General Information of the Compound
Compound ID
CP0522060
Compound Name
8-(bis(2-chlorophenyl)methyl)-N-isopropyl-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide
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Structure
Formula
C30H32Cl2N2O
Molecular Weight
507.505
Canonical SMILES
CC(C)NC(=O)C1(CC2CCC(C1)N2C(c1ccccc1Cl)c1ccccc1Cl)c1ccccc1
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InChI
InChI=1S/C30H32Cl2N2O/c1-20(2)33-29(35)30(21-10-4-3-5-11-21)18-22-16-17-23(19-30)34(22)28(24-12-6-8-14-26(24)31)25-13-7-9-15-27(25)32/h3-15,20,22-23,28H,16-19H2,1-2H3,(H,33,35)
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InChIKey
WSYZPVUHMNOUKM-UHFFFAOYSA-N
Physicochemical Property
logP
7.1722
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
32.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44574892
ChEMBL ID
CHEMBL467699
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 333 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10 nM
   TI
   LI
   LO
   TS