24H29N3O
Molecular Weight
375.516
Canonical SMILES
O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCCc2ccccc12
    Show/Hide
InChI
InChI=1S/C24H29N3O/c28-23-24(27(18-25-23)20-10-2-1-3-11-20)14-16-26(17-15-24)22-13-7-5-9-19-8-4-6-12-21(19)22/h1-4,6,8,10-12,22H,5,7,9,13-18H2,(H,25,28)
    Show/Hide
InChIKey
FSQXIBWOJFQYMW-UHFFFAOYSA-N
Physicochemical Property
logP
3.8826
Rotatable Bonds
2
Heavy Atom Count
28
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 18782384
ChEMBL ID
CHEMBL442090
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01200, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1906 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 203 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 673 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 14.5 nM
   TI
   LI
   LO
   TS