General Information of the Compound
Compound ID
CP0382639
Compound Name
N-benzyl-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
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Structure
Formula
C35H44N4O4
Molecular Weight
584.761
Canonical SMILES
COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(CC(=O)NCc3ccccc3)c2=O)C(C)C)c1
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InChI
InChI=1S/C35H44N4O4/c1-25(2)32(43-33-22-29(42-4)15-14-26(33)3)18-21-37-19-16-28(17-20-37)39-31-13-9-8-12-30(31)38(35(39)41)24-34(40)36-23-27-10-6-5-7-11-27/h5-15,22,25,28,32H,16-21,23-24H2,1-4H3,(H,36,40)
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InChIKey
ISDZBFORXHKYAN-UHFFFAOYSA-N
Physicochemical Property
logP
5.56702
Rotatable Bonds
12
Heavy Atom Count
43
Polar Areas
77.73
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44437647
ChEMBL ID
CHEMBL238600
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 432 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 569 nM
   TI
   LI
   LO
   TS
2
Ki = 29 nM
   TI
   LI
   LO
   TS