General Information of the Compound
Compound ID
CP0449602
Compound Name
1-pyrimidin-2-yl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)piperidine-4-carboxamide
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Structure
Formula
C26H35N5O
Molecular Weight
433.6
Canonical SMILES
O=C(NCCCN1CCC2(CCc3ccccc23)CC1)C1CCN(CC1)c1ncccn1
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InChI
InChI=1S/C26H35N5O/c32-24(22-8-17-31(18-9-22)25-28-13-3-14-29-25)27-15-4-16-30-19-11-26(12-20-30)10-7-21-5-1-2-6-23(21)26/h1-3,5-6,13-14,22H,4,7-12,15-20H2,(H,27,32)
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InChIKey
OICZWBPIOMFLGW-UHFFFAOYSA-N
Physicochemical Property
logP
3.1793
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
61.36
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44407080
ChEMBL ID
CHEMBL202541
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 1000 nM
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